AIDS EPIDEMIC AND NEOPLASMS NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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AIDS EPIDEMIC AND NEOPLASMS

Cancer Growth Prog; 6:184-9 1989. Unique Identifier : AIDSLINE ICDB/90660474
Dawson RB; Dept. of Pathology, Univ. of Maryland Sch. of Medicine,; Baltimore, MD 21201

Abstract: Since the first recorded appearance of AIDS in the early 1980s, it has been associated with neoplasms, most prominently Kaposi's sarcoma (KS). However, there are considerable differences between KS as seen in AIDS and classic KS. A major difference between the two is that survival among those with AIDS-associated KS averages 18 mo, whereas in Eastern European or Central African patients with KS, survival can be up to 50 yr, and spontaneous regressions may occur. Endemic KS and KS in AIDS show strikingly different responses to vinblastine chemotherapy or radiotherapy. The AIDS epidemic and neoplasms are reviewed under the following headings: the spectrum of immunodeficiency syndromes in AIDS, morphologic and clinical features of KS in AIDS, AIDS patients with KS in the early 1980s, AIDS and KS with other neoplasms and infections, and secondary KS due to immunosuppressive drugs or renal transplantation. Both classic KS and KS in AIDS have been associated with other neoplasms. For classic KS, these include Hodgkin's disease, acute myeloid leukemia, and multiple myeloma; for KS in AIDS, the associated neoplasms include adenocarcinoma of the lung, multiple myeloma, histiocytic lymphoma, and hepatoma. Endemic KS and KS in AIDS show strikingly different responses to vinblastine chemotherapy or radiotherapy. There have been 29 reports (through 1980) of KS occurring in renal allograft recipients receiving long-term immunosuppressive therapy. (77 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS *Disease Outbreaks Human Kidney Transplantation Male Neoplasms/*ETIOLOGY Neoplasms, Multiple Primary/ETIOLOGY Opportunistic Infections/ETIOLOGY Risk Factors Sarcoma, Kaposi's/ETIOLOGY Skin Neoplasms/ETIOLOGY JOURNAL ARTICLE REVIEW, TUTORIAL REVIEWKWDacquiredimmunodeficiencysyndrome/KWDcomplicationsKWDdiseaseoutbreakshumankidneytransplantationmaleneoplasms/KWDetiologyneoplasms,multipleprimary/etiologyopportunisticinfections/etiologyriskfactorssarcoma,kaposi's/etiologyskinneoplasms/etiologyjournalarticlereview,tutorialreview
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Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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