Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.
AIDS VACCINE RESEARCH AND CLINICAL TRIALS
AIDS Vaccine Research and Clinical Trials. Putney SD and Bolognesi DP, eds. New York, Marcel Dekker, 480 p., 1990.. Unique Identifier : AIDSLINE ICDB/91676940 Anonymous; No affiliation given
Abstract:
Recently, impressive strides have been made in the development of vaccines against complex viruses such as hepatitis B. However, HIV has several characteristics that make it a more formidable challenge: it is a retrovirus; it varies the amino-acid sequence of the envelope and other immune targets; readily available animal models of infection and disease do not exist; and clinical trials may be difficult to conduct. This book assembles reports and summaries from researchers involved in the development of a vaccine for HIV. Topics include features of the HIV envelope and development of a subunit vaccine; prospects for immunologic intervention in the interaction of HIV with its cellular receptor (CD4); implications of the structure and function of the HIV envelope for vaccine development; conserved and divergent features of HIV and simian immunodeficiency viruses (SIV); genetic variability of HIVs; application of T-cell immunity and vaccine engineering to the AIDS virus; anti-HIV-1 antibody-dependent cellular cytotoxicity; cytotoxic T-lymphocyte responses to HIV-1 in infected individuals; biochemical and immunologic characterizations of HIV envelope glycoproteins expressed by recombinant vaccinia virus; large-scale production, purification, and immunologic analysis of a vaccinia recombinant-derived HIV-1 gp160; CD4-gp120 interaction (idiotype mimicry as putative vaccines and therapeutics against HIV infection); theoretical considerations underlying a modified noninfectious whole-virus approach to prophylactic and therapeutic immunization against AIDS; equine infectious anemia virus as a natural model for the immunologic management of lentivirus infections; induction of protective immunity against an immunosuppressive mouse retrovirus providing possible parallels with HIV; epitopes responsible for fusion and virus neutralization in the glycoprotein of ovine and caprine lentiviruses; infection of nonhuman primates with HIV and SIV; aspects of HIV-related viruses relevant to vaccine development; use of SIV for AIDS vaccine research; a specific antibody activity that neutralizes HIV infectivity in vivo; recombinant-derived hepatitis B vaccine as a paradigm for other subunit vaccines; epidemiologic and prevention aspects of HIV-1 infection in central Africa; clinical trials of AIDS vaccines; and regulatory, scientific, and ethical issues associated with AIDS vaccines.
Keywords: Animal Antibody Formation/*IMMUNOLOGY Epitopes/IMMUNOLOGY Human HIV/*IMMUNOLOGY HIV Antigens/IMMUNOLOGY HIV Infections/IMMUNOLOGY/*PREVENTION & CONTROL Viral Vaccines/*ADMINISTRATION & DOSAGE/IMMUNOLOGY MONOGRAPH 912130
M91C4071
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Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.
