Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by western blot and radioimmune assay. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by western blot and radioimmune assay.

Neurology. 1990 Aug;40(8):1251-3. Unique Identifier : AIDSLINE MED/90340497
Weinshenker BG; Dekaban G; Rice GP; University Hospital, London, ON, Canada.

Abstract: We were unable to identify an antibody to either HTLV-I or HIV-1 in patients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.
Keywords: Blotting, Western Enzyme-Linked Immunosorbent Assay Human HIV Antibodies/ANALYSIS HIV Seropositivity HIV-1/ISOLATION & PURIF HTLV-I/ISOLATION & PURIF HTLV-I Antibodies/ANALYSIS Multiple Sclerosis/IMMUNOLOGY/*MICROBIOLOGY Nervous System Diseases/IMMUNOLOGY/MICROBIOLOGY Radioimmunoassay Reference Values Retroviridae/*ISOLATION & PURIF Support, Non-U.S. Gov't JOURNAL ARTICLEKWDblotting,westernenzyme-linkedimmunosorbentassayhumanhivantibodies/analysishivseropositivityhiv-1/isolation&purifhtlv-i/isolation&purifhtlv-iantibodies/analysismultiplesclerosis/immunology/KWDmicrobiologynervoussystemdiseases/immunology/microbiologyradioimmunoassayreferencevaluesretroviridae/KWDisolation&purifsupport,non-uKWDsKWDgov'tjournalarticle
901130
M90B0669

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