The extent of the spread of AIDS and the degree of its pathogenicity match those of the great epidemics of the past. The virulence is due to several unique attributes of the AIDS agent, the human immunodeficiency virus. It is spread by intimate contact, affording little exposure to neutralizing antibodies. As a retrov
The research presented in this thesis was designed to identify (1) T-lymphocyte surface molecules involved in target recognition and (2) tumor surface antigens involved in tumor rejection and/or tumor growth. In the first series of experiments, a panel of rat monoclonal antibodies was prepared against the AKR T lympho
In all known retroviruses, the pol gene (which encodes the reverse transcriptase and integrase functions) lies downstream of the gag gene, which codes for the structural proteins of the virus core. In most retroviruses, gag and pol lie in different translational reading frames, either directly overlapping or else with
Cancer Growth Prog; 1:162-70 1989. Unique Identifier : AIDSLINE ICDB/90657733
Curt GA; Chabner BA; NCI, Bethesda, MD 20892
Considerable advances have been made against several types of cancer, with large improvements in long-term survival for acute lymphocytic leukemia, Hodgkin s disease, diffuse lymphoma, testicular cancer, choriocarcinoma, childhood sarcomas, postmenopausal Stage II breast cancer, and small cell lung cancer (limited sta
Although powerful means of exploring genetic expression and regulation exist, the benefits of immunologic probes of cell surface components have not lessened. The delineation of the structural determinants of recognition, in both antibody-mediated and cell-mediated immunity, has focused attention on a group of related
Transformation by a molecularly cloned transformation-defective (td) mutant of Rous sarcoma virus (RSV) with an internal deletion in its onc gene, src, was studied both in chickens and in chicken embryo fibroblasts in tissue culture. Tumor formation (fibrosarcomas at the injection site in the wing, and internal tumors
Epstein-Barr virus is a human herpesvirus that induces a variety of lymphoproliferative disorders and is implicated in the etiology of two cancers, nasopharyngeal carcinoma and Burkitt s lymphoma. The virus contains at least three glycoproteins in its outer envelope, gp350, gp250, and gp85. When this work began, gp85
The unique pathogenesis of lentiviral infections in humans and ruminant animals may be explained, in part, by the complex mechanisms regulating transcription and translation of their viral genes. The studies described here address two central issues of visna virus gene regulation: (1) transcription of viral genes in i
The endogenous opioids are a ubiquitous class of neuropeptides which circulate in human plasma and show widespread distribution in the central and peripheral nervous system. The production and secretion of opioid peptides is not restricted to neurons; it also occurs in cells of lymphoreticular origin. However, the imm
The surface glycoproteins T4 (CD4) and T8 (CD8) define different functional subsets of T lymphocytes and may act as recognition molecules mediating appropriate interactions between the T cell and its target. T4 may also serve as a receptor for HIV. The elucidation of the structure of the T4 glycoprotein and its role i
Cancer Growth Prog; 7:195-213 1989. Unique Identifier : AIDSLINE ICDB/90658282
Ulirsch RC; Gomez DM; Hematology Section, Dept. of Pathology, Loyola Univ. of Chicago; Medical Center, Maywood, IL 60153
Effusions may develop in any of the serous membrane-lined body cavities. The peritoneal, pleural, and pericardial spaces are the principal mesothelial-lined cavities that cause clinical diagnostic problems. Excessive accumulation of fluid in these spaces may compromise normal organ functions. Diagnosis, classification
We have studied the binding of the T-cell surface protein CD2 by anti-CD2 antibodies and by a physiologic ligand, LFA-3, using a mutational approach. Similarly, the binding of HIV to CD4, another T-cell surface protein, was studied by first examining the interaction between CD4 and anti-CD4 monoclonal antibodies. CD2
Ilardi I; Leone F; Istituto di malattie infettive, Universita La Sapienza,; Policlinico Umberto I, Roma.
The authors describe the most common techniques used for the detection of Cryptosporidium spp. in the faeces. Coproparasitological investigations have been carried out on 216 patients anti-HIV seropositives, 192 of them with no symptoms, 5 with ARC and 19 with AIDS. The techniques that have been used are: the FPC conc
In 1987 the number of cases of early symptomatic syphilis increased by 1.5% to 1211 cases (3.2 per 100 thousand). Early asymptomatic syphilis was diagnosed in 2.5 per 100 thousand of the population, that is 5% less than in the preceding year. In all, 2136 cases of early syphilis were recorded, that is 1% less than in
NIDA Res Monogr. 1988;90:302-10. Unique Identifier : AIDSLINE MED/90043973
Stimson G; Alldritt L; Dolan K; Donoghoe M; Monitoring Research Group, University of London Goldsmiths'; College, UK.
In 1987 the UK government launched experimental schemes for distributing injecting equipment to injecting drug users in order to help prevent the spread of Human Immunodeficiency Virus. This paper reports on the first few months of the schemes, and provides some initial evidence of changes in clients risk behaviours.
The effects were studied in vitro of a score of various additives to toilet soaps on strains of Candida albicans isolated from patients. Their effect on the basic properties of toilet soaps was studied, determining foam production and the index of foam stability, and their resistance to high temperature was determined
Snyder HS; Department of Emergency Medicine, Albany Medical Center Hospital,; NY 12208.
Neurological manifestations are present in 30% to 60% of patients with acquired immunodeficiency syndrome (AIDS) and may be the initial presentation in 10% to 20% of cases. Central nervous system toxoplasmosis now represents the most common focal brain lesion in patients with AIDS and possibly the most common opportun
Roy C; Knaak C; Garvie P; Limmer B; Campione-Piccardo J; Molecular Virology Laboratory, Health and Welfare Canada, Ottawa,; Ont.
A plasmid (pBH10R3) containing a 9-kb Sst I fragment of HIV-1 (clone BH-10) inserted in pSP64, an in vitro expression vector, has been used for the transcription of anti-sense HIV-1 RNA. With this system, the transcripts obtained in vitro were not usually full length (1 to 2 kb long) and they predominantly span the 3
Fiore JR; Casalino C; Fico C; Monno L; Esposito M; Angarano G; Pastore G
To clarify the biological, clinical and prognostic relevance of HIV isolation from plasma and explain the relation to p24 antigenemia, we studied these two markers in 67 anti-HIV positive subjects in different stages of the disease. The results suggest that discordances between these two parameters are not dependent o
Blood. 1989 Nov 1;74(6):1876-9. Unique Identifier : AIDSLINE MED/90028705
Offit K; Jhanwar S; Ebrahim SA; Filippa D; Clarkson BD; Chaganti RS; Laboratory of Cancer Genetics and Cytogenetics, Sloan-Kettering; Institute, New York, NY.
Of 187 specimens of non-Hodgkin s lymphoma and four hyperplastic lymphoid proliferations with clonal chromosome abnormalities ascertained serially over a 4 1/2-year period, nine cases with t(3;22)(q27;q11) were identified. Seven of the lymphomas were diffuse tumors, predominantly l
Blood. 1989 Nov 1;74(6):2295-301. Unique Identifier : AIDSLINE MED/90028766
Singer RH; Byron KS; Lawrence JB; Sullivan JL; Department of Cell Biology, University of Massachusetts Medical; School, Worcester 01655.
We have demonstrated that a sensitive, nonisotopic in situ hybridization (ISH) assay can be used to detect HIV-infected cells from seropositive, asymptomatic individuals. Our assay is based on the detection of a biotinated HIV DNA probe hybridized to human immunodeficiency virus (HIV)-infected peripheral blood lymphoc
Blood. 1989 Nov 15;74(7):2471-5. Unique Identifier : AIDSLINE MED/90028791
Ng VL; Chen KH; Hwang KM; Khayam-Bashi H; McGrath MS; Department of Medicine, University of California, San Francisco.
We observed and characterized paraproteins present in the serum of seven human immunodeficiency virus type 1 (HIV-1)-infected individuals. Immunoglobulin (Ig) subclass typing performed on these paraproteins identified five as IgG1 kappa, one as an IgG3 lambda, and one as an IgA lambda. The IgG1 kappa paraproteins, pur
Blood. 1989 Nov 15;74(7):2585-91. Unique Identifier : AIDSLINE MED/90028806
Anderson DW; Epstein JS; Lee TH; Lairmore MD; Saxinger C; Kalyanaraman VS; Slamon D; Parks W; Poiesz BJ; Pierik LT; et al; Center for Biologics Evaluation and Review, FDA, Bethesda, MD; 20892.
We wished to develop criteria for serological confirmation of human T-lymphotropic virus type I (HTLV-I) infection in healthy donors. Selected serum or plasma samples reactive by HTLV-I enzyme immunosorbent assay or gel-agglutination assays with at least one viral-specific band on Western immunoblot (WIB) were tested
Can J Public Health. 1989 Sep-Oct;80(5):319-24. Unique Identifier : AIDSLINE MED/90030004
Soskolne CL; Robson E
The public health response to AIDS has been neglectful. Successive windows of opportunity for primary prevention have been lost, especially in low prevalence regions. However, an early response to preventing HIV infection is reported from Edmonton, a centre estimated as being 2-3 years behind larger North American cit
Goussard B; Zabe D; Meudec JM; Karhemere B; Salaun JJ; Institut National de Recherche Bio-Medicale, Kinshasa, Zaire.
880 suspect sera were analysed for HIV2 antibodies (ELISA, Western Blot) during the 2nd and 3rd trimester of 1988. Results show that Kinshasa is not yet an endemic zone for this virus. The authors recommend the use of a mixed test for diagnostics.
van Kamp GJ; Wolters EC; Department of Clinical Chemistry, Free University Hospital,; Amsterdam, The Netherlands.
An immune response within the central nervous system (CNS) is reflected by an increase of immunoglobulin concentrations in the cerebrospinal fluid. IgM is considered the first class of immunoglobulins to be increased after infection. Calculation of the IgM and IgG-index reflects immunological activity within the CNS.
Herdman RC; Forster S; Stafford ND; Pinching AJ; Department of Otolarynglogy, St. Mary's Hospital, London, UK.
Between October 1984 and December 1987, 219 patients who fulfilled the criteria for Acquired Immune Deficiency Syndrome (AIDS), as set out by the Centers for Disease Control, Georgia , were seen at St. Mary s Hospital, London. The most common otolaryngological manifestations of the
Webster AD; Lever A; Spickett G; Beattie R; North M; Thorpe R; Division of Immunological Medicine, Clinical Research Centre,; Harrow, Middlesex, England.
A patient with a history of at least 10 years common variable hypogammaglobulinaemia seroconverted to HIV-1 and became hypergammaglobulinaemic. The HIV isolated from his blood did not polyclonally activate B cells from normal donors. The mechanism of the hypergammaglobulinaemia is discussed.
Kolin E; Mena IG; Department of Radiology, UCLA School of Medicine, Harbor-UCLA; Medical Center, Torrance 90509.
Acalculous inflammatory biliary disease has been reported in patients with acquired immune deficiency syndrome (AIDS). AIDS-related cholangitis manifests the intrahepatic and extrahepatic biliary changes seen in sclerosing cholangitis, including strictures, dilatation, and decreased arborization. Biliary scanning was
Bhat S; Heurich AE; Vaquer RA; Dunn EK; Strashun AM; Kamholz SL; Department of Medicine, State University of New York-Health; Science Center, Brooklyn.
Hypertrophic osteoarthropathy (HOA) is a systemic disorder primarily affecting the bones, joints, and soft tissues and developing in association with another disease process. Acute pyogenic pulmonary processes (empyema, lung abscess) are occasionally accompanied by transient HOA, but reversible HOA has not previously
Dtsch Med Wochenschr. 1989 Oct 13;114(41):1562-5. Unique Identifier : AIDSLINE MED/90032314
Battegay M; Greminger P; Luthy R; Departement fur Innere Medizin, Medizinische Poliklinik,; Universitatsspital Zurich.
