Increased erythrocyte adenosine deaminase activity in children with perinatal human immunodeficiency virus infection. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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Increased erythrocyte adenosine deaminase activity in children with perinatal human immunodeficiency virus infection.

Pediatr Infect Dis J. 1989 Dec;8(12):862-5. Unique Identifier : AIDSLINE MED/90174822
Palomba E; David O; Boltri A; Gabiano C; Tovo PA; Department of Pediatrics, University of Turin, Italy.

Abstract: Erythrocyte adenosine deaminase (ADA) activity was assessed in 33 children born to human immuno-deficiency virus (HIV)-positive mothers. The enzyme values were significantly increased in infected, symptom-free children compared with a control group of HIV-negative subjects (mean +/- SD: 0.34 +/- 0.01 unit/ml red blood cells (RBC) vs. 0.25 +/- 0.04 unit/ml RBC, P less than 0.01) and a further significant increase was found in symptomatic children (0.45 +/- 0.02 unit/ml RBC, P less than 0.01 vs. infected, symptom-free children). ADA values were slightly enhanced also in the group of infants in whom the state of HIV infection was indeterminate (0.29 +/- 0.03 unit/ml RBC, P not significant vs. controls). These data indicate that increased erythrocyte ADA activity may be a useful though indirect marker of HIV infection in children at risk and be of possible prognostic relevance. Since increased values were present also in children without overt infections or hematologic disorders, and ADA activity of erythrocytes obtained from healthy donors did not increase after 1 hour incubation with patients' serum, HIV could induce large amounts of cellular enzyme infecting directly erythroid precursor cells.
Keywords: Adenosine Deaminase/*ANALYSIS Analysis of Variance Child, Preschool Erythrocytes/*ENZYMOLOGY Human HIV Infections/*CONGENITAL/ENZYMOLOGY Infant Nucleoside Deaminases/*ANALYSIS Prognosis Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadenosinedeaminase/KWDanalysisanalysisofvariancechild,preschoolerythrocytes/KWDenzymologyhumanhivinfections/KWDcongenital/enzymologyinfantnucleosidedeaminases/KWDanalysisprognosissupport,non-uKWDsKWDgov'tjournalarticle
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M9060597

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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