Regulation of cytokine gene expression: gene activation in type I IFN and IL-2 systems. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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Regulation of cytokine gene expression: gene activation in type I IFN and IL-2 systems.

Princess Takamatsu Symp. 1988;19:279-86. Unique Identifier : AIDSLINE MED/90062022
Taniguchi T; Fujita T; Yamada G; Hatakeyama M; Ishizaka E; Miyamoto M; Maruyama M; Shibuya H; Institute for Molecular and Cellular Biology, Osaka University,; Japan.

Abstract: Cytokines represent essential soluble mediators in cell-to-cell communication and they are known to play crucial roles in many biological processes, including viral infection, inflammation and immunity. We have been focusing on two cytokine systems, the interferon (IFN) and interleukin 2 (IL-2) systems each of which respectively plays a key role in viral infections and the immune response. In both cases, expression of those cytokines and, in the case of IL-2 system, the receptor is tightly regulated at the transcriptional level. Recent studies in our laboratory as well as others have uncovered the mechanism(s) operating in the regulation of those genes and have provided further insights on how the two cytokine systems operate and what is the biological significance of gene regulation in these systems. Here, we summarize the current understanding of the IFN system and IL-2 system in the context of host defense against viral infections and T cell neoplasms, respectively.
Keywords: Amino Acid Sequence Animal Base Sequence *Gene Expression Regulation HTLV-I Infections/IMMUNOLOGY Interferon Type I/*GENETICS Interleukin-2/*GENETICS Mice Molecular Sequence Data Support, Non-U.S. Gov't Trans-Activators/GENETICS JOURNAL ARTICLEKWDaminoacidsequenceanimalbasesequenceKWDgeneexpressionregulationhtlv-iinfections/immunologyinterferontypei/KWDgeneticsinterleukin-2/KWDgeneticsmicemolecularsequencedatasupport,non-uKWDsKWDgov'ttrans-activators/geneticsjournalarticle
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M9030722

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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