Jejunal mucosal architecture and fat absorption in male homosexuals infected with human immunodeficiency virus. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Jejunal mucosal architecture and fat absorption in male homosexuals infected with human immunodeficiency virus.

Q J Med. 1988 Dec;69(260):1009-19. Unique Identifier : AIDSLINE MED/90083615
Miller AR; Griffin GE; Batman P; Farquar C; Forster SM; Pinching AJ; Harris JR; Department of Communicable Diseases, St George's Hospital Medical; School, Tooting, London.

Abstract: Diarrhoea and weight loss are common features of human immunodeficiency virus (HIV) disease. The mechanism of diarrhoea occurring in the absence of known enteropathogens is currently unknown. We have measured fat absorption, using the 14C triolein breath test, and quantitatively assessed jejunal villous architecture in 20 male homosexuals at various clinical stages of HIV disease. Enteropathogens were not detected in any subject at the time of jejunal biopsy in stool or jejunal mucosa. Partial villous atrophy was the sole histological abnormality and was detected at any clinical stage of HIV disease. The 14C triolein breath test quantitatively correlated with the degree of jejunal villous atrophy. In addition subjective presence of diarrhoea was related to the detection of fat malabsorption. Thus diarrhoeal disease in HIV infected patients in the absence of enteropathogens may be due to jejunal enteropathy and may be present at early clinical stages of HIV disease.
Keywords: Acquired Immunodeficiency Syndrome/METABOLISM/PATHOLOGY Adult Diarrhea/PATHOLOGY Dietary Fats/*METABOLISM *Homosexuality Human HIV Seropositivity/METABOLISM/*PATHOLOGY Intestinal Absorption Intestinal Mucosa/METABOLISM/*PATHOLOGY Jejunum/METABOLISM/*PATHOLOGY Male Middle Age Support, Non-U.S. Gov't JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/metabolism/pathologyadultdiarrhea/pathologydietaryfats/KWDmetabolismKWDhomosexualityhumanhivseropositivity/metabolism/KWDpathologyintestinalabsorptionintestinalmucosa/metabolism/KWDpathologyjejunum/metabolism/KWDpathologymalemiddleagesupport,non-uKWDsKWDgov'tjournalarticle
900330
M9030699

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1990. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1990. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .