t(3;22)(q27;q11): a novel translocation associated with diffuse non-Hodgkin's lymphoma [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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t(3;22)(q27;q11): a novel translocation associated with diffuse non-Hodgkin's lymphoma [see comments]

Blood. 1989 Nov 1;74(6):1876-9. Unique Identifier : AIDSLINE MED/90028705
Offit K; Jhanwar S; Ebrahim SA; Filippa D; Clarkson BD; Chaganti RS; Laboratory of Cancer Genetics and Cytogenetics, Sloan-Kettering; Institute, New York, NY.

Abstract: Of 187 specimens of non-Hodgkin's lymphoma and four hyperplastic lymphoid proliferations with clonal chromosome abnormalities ascertained serially over a 4 1/2-year period, nine cases with t(3;22)(q27;q11) were identified. Seven of the lymphomas were diffuse tumors, predominantly large cell type. The eighth tumor, a follicular small cleaved cell lymphoma, exhibited a t(3;22) and a t(14;18)(q32;q21). The ninth case was a lymph node from a human immunodeficiency virus-positive patient which showed atypical hyperplasia. Overall survival of t(3;22) diffuse lymphoma patients was not different from that of patients with abnormal karyotypes without t(3;22). The t(3;22) diffuse tumors studied showed a disproportionate frequency of lambda light chain on their cell surfaces, a finding similar to that observed in t(8;22)(q24;q11) Burkitt's lymphomas. Our results indicate that the t(3;22)(q27;q11) is the third most common recurring translocation in diffuse non-Hodgkin's lymphoma.
Keywords: Adult Aged *Chromosomes, Human, Pair 22 *Chromosomes, Human, Pair 3 Female Human Karyotyping Lymphoma, Non-Hodgkin's/*GENETICS Male Middle Age Support, U.S. Gov't, P.H.S. *Translocation (Genetics) JOURNAL ARTICLEKWDadultagedKWDchromosomes,human,pair22KWDchromosomes,human,pair3femalehumankaryotypinglymphoma,non-hodgkin's/KWDgeneticsmalemiddleagesupport,uKWDsKWDgov't,pKWDhKWDs
Comment in: Blood 1990 May 15;75(10):2094
900228
M9020544

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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