Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.
ONCOGENESIS: ONCOGENES IN SIGNAL TRANSDUCTION AND CELL PROLIFERATION
Adv Applied Biotechnol Ser; 6:1-343 1990. Unique Identifier : AIDSLINE ICDB/91677155 Anonymous; No affiliation given
Abstract:
So far about 55 oncogenes have been identified. The products of many of these genes have been identified in cells and great efforts are now being made to understand the biology and role of these oncogene products in cell development and growth. Just how these gene products interact and affect the initiation of cell growth and proliferation at an abnormal or detrimental level remains to be determined. This volume includes papers presented at the First International Conference on Gene Regulation, Oncogenesis and AIDS, held in Loutraki, Greece, on 15-21, September 1989. Topics include platelet-derived growth factor (PDGF) in human proliferative diseases; PDGF-signaling pathways in malignancy; the structure and expression of pp90(rsk), a highly conserved mitogen-responsive serine-specific kinase; mos proto-oncogene function; specific point mutations potentiating tumor-suppressing activity in Krev-1; dominant negative mutations of ras oncogenes; ras oncogenes in multistep carcinogenesis; ras p21 oncoprotein expression in human cervical intraepithelial neoplasias and other benign conditions of the uterine cervix; long terminal repeat insertion 5' of normal proto-ras elicits transformation and proto-jun upregulation; a 90,000-dalton heat shock protein gene (increased expression in the human mammary cell line HBL100 converted to a tumorigenic phenotype by the EJ/T24 Harvey ras oncogene); heterogeneity of proto-myb product in chicken hematopoietic tissues; the myb oncogene (transcriptional regulation and translation); regulation of the G0/G1 transition genes by c-myc; lack of correlation between c-myc and transferrin receptor expression in proliferating HL60 cells; regular fragmentation of chromatin upon treatment with detergent; the ets family of genes in leukemias and other human diseases; molecular characterization of the ets gene family; chicken, mouse and human ets-1 proteins with the same predicted mass but different electrophoretic mobilities; structural and functional characterization of the promoter of human ets-2 oncogene; identification and characterization of the ets family of nuclear oncoproteins; studies of the leukemogenic and mitogenic properties of v-ets using mouse retroviral vectors; the biochemical and biological properties of the ets genes; functional domains of the ets family proteins; developmental expression and phylogenetic analysis of the ets proto-oncogenes; and BCR protein complexes in Philadelphia chromosome-positive and negative leukemic cells.
Keywords: Animal Cell Division/*PHYSIOLOGY Cell Transformation, Neoplastic/*GENETICS Gene Expression Regulation, Neoplastic/*PHYSIOLOGY Human Oncogenes/*GENETICS Signal Transduction/*PHYSIOLOGY MONOGRAPH 912130
M91C4083
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Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.
