CONCEPTS OF CANCER BIOLOGY: TUMOR IMMUNOLOGY NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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CONCEPTS OF CANCER BIOLOGY: TUMOR IMMUNOLOGY

Comprehensive Textbook of Oncology. Second Edition. Moossa AR et al, eds. Baltimore, Williams and Wilkins, p. 101-19, 1991.. Unique Identifier : AIDSLINE ICDB/91676538
Anonymous; No affiliation given

Abstract: There is justifiable optimism for a renewed intensification of efforts to translate modern immunology and molecular technology into tumor immunotherapeutic protocols. Activating the immune system can cause a response against quiescent tumor cells and lymphocytes can retain long-term memory for tumor-specific reactivity. Tumor immunology is reviewed in four chapters: (1) overview of tumor immunology (antigen presentation, T-cell activation, tumor antigens, and gene transfection); (2) current views on immune surveillance (tumor cell immunogenicity, immune surveillance in operation, and tumor surveillance without immunogenicity); (3) immunologic mechanisms of tumor cell killing (monoclonal antibodies, cellular immunity [antigen-restricted and antigen-unrestricted lymphocytes, monocytes/macrophages and neutrophils, and enhancement of effector cell killing], cytokines, and nonspecific immunostimulants); and (4) malignancies associated with immune deficiencies (malignancies in organ transplant recipients [cancers of the skin and lips, non-Hodgkin's lymphoma, Kaposi's sarcoma, and carcinomas of the vulva and perineum], cancers following cyclosporine therapy, cancers in nontransplant patients (pts) given immunosuppressive therapy, second cancers in pts given cytotoxic therapy, primary immunodeficiency states, cancers in AIDS [Kaposi's sarcoma, lymphomas, and other cancers], and possible causes of cancer in immunodeficient pts).
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Antigens, Neoplasm/IMMUNOLOGY Cytokines/PHYSIOLOGY Cytotoxicity, Immunologic/IMMUNOLOGY Human Immune Tolerance/IMMUNOLOGY Immunologic Surveillance Neoplasms/*IMMUNOLOGY T-Lymphocytes/IMMUNOLOGY MONOGRAPHKWDacquiredimmunodeficiencysyndrome/immunologyantigens,neoplasm/immunologycytokines/physiologycytotoxicity,immunologic/immunologyhumanimmunetolerance/immunologyimmunologicsurveillanceneoplasms/KWDimmunologyt-lymphocytes/immunologymonograph
912130
M91C4074

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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