HUMAN IMMUNOGENETICS: BASIC PRINCIPLES AND CLINICAL RELEVANCE

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

HUMAN IMMUNOGENETICS: BASIC PRINCIPLES AND CLINICAL RELEVANCE

Immunol Ser; 43:1-828 1989. Unique Identifier : AIDSLINE ICDB/90657857
Anonymous; No affiliation given

Abstract: Although powerful means of exploring genetic expression and regulation exist, the benefits of immunologic probes of cell surface components have not lessened. The delineation of the structural determinants of recognition, in both antibody-mediated and cell-mediated immunity, has focused attention on a group of related issues, including immune recognition in vivo, the complex cellular interactions involved in autoimmune disease, maternal-fetal recognition, inflammation, differentiation and maturation of tissues, and malignant cell expansion and metastasis. Central to these considerations are the restriction of cognition and putative signaling and receptor function imposed by histocompatibility elements during immune responses. Immune regulation via networks that see other antibodies in turn also is a legitimate immunogenetics-related area. This volume covers (1) approaches and tools of immunogenetics, (2) immunogenetics of immunity, (3) immunogenetics of histocompatibility and related systems, (4) immunogenetics of tumor and viral antigens, and (5) immunogenetics of blood and serum components. Topics discussed include acquiring immunogenetic data; human gene mapping and linkage analysis; laws of transplantation; maternal-fetal immunogenetics; molecular biology (tools and applications); monoclonal antibodies applied to tumor-associated antigens (CO17-1A antigen); clonal nature of the immune response; lymphoid cell development; antigen-specific immune regulation; immunoglobulin (Ig) genes; Ig allotypes; autoimmune states; immunodeficiency states; comparative immunogenetics of the major histocompatibility complex; molecular genetics of the human leukocyte; minor histocompatibility loci; human leukocyte antigens and disease; Qa/Tla antigens; T-lymphocyte associative recognition; the T/t complex and the genetic control of mouse development; Epstein-Barr virus and its antigens; human T-lymphotropic viruses; immunogenetic analysis of the immune response to hepatitis B virus antigens; immunogenetics of murine and feline retroviruses; immunologic response to influenza virus infection; retroviral-related genes, proto-oncogenes, and breast cancer; human melanoma-associated antigens; the ABO, Hh, secretor, and Lewis systems; the Ii and P blood group systems; MNSs and Gerbich blood group systems; the Rh blood group system; and complement genetics.

Keywords: Animal Human *Immunogenetics MONOGRAPH
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