A pneumothorax occurred in a 29-year-old HIV-positive woman with rapidly progressive dyspnoea at rest and left-thoracic pain, dry cough and fever. Sputum test revealed Pneumocystis carinii pneumonia. Treatment was started with 20 mg/kg trimethoprim and 100 mg/kg sulfamethoxazole, but was poorly tolerated and changed f
Peters M; Schurmann D; Mayr AC; Heterzer R; Pohle HD; Ruf B; II. Department of Internal Medicine Rudolf Virchow University; Hospital Wedding, FRG.
Infections caused by mycobacteria other than Mycobacterium tuberculosis (MOTT) have often been described as common in AIDS patients. To evaluate whether infections with MOTT are specific for HIV related immunosuppression or are also frequent in patients with immunosuppression of different aetiology, data on the freque
In a survey that measured AIDS knowledge, perceived risk and prevention among 404 sexually active adolescent women who were family planning clinic patients in Baltimore, knowledge about AIDS was high, with the average respondent answering seven out of nine questions correctly. Slightly more than half of the teenagers
Dev Med Child Neurol. 1989 Oct;31(5):675-8. Unique Identifier : AIDSLINE MED/90033814
Ramesh V; Gardner-Medwin D; Gibson M; Colquhoun I; Department of Child Health, Medical School, Newcastle upon Tyne.
A three-year-old boy is reported who had congenital spastic paraparesis caused by severe segmental narrowing of the spinal cord. X-rays of the spine showed thoracolumbar scoliosis and anomalies of the thoracic vertebrae from T5 to T11. Myelography, with CT scanning, demonstrated severe narrowing of the T5 to T12 segme
Favre O; Heyraud JP; Chossegros P; Retornaz G; Ouzan D; Neyrat M; Trepo C; Unite d'Hepatologie, Hotel-Dieu, Lyon.
Clinical expression and outcome of hepatis B virus infections associated with human immunodeficiency virus infection (without AIDS) were studied in 17 homosexuals during 23 months. In an attempt to distinguish the respective impacts of homosexuality from that of human immuno-deficiency virus, patient were compared wit
Spire B; Sire J; Zachar V; Rey F; Barre-Sinoussi F; Galibert F; Hampe A; Chermann JC; Unite de Recherches sur les Retrovirus et Maladies Associees,; U 322 de l'INSERM, Campus Universitaire de Luminy, Marseille,; France.
A highly cytopathic strain of HIV1, named HIV1-NDK, has been isolated from a Zairian patient affected with AIDS. This isolate is 10(4) times more cytopathic and infectious than the prototype. To correlate the high cytopathic properties of this strain with genetic variations, we have cloned and sequenced the genome of
McMillan A; Bishop PE; Genitourinary Medicine Unit, Royal Infirmary, Edinburgh.
Fifty four men with anogenital warts were studied; 22 had concurrent infection with the human immunodeficiency virus (HIV). The median duration of the warts before and after the start of treatment of seven HIV infected and 10 non-infected heterosexual men was similar. In homosexual men, however, the duration of the le
Joyce PW; Haye KR; Ellis ME; Manchester Royal Eye Hospital.
A case is reported of secondary syphilis with ocular signs in a patient who had antibodies to human immunodeficiency virus (HIV) and hepatitis B infections and from whose urine cytomegalovirus was cultivated. Treatment with penicillin resulted in rapid recovery from his retinitis a
Sonnex C; Hart GJ; Williams P; Adler MW; Academic Department of Genitourinary Medicine, University College; and Middlesex School of Medicine, London.
The use of condoms to prevent the further spread of human immunodeficiency virus (HIV) infection is one of the main themes of the government s health education campaign against AIDS. A study of the use of and attitudes towards condoms in 222 heterosexual men and women attending a department of genitourinary medicine (
Fitzpatrick R; Hart G; Boulton M; McLean J; Dawson J; Department of Community Medicine and General Practice, Radcliffe; Infirmary, University of Oxford, UK.
Three hundred and fifty six homosexually active men were recruited in 1988 for a study by interview of sexual behaviour. Thirty two per cent had homosexual passive anal sex in the previous month and 60% in the year before interview. Anal sex and unprotected anal sex were more common with regular than non-regular partn
O'Farrell N; Hoosen AA; Kharsany AB; van den Ende J; Ngwelezana Hospital, Empangeni, Natal, South Africa.
One hundred and ninety three consecutive pregnant women attending peripheral antenatal clinics attached to Ngwelezana Hospital, Empangeni, Kwa-Zulu, were examined for evidence of sexually transmitted pathogens. The following incidences were found: Trichomonas vaginalis 49.2% (95), Candida spp 38.3% (74), Chlamydia tra
Azidothymidine is a new antiviral drug that acts by competitive inhibition of reverse transcriptase of retroviruses. Azidothymidine is now widely used in treatment of patients with AIDS or ARC; the most important side effects of this drug are anaemia and neutropenia. Recently pigmentary changes of the nails (diffuse p
Badellino F; Moresco L; Gipponi M; Cafiero F; Perasole A; Pagano G; Alessandrini A; Nicolo G; Divisione di Oncologia Chirurgica, Istituto Nazionale per la; Ricerca sul Cancro, Genova.
Thirty-three anti-HIV positive patients with persistent generalized lymphadenopathy (PGL) who underwent lymph-node biopsy were studied to assess the diagnostic and prognostic relations existing between clinical, histological and laboratory findings. Patients were also examined for known risk factors, laboratory and ba
Health Bull (Edinb). 1989 May;47(3):120-32. Unique Identifier : AIDSLINE MED/90036036
Thompson C
The variation in attendance at the department of Genitourinary Medicine in Edinburgh was studied for the period 1980 to 1987. A general decrease in the diagnosis of most specific sexually acquired infections is noted, with the exception of genital warts, the incidence of which continues to escalate. These changes init
Duschet P; Schwarz T; Gschnait F; Dermatologische Abteilung, im Krankenhaus der Stadt Wien-Lainz.
Plasmapheresis represents a new and powerful treatment for solar urticaria and has been performed in a couple of patients so far. Since therapeutic responses have been observed exclusively in cases exhibiting a pathogenetically important serum factor, plasmapheresis seems to work specifically by elimination of this ph
Owing to the unique nature of the human immunodeficiency virus (HIV), AIDS infection presents a unique set of problems. This paper focuses on one local health department s response to AIDS. Ottawa County, Michigan, is largely rural and has a low seroprevalence of HIV infection. The Ottawa County Health Department has
Brown LK; Fritz GK; Barone VJ; Department of Child and Family Psychiatry, Brown University; Program in Medicine, Rhode Island Hospital, Providence 02903.
Prevention, through school-based education campaigns, has been suggested as a response to the AIDS crisis although the impact of such education is unproven. The seventh and tenth grade classes (n = 313) in one Rhode Island school district were surveyed regarding AIDS knowledge, attitudes, and coping skills before and
Nader PR; Wexler DB; Patterson TL; McKusick L; Coates T; Department of Pediatrics, University of California, La Jolla; 92093-0631.
Beliefs about AIDS were surveyed among opportunistic samples of 1572 adolescents to compare four subgroups of youth: urban public high school students; suburban private school students; youth incarcerated in a detention facility; and a group who were contacted through a gay youth organization. The questionnaire items
Van Gorp WG; Miller EN; Satz P; Visscher B; West Los Angeles VA Medical Center, Psychology Service 90073.
This study examined the pattern of neuropsychologic abnormalities in three groups of subjects: 20 patients diagnosed with Acquired Immunodeficiency Syndrome (AIDS); 14 patients diagnosed with AIDS Related Complex (ARC); and 13 seronegative controls. Subjects with past history of chronic substance abuse, neurologic dis
Stormer RS; Falkinham JO 3d; Department of Biology, Virginia Polytechnic Institute and State; University, Blacksburg 24061.
Unpigmented colonial variants were isolated from pigmented Mycobacterium avium isolates recovered from patients with acquired immunodeficiency syndrome and the environment. The variants were interconvertible: the rate of transition from unpigmented to pigmented type was 4.0 x 10(-5) variants per cell per generation. T
Carman WF; Williamson C; Medical Research Council AIDS Virus Research Unit, University of; the Witwatersrand, Johannesburg, South Africa.
Two methods are described for the detection of in vitro enzymatically amplified DNA. The first method involves solution hybridization of labeled oligonucleotides to amplified products. Hybridization of primers to a dilution series of known concentration of amplified DNA showed that approximately 5 pg of DNA could be d
Emskoetter T; von Laer D; Veismann S; Ermer M; Department of Neurology, University of Hamburg, F.R.G.
We assessed the capacity of cerebrospinal fluids (CSF) and sera from human immunodeficiency virus (HIV)-seropositive patients to neutralize HIV and to mediate specific antibody-dependent lysis of HIV-infected target cells. A local HIV-specific intrathecal antibody synthesis was found in all stages of HIV infection reg
Herbst JS; Morgan J; Raab-Traub N; Resnick L; Department of Dermatology, Mount Sinai Medical Center, Miami; Beach, FL 33140.
To compare the therapeutic effects of surgical excision and orally administered acyclovir therapy on symptomatic oral hairy leukoplakia, 45 homosexual men who were seropositive for human immunodeficiency virus participated in a 3-month open-label study. In the 14 patients who ha
Shaw JC; Levinson W; Montanaro A; Oregon Health Sciences University.
Kaposi s sarcoma and disseminated sporotrichosis of the skin and joints developed simultaneously in a homosexual man with antibodies to human immunodeficiency virus. There was no identified source of exposure to Sporothrix organisms. Sporotrichosis may be a presenting opportunistic infection associated with acquired i
This paper reports on an AIDS education campaign at a California college campus. A pretest-posttest design was used to determine whether the AIDS-related attitudes of students, faculty, and staff were affected by an AIDS Awareness Week. The results showed that the awareness week was successful in exposing the campus c
Ciraru-Vigneron N; Rafowicz E; Nguyen-Tan Lung R; Brunner C; Barrier J; Service de Gynecologie-Obstetrique, Universite Paris VII,; Hopital Lariboisiere, Paris.
The principal obstetrical and paediatric sequelae were studied in 22 heroin addicts who were followed up at Lariboisiere Hospital in Paris between 1980 and 1984. The main effects were on the fetus with 45% showing growth retardation below the 10th percentile, 65% fetal distress, 9% prematurity; 33% had infections and
J Immunol. 1989 Nov 1;143(9):3064-8. Unique Identifier : AIDSLINE MED/90038546
Freimuth WW; Depper JM; Nabel GJ; Howard Hughes Medical Institute, Department of Internal Medicine,; University of Michigan Medical Center, Ann Arbor 48109.
The IL-2R alpha enhancer contains an 11 bp sequence that resembles kappa B, a regulatory element associated with several genes, including Ig kappa-L chain and human immunodeficiency virus. Although nuclear factor of the kappa-enhancer in B cells (NF-kappa B) binding is activated by PMA, TNF-alpha, and IL-1, activation
Jason J; Ou CY; Moore JL; Lawrence DN; Schochetman G; Evatt BL; Center for Infectious Diseases, Atlanta, Georgia.
Polymerase chain reaction (PCR) was used to detect human immunodeficiency virus (HIV)-1 DNA in peripheral blood mononuclear cells to assess in hemophilic men whether any were HIV-seropositive but uninfected or seronegative but infected and in seronegative sex partners of seropositive hemophilic men whether any were in
Heise W; Nehm K; L'Age M; Averdunk R; Gunther T; II. Innere Abteilung, Auguste-Viktoria-Krankenhaus Berlin.
The concentrations of Mg, Zn, Cu and albumin, and pseudocholinesterase activity were measured in the sera of 31 AIDS patients, 27 belonging to group IVC1 and 4 to group IVC2. Mean values for all patients were within the normal ranges. Only two patients showed hypozincaemia. A correlation was found between the concentr
Severson RK; Davis S; Thomas DB; Stevens RG; Heuser L; Sever LE; Division of Epidemiology, University of Minnesota, Minneapolis; 55455.
The relationship between prior allergies and adult acute myelocytic leukemia was investigated in a population-based case-control study. Based on data from personal interviews of 98 cases and 133 controls, a history of any type of allergy was associated with a significantly decreased risk of acute myelocytic leukemia (
Solomon R; Thompson J; Gillespie D; Department of Neoplastic Diseases, Hahnemann University,; Philadelphia, Pennsylvania 19102.
