Characterization of the serologic profile of children with human immunodeficiency virus infection: correlation with clinical status. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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Characterization of the serologic profile of children with human immunodeficiency virus infection: correlation with clinical status.

Clin Immunol Immunopathol. 1989 Nov;53(2 Pt 1):233-42. Unique Identifier : AIDSLINE MED/90003897
Kamani N; Krilov LR; Wittek AE; Hendry RM; Division of Allergy-Immunology, Children's Hospital of; Philadelphia, Pennsylvania 19104.

Abstract: Serum samples from 28 children with symptomatic human immunodeficiency virus (HIV) infection were studied for the presence of HIV antigen. Their humoral immune response profile, including anti-HIV specific isotypic responses and neutralizing titers, was characterized. Additionally, serum specimens from 12 of these children were tested for their ability to mediate antibody-dependent cellular cytotoxicity (ADCC) against HIV envelope antigens. Analysis of our results showed that children with acquired immunodeficiency syndrome (AIDS) were much more likely to have serum antigenemia and an absence of anti-p24 antibodies than those with AIDS-related complex (ARC). A significant association was also noted between a more stable clinical status and a strong anti-p24 antibody response with detectable antibodies to other HIV antigens in multiple antibody subclasses. This suggests that the longitudinal evaluation of antigen/antibody profiles may aid in the assessment of prognosis for children with HIV infection. Sera from 6/6 patients with ARC and 4/6 patients with AIDS were able to mediate ADCC. No correlation was found between clinical status and the titers of neutralizing antibodies.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antibody Specificity Antibody-Dependent Cell Cytotoxicity AIDS-Related Complex/*IMMUNOLOGY Blotting, Western Burkitt's Lymphoma/IMMUNOLOGY Child Child, Preschool Human HIV Antibodies/IMMUNOLOGY HIV Antigens/IMMUNOLOGY HIV Seropositivity/IMMUNOLOGY Infant Neutralization Tests Opportunistic Infections/IMMUNOLOGY JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDimmunologyantibodyspecificityantibody-dependentcellcytotoxicityaids-relatedcomplex/
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M9010484

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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