Diagnosis or exclusion of systemic cytomegalovirus (CMV) disease in AIDS patients during febrile episodes by the level of the CMV antigenemia (CMV-Ag) test.

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

Diagnosis or exclusion of systemic cytomegalovirus (CMV) disease in AIDS patients during febrile episodes by the level of the CMV antigenemia (CMV-Ag) test.

Int Conf AIDS. 1991 Jun 16-21;7(2):252 (abstract no. W.B.2280). Unique Identifier : AIDSLINE ICA7/3228091
Sprenger HG; Weits J; ven der Giessen M; Steunebrink G; Schirm J; The TH; University Hospital, Groningen, The Netherlands

Abstract: OBJECTIVE: To determine the role of CMV during febrile periods by detection of antigenemia and viremia. METHODS: Prospectively 33 CMV seropositive AIDS patients were studied. CMV-Ag (semi-quantitatively expressed as a low or high number of CMV-Ag positive cells per 50.000 leucocytes) and CMV isolation from blood (viremia) were determined during febrile periods twice weekly. RESULTS: Fifty-six febrile periods occurred. CMV-Ag and viremia were both present in 24 (43%) periods. Altogether CMV-Ag was positive in 34 (61%) periods [21 patients (64%)]. In 9 patients (27%) with 10 periods (18%) a high number of CMV-Ag positive cells was detected. In all these periods disseminated CMV disease was present as proven by exclusion of other causes and disappearance of fever with CMV treatment. This CMV syndrome occurred only in patients with AIDS for more than 1 year. A low number of CMV-Ag positive cells was present during 24 periods (43%), in which CMV was only present as a co-pathogen (especially together with Mycobacterium Avium). Two patients had CMV retinitis during this systemic CMV syndrome. CONCLUSIONS: With the CMV antigenemia assay it is possible to suggest or exclude quickly the significance of CMV disease in febrile periods of AIDS patients.

Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Antigens, Surface/*ANALYSIS Antigens, Viral/*ANALYSIS Cytomegalovirus/*IMMUNOLOGY Cytomegalovirus Infections/COMPLICATIONS/*DIAGNOSIS Human Retinitis/COMPLICATIONS/DIAGNOSIS Viremia/COMPLICATIONS/*DIAGNOSIS ABSTRACT
912130
M91C1764

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