Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.
IMMUNE SYSTEM AND CANCER
Immune System and Cancer. Tokyo, 1988. Hamaoka T et al, eds. Philadelphia, Taylor and Francis, 347 p., 1989.. Unique Identifier : AIDSLINE ICDB/91662231 Anonymous; No affiliation given
Abstract:
This book contains the proceedings of the 19th International Symposium of The Princess Takamatsu Cancer Research Fund, which presented results in a number of areas of immune cell biology directed toward the problems of cancer. Keynote lectures addressed immunologic aspects of B-cell-derived tumors in humans and rodents and interactions among receptors in regulation of T-lymphocyte responses. These subjects were discussed: transformation by viral or cellular oncogene, growth factor and growth control, T-cell development and repertoire selection, mechanisms of antigen recognition, role of receptors on T cells in immune responses, tumor antigens and antitumor immune responses, and molecular and cellular mechanisms of antitumor immune responses. Papers addressed these topics: human retroviruses and herpes viruses in immune dysfunctions and neoplasia; neu oncogene product in cell transformation and normal development; immunologic abnormalities in human interleukin-2 (IL-2)/IL-2 receptor L chain transgenic mice; possible roles of ATL-derived factor in IL-2 receptor and Fc epsilon R2 gene activation in lymphocyte transformation; T-cell antigen receptor (TCR) as a complex signal-transducing molecule; T-cell repertoire selection in TCR transgenic mice; role of thymic-stroma-derived T-cell growth factor in the growth of immature thymocytes and T-cell repertoire selection; T-cell selection in the thymus; rearrangement, deletion, and translocation of the human delta T-cell receptor; analysis of CD4 and CD2 receptor function; mechanisms of immunodominance in T-cell recognition and applications to vaccine design; molecular basis of antigen presentation; immune recognition and effector function in subsets of CD4 T cell; immune mechanisms of tissue destruction in vivo; expression of TCR V beta 8 determinants on antigen-specific T-helper factor; molecular polymorphism and suppressive signal transduction of I-J as a second TCR for self; activation of immune responses to prevent malignant tumor growth by in vivo administration of anti-CD3 monoclonal antibody, analysis of melanoma antigen and its involvement in tumor-escape mechanisms; genes encoding T-cell-defined tum- antigens; induction of tumor-specific in vivo protective immunity with tumor-antigen-pulsed antigen-presenting cells; gene activation in type I IFN and IL-2 systems; requirements for T-cell recognition and elimination of retrovirally transformed cells; cytotoxic T-cell clones against human autologous cancers; properties of target molecule of murine LAK cells and clones; targeting of cytotoxic cells against tumors with heterocross-linked bispecific antibodies; and immunotoxins for therapy of cancer, AIDS, and immune dysfunctions.
Keywords: Animal Antigens, Neoplasm/*IMMUNOLOGY B-Lymphocytes/*IMMUNOLOGY Cell Line Cytotoxicity, Immunologic/IMMUNOLOGY Human Lymphocyte Transformation/IMMUNOLOGY Neoplasms/*IMMUNOLOGY Receptors, Antigen, T-Cell/IMMUNOLOGY T-Lymphocytes/*IMMUNOLOGY Tumor Cells, Cultured/*IMMUNOLOGY MONOGRAPH 910430
M9140691
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Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.
