Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
MANIPULATING THE MAMMALIAN GENE
J Cell Biochem; (Suppl 14A):337-82 1990. Unique Identifier : AIDSLINE ICDB/90665403 Anonymous; No affiliation given
Abstract:
Abstracts are presented from a symposium on manipulating the mammalian genome, held January 22-28, 1990, in Tamarron, CO, as part of the 19th Annual UCLA Symposia on Molecular and Cellular Biology. Plenary and poster sessions focused on developmental genetics, generation of dominant mutants using transgenic mice, generation of mouse mutants by gene disruption or gene inhibition, generation of targeted mouse mutants, the X chromosome, gene therapy, genome mapping, and insertional and targeted mutations. Among the specific topics were transgenic mice as disease models; molecular analysis of mouse W/c-Kit locus; imprinting by DNA methylation; molecular genetic analysis of cell lineage development; tumor development and progression in v-jun transgenic mice; lethal mutations cause by DNA insertion; retroviral insertional mutagenesis; activity of the myc family of nuclear oncogenes in normal and malignant cells; structure and function of the human Y chromosome; retroviral gene transfer into human hematopoietic cells; retrovirus vectors; engraftment of normal and leukemic hematopoietic cells into immune-deficient SCID and BNX mice; treatment of HIV-1-infected hu-PBL-SCID mice by CD4 gene therapy; mapping the mouse X chromosome; applications of a molecular genetic linkage map of the mouse genome; genomic imprinting; the homeobox locus in mice; cis-platinum resistance in HeLa cells associated with the chloramphenicol acetyltransferase gene; HIV TAT regulatory protein in transgenic mice; integrin expression in embryonic stem cells; reconstitution of mutant W mice with cultured neural crest-derived melanoblasts; prothrombin gene transcription rate during gestation in the fetal lamb model; mammalian mitochondrial DNA; Moloney murine leukemia virus silencer; sperm vectors; analysis of myogenesis; mutant keratin protein expression in F9 embryonal carcinoma cells; cytokine gene expression in mouse embryogenesis; null mutations in c-mos and c-abl proto-oncogenes; inactivation of murine CD2 and CD4 genes; functional analysis of the mouse Dmd gene; disruption of the RAS GTPase-activating protein in NIH3T3 cells; inactivation of the c-fos gene in ES cells; inactivation of the c-abl proto-oncogene; expression of lymphokine genes using retroviral vectors; gene therapy for treatment of AIDS; isolation of DNA from methotrexate-resistant mouse L5178Y cells; intracellular immunity to HIV-1 in CD4+ HeLa cells; and amplification of c-myc, erbB-2, and int-2 genes in human breast cancer.
Keywords: Animal Chromosome Mapping DNA Damage Gene Therapy/*METHODS *Genetic Techniques Human Mice Mice, Transgenic Models, Genetic Mutation Transfection/GENETICS MONOGRAPH 901030
M90A0676
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Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
