FUNDAMENTAL IMMUNOLOGY. SECOND EDITION

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

FUNDAMENTAL IMMUNOLOGY. SECOND EDITION

Fundamental Immunology. Second Edition. Paul WE, ed. New York, Raven, 1123 p., 1989.. Unique Identifier : AIDSLINE ICDB/90665505
Anonymous; No affiliation given

Abstract: Fundamental Immunology is an advanced textbook that provides a sophisticated treatment of the main areas of modern immunology. This volume covers the cells and organs of the immune system; antigens, antibodies, and receptors; lymphocyte activation, proliferation, and differentiation; the major histocompatibility complex (MHC); regulation of the immune response; effector mechanisms of immunity; critical techniques in immunology (flow cytometry, fluorescence-activated cell sorting, and long-term culture of immunocompetent cells); and immunologic mechanisms in disease. Specific topics include the history of immunology; B lymphocytes; T lymphocytes and the thymus; macrophages, antigen-presenting cells, and antigen handling and presentation; lymphoid tissues and organs; evolution of the immune system; immunogenicity and antigen structure; immunoglobulin (Ig) structure and function; molecular genetics of Igs; T-lymphocyte receptors; antigen-antibody interactions and monoclonal antibodies; T-lymphocyte activation; B-lymphocyte activation and proliferation; Ig secretion; accessory molecules; MHC antigens and genes; MHC control of T-cell recognition; immunologic tolerance; T-cell-mediated regulation (help and suppression); T-cell-derived lymphokines; macrophage-derived mediators (interleukin-1, tumor necrosis factor, interleukin-6, interferon, and related cytokines); idiotypic networks; complement; phagocytosis; inflammation; functions and mechanisms of lysis induced by cytotoxic T lymphocytes and natural killer cells; delayed-type hypersensitivity and the induction of activated, cytotoxic macrophages; autoimmunity and autoimmune diseases; allergy; transplantation and graft rejection; tumor immunology; immunoparasitology; vaccines; primary immunodeficiency diseases; and immunology of HIV infection.

Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Animal Antibody Formation/PHYSIOLOGY Human Immunity, Cellular/PHYSIOLOGY Neoplasms/*IMMUNOLOGY Transplantation Immunology/*IMMUNOLOGY MONOGRAPH
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