MOLECULAR PATHWAYS OF CYTOKINE ACTION

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

MOLECULAR PATHWAYS OF CYTOKINE ACTION

J Cell Biochem; (Suppl 14B):1-48 1990. Unique Identifier : AIDSLINE ICDB/90665510
Anonymous; No affiliation given

Abstract: Abstracts are presented from the plenary and poster sessions of the symposium on the molecular pathways of cytokine action, held January 27 to February 3, 1990, in Park City, UT, as part of the 19th Annual UCLA Symposia on Molecular and Cellular Biology. Discussions covered control of DNA synthesis and cell proliferation; oncogenesis; regulation of immune function; T-cell traffic and endothelial cell interactions; non-MHC-restricted recognition and lysis; neuromodulation; biotherapeutic targeting strategies; differentiation; resistance to bacterial and parasitic disease; DNA, RNA, HIV, and other retrovirus expression; aging and the immune neuromodulatory macromolecules; and modulation of virus expression. Specific topics included the T-cell repertoire, modulation of DNA replication, epidermal growth factor receptor, retinoblastoma susceptibility gene product, cytotoxic lymphocyte induction, adhesion of normal and neoplastic cells to endothelium, homing receptors, organ specificity of metastasis, susceptibility of tumors to natural killing, macrophage activation for tumor cell killing, neurotropic coronavirus infection, recognition of vasoactive intestinal peptide, interactions between the immune system and CNS, lysis of human renal and ovarian cancer cells, lymphokine-enhanced drug delivery, leukoregulin regulation of target cell sensitivity to killing, cancer therapy with radiolabeled antibodies, 5-fluorouracil effects on two human colon cancer cell lines, signal transduction in monocytic differentiation, interferons, antiviral activities of tumor-necrosis factor (TNF), cytokine regulation of HIV expression, effect of aging on lymphokines, transfer of interleukin-3 gene into human hematopoietic cells, interleukin-1 activity and biosynthesis, interleukin and TNF effects, c-src kinase activity in human colorectal carcinoma cell lines, macrophage-mediated antibody-dependent antitumor cytotoxicity, expression and biologic activities of transforming growth factor alpha, and erythropoietin inhibitory and potentiating activities.

Keywords: Animal Biological Factors/*PHYSIOLOGY Cell Division/*PHYSIOLOGY Cell Line Cytotoxicity, Immunologic/*PHYSIOLOGY Gene Expression Regulation/PHYSIOLOGY Human Tumor Cells, Cultured/*PHYSIOLOGY MONOGRAPH
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M90A0674

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