CSF-IgM measurement in neurovenereological disease. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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CSF-IgM measurement in neurovenereological disease.

Clin Chim Acta. 1989 Aug 31;183(3):295-300. Unique Identifier : AIDSLINE MED/90030935
van Kamp GJ; Wolters EC; Department of Clinical Chemistry, Free University Hospital,; Amsterdam, The Netherlands.

Abstract: An immune response within the central nervous system (CNS) is reflected by an increase of immunoglobulin concentrations in the cerebrospinal fluid. IgM is considered the first class of immunoglobulins to be increased after infection. Calculation of the IgM and IgG-index reflects immunological activity within the CNS. Insight in this activity is essential in the diagnosis of several neurological diseases, especially neurosyphilis. A new fast solid phase, double sandwich enzyme-immuno assay for the measurement of IgM in the CSF is described and applied in 71 neurovenereological patients.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/CEREBROSPINAL FLUID/ *COMPLICATIONS Central Nervous System Diseases/COMPLICATIONS Enzyme-Linked Immunosorbent Assay Human IgG/ANALYSIS/*CEREBROSPINAL FLUID IgM/ANALYSIS/*CEREBROSPINAL FLUID Neurosyphilis/CEREBROSPINAL FLUID/COMPLICATIONS/*IMMUNOLOGY Syphilis/CEREBROSPINAL FLUID/COMPLICATIONS/IMMUNOLOGY JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/blood/cerebrospinalfluid/KWDcomplicationscentralnervoussystemdiseases/complicationsenzyme-linkedimmunosorbentassayhumanigg/analysis/KWDcerebrospinalfluidigm/analysis/KWDcerebrospinalfluidneurosyphilis/cerebrospinalfluid/complications/KWDimmunologysyphilis/cerebrospinalfluid/complications/immunologyjournalarticle
900228
M9020534

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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