Subcellular localization of HPA-23 in different rat organs: electron microprobe study. NLM AIDSLINE Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

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Subcellular localization of HPA-23 in different rat organs: electron microprobe study.

Exp Mol Pathol. 1990 Dec;53(3):255-64. Unique Identifier : AIDSLINE MED/91078465
Berry JP; Galle P; SC 27 de l'INSERM, Centre de Microanalyse Appliquee a la; Biologie du CNRS, Faculte de Medecine, Creteil, France.

Abstract: The anti-viral drug HPA-23 (ammonium 21-tungsto-9-antimonate) has been proposed for use in the combat against AIDS. The two elements tungsten (W) and antimony (Sb) in the molecule enable the intracellular localization and possible breakdown of the product to be studied using electron probe microanalysis methods. Such studies have been carried out after intravenous injection of different doses of HPA-23 in the rat followed by removal of the liver, kidney, thymus, spleen, bone marrow, and lung. HPA-23 was concentrated in the lysosomes and localized in the macrophages of different tissues (thymus, spleen, and bone marrow). The W/Sb ratio was identical in these macrophages. This localization is perhaps relevant to the mechanism of action of HPA-23.
Keywords: Animal Antimony/*PHARMACOKINETICS Antiviral Agents/*PHARMACOKINETICS Dose-Response Relationship, Drug Electron Probe Microanalysis Rats Support, Non-U.S. Gov't Tissue Distribution Tungsten/*PHARMACOKINETICS JOURNAL ARTICLEKWDanimalantimony/KWDpharmacokineticsantiviralagents/KWDpharmacokineticsdose-responserelationship,drugelectronprobemicroanalysisratssupport,non-uKWDsKWDgov'ttissuedistributiontungsten/KWDpharmacokineticsjournalarticle
910430
M9140646

Copyright © 1991 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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