Peripheral blood mononuclear cells from HIV-1-infected persons were mixed with 5 M guanidine thiocyanate, and HIV-1-specific probes were hybridized with target RNA directly in the lysate. No RNA purification was needed. Hybrids were purified by repeated capture on superparamagnetic beads coated with oligo(dT) in a dev
Ayabe M; Shichijo S; Yokoyama MM; Department of Immunology, Kurume University School of Medicine,; Japan.
A method that could be facilitated for the quantitation and qualitation of gangliosides in human plasma was developed and applied in the present study for characterization of ganglioside patterns in plasmas of patients with neoplastic diseases including gastric cancer, adult T-cell leukemia (ATL), and acute lymphocyti
J Public Health Dent. 1989 Fall;49(4):201-5. Unique Identifier : AIDSLINE MED/90040391
ter Horst G; Hammann-Konings GM; van Hegten MJ; Maritz BM; Meijer KL; Meyland YM; van der Waag C; Department of Social Dentistry, Academic Centre for Dentistry; Amsterdam, The Netherlands.
In March 1988 all Amsterdam dentists (N = 470) were sent a questionnaire to assess the extent of compliance with guidelines from the Health Council to prevent HIV transmission in dental practice. Response rate was 62 percent. Gloves, masks, and other protective garments were widely used. Other infection control proced
Buskila D; Tenenbaum J; University of Toronto, Rheumatic Disease Unit, Mount Sinai; Hospital, ON, Canada.
Septic bursitis is a well described entity in immunocompromised patients. Common factors contributing to an immunocompromised state are alcoholism and corticosteroid therapy. We describe 2 patients with Staphylococcus aureus olecranon bursitis with evidence of human immunodeficiency virus (HIV) infection and no other
JAMA. 1989 Nov 10;262(18):2572-6. Unique Identifier : AIDSLINE MED/90041097
Francis DP; Anderson RE; Gorman ME; Fenstersheib M; Padian NS; Kizer KW; Conant MA; Center for Prevention Services, Centers for Disease Control,; Atlanta, Ga.
We propose establishing private and public outpatient facilities where persons with human immunodeficiency virus, type 1 (HIV-1), infection can receive state-of-the-art clinical and behavioral follow-up, treatment, and assistance. The possible advantages of enrolling HIV-1-positive persons into long-term follow-up are
JAMA. 1989 Nov 24;262(20):2859-63. Unique Identifier : AIDSLINE MED/90041148
Conway GA; Colley-Niemeyer B; Pursley C; Cruz C; Burt S; Rion P; Heath CW Jr; Bureau of Preventive Health Services, South Carolina Department; of Health and Environmental Control, Columbia.
An evaluation of the completeness and accuracy of case reporting of the acquired immunodeficiency syndrome (AIDS) for the 18-month period from January 1, 1986, through June 30, 1987, was conducted for South Carolina. A total of 596,585 hospital discharge billing records were searched by computer for conditions definin
JAMA. 1989 Dec 8;262(22):3161-5. Unique Identifier : AIDSLINE MED/90041213
Garland FC; Mayers DL; Hickey TM; Miller MR; Shaw EK; Gorham ED; Bigbee LR; McNally MM; Department of Epidemiology, Naval Health Research Center, San; Diego, Calif. 92138-9174.
From 1986 through 1988, the US Navy and US Marine Corps administered 1,956,631 enzyme-linked immunosorbent assay screening tests for antibodies to the human immunodeficiency virus to 1,070,511 active-duty enlisted and officer personnel. This study identified all persons who had an initial test with negative results. T
Serum antibodies to cytoskeletal systems were measured by indirect immunofluorescence using human skin fibroblasts and HEp2 cells as substrate. Healthy adults had IgM antibodies to vimentin and cytokeratin at 60 times serum dilution. IgG concentration did not have a correlation with IgG anti-cytoskeletal system antibo
We report a rare case of adult T cell leukemia/lymphoma (ATLL) in which cardiac invasion was clinically demonstrated and treated effectively. A 45-year-old female was admitted because of exertional dyspnea and cervical tumors. The leukocyte count was 19,100/microliters with 20% of flower cells. HTLV-I antibody was pos
J S C Med Assoc. 1989 Oct;85(10):481-7. Unique Identifier : AIDSLINE MED/90042228
Sy FS; Freeze-McElwee Y; Garrison CZ; Jackson KL
Our study reveals that high school and college students in South Carolina have a fairly high level of knowledge about AIDS. High school students have lower level of knowledge about AIDS than college students. High school students also have higher perception of risk of acquiring HIV infection and do not consider the AI
Greco D; Benedetti P; Pezzotti P; Tumbarello M; Ricci F; Vella S; Salmaso S
Since 1982, 2911 adult AIDS cases have been officially reported in Italy up to December 31, 1988. The clinical presentation of all cases, reported to the Istituto Superiore di Sanita, Rome, and contained into the National AIDS Register, has been analyzed, with particular attention t
A patient with Kaposi s sarcoma of the oral cavity is reported. The intralesional use of vinblastine may be an effective treatment for small Kaposi s sarcoma lesions of the mouth or the skin that are painful or create cosmetic problems.
Adler CH; Stern MB; Brooks ML; Department of Neurology, University of Pennsylvania School of; Medicine, Philadelphia.
A 24-year-old man with an 11-year history of i.v. drug use rapidly developed parkinsonism clinically indistinguishable from MPTP toxicity and Parkinson s disease. Although tests were negative for the human immunodeficiency virus, radiologic evaluation revealed bilateral striatal lesions. Stereotactic biopsy demonstrat
Ned Tijdschr Geneeskd. 1989 Nov 11;133(45):2226-9. Unique Identifier : AIDSLINE MED/90044254
van Deutekom H; Manos GE; Danner SA; Jansen HM; Coutinho RA
Of 225 patients in whom AIDS was diagnosed in the period January 1982 to March 1988 at the Academic Medical Centre, Amsterdam, the tuberculosis incidence and the clinical and demographic characteristics were recorded retrospectively. Tuberculosis was diagnosed in 18 patients (8%). The most frequent risk factor of AIDS
Herskovitz S; Siegel SE; Schneider AT; Nelson SJ; Goodrich JT; Lantos G; Department of Neurology, Albert Einstein College of Medicine,; Montefiore Medical Center, Bronx, NY 10467.
The alpha 1-antitrypsin (AAT) phenotype was determined by isoelectric focusing in 215 male homosexuals and compared with those in 208 male heterosexuals. The incidence of abnormal phenotypes was 16.3% in the homosexual group which was significantly different (p less than 0.03) than the 8.7% in the heterosexual group.
Embree JE; Braddick M; Datta P; Muriithi J; Hoff C; Kreiss JK; Roberts PL; Law BJ; Pamba HO; Ndinya-Achola JO; et al; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.
A malformation syndrome has been proposed in infants with acquired immunodeficiency syndrome or acquired immunodeficiency syndrome-related complex secondary to congenital infection with human immunodeficiency virus (HIV) in the United States and Europe. To determine whether embryopathy
Nord Med. 1989;104(11):283-4, 288. Unique Identifier : AIDSLINE MED/90045918
Pedersen C; Nielsen JO
American and English studies indicate that the risk of infection inherent in parenteral exposure to HIV via cuts or abrasions amounts to 0.25 to 0.5 per cent. Rules of procedure for prevention of blood-borne infection have been devised by the medical authorities in most countries. Simple changes in the routines can re
Pol Tyg Lek. 1989 Feb 13-20;44(7-8):206-8. Unique Identifier : AIDSLINE MED/90046242
Medras M; Blok K; Terpilowski L
Fourteen female patients married to infertile men were artificially inseminated with the semen of unknown donors within 1985-1987. Over 150 inseminations (no complications except sporadic pain) produced 7 pregnancies out of which 5 were finished with the delivery of healthy babies, one was terminated in the seventh we
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8088-92. Unique Identifier : AIDSLINE GENBANK/M25381
Olmsted RA; Hirsch VM; Purcell RH; Johnson PR; Department of Microbiology, Georgetown University, Rockville, MD; 20852.
We determined the complete nucleotide sequence of an infectious proviral molecular clone (FIV-14) of the feline immunodeficiency virus (FIV). FIV-14 has a genome organization similar in complexity to other lentiviruses. In addition to three large open reading frames representing the gag, pol, and env genes, at least f
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8526-30. Unique Identifier : AIDSLINE MED/90046830
Smith MR; Greene WC; Howard Hughes Medical Institut, Department of Medicine, Duke; University Medical Center, Durham, NC 27710.
We have investigated the biochemical basis for negative regulation of interleukin 2 receptor alpha-chain (IL-2R alpha) gene expression. Transient transfection studies employing internally deleted forms of the IL-2R alpha promoter localized a negative regulatory element (NRE) between nucleotides -400 and 368 relative t
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8575-9. Unique Identifier : AIDSLINE MED/90046840
Cheng-Mayer C; Weiss C; Seto D; Levy JA; Department of Medicine, University of California School of; Medicine, San Francisco 94143-0128.
The biologic, serologic, and molecular properties of isolates of human immunodeficiency virus type 1 (HIV-1) from the central nervous system (CNS) were determined and compared to those of isolates from peripheral blood and lymph nodes. Among these were pairs of CNS and blood isolates obtained from six infected individ
Proc Natl Acad Sci U S A. 1989 Nov;86(22):8655-9. Unique Identifier : AIDSLINE MED/90046851
Bryant ML; Heuckeroth RO; Kimata JT; Ratner L; Gordon JI; Department of Pediatrics, Washington University School of; Medicine, Saint Louis, MO 63110.
Myristoyl-CoA:protein N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the cotranslational linkage of myristate to the N-terminal glycine residues of several cellular, viral, and oncoproteins. We have recently synthesized a series of sulfur- and oxygen-substituted analogs of myristic acid that are similar in length
Gallicchio VS; Doukas MA; Hulette BC; Hughes NK; Gass C; Hematology/Oncology Division, University of Kentucky Medical; Center, Lexington.
3 -Azido-3 -deoxythymidine ( AZT ) has attained wide clinical utility in the treatment of acquired immunodeficiency syndrome (AIDS). Unfortunately, associated with AZT use, is the development of severe hematopoietic toxicity as manifested by anemia, neu
Cianciara D; Gorynski P; Grzybowski A; Supranowicz P; Zdunkiewicz L
The paper presents the results of an inquiry examination among teenagers between 17 and 19 years of age. The article discusses sources of information on AIDS used by teenagers and the level of this knowledge. It was found that the knowledge of methods of protection against HIV virus infection during a sexual contact w
Two cases are presented of Kaposi s sarcoma (SK) associated with AIDS and gastrointestinal affectation. The visceral extension of Kaposi s sarcoma has been related to a poorer prognosis, and in some cases, it is responsible for the appearance of symptoms, particularly gastrointestinal hemorrhage. The radiological patt
We present five patients with AIDS and enteropathy in whom the chronic diarrheal syndrome disappeared with a gluten-free diet. We hypothesize on the interrelations between celiac disease and enteropathy in AIDS, and propose that in similar cases, it may be a useful therapeutic alternative.
HIV infection is distributed so that stigmatized groups (gay and bisexual men, IVDU, blacks, and Hispanics) form the majority of cases. Consequences of AIDS-related stigma have resulted in unnecessary discrimination: loss of job, loss of home, denial of insurance, and estrangement from family and friends. Because AIDS
Despite the inroads that have been made in the treatment and diagnosis of HIV infection, many health care providers have an attitude of hopelessness and pity. Those of us who believe ourselves to be healthy have goals, aspirations, plans, and projects that guide our living. These are our reasons for living: they provi
Rev Med Brux. 1989 Oct;10(8):336-9. Unique Identifier : AIDSLINE MED/90048364
De Wit S; Clumeck N
Heterosexual bidirectional transmission of HIV is now clearly proved. In Western countries, and in particular in Belgium , the existence of clusters of heterosexual transmission demonstrates that, as in Central Africa, the epidemic could spread among heterosexuals. Sexual contacts
Dretler RH; Rausher DB; Dekalb General Hospital, Decatur, Georgia.
