Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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Immunological abnormalities of acquired immunodeficiency syndrome and related disorders in patients from Rio de Janeiro, Brazil.

Mem Inst Oswaldo Cruz. 1988 Jul-Sep;83(3):305-11. Unique Identifier : AIDSLINE MED/90158149
Miranda-Silva W; Galvao-Castro B; Bonecini-Almeida MG; Daniel-Ribeiro CT; Sion FS; De Sa CA; Instituto Oswaldo Cruz, Departamento de Imunologia-WHO; Collaborating Centre of AIDS, Rio de Janeiro, Brasil.

Abstract: The immunological profile of acquired immunodeficiency syndrome (AIDS) and chronic lymphadenopathy syndrome (CLAS) in 15 and 11 Brazilian patients, respectively, was studied. The AIDS patients showed reduced percentage of total T (CD3) and T-helper-inducer (CD4) lymphocytes, relative increase in numbers of T-suppressor-cytotoxic (CD8) cells and a marked inversion of T-helper-inducer/suppressor-cytotoxic (CD4/CD8) ratio. Lymphoproliferative responses to PHA, ConA, PPD and PWM were diminished. Hypergammaglobulinemia and high levels of circulating immune complexes were also found. The CLAS patients also showed important immunological alterations, but not so intense as those with AIDS. These data seems to be similar to those observed in other parts of the world.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Adolescence Adult Antigen-Antibody Complex/ANALYSIS AIDS-Related Complex/*IMMUNOLOGY Brazil Female Homosexuality Human Immunoglobulins/ANALYSIS Male Middle Age Sex Behavior Support, Non-U.S. Gov't T-Lymphocytes/ANALYSIS T-Lymphocytes, Helper-Inducer/ANALYSIS JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDimmunologyadolescenceadultantigen-antibodycomplex/analysisaids-relatedcomplex/KWDimmunologybrazilfemalehomosexualityhumanimmunoglobulins/analysismalemiddleagesexbehaviorsupport,non-uKWDsKWDgov'tt-lymphocytes/analysist-lymphocytes,helper-inducer/analysisjournalarticle
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