Nucleotide sequence of HIV1-NDK: a highly cytopathic strain of the human immunodeficiency virus. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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Nucleotide sequence of HIV1-NDK: a highly cytopathic strain of the human immunodeficiency virus.

Gene. 1989 Sep 30;81(2):275-84. Unique Identifier : AIDSLINE MED/90034200
Spire B; Sire J; Zachar V; Rey F; Barre-Sinoussi F; Galibert F; Hampe A; Chermann JC; Unite de Recherches sur les Retrovirus et Maladies Associees,; U 322 de l'INSERM, Campus Universitaire de Luminy, Marseille,; France.

Abstract: A highly cytopathic strain of HIV1, named HIV1-NDK, has been isolated from a Zairian patient affected with AIDS. This isolate is 10(4) times more cytopathic and infectious than the prototype. To correlate the high cytopathic properties of this strain with genetic variations, we have cloned and sequenced the genome of this isolate. The principal feature which could be drawn from the fine analysis of the HIV1-NDK sequence is that the variability is not clustered in one particular region but rather spread out all along the genome. Only minor differences seem to be responsible for the acute biological effect of HIV1-NDK.
Keywords: Amino Acid Sequence Animal Base Sequence Cloning, Molecular Comparative Study Cytopathogenic Effect, Viral/GENETICS Eukaryotic Cells Female Genes, Viral/*GENETICS Genomic Library Human HIV-1/*GENETICS/ISOLATION & PURIF Male Molecular Sequence Data Restriction Mapping Sequence Homology, Nucleic Acid Software Support, Non-U.S. Gov't Transfection/GENETICS Zaire JOURNAL ARTICLEKWDaminoacidsequenceanimalbasesequencecloning,molecularcomparativestudycytopathogeniceffect,viral/geneticseukaryoticcellsfemalegenes,viral/KWDgeneticsgenomiclibraryhumanhiv-1/KWDgenetics/isolation&purifmalemolecularsequencedatarestrictionmappingsequencehomology,nucleicacidsoftwaresupport,non-uKWDsKWDgov'ttransfection/geneticszairejournalarticle
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M9020515

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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