Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
SYNTHETIC PEPTIDES: APPROACHES TO BIOLOGICAL PROBLEMS
J Cell Biochem; (Suppl 14C):213-48 1990. Unique Identifier : AIDSLINE ICDB/90665863 Anonymous; No affiliation given
Abstract:
A symposium on synthetic peptides was part of the University of California at Los Angeles series held in Frisco, Colorado, February 27 to March 4, 1990. Plenary and poster sessions covered the following topics: peptide synthesis and characterization, structure determination, peptide and protein modeling, pattern recognition and structure prediction, immune modulatory peptides, peptides related to AIDS, growth factors and lymphokines, and peptide hormones and neuropeptides. Specific topics included laser desorption/ionization mass spectrometry of large proteins, nuclear magnetic resonance studies of protein-protein and protein-calcium interactions, catalytic antibodies, synthesis and conformational studies of the amyloid-forming protein of Alzheimer's disease, prediction of protein interaction sites, identification of protein function from primary sequence information, antibacterial peptides, regulation of lymphocyte activation by the constant region of Ig, CD8 as an immunomodulatory peptide, design and synthesis of HIV protease inhibitors, structure-function relationships of basic fibroblast growth factor, amphiregulin (a new growth factor), biologically active peptides from laminin, structural model of neuropeptide Y, design and applications of bradykinin antagonists, effect of covalently linked oligosaccharides on peptide conformation, structural studies of peptides derived from antithrombin, repeat peptide motifs that contain reverse turns and modulate DNA condensation in chromatin, CD4 binding of HIV envelope glycoprotein and HIV infectivity in vitro, structure and function of mutant and wild-type zinc finger peptides from yeast transcription factor ADR1, electrochemiluminescence for study of enzyme-inhibitor interactions, de novo design and synthesis of alpha/beta barrel protein, development of immunopotentiating systems for B epitope of Plasmodium falciparum CS-protein, tailoring and antigen presentation of synthetic peptides for the induction of determinant specific humoral immune responses, design and characterization of a potent synthetic immunogen against HIV, type-specific and cross-reactive antigenic determinants of three human retroviruses, a peptide-based assay for inhibitors of the HIV-1 protease, analysis of the topography and dynamics of ligand-receptor interactions using fluorescent peptide probes, somatostatin-receptor interactions, HIV aspartyl-protease-targeted inhibitors, design of protein kinase C inhibitors, and an epitope library.
Keywords: Animal Chemistry Human HIV-1/DRUG EFFECTS Peptide Mapping Peptides/*CHEMICAL SYNTHESIS Protease Inhibitors Protein Conformation Proteins/*CHEMICAL SYNTHESIS Structure-Activity Relationship MONOGRAPH 901030
M90A0672
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Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
