Anti-human T-cell lymphotrophic virus type I antibody-positive adult T-cell leukemia/lymphoma with no monoclonal proviral DNA. A clinicopathologic and immunologic study.

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

Anti-human T-cell lymphotrophic virus type I antibody-positive adult T-cell leukemia/lymphoma with no monoclonal proviral DNA. A clinicopathologic and immunologic study.

Cancer. 1989 Dec 15;64(12):2515-24. Unique Identifier : AIDSLINE MED/90058412
Yoshida T; Kikuchi M; Ooshima K; Takeshita M; Kimura N; Kozuru M; Satoh H; First Department of Pathology, School of Medicine, Fukuoka; University, Japan.

Abstract: Proviral DNA of adult T-cell leukemia virus (HTLV-I) was examined by the standard Southern blotting method in lymph nodes of 45 patients with anti-HTLV-I antibody (ATLA)-positive adult T-cell leukemia/lymphoma (ATLL). Six of these patients revealed no monoclonal proviral HTLV-I DNA in tumor cells. These six patients showed typical flower cells in peripheral blood; they comprised five cases of the smoldering type and one of lymphoma type. They showed a longer clinical course than ATLL patients with integrated proviral HTLV-I DNA. Five of the six patients were alive from 8 to 36 months after onset; the other patient died 9 months after onset. Histologically, they exhibited features of T-cell malignancy but with absence of the typical cerebriform giant cells that are usually present in ATLL. The tumor cells represented T-cell markers, usually CD4, but CD25 was negative. Rearrangement of the T-cell receptor gene C beta was found in four of the six cases. On the basis of these results, cases of ATLL with no monoclonal proviral HTLV-I DNA should be clinicopathologically differentiated from those with integrated proviral DNA.

Keywords: Adult Aged DNA, Viral/*ANALYSIS Female Human HTLV-I/*GENETICS/IMMUNOLOGY HTLV-I Antibodies/ANALYSIS Leukemia, Lymphocytic/IMMUNOLOGY/*MICROBIOLOGY/PATHOLOGY Leukemia, T-Cell/IMMUNOLOGY/*MICROBIOLOGY/PATHOLOGY Male Middle Age Proviruses/*GENETICS Support, Non-U.S. Gov't JOURNAL ARTICLE
900330
M9030668

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