IMMUNOPHYSIOLOGY: THE ROLE OF CELLS AND CYTOKINES IN IMMUNITY AND INFLAMMATION

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

IMMUNOPHYSIOLOGY: THE ROLE OF CELLS AND CYTOKINES IN IMMUNITY AND INFLAMMATION

Immunophysiology: The Role of Cells and Cytokines in Immunity and Inflammation. Oppenheim JJ and Shevach EM, eds. New York, Oxford University Press, 424 p., 1990.. Unique Identifier : AIDSLINE ICDB/90665404
Anonymous; No affiliation given

Abstract: Studies over the past decade have demonstrated that exogenous stimulants induce multiple cellular responses and lead to the production of numerous inflammatory cell-derived cytokines. These cytokines exert pleiotropic effects on a variety of immune and inflammatory cells as well as on all other tissues and organs that serve to maintain the integrity of the host. The present text provides a broad, comprehensive analysis of the normal immunologic processes of vertebrates. Topics include history of immunophysiology, structure and organization of the lymphatic system, interleukin 2, lymphokine-induced molecular signal transduction, the action of interleukins and interferons on B lymphocytes, intercellular interactions in the immune response, physiology of immunoglobulins, physiologic functions of complement, lymphokine regulation of hematopoietic cell development, interferons, immunophysiologic role of interleukin 1, cachectin (tumor necrosis factor) as an endogenous mediator of shock and inflammatory response, role of cytokines in endotoxin-mediated host responses, the acute-phase response, role of chemotactic and inflammatory cytokines, role of epidermal cytokines, neuroendocrine immune interactions, effect of growth factors on immunity and inflammation, nature and physiology of natural effector cells, lymphocyte cytotoxic mechanisms, activation of macrophages for cytotoxic and suppressor effector functions, role of cells and factors in immune suppression in animal models, and role of suppressor T cells and suppressor circuits.

Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Animal Biological Factors/*PHYSIOLOGY Human Immunity, Cellular/*PHYSIOLOGY Inflammation/*IMMUNOLOGY MONOGRAPH
901030
M90A0675

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