AIDS patients have been seen with a variety of ulcerating esophageal lesions, which may be refractory to both diagnostic approaches and empiric medical intervention. There are reports of these ulcers eroding vessels and severely limiting oral nutrition. After the report of success with prednisone therapy for oral and
Rev Hosp Clin Fac Med Sao Paulo. 1989 Jan-Feb;44(1):33-5. Unique Identifier : AIDSLINE MED/90048611
Dorlhiac-Llacer PE; Novaes MM; Chamone D de A
The frequency of ELISA-positive blood donors tested for HIV antibodies at Fundacao Hemocentro de Sao Paulo was 0.45% (526/116,354). Of these positive donors 38 in 100 tested (0.38% were confirmed by Western blot, giving a projected frequency of truly positive HIV antibody and ELISA-positive) of 0.171%. The higher the
We studied the HIV prevalence among oil workers and their families in a middle size population. Results were analyzed and compared with previous reports from USA, Brazil , and other cities in Mexico . There were no differences in prevalence betwee
Deep mycoses present new aspects characterized by deep, visceral mycotic localisations and septicemia, particularly in immunocompromised conditions. In immunodepressed patients (leukaemia, transplantation), the granulopenia descending to 500 elements/ml leads not only to invasive aspergillosis and candidosis but also
Cryptococcus neoformans is a ubiquitous encapsulated yeast present in soil. The usual contamination is by the respiratory route with ensuing dissemination in predisposed patients. Acquired immunodeficiency syndrome is the leading predisposing factor and illustrates the role of cellular immunity. Corticosteroid therapy
The indications of blood products are now well established, and the optimal use of these products requires a perfect knowledge of both their characteristics and the risks created by their transfusion to patients. The description, since 1982, of HIV infection following the administration of blood components and plasma
The possibility of transfusion-induced HIV infection by some blood components and plasma derivatives has been recognized since 1982. The implementation of preventive measures has virtually eradicated the risk of HIV transmission by some blood products and dramatically reduced this risk with other blood products. Howev
Singapore Med J. 1989 Aug;30(4):404-5. Unique Identifier : AIDSLINE MED/90049319
Chew SK; Monteiro EH
A patient with the acquired immunodeficiency syndrome (AIDS) presenting with isospora belli infection is reported. The difficulties encountered in the diagnosis and therapy of isosporiasis are discussed. The diarrhoea responded to treatment with intravenous fluid replaceme
Lewis DK; Watters JK; Anthropology Board, University of California, Santa Cruz 95065.
This study of 155 female i.v. drug users found that black women had higher HIV seroprevalence than white women (21% compared to 7%, respectively, odds ratio = 3.59, 95% CI 1.28-9.98). To attempt to explain why black female i.v. drug users were more likely to test HIV antibody positive, the ethnic distribution of a ser
Jagemann V; Vorsitzender der Medizinischen Kommission des Deutschen; Ringerbundes.
If the usual hygiene precautions are observed, sports--including competitive sports between two contestants--will not entail any concrete HIV infection risk, according to the present state of knowledge.
Tidsskr Nor Laegeforen. 1989 Oct 30;109(30):3119-20. Unique Identifier : AIDSLINE MED/90050068
Skogstad M
It is very likely that the degree of HIV-seropositive prevalence in prisons reflects the HIV epidemic among drug users outside prisons. A thorough epidemiologic survey among prisoners is therefore important. 23% of all known HIV-positive male drug users in Norway have been diagnose
Todays OR Nurse. 1989 Oct;11(10):15-9. Unique Identifier : AIDSLINE MED/90050443
Spechko PL
When a person contracts HIV, the initial acute infection is followed by a prolonged asymptomatic or mildly symptomatic period; lab values may be completely normal. By the time AIDS is diagnosed, the cell-mediated immune system is irreversibly damaged; virtually all patients die within 5 years. The pace of progression
Todays OR Nurse. 1989 Oct;11(10):20-6. Unique Identifier : AIDSLINE MED/90050444
Jackson MM; Lusby G; Bouvier B
The statistical probability of seroconversion is proportional to the number of needlesticks incurred and the likelihood that the needlesticks will be with HIV infected blood. Careful adherence to recommended operating room practices, combined with meticulous attention to handling needles and sharps, should result in f
Todays OR Nurse. 1989 Oct;11(10):33-7. Unique Identifier : AIDSLINE MED/90050446
Kadzielski MA
1. Ethical and legal issues relate to the healthcare professional s ethical and legal duty to treat the patient, maintain confidentiality of patient information, and protect themselves and warn other professionals. 2. Refusal to care for a patient with HIV infection because the disease is new or the professional s fea
Todays OR Nurse. 1989 Oct;11(10):8-14. Unique Identifier : AIDSLINE MED/90050447
Jackson MM; Lynch P
Although hepatitis B virus and HIV are similar, they are not transmitted with equal ease; the blood of persons with HIV has fewer infectious particles, which reduces the likelihood of transmitting the virus from average exposures. At present, the number of health-care workers who have developed AIDS as a result of occ
In a rural hospital in Malawi a protocol was developed for the treatment of severely anaemic children to improve the chances of survival of children with haemoglobin levels of 5 g/dl or less (referred to here as severe anaemia), and also to reduce the risks of transmission of human
We describe a method of psychosocial counselling that we have used with HIV-infected patients in Zambia . The protocol included providing the patient with factual information about HIV infection, understanding the patient s concept of their illness, and teaching the need to change s
Ugeskr Laeger. 1989 Oct 16;151(42):2715-9. Unique Identifier : AIDSLINE MED/90050712
Misfeldt JC; Senderovitz F; Melbye M; Olsen J
All of the tenth grade pupils in schools in Greenland participated in an investigation about the sexual behaviour of young Greenlanders and their knowledge about AIDS. This formed part of monitoring of the stop-AIDS campaign in Gree
Krause H; Wunderlich V; Uckert W; Department of Virology, Academy of Sciences of the German; Democratic Republic, Berlin.
Unintegrated circular proviral DNA of a type D retrovirus (PMFV) isolated from a permanent human cell line was molecularly cloned in the bacteriophage vector L47.1 and subcloned in the plasmid vector pGEM-2. A restriction endonuclease map of PMFV DNA was established using 10 different enzymes for single and multiple d
Adachi Y; Hatanaka M; Department of Serology and Immunology, Kyoto University, Japan.
The U3 region within the long terminal repeat (LTR) of human T-cell leukemia virus type-I (HTLV-I) contains elements responsible for transcriptional trans-activation. DNA-binding activities of nuclear proteins for each region of LTR were demonstrated using the gel retardation assay. The existence of cellular protein(s
Wis Med J. 1989 Oct;88(10):16-8. Unique Identifier : AIDSLINE MED/90051407
Tesch BJ; Simpson DE; Kirby BD
To assess the level of understanding about AIDS among future health care professionals, we developed and administered a 31-item test covering five AIDS-related knowledge domains to selected undergraduate students, medical school applicants, medical students and pre-clinical nursing students. The percentage of correct
Z Orthop. 1989 Jul-Aug;127(4):499-502. Unique Identifier : AIDSLINE MED/90051658
Harle A; Orthop. Univ.-Klinik, Munster.
In addition to the original assignments, as prevention of bacterial infections, hospital hygiene nowadays has to be concerned with the reduction of infection risks for the medical staff. AIDS isn t only a tremendous threat to the society, but may severely influence bone and joint surgery. The indications for surgical
Z Orthop. 1989 Jul-Aug;127(4):503-5. Unique Identifier : AIDSLINE MED/90051659
Gallwas HU; Universitat Munchen, Institut fur Politik und Offentliches; Recht.
The prevention of HIV infection in hospital, if at all possible, is a general legal obligation. For that reason, special preventive measures against infection are required for blood transfusions, transplantations or semen donations. On the other hand, comprehensive information on the risks of infection and the permane
The necessary obligation to carefulness at homogeneous transplantation of bone in concern of the AIDS epidemiology are being presented. According to the actual state of the HIV epidemiology a single examination of femur head donors contains an almost unmeasurable small risk of a virus transmission. Prior condition to
Giangaspero F; Scanabissi E; Baldacci MC; Betts CM; Institute of Anatomic Pathology, University of Bologna, Italy.
Human immunodeficiency virus (HIV) encephalitis in children with AIDS includes a diffuse white matter disease associated with an inflammatory cell infiltrate that features multinucleated giant cells. Cerebral cortex is relatively preserved and only focal loss of Purkinje cells in the cerebellum has been observed. We d
Mori S; Takami T; Nakamine H; Miyayama H; Nakamura S; Department of Pathology, University of Tokyo, Japan.
Lymph nodes of human immunodeficiency virus (HIV)-infected patients were studied histologically and immunohistochemically to elucidate the pattern of involution of various histiocytes in AIDS. Specimens consisted of one node with hyperplasia, five with atrophy, and three with severe atrophy. Antibodies such as L25, ID
Sun NC; Shapshak P; Lachant NA; Hsu MY; Sieger L; Schmid P; Beall G; Imagawa DT; Department of Pathology, Harbor-UCLA Medical Center, Torrance,; California 90509.
Bone marrow examinations were performed on 20 patients with acquired immune deficiency syndrome (AIDS) and 39 with AIDS-related complex (ARC). Fever of unknown origin and thrombocytopenia were common in ARC, but anemia and leukopenia were most frequent in AIDS. Changes in stromal cells and perivascular cuffing of plas
Am J Gastroenterol. 1989 Nov;84(11):1449-51. Unique Identifier : AIDSLINE MED/90053480
Hasan FA; Jeffers LJ; Welsh SW; Reddy KR; Schiff ER; Department of Medicine, University of Miami School of Medicine,; Florida.
A 44-yr-old homosexual male with symptomatic human immune deficiency virus (HIV) infection presented with abdominal pain, hepatosplenomegaly, and rising serum alkaline phosphatase. Laparoscopy revealed multiple purplish nodules on the surface of the liver. Histopathology of the lesions was consistent with Kaposi s sar
Am J Hematol. 1989 Nov;32(3):178-83. Unique Identifier : AIDSLINE MED/90053524
Stehr-Green JK; Jason JM; Evatt BL; Division of Host Factors, Centers for Disease Control, Atlanta,; GA 30333.
National AIDS surveillance suggests that approximately 3.5% of all hemophilic patients in the United States have developed AIDS as of February 1988; however, the cumulative incidence of AIDS among seropositive patients at individual hemophilia treatment centers (HTCs) has been reported
Am J Hematol. 1989 Nov;32(3):184-9. Unique Identifier : AIDSLINE MED/90053525
Mathew A; Raviglione MC; Niranjan U; Sabatini MT; Distenfeld A; Division of Hematology, Cabrini Medical Center, New York, NY; 10003.
To establish the indications for splenectomy in patients with human immunodeficiency virus (HIV) infection we retrospectively analyzed 12 patients who underwent splenectomy. Patients with HIV infection who had immune thrombocytopenic purpura (ITP) were excluded as they had no splenomegaly and a definite indication for
Am J Hematol. 1989 Nov;32(3):200-4. Unique Identifier : AIDSLINE MED/90053528
Gold JE; Castella A; Zalusky R; Department of Medicine, Beth Israel Medical Center, Mount Sinai; School of Medicine, City University of New York, NY 10003.
B-cell non-Hodgkin lymphoma (NHL) has been well described in association with human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS). Many of these lymphomas are of the diffuse, aggressive, subtype B-cell NHL, including Burkitt and Burkitt-like lymphoma. Recently, there have been reports
Am J Public Health. 1989 Nov;79(11):1544-8. Unique Identifier : AIDSLINE MED/90053923
Avins AL; Lo B; Division of General Internal Medicine, San Francisco General; Hospital, CA 94110.
Epidemiologic studies involving HIV (human immunodeficiency virus) antibody testing create ethical dilemmas, particularly about notifying asymptomatic seropositive subjects. Four study designs address this problem: mandatory notification, optional notification, anonymous testing, and blind testing. No single design co
Am J Public Health. 1989 Nov;79(11):1563-4. Unique Identifier : AIDSLINE MED/90053931
Sorvillo FJ; Lieb L; Mascola L; Waterman SH; Acute Communicable Disease Control Unit, County of Los Angeles; Department of Health Services, CA 90012.
