EFFECT OF ISOPRINOSINE (ISO) ON UPTAKE AND METABOLISM OF 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) IN HUMAN PURIFIED MONOCYTES (HPM) (MEETING ABSTRACT) NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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EFFECT OF ISOPRINOSINE (ISO) ON UPTAKE AND METABOLISM OF 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) IN HUMAN PURIFIED MONOCYTES (HPM) (MEETING ABSTRACT)

Proc Annu Meet Am Assoc Cancer Res; 32:A2352 1991. Unique Identifier : AIDSLINE ICDB/91675155
Riva C; Barra Y; Yeramian P; INSERM 278, Faculte de Pharmacie, Marseille, France

Abstract: AIDS patients currently treated with AZT may undergo concomitant treatment with ISO (immunomodulating drug). Therefore, uptake and metabolism of AZT in presence of ISO were investigated in HPM. HPM were exposed over 4 hr to AZT (1 to 15 uM), combined with ISO, at 2 ratios of concentrations of AZT/ISO (1:1, 1:10). The uptake of AZT was rapid and dose-dependent into HPM and was not modified by ISO. AZT metabolite formation was not dose-dependent and was plateauing after 2 hr. The major metabolite was AZTMP. The addition of ISO increased considerably AZTDP and AZTTP formation at 1 hr while at 4 hr, only AZT and AZTMP were found at great levels. These in vitro results indicate that ISO did not alter AZT uptake and demonstrate a favorable effect on AZT metabolism under conditions of short-term exposure of 1 hr.
Keywords: Cells, Cultured Human Inosine Pranobex/METABOLISM/*PHARMACOLOGY Monocytes/DRUG EFFECTS/*METABOLISM Thymine Nucleotides/METABOLISM Zidovudine/*ANALOGS & DERIVATIVES/METABOLISM ABSTRACT

KWDcells,culturedhumaninosinepranobex/metabolism/KWDpharmacologymonocytes/drugeffects/KWDmetabolismthyminenucleotides/metabolismzidovudine/KWDanalogs&derivatives/metabolismabstract
910830
M9181005

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