Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.
BOVINE LEUKEMIA VIRUS (BLV): A MODEL VIRUS FOR THE HUMAN T LYMPHOCYTOTROPHIC RETROVIRUSES
Diss Abstr Int [B]; 51(9):4222 1991. Unique Identifier : AIDSLINE ICDB/91676137 Johnson R; Michigan State Univ.
Abstract:
The objective of these studies was to investigate the potential of BLV infection in sheep as a model system for studying the biology of leukemogenic retroviruses of animals and humans. A prospective study of the serologic, hematologic, and histologic changes of sheep infected with BLV was done. Whole blood from a BLV seropositive cow was used to infect 8 sheep with BLV. Antibodies to BLV were detectable in the sheep 3 wk after exposure and have persisted for 120 wk. All control sheep have remained seronegative. There were no differences between the hematologic counts and percentages of the infected and control sheep during the first 120 wk of this study. However, one sheep did develop a leukopenia and lymphopenia 95 wk after infection and died of histologically-confirmed lymphosarcoma 10 days later. A colony assay for culturing sheep peripheral blood lymphocytes in soft agar was standardized according to several important technical parameters. This assay was then used to study colony formation by lymphocytes from bovine leukemia virus-infected, aleukemic sheep as an alternative means of evaluating possible abnormalities in the interleukin 2 (IL 2)/interleukin 2 receptor system in these sheep. There was no difference in the number of lymphocyte colonies formed by cells from BLV-infected and control sheep. Nor was there a difference in the number of colonies formed by lymphocytes from the BLV-infected sheep when autologous serum was replaced with either pooled serum from the infected sheep or from the control sheep. Thus, we were not able to demonstrate abnormalities in IL 2 activity in aleukemic sheep infected with BLV by using a lymphocyte colony assay. The biological similarities between BLV and human T lymphocytotrophic retroviruses, especially HTLV I, suggests that BLV-infected sheep may prove to be a useful animal model for studying mechanisms of leukemogenesis induced by both human and animal lymphocytotrophic oncogenic retroviruses. (Full text available from University Microfilms International, Ann Arbor, MI, as Order No. AAD91-02691).
Keywords: Animal *Disease Models, Animal Human HTLV-BLV Viruses/*PATHOGENICITY Leukemia Virus, Bovine/*PATHOGENICITY Leukemia, Experimental/*BLOOD/PATHOLOGY Sheep THESIS 912130
M91C4080
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Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.