In Los Angeles County from 1983-1988, rates of amebiasis declined 65 percent among White males 15-44 years. No such decline occurred among White females 15-44 years or White males less than 15. Reported acquired immunodeficiency syndrome (AIDS) cases in the district of highest AIDS incidence has followed the initial d
Am J Public Health. 1989 Dec;79(12):1643-7. Unique Identifier : AIDSLINE MED/90053952
Quesenberry CP Jr; Fireman B; Hiatt RA; Selby JV; Division of Research, Kaiser Permanente Medical Care Program,; Oakland, CA 94611.
Survival analysis techniques were used in estimating lifetime inpatient utilization among patients diagnosed with acquired immunodeficiency syndrome (AIDS) using data on 863 members of the Kaiser Permanente Medical Care Program in the Northern California Region diagnosed with AIDS between January 1, 1981 and June 30,
Am J Trop Med Hyg. 1989 Nov;41(5):601-16. Unique Identifier : AIDSLINE MED/90053993
Lo SC; Dawson MS; Wong DM; Newton PB 3d; Sonoda MA; Engler WF; Wang RY; Shih JW; Alter HJ; Wear DJ; American Registry of Pathology, Armed Forces Institute of; Pathology.
Monoclonal antibodies (Mabs) were developed against antigens from a pure culture of Mycoplasma incognitus grown in modified SP-4 medium. All the Mabs obtained were shown to react only with M. incognitus, and not with other species of human mycoplasma. The Mabs identified M. incognitus immunohistologically in thymus, l
Kinney EL; Monsuez JJ; Kitzis M; Vittecoq D; Reed Institute, Miami, Florida.
Although the diagnosis of AIDS-associated heart disease is becoming routine, its treatment has not been reported except in anecdote. Also, it has been unclear whether the odds of successful treatment are altered because of the presence of cardiac involvement per se. This communication reports the authors treatment of
Yajko DM; Nassos PS; Sanders CA; Hadley WK; Department of Laboratory Medicine, University of California, San; Francisco General Hospital Medical Center.
The murine macrophage continuous cell line J774 was used to measure the ability of antimicrobial agents, either singly or in combination, to kill intracellular Mycobacterium avium complex. All of 14 strains of M. avium complex, isolated from patients with AIDS, grew inside J774 cells during an incubation period of 7 d
Limper AH; Offord KP; Smith TF; Martin WJ 2d; Department of Internal Medicine, Mayo Clinic, Rochester,; Minnesota.
Pneumocystis carinii pneumonia has emerged as a significant cause of morbidity and mortality in immunocompromised patients with and without AIDS. To determine differences in P. carinii pneumonia in patients with and without AIDS, the P. carinii parasite numbers, lung inflammatory cell populations, gas exchange, and su
Ann Neurol. 1989 Oct;26(4):523-30. Unique Identifier : AIDSLINE MED/90055055
Moore GR; Traugott U; Scheinberg LC; Raine CS; Department of Pathology (Neuropathology), Albert Einstein College; of Medicine, Bronx, NY.
Tropical spastic paraparesis is a neurological disorder that is most commonly seen in certain tropical (mainly Caribbean) areas and that presents as a progressive spastic paraparesis and urinary dysfunction. Recent studies have revealed an association between tropical spastic paraparesis and human T-cell lymphotropic
To determine whether neurological and neuropsychological abnormalities are associated with clinical manifestations of human immunodeficiency virus type 1 (HIV-1) infection in men who do not have acquired immunodeficiency syndrome (AIDS), we performed a historical prospective and cross-sectional study. One hundred HIV-
Ann Neurol. 1989 Nov;26(5):601-11. Unique Identifier : AIDSLINE MED/90055069
McArthur JC; Cohen BA; Selnes OA; Kumar AJ; Cooper K; McArthur JH; Soucy G; Cornblath DR; Chmiel JS; Wang MC; et al; Johns Hopkins Medical Institutions, Baltimore, MD.
Accurate description of the prevalence of neurological impairment in healthy individuals who are infected with human immunodeficiency virus type 1 (HIV-1) has relevance for public health policy, for employment issues, and for planning future health needs. Within the Multicenter AIDS Cohort Study, we determined the cro
Ann Neurol. 1989 Nov;26(5):679-81. Unique Identifier : AIDSLINE MED/90055080
Brew BJ; Hardy W; Zuckerman E; Chien N; Paul M; Rosenblum M; Gadler H; Vahlne A; Gold J; Armstrong DA; et al; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY.
Assessment of antibodies against human T-lymphotropic virus type I (HTLV-I) by enzyme-linked immunoassay, immunofluorescence, and Western blot was undertaken in patients with pathologically or clinically diagnosed acquired immunodeficiency syndrome-related vacuolar myelopathy to determine whether this retrovirus could
Early pathological abnormalities in human immunodeficiency virus (HIV-1)-related dementia have not been well documented. We report a homosexual man with fatigue and intermittent diarrhea in whom early HIV-1-related dementia was demonstrated during neurological screening in the Mult
Naik S; Ruck R; Wadsworth Center for Laboratories and Research, New York State; Department of Health, Albany 12201-0509.
The in vitro activities of 12 macrolide compounds against 28 Mycobacterium avium complex strains isolated from patients with acquired immunodeficiency syndrome were determined by the conventional proportion method and by the BACTEC method. Clarithromycin (A-56268; TE-031), a new macrolide compound, was the most active
Berger TG; Tappero JW; Kaymen A; LeBoit PE; Department of Dermatology, San Francisco General Hospital, CA.
Two patients with acquired immunodeficiency syndrome developed simultaneous Kaposi s sarcoma and bacillary (epithelioid) angiomatosis. The distinguishing clinical and histologic features of these two vascular proliferations associated with human immunodeficiency virus disease are described. The lesions of bacillary (e
Curtis H; Lawrence C; Tripp J; Department of Child Health, Postgraduate Medical School.
A study on 761 teenagers aged 15-17 years showed that 56% of both sexes had had a steady or serious relationship. For about 40% of both sexes intercourse was a part of this relationship. Teenagers know how AIDS is transmitted, but only one third indicated personal concern about the epidemic. Only a fifth anticipate a
de Blic J; Blanche S; Danel C; Le Bourgeois M; Caniglia M; Scheinmann P; Service de pneumologie et d'allergologie infantiles, Hopital des; Enfants Malades, Paris, France.
The value of taking microbiological and cytological specimens by flexible bronchoscopy and bronchoalveolar lavage under local anaesthesia was assessed on 43 occasions in 35 HIV infected children, aged 3 months to 16 years, with interstitial pneumonitis. In acute interstitial pneumonitis (n = 22, 26 specimens from bron
Occurrence of intra-alveolar hemorrhage (whose theoretical causes are briefly reviewed) in an immunocompromised host raises a number of practical problems, mainly related to the interpretation of bronchoalveolar lavage (BAL) studies undertaken to identify one or more etiologies. An open lung biopsy is often needed in
Young FE; Nightingale SL; Cooper EC; Trapnell CB; Division of Antiviral Drug Products, Food and Drug; Administration, Rockville, MD 20857.
Aerosolized pentamidine isethionate (NebuPent, LyphoMed Inc, Rosemont, Ill) was recently approved by the US Food and Drug Administration for use in prophylaxis against Pneumocystis carinii pneumonia in individuals infected with the human immunodeficiency virus who are at high risk for this infection. The recommended d
Arch Sex Behav. 1989 Oct;18(5):401-19. Unique Identifier : AIDSLINE MED/90055783
Earls CM; David H; Departement de psychologie, Universite de Montreal, Quebec,; Canada.
A semistructured questionnaire was administered to 50 male prostitutes and 50 nonprostitutes matched on age, sex, and socioeconomic status. The questionnaire focused on areas pertaining to family, sexual and criminal history, current life situation, sexual practices with clients, substance abuse, etc. In addition, the
Lowenfels AB; Wormser GP; Jain R; Department of Surgery, New York Medical College, Valhalla 10595.
To evaluate the occupational risk of human immunodeficiency virus (HIV) infection, we surveyed 202 surgeons working in the New York City metropolitan area. One hundred seventy-three (86%) surgeons reported at least one puncture injury in the preceding year (median number, 2 per year; interquartile range, 1 to 4 per ye
Nyska A; Waner T; Pirak M; Albeck M; Sredni B; Life Science Research Israel, Ness Ziona.
Male and female Sprague Dawley rats were injected intraperitoneally for 4 weeks with ammonium trichloro (dioxyethylene-0-0 -) tellurate, an immunomodulating drug at doses ranging from 3 to 24 mg/kg/week. Routine laboratory examinations included body weight, food consumption, clinical chemistry and hematological examin
Opportunistic infections are frequent in AIDS patients, particularly in the last phase of the disease, when they occur both singly and in combination with other conditions (for example KAPOSI s sarcoma). These opportunistic infections are the cause of death in over 90% of cases. Their incidence ist proof of cellular i
Penning R; Tutsch-Bauer E; Beer G; Gurtler L; Spann W
Since May 1987 all postmortem cases at the Munich Institute of Forensic Medicine were screened for HIV-antibodies. If possible, testing was carried out before the postmortem examination in order to allow specific protective measures. 19 of 2631 consecutively tested corpses (= 0.7%) were HIV-infected. Since 1986, the o
Bitterlich G; Larcher C; Solder B; Hengster P; Myones BL; Hofbauer J; Schulz TF; Wachter H; Dierich MP; Institute for Hygiene, University of Innsbruck, Austria.
The effect of D-penicillamine on the replication of the Human Immunodeficiency Virus (HIV) in H9 T-lymphoblastoid cells was evaluated. HIV-infected and uninfected H9 cells were incubated for a period of 6 weeks with various concentrations of D-penicillamine. During the first 8 days, D-penicillamine (at concentrations
In this review, Warner Greene and colleagues discuss recent studies that have revealed an intriguing molecular interplay between two pathogenic human retroviruses, HIV-1 and HTLV-1, and certain cellular genes that normally control T-cell growth. Activation of T cells during an immune response results in the induction
Tracey KJ; Cerami A; Department of Neurosurgery, New York Hospital-Cornell University; Medical Center.
The studies reviewed here represent but a fraction of those published in the field last year, but they serve to illustrate two important points: (1) the cytokine network possesses enormous diversity of biological function, and (2) it is redundant, such that overlapping and synergistic effects are observed between many
Blood. 1989 Nov 1;74(6):2043-52. Unique Identifier : AIDSLINE MED/90028731
Hege KM; Daleke DL; Waldmann TA; Matthay KK; Department of Pediatrics, University of California, San Francisco; 94143.
Adult T-cell leukemia (ATL) is a rapidly progressive and usually fatal malignancy of mature T cells characterized by the expression of large numbers of interleukin-2 ( IL-2 ) receptors on the cell surface. Anti-Tac, a monoclonal antibody directed against the IL-2 recepto
Collins FM; Trudeau Institute, Inc., Saranac Lake, New York 12983.
The mycobacteria are an important group of acid-fast pathogens ranging from obligate intracellular parasites such as Mycobacterium leprae to environmental species such as M. gordonae and M. fortuitum. The latter may behave as opportunistic human pathogens if the host defenses have been depleted in some manner. The num
Severin MJ; Department of Medical Microbiology, Creighton University School; of Medicine, Omaha, Nebraska 68178.
Many legal issues will affect the health care worker during the AIDS pandemic. These issues are now beginning to be contested in our courts. It is certain that their numbers will continue to grow in the foreseeable future. As local, state, and federal governments design and implement new laws concerning PWA, mechanism
Childs Nerv Syst. 1989 Oct;5(5):281-7. Unique Identifier : AIDSLINE MED/90030268
Iannetti P; Falconieri P; Imperato C; Pediatric Department, I Chair, Universita di Roma La Sapienza,; Italy.
