Depression in the context of human immunodeficiency virus infection: implications for treatment.

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

Depression in the context of human immunodeficiency virus infection: implications for treatment.

J Clin Psychiatry. 1990 Dec;51(12):497-501. Unique Identifier : AIDSLINE MED/91079125
Hintz S; Kuck J; Peterkin JJ; Volk DM; Zisook S; Department of Psychiatry, University of California, San Diego.

Abstract: A chart review of 90 male outpatients was conducted to document the type of depressive symptomatology associated with HIV infection and to review the nature of antidepressant treatment provided in two university-affiliated outpatient settings. Forty-five individuals who tested positive for HIV infection and who were treated with antidepressant medications were compared with a like number of individuals who had no known risk factors as determined by chart review for HIV infection. Although depressive symptoms were generally similar among the two groups, HIV-positive individuals reported greater decreases in sleep and appetite than the HIV-negative comparison group. Overall, imipramine and fluoxetine earned the most favorable efficacy ratings while producing minimal side effect ratings in both HIV-positive and HIV-negative patients. Among the HIV-positive patients, the asymptomatic group had a better response to treatment with antidepressant medications than either the ARC or AIDS patient groups.

Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PSYCHOLOGY Adult Antidepressive Agents/ADVERSE EFFECTS/*THERAPEUTIC USE AIDS-Related Complex/COMPLICATIONS/PSYCHOLOGY Comparative Study Depressive Disorder/*DRUG THERAPY Drug Evaluation Fluoxetine/ADVERSE EFFECTS/THERAPEUTIC USE Human HIV Seropositivity/COMPLICATIONS/PSYCHOLOGY Imipramine/ADVERSE EFFECTS/THERAPEUTIC USE Male Medical Records Middle Age Retrospective Studies Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE
910430
M9140641

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1991. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1991. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .