Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
CHARACTERIZATION OF IMMUNE DYSFUNCTION IN CATS WITH FELINE LEUKEMIA VIRUS-INDUCED IMMUNODEFICIENCY DISEASE
Diss Abstr Int [B]; 50(3):911 1989. Unique Identifier : AIDSLINE ICDB/90659542 Pardi D; Colorado State Univ.
Abstract:
A panel of in vitro assays was used to investigate the nature of the immune dysfunction in cats infected with a naturally occurring FeLV isolate (designated FeLV-FAIDS) which induces a fatal immunodeficiency syndrome in 100% of experimentally infected cats. Concanavalin A-induced blastogenesis, xenogeneic mixed lymphocyte reaction assays, stimulation of lymphocytes by soluble protein antigen, and cytotoxic T lymphocyte assays were used to evaluate T cell and antigen-presenting cell function. During the asymptomatic period preceding immunodeficiency disease, I was unable to detect any significant differences in the responses of T cells from groups of FeLV-FAIDS-infected and normal cats. However, early in the course of disease, humoral immune responses in the FeLV-FAIDS-infected cats were dramatically impaired. As early as 7 weeks postinoculation, the ability to mount either an IgM or IgG response to soluble protein antigens was lost. B cell function, as analyzed by lipopolysaccharide-induced blastogenesis, and relative numbers of B cells, as analyzed by immunofluorescence, were not significantly different between the FeLV-FAIDS-infected and normal cats. It, therefore, appeared that T cell-mediated help of cellular immune responses and B cell numbers and function were unaffected in FeLV-FAIDS-infected cats. These cats were, however, unable to produce antibodies in response to antigenic challenge. These results suggest that FeLV-FAIDS infection impairs a subpopulation of T helper cells whose primary function is to provide help for the production of antibody. This impairment of humoral immunity appears to be a major component of the immunodeficiency syndrome in FeLV-FAIDS-infected cats. (Full text available from University Microfilms International, Ann Arbor, MI, as Order No. AAD89-11824)
Keywords: Animal Antibody Formation B-Lymphocytes/IMMUNOLOGY Cat Diseases/*IMMUNOLOGY Cats Immunity, Cellular Immunologic Deficiency Syndromes/IMMUNOLOGY/*VETERINARY Leukemia/IMMUNOLOGY/*VETERINARY Leukemia Virus, Feline/IMMUNOLOGY T-Lymphocytes/IMMUNOLOGY T-Lymphocytes, Helper-Inducer/IMMUNOLOGY THESIS 900530
M9051026
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Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