Central nervous system (CNS) involvement is very frequently observed in pediatric AIDS. Clinical manifestations include encephalopathy, cognitive deficits, acquired microcephaly, neurological signs, myelopathy, and peripheral neuropathy . Neurological complications can
Nemoto H; Sunohara N; Matsuda Y; Satoyoshi E; Yagishita A
A case of symptomatic adrenoleukodystrophy (ALD) heterozygote, manifested by spastic paraparesis, was reported. The patient s 9 year-old grandson had ALD, and her 34 year-old daughter, who was the mother of the case of ALD, was asymptomatic but accompanied by elevation of serum very long chain fatty acid (VLCFA). The
Community Ment Health J. 1989 Fall;25(3):185-96. Unique Identifier : AIDSLINE MED/90031442
Knox MD; Department of Community Mental Health, University of South; Florida, Tampa 33612.
Mental Health concomitants of the AIDS crisis are reviewed along with recommendations for a community mental health response. Proposed interventions range from traditional clinical services to support groups, case management, day treatment, training of caregivers, outreach, consultation, and community education. It is
Sandstrom E; Department of Dermatovenereology, Sodersjukhuset, Stockholm,; Sweden.
A rapid expansion of our knowledge of drugs that intervene with human immunodeficiency virus (HIV) infection has taken place. This review covers known and potential anti-HIV targets, including receptor blocking agents, membrane stabilisers, reverse transcriptase inhibitors and chain terminators, RNases, agents alterin
Rieder HL; Cauthen GM; Comstock GW; Snider DE Jr; Division of Tuberculosis Control, Centers for Disease Control,; Atlanta, GA 30333.
Over the past 30 years, the risk of tuberculous infection is estimated to have declined by approximately 8.3 per cent annually. Over that period, the incidence of tuberculosis declined between 5 and 6 per cent annually, and the mortality rate has declined by about 7.3 per cent annually. However, tuberculosis has not r
Schwendemann G; Schulz M; Neurologische Klinik der Universitatsklinik Essen.
Immunoneuropathies constitute but a small percentage of polyneuropathies, compared to metabolic or toxic neuropathies. However, refined techniques of immunochemistry and biopsy have increasingly improved the etiological characterisation of immunoneuropathies. This review deals with the present diagnostic tools for inv
Brook MG; Karayiannis P; Thomas HC; Academic Department of Medicine, St. Mary's Hospital Medical; School, London, United Kingdom.
Twenty-one pretreatment variables were assessed for their significance in response prediction using data from 114 patients given alpha-interferon for chronic hepatitis B virus infection. In those patients who had received a minimum of 90 million units per m2 total dose over 12 weeks, a negative anti-human immunodefici
Int J Cancer Suppl. 1989;4:2-5. Unique Identifier : AIDSLINE MED/90035655
Nerurkar LS; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Human retroviruses are associated with a wide spectrum of clinical entities including cancers, immune deficiency and neurological disorders. They have become the focal point of all retrovirology by virtue of their extreme clinical relevance, their novel and complex biologic and genetic properties, as well as their reg
Int J Psychiatry Med. 1989;19(2):165-72. Unique Identifier : AIDSLINE MED/90035800
Fernandez F; Levy JK; Mansell PW; Baylor College of Medicine, Houston.
Delirium is the most common neuropsychiatric complication of hospitalized AIDS patients. Typically, delirium is multifactorial in etiology and a complete evaluation to rule out all treatable, contributable medical conditions should be the first stage in the approach to a delirious AIDS patient. While a search for prob
Int J Tissue React. 1989;11(1):1-5. Unique Identifier : AIDSLINE MED/90035843
Morozov VA; Ilyinskii PO; Uckert WA; Wunderlich W; Ilyin KV; All-Union Cancer Research Center AMS, Moscow, USSR.
The sera of patients with lymphadenopathies (children, suffering from primary immune deficiencies) and AIDS were analysed for the presence of antibodies against D-type retroviruses by means of radioimmunoprecipitation (RIP) and Western blotting. It was established that these sera contain the antibodies derived against
von Wedel H; von Wedel UC; Zorowka P; Universitats-HNO-Klinik Koln.
On the basis of certain fundamental data for pathological hearing in children and its effects on speech development an attempt is made to summarise the most important considerations regarding the primary choice of a device and the subsequent procedures of fitting to optimise the benefits over a range of ages, from the
Fullilove MT; Department of Psychiatry, University of California School of; Medicine, San Francisco.
While it is not yet known what role anxiety may play in causing or exacerbating the immunologic aberration characteristic of acquired immune deficiency syndrome (AIDS), human immunodeficiency virus (HIV) infection is associated with a high incidence of psychologic and neuropsychiatric complications, including anxiety
Fernandez F; Department of Psychiatry, Baylor College of Medicine, Houston,; TX.
Acquired immune deficiency syndrome (AIDS) and human immunodeficiency virus (HIV)-related disorders are increasingly prevalent. They have psychopathologic and neuropsychiatric complications that warrant a systematic neurobehavioral assessment and a differential diagnosis of emotional disturbances in HIV-infected patie
A total of 215 serum samples were tested for antibodies against human immunodeficiency virus type 2 (HIV-2) with an immunofluorescence assay (IFA). Some samples originated from Denmark and some originated from
Tori CD; California School of Professional Psychology, Alameda/Berkeley; 94501.
Maladaptive behavioral and personality reactions to severe stressors among Mexican homosexual men were assessed by comparing substance abuse and Rorschach data obtained from three samples: (a) homosexuals residing illegally in the United States (n = 40), (b) homosexuals living in
Kovacs JA; Masur H; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland 20892.
Note from Dr. Merle A. Sande--We have recently come to appreciate the fact that successful chemotherapy of opportunistic infections in patients with AIDS is akin to treatment of certain malignancies: In both instances, induction, followed by maintenance, therapy is required. Although control of initial infections is u
Bernstein ZP; Gworek MA; Small BM; Department of Medicine, State University of NY, Buffalo.
We investigated the hematologic presentation of acquired immunodeficiency syndrome (AIDS) patients in our hospital to determine what abnormalities existed, and which of these could be assigned to any particular risk subgroup. Twentyseven AIDS patients were entered into the study; fifteen homo-bisexual males and twelve
Terunuma H; Iwasaki Y; Tsukamoto T; Konno H; Yamamoto T; Ohara Y; Department of Neurological Sciences, Tohoku University School of; Medicine, Sendai, Japan.
A close association between human T-lymphotropic virus type I (HTLV-I) infection and a group of chronic myelopathies of unknown etiology has recently been established and the name HTLV-I associated myelopathy (HAM) has been coined. Although the mechanism of neural tissue damage in HAM remains virtually unknown, severa
Belec L; Gherardi R; Georges AJ; Schuller E; Vuillecard E; Di Costanzo B; Martin PM; Institut Pasteur, Bangui, Central African Republic.
Four cases of infranuclear facial palsy associated with infection by the human immunodeficiency virus in young heterosexual African patients are reported. Two cases were healthy HIV carriers, one patient manifested AIDS-related complex, and one case fulfilled the CDC criteria for AIDS. Two patients had a typical Bell
Yana C; Frija J; Cyna-Gorse F; Ollier P; Lecompte T; Decazes JM; Roge P; Laval-Jeantet M; Service de Radiologie, Hopital Saint-Louis, Paris.
Six cases of non-lithiasic cholecystitis and 7 cases of inflammatory cholangitis caused by cryptosporidium and/or cytomegalovirus infections have been studied in HIV-1 + patients. All patients were examined with ultrasound and 5 with computed tomography (CT). The appearance is the
Acquired immunodeficiency syndrome (AIDS) was first noticed in 1981 by Centers for Disease Control (CDC). Since then, the number of patients has continued to increase and reached 151,790 by the end of April 1989. AIDS is caused by the infection of Human Immunodeficiency Virus (HIV), which infects CD4+ cells including
Bourgoignie JJ; Department of Medicine, University of Miami School of Medicine,; Florida.
More than 87,000 patients with acquired immunodeficiency syndrome (AIDS) were reported to the Centers for Disease Control in the United States , of whom more than half died through January 1989. When the AIDS epidemic is considered worldwide, these numbers should be doubled at least [27
Mo Med. 1989 Nov;86(11):741-3. Unique Identifier : AIDSLINE MED/90043562
Powderly WG
Zidovudine, or azidothymidine ( AZT ), is the only drug currently approved for treating patients with HIV infection. Though it effectively inhibits the disease, the drug s use is associated with a number of side effects, some grave. Management of zidovu
Effect of the structure of cloned env gene of HIV virus on the level of its expression has been studied. The deletion of the hydrophobic region from the env gene has been shown to increase considerably the biosynthesis of antigen-specific proteins in Escherichia coli cells. At the same time, the low level of expressio
Fromtling RA; Abruzzo GK; Ruiz A; Department of Basic Microbiology, Merck Institute for Therapeutic; Research, Rahway, New Jersey 07065-0900.
Studies on the distribution, epidemiology and pathogenesis of Cryptococcus neoformans on the island of Puerto Rico are few. We have studied mouse virulence and in vitro antifungal susceptibility of 133 isolates of C. neoformans: 121 environmental and 12 clinical (9 from AIDS pa
Ruiz A; Velez D; Fromtling RA; Department of Biology, College of Arts and Sciences, University; of Puerto Rico, Mayaguez.
Until the present decade, no studies had been conducted in Puerto Rico on the saprophytic distribution and variety of Cryptococcus neoformans. Samples (522) of pigeon droppings from 14 western towns were tested for the presence of C. neoformans. The yeast was recovered from 24.
Nature. 1989 Nov 16;342(6247):299-302. Unique Identifier : AIDSLINE MED/90044107
Lapatto R; Blundell T; Hemmings A; Overington J; Wilderspin A; Wood S; Merson JR; Whittle PJ; Danley DE; Geoghegan KF; et al; Department of Crystallography, Birkbeck College, London, UK.
Knowledge of the tertiary structure of the proteinase from human immunodeficiency virus HIV-1 is important to the design of inhibitors that might possess antiviral activity and thus be useful in the treatment of AIDS. The conserved Asp-Thr/Ser-Gly sequence in retroviral proteinases suggests that they exist as dimers s
Michel C; Dosquet P; Viron B; Mignon F; Service de Nephrologie A, Hopital Tenon, Paris.
A decade after its first introduction, the advantages and drawbacks of continuous ambulatory peritoneal dialysis over hemodialysis remain controversial. This present paper is a review of the literature, focused on the indications of this dialysis modality in different circumstances: extra-renal pathology, systemic dis
Shapiro CN; Schulz SL; Lee NC; Dondero TJ; Center for Infectious Diseases, Centers for Disease Control,; Atlanta, Georgia.
In this review, available human immunodeficiency virus (HIV) seroprevalence data are presented for United States women attending clinics related to reproductive health and for women in other settings. At family planning clinics, prenatal clinics, and in delivery room settings (cord blo
Itoh M; Inoue J; Toyoshima H; Akizawa T; Higashi M; Yoshida M; Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
Human retroviruses, human T cell leukemia viruses (HTLV) and human immunodeficiency viruses (HIV), express two classes of mRNAs; fully spliced mRNA in the early phase and intron-containing mRNA in a later phase. The expressions of HTLV-1 rex and HIV rev by early mRNAs are essential for the later phase of expression of
Transient transfection of ras expression vectors into human fibroblasts and astrocytes has been used to test the hypothesis that p21 ras, a known membrane signal transductor, may participate in pathways linking cellular activation and human immunodeficiency virus (HIV) reactivation. Expression vectors carrying the chl
Mori K; Boiziau C; Cazenave C; Matsukura M; Subasinghe C; Cohen JS; Broder S; Toulme JJ; Stein CA; Medicine Branch, National Cancer Institute, Bethesda, MD 20892.
Oligodeoxynucleotides with a phosphorus atom in which one of the non-bridging oxygen atoms is substituted by selenium were prepared and investigated with respect to their antisense properties. A general synthesis of phosphoroselenoate analogs of oligonucleotides is described using potassium selenocyanate as the seleni
Proc Natl Acad Sci U S A. 1989 Oct;86(20):7731-5. Unique Identifier : AIDSLINE MED/90046669
Webb NR; Madoulet C; Tosi PF; Broussard DR; Sneed L; Nicolau C; Summers MD; Department of Entomology, Texas A & M University, College Station; 77843.
CD4 is an integral membrane glycoprotein that acts as the cellular receptor for human immunodeficiency virus (HIV). A cDNA encoding full-length CD4 was inserted into the genome of Autographa californica nuclear polyhedrosis virus under transcriptional regulation of the viral polyhedrin gene promoter. The recombinant v
Proc Natl Acad Sci U S A. 1989 Oct;86(20):7790-4. Unique Identifier : AIDSLINE MED/90046681
Agrawal S; Ikeuchi T; Sun D; Sarin PS; Konopka A; Maizel J; Zamecnik PC; Worcester Foundation for Experimental Biology, Shrewsbury, MA; 01545.
Antisense oligodeoxynucleotides, both the phosphorothioate analogues and unmodified oligomers of the same sequence, inhibit replication and expression of human immunodeficiency virus already growing in tissue cultures of MOLT-3 cells with much greater efficacy than do mismatched (random) oligomers and homooligomers of
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8222-6. Unique Identifier : AIDSLINE MED/90046768
Malim MH; Bohnlein S; Fenrick R; Le SY; Maizel JV; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, NC 27710.
The known primate lentiviruses can be divided into two subgroups consisting of the human immunodeficiency virus type 1 (HIV-1) isolates and the related HIV type 2 (HIV-2) and simian immunodeficiency virus (SIV) isolates. HIV-1 has been shown to encode a post-transcriptional trans-activator of viral structural gene exp
Proc Natl Acad Sci U S A. 1989 Nov;86(22):8907-11. Unique Identifier : AIDSLINE MED/90046898
Haluska FG; Russo G; Kant J; Andreef M; Croce CM; Fels Institute for Cancer Research and Molecular Biology,; Philadelphia, PA 19140.
Non-Hodgkin lymphoma is a common feature of AIDS. Approximately 30-40% of these tumors exhibit clinical features suggestive of endemic Burkitt lymphoma: they are aggressive malignancies that occur in association with Epstein-Barr virus infection, they arise in the setting of immunosuppression, and they carry t(8;14) t
The topic of esophagitis due to Candida (ED), the most frequent infection of the esophagus, is reviewed. In recent years we have seen increased interest in candida esophagitis, fundamentally due to its relation with AIDS, for which it constitutes a diagnostic criteria. Candida esophagitis, although it can appear in ap
Rev Med Brux. 1989 Oct;10(8):320-6. Unique Identifier : AIDSLINE MED/90048362
Als C; Stoffels G
Clinical concepts about the acquired immunodeficiency syndrome, are evolving constantly. Laboratory tests are used to prove the infection virologically and serologically, to quantify the importance of immunodeficiency and to give a tentative prognosis. We discuss three classification systems (CDC, Haverkos, Walter Ree
Larson A; Health Transition Centre, Australian National University,; Canberra.
The literature relating to the social context of sexual relations in East and Central Africa has several implications for the heterosexual transmission of human immunodeficiency virus (HIV). Colonially created cities in the region still discriminate economically and socially against women. Rapid urbanization is occurr
Genta RM; Department of Pathology, Veterans Administration Hospital,; Cincinnati, Ohio.
Opportunistic disseminated strongyloidiasis is an important cause of morbidity and mortality in immunocompromised patients. However, the worldwide prevalence of Strongyloides stercoralis is difficult to determine because adequate data are lacking. In this paper more than 100 epidemiologic studies reporting on the prev
Hook EW 3d; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland.
Benzathine penicillin continues to be the cornerstone of recommended therapy for syphilis. Recent increases in the syphilis rates in the United States and concerns about the adequacy of currently recommended therapy for syphilis in patients with concomitant human immunodeficiency virus
Yeast-like fungi that are commonly found on the skin and in the digestive tract of healthy people may be responsible for deep infections as well as for cutaneous and mucosal diseases. Such deep infections have long been known in the case of Candida spp.; they are facilitated by immunosuppression or by factors that ena
Science. 1989 Oct 27;246(4929):488-91. Unique Identifier : AIDSLINE MED/90049154
Hart CE; Ou CY; Galphin JC; Moore J; Bacheler LT; Wasmuth JJ; Petteway SR Jr; Schochetman G; Centers for Disease Control, Atlanta, GA 30333.
Host cell factors act together with regulatory genes of the human immunodeficiency virus (HIV) to control virus production. Human-Chinese hamster ovary hybrid cell clones were used to probe for human chromosomes involved in regulating HIV gene expression. DNA transfection experiments showed that 4 of 18 clones had hig
Considerable attention, both in the scientific literature and in the popular media, has focused recently on the accuracy of tests for HIV antibodies. Many have pointed to the dangers of falsely identifying persons as being infected, and they have stressed that the predictive power of a positive test result may be smal
Todays OR Nurse. 1989 Oct;11(10):27-32. Unique Identifier : AIDSLINE MED/90050445
Santangelo J; Large KM
1. The development of effective drugs targeted at the underlying causative agent of AIDS (eg, HIV) is paramount to reducing morbidity and mortality. 2. Antiretroviral drugs may either inhibit HIV replication at the reverse transcriptase phase of the replication cycle or they may attack the cycle before HIV enters the
Chiodi F; Valentin A; Keys B; Schwartz S; Asjo B; Gartner S; Popovic M; Albert J; Sundqvist VA; Fenyo EM; Department of Virology, Karolinska Institute, Stockholm.
Virus has been isolated from the blood and cerebrospinal fluid (CSF) of eight subjects with varying severity of human immunodeficiency virus type 1 (HIV-1) infection and from the frontal lobe of one patient with AIDS. The five patients with AIDS-related complex (ARC) and AIDS also showed neurological/psychiatric compl
Delassus S; Sonigo P; Wain-Hobson S; Laboratoire de Biologie et Immunologie Moleculaires des; Retrovirus, INSERM U163, CNRS LA 271, Institut Pasteur, Paris,; France.
Gibbon ape leukemia virus (GaLV) is a highly oncogenic C-type retrovirus capable of inducing myeloid leukemia in juvenile gibbons. GaLV is antigenically most closely related to a new world monkey virus, simian sarcoma associated virus (SSAV), and less to the murine and feline C-type leukemia viruses. To begin to under
Rey MA; Krust B; Laurent AG; Guetard D; Montagnier L; Hovanessian AG; Unite d'Oncologie Virale (URA CNRS 153), Institute Pasteur,; Paris, France.
A new isolate of the human immunodeficiency virus (HIV) related to the HIV-2 strain was isolated from peripheral blood lymphocytes of an Ivory Coast patient with AIDS. This isolate referred to as HIV-2 EHO could be differentiated by its envelope precursor and external glycopro
Cochrane AW; Chen CH; Kramer R; Tomchak L; Rosen CA; Department of Molecular Oncology, Roche Institute of Molecular; Biology, Nutley, New Jersey.
A genetic approach was used to facilitate purification of human immunodeficiency virus (HIV) rev protein. A recombinant protein containing a stretch of six histidine residues at the amino terminus was engineered and overexpressed in Escherichia coli. Purification of greater than 95% was achieved in a single step using
Z Orthop. 1989 Jul-Aug;127(4):494-8. Unique Identifier : AIDSLINE MED/90051657
Frosner GG; Institut fur Virologie der Universitat Munchen.
Since hepatitis-B immune prophylaxis is possible, HIV infection could become the most important risk of infection facing medical personnel. Today, it must be assumed that HIV infection almost always leads to the fatal disease AIDS. The principal source of infection for medical personnel is patients blood. The disease
Vacuolar myelopathy (VM) is a frequent neurological complication of the acquired immune deficiency syndrome (AIDS). A suspected connection between VM and human immunodeficiency virus (HIV) has been based only on HIV isolation from affected spinal cord tissue. We report here an AIDS patient dying after 14 months of pro
Adv Exp Med Biol. 1989;254:55-60. Unique Identifier : AIDSLINE MED/90052862
Greene WC; Bohnlein E; Siekevitz M; Ballard DW; Franza BR; Lowenthal JW; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina.
Am J Gastroenterol. 1989 Nov;84(11):1445-8. Unique Identifier : AIDSLINE MED/90053479
Lisker-Melman M; Pittaluga S; Pluda JM; Kleiner DE; Thompson P; Martin P; Yarchoan R; Di Bisceglie AM; Liver Diseases Section, National Institute of Diabetes and; Digestive and Kidney Diseases, National Cancer Institute,; Bethesda, Maryland.
We describe the case of a homosexual man with asymptomatic infection with human immunodeficiency virus and hepatitis B virus who developed primary hepatic lymphoma. The lymphoma presented with rapid enlargement of the liver, and ultrasound examination revealed multiple hypoechoic lesions within the liver. Histological
Am J Trop Med Hyg. 1989 Nov;41(5):504-11. Unique Identifier : AIDSLINE MED/90053981
Wabwire-Mangen F; Shiff CJ; Vlahov D; Kline R; Serwadda D; Sewankambo NK; Mugerwa RD; Quinn TC; Johns Hopkins University, School of Hygiene and Public Health,; Baltimore, Maryland.
We conducted a cross-sectional study to determine the serological response to malaria in an HIV-1 infected population and in a control population in a region of high malaria transmission. The study group consisted of 66 hospitalized patients with clinical acquired immunodeficiency syndrome (AIDS) and 70 trauma patient
Anal Biochem. 1989 Aug 15;181(1):96-105. Unique Identifier : AIDSLINE MED/90054325
Coutlee F; Bobo L; Mayur K; Yolken RH; Viscidi RP; Eudowood Division of Infectious Diseases, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205.
A quantitative, nonisotopic hybridization assay which measures specific DNA-RNA hybrids is described. A biotinylated RNA probe is reacted in solution with a DNA target and the labeled hybrids are immobilized onto a solid phase surface with an antibiotin antibody. Bound hybrids are detected with a beta-galactosidase-la
Ryan JL; Veterans Administration Medical Center, Medical Service, West; Haven, CT 06516.
The appropriate use of antibiotics in nosocomial infections has been a goal of infectious disease practitioners and hospital epidemiologists since the emergence of resistant staphylococci more than 30 years ago. This challenge has assumed new proportions in the 1980s for many reasons. First, resistant gram-positive an
Ann Biol Clin (Paris). 1989;47(7):438-50. Unique Identifier : AIDSLINE MED/90054559
Petithory JC; Milgram M; Siodlak F; Department de Biologie Medicale E. Brumpt, Centre Hospitalier,; Gonesse.
Parasitosis opportunist are becoming clearer thanks to a better knowledge of immunological mechanisms, especially in AIDS. Child immunological immaturity and corticotherapy are the two other main immunodeficiencies among opportunist parasitosis. For the protozoosis, coccidiosis (especially toxoplasmosis), cryptosporid
Ann Intern Med. 1989 Nov 15;111(10):813-26. Unique Identifier : AIDSLINE MED/90054689
Masur H; Lane HC; Kovacs JA; Allegra CJ; Edman JC; National Institutes of Health, Clinical Center, Bethesda, MD; 20892.
Pneumocystis carinii is an intriguing organism found almost exclusively in the lungs. Very little is known about this organism s biologic or epidemiologic character. Over the past two decades, P. carinii has been recognized with increasing frequency as a cause of pneumonia in cancer patients, transplant recipients, an
Lombardo JM; Horsburgh CR; Denny TN; Michaels J; Schable C; Meyenhofer MF; Shriver K; Sharer LR; Ou CY; Rayfield MA; et al; Department of Pathology, University of Medicine and Dentistry of; New Jersey, Newark.
The variability and discordance of human immunodeficiency virus type 1 (HIV-1) antibody enzyme immunoassay determinations on serial specimens derived, to our knowledge, from the first documented case of HIV-2 infection in North America are described. The initial specimen was weakly reactive, but two subsequent serum s
Cupples JB; Blackie SP; Road JD; Department of Pathology, University Hospital, University of; British Columbia, Vancouver, Canada.
A 62-year-old man with untreated, well-differentiated lymphocytic lymphoma, presenting with progressive dyspnea, was found on open lung biopsy to have multiple necrotizing granulomas that on frozen section were initially called tuberculosis. Routine Grocott methenamine-silver stain showed these to contain Pneumocystis
Gendelman HE; Orenstein JM; Baca LM; Weiser B; Burger H; Kalter DC; Meltzer MS; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland.
We examined the structural variability of the external glycoprotein (gp130) of a cloned simian immunodeficiency virus (SIV) in culture. Cloned SIVmac142 was either permanently propagated in HUT-78 cells or sequentially passaged in MT-2 cells. After 12, 24 and 60 passages of permanent or lytic cell-culture systems, vir
Odehouri K; De Cock KM; Krebs JW; Moreau J; Rayfield M; McCormick JB; Schochetman G; Bretton R; Bretton G; Ouattara D; et al; Projet RETRO-Cl, Abidjan, Cote d'Ivoire.
In September 1987, a seroprevalence study of HIV-1 and HIV-2 infection was conducted among 956 people from different groups in Abidjan, Cote d Ivoire . Groups examined were hospitalized patients (Internal Medicine and Infectious Disease Departments, Centre Hospitalier Universit
Konde-Lule JK; Berkley SF; Downing R; Institute of Public Health, Makerere University, Kampala, Uganda.
A survey of the knowledge, attitudes and practices of 3928 Ugandans concerning AIDS was done in two semi-rural communities in August 1987. Eighty-eight per cent of the respondents knew that AIDS could be acquired from other people and that having multiple sexual partners was high-risk behaviour. There were, however, m
Latif AS; Katzenstein DA; Bassett MT; Houston S; Emmanuel JC; Marowa E; Department of Medicine, University of Zimbabwe Medical School,; Harare.
Seventy-five married men found to be positive for HIV-1 in Harare, Zimbabwe , were interviewed in order to define behaviours associated with acquisition of infection and to determine factors associated with transmission of infection to their wives. The majority of infected men rep
Hooykaas C; van der Pligt J; van Doornum GJ; van der Linden MM; Coutinho RA; Municipal Health Service of Amsterdam, Department of Public; Health, The Netherlands.
To study the prevalence of HIV and other sexually transmitted diseases (STDs), sexual behaviour and condom use among heterosexuals, 193 women and 157 men entered a longitudinal study. Participants were recruited through an STD clinic, and had had five or more heterosexual partners in the preceding 6 months but had no
Beck EJ; Donegan C; Cohen CS; Kenny C; Moss V; Underhill GS; Terry P; Jeffries DJ; Pinching AJ; Miller DL; et al; Academic Department of Community Medicine, St Mary's Hospital; Medical School, London, UK.
Between September 1985 and June 1988, 6923 people (4550 men and 2373 women) were tested for HIV-1 antibodies at a sexually transmitted disease clinic, London, UK. Of the 6923 individuals tested, 558 (8%) were seropositive, of whom 523 (94%) were men and 35 (6%) women. Of the seropositives, 84% were homosexual or bisex
Conlon CP; Banda HM; Luo NP; Namaambo MK; Perera CU; Sikweze J; Department of Medicine, University Teaching Hospital, Lusaka,; Zambia.
The prevalence of infection with mycobacteria, both typical and atypical, is increasing along with prevalence of infection with HIV. Patients with pulmonary tuberculosis (PTB) and patients with chronic diarrhoea are forming a growing proportion of the patient population in hospitals in central Africa. To investigate t
Blood. 1989 Nov 15;74(7):2596-9. Unique Identifier : AIDSLINE MED/90028808
Lairmore MD; Jason JM; Hartley TM; Khabbaz RF; De B; Evatt BL; Division of Viral Diseases, Centers for Disease Control, Atlanta,; GA 30333.
Concern for transmission of human T-cell lymphotropic virus, type 1 (HTLV-1) infection to recipients of infected cellular blood products has prompted development of tests to eliminate blood units with HTLV-I antibodies. Most hemophilic men from the United States became infected with hu
Brook MG; Chan G; Yap I; Karayiannis P; Lever AM; Jacyna M; Main J; Thomas HC; Academic Department of Medicine, St Mary's Hospital Medical; School, London.
OBJECTIVE--To confirm the findings of pilot studies that interferon alfa is an effective treatment of Europid men with chronic hepatitis B virus infection. DESIGN--Randomised controlled trial of three months treatment with interferon alfa followed by 12 months of observation. SETTING--Outpatient clinic of a tertiary r
OBJECTIVE--To assess current practice and opinions of general practitioners in London about managing psychological and social problems relating to HIV infection. DESIGN--A stratified random sample of general practitioners, including those with a range of experience of people with HIV infection, were interviewed by med
Chin TW; Plaeger-Marshall S; Haas A; Ank BJ; Stiehm ER; Department of Pediatrics, UCLA School of Medicine 90024.
Cytotoxic mechanisms (e.g., natural killer (NK) lysis, antibody-dependent cellular cytotoxicity, and cytotoxic T lymphocyte lysis) play an important role in host defense against various infections and neoplasms. Lymphokine-activated killer (LAK) cytotoxicity, induced in vitro by incubating mononuclear cells with inter
Dan Med Bull. 1989 Oct;36(5):490-1. Unique Identifier : AIDSLINE MED/90031799
Pedersen C; Lindhardt BO; Lauritzen E; Gaub J; Dickmeiss E; Department of Infectious Diseases, Hvidovre Hospital, Copenhagen.
A total of 228 stored serum samples from 140 high risk individuals was examined for serological markers of human immunodeficiency virus (HIV) infection by second generation enzyme-linked immunosorbent assay, immunoblot, and HIV antigen assay. All the samples were negative in first generation enzyme-linked immunoassay
Arima T; Takamizawa A; Mori C; Murakami S; Kaji C; Fujita J; First Department of Internal Medicine, Okayama University Medical; School, Japan.
A lambda gt11-random-primed-cDNA clone specific for chronic hepatitis C was isolated from pooled serum presumably infected by hepatitis C virus. The translation product of the clone detect 50% of patients with chronic hepatitis C in 4 test panels but none of the patients with acute hepatitis C, other liver diseases or
Hospitals. 1989 Nov 5;63(21):64. Unique Identifier : AIDSLINE MED/90034802
Eubanks P
A recent survey refutes the assumption that services for postacute AIDS patients are more accessible in communities with a high number of such patients, and projects a growing demand for these services nationwide.
We describe a mathematical technique and an associated computer program for comparing, evaluating and optimizing diagnostic tests. The technique combines receiver operating characteristic (ROC) analysis with information theory and cost-benefit analysis to accomplish this. The program is menu driven and highly interact
Ridgway EJ; Brown JM; Department of Microbiology, Whittington Hospital, Highgate Hill,; London, U.K.
Listeria monocytogenes is an unusual pathogen in the acquired immune deficiency syndrome (AIDS). We report a case of meningitis caused by L. monocytogenes in a patient with AIDS dementia who had eaten cheese from which a similar organism was isolated.
Sasayama K; Oe T; Inuyama M; Tanigawa H; Kawamura K; Yasuoka A; Yamada H; Dohtsu Y; Hayashi T; Kohno S; et al
A 75 year old woman who was admitted to Higashisaga National Hospital due to chronic bronchitis showed a high fever (39.2 degrees C) and marked lymphadenopathy of the bilateral inguinal lymph-nodes. Chest X-ray showed diffuse infiltration. Cryptococcus was detected in biopsied lymph-nodes. Although 5-fluorocytosine, m
Miller CH; Levy NB; Department of Medical Pathology, University of California Davis,; School of Medicine 95616.
Anticoagulant and room temperature storage of peripheral blood was evaluated in healthy and diseased persons (AIDS and CLL) for its effect upon lymphocyte phenotyping by flow cytometry. Whole blood was stored in either Li heparin, EDTA, or ACD for up to 96 hours. Aliquots at 5 time intervals were evaluated using CD3,
JAMA. 1989 Nov 17;262(19):2714-5. Unique Identifier : AIDSLINE MED/90041125
The American Heart Association and the American Red Cross used the findings from the 1985 National Conference on Standards and Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiac Care to establish their policy on the risk of infection during cardiopulmonary resuscitation (CPR) training and rescue. Findi
Of the two cases of angioimmunoblastic lymphadenopathy described, one had arisen after infection by a non-A non-B hepatitis virus and HIV. The possible cause of the immunological changes that triggered the disease are discussed as are its clinical picture, course and treatment. In the first case a 6 month remission pe
Hennighausen L; Furth PA; Pittius CW; Laboratory of Biochemistry and Metabolism, National Institutes of; Health, Bethesda, MD 20892.
kappa B elements have been described as lymphoid-specific transcriptional activators. Here we show that kappa B elements are able to stimulate expression from test promoters more than 100-fold in T47D and 3T3 non-lymphoid cells. We also demonstrate that nuclear proteins from T47D cells form two prominent complexes wit
Proc Natl Acad Sci U S A. 1989 Oct;86(20):7828-32. Unique Identifier : AIDSLINE MED/90046689
Gatignol A; Kumar A; Rabson A; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, MD 20892.
Human immunodeficiency virus type 1 (HIV-1) trans-activator protein Tat activates the expression of its viral long terminal repeat (LTR) through a target transactivation-responsive element termed TAR. We have constructed cell lines that constitutively express the HIV-1 Tat protein. Analyses of nuclear proteins from th
de Andrade AL; Martelli CM; Pinheiro ED; Santana CL; Borges FP; Zicker F
Screening tests of 62,814 blood donations carried out between October 85 and October 87 in all five blood banks of Goiania, Central Brazil , were analysed. The private institutions (3 blood banks) collected 80% of all donations and the remaining were collected by public blood banks.
Sex Transm Dis. 1989 Jul-Sep;16(3):123-6. Unique Identifier : AIDSLINE MED/90049614
Bogaerts J; Ricart CA; Van Dyck E; Piot P; Centre Hospitalier de Kigali, Rwanda.
The etiology of genital ulcer disease was determined in 210 consecutive patients (110 men and 100 women) who presented at a clinic in Kigali, Rwanda , because of genital ulcers. When mixed infections are included, syphilis (21%), chancroid (24%), and
Piszkiewicz D; Sun CS; Tondreau SC; Hyland Division, Baxter Healthcare Corporation, Duarte,; California 91010.
Cold supernatant which was prepared from factor VIII:C containing cryoprecipitate was seeded with HIV-1, then treated with a mixture of tri (n-butyl) phosphate (TNBP) and triton X-100. A greater than 10(11)-fold reduction of HIV-1 infectivity was observed. In a separate experiment, cold supernatant which had been seed
Dallo S; Maa JS; Rodriguez JR; Rodriguez D; Esteban M; Department of Biochemistry, State University of New York Health; Science Center, Brooklyn 11203.
Attenuated variants of vaccinia virus have excellent potential for the construction of safe recombinant live vaccines. In this investigation, highly attenuated variants of vaccinia virus with several genetic markers and a variant recombinant were tested in Balb/c mice for their ability to induce humoral immune respons
Am J Hematol. 1989 Dec;32(4):305-10. Unique Identifier : AIDSLINE MED/90053548
Karnad AB; Martin AW; Koh HK; Brauer MJ; Novich M; Wright J; Department of Hematology-Oncology, Boston City Hospital.
High grade B-cell lymphoma and leukemia have been well described in patients with the acquired immunodeficiency syndrome (AIDS). Malignant transformation of more differentiated lymphoid cells has not been well described in these patients. We report a 26-year-old man with AIDS-associated multiple myeloma, who had a hig
Ann Neurol. 1989 Oct;26(4):515-22. Unique Identifier : AIDSLINE MED/90055054
Kawanishi T; Akiguchi I; Fujita M; Kameyama M; Hatanaka M; Department of Neurology, Faculty of Medicine, Kyoto University,; Japan.
To elucidate the possible association of human T-lymphotropic virus type I (HTLV-I) and chronic neurological diseases, 156 serum samples from patients with various neurological diseases, including multiple sclerosis, chronic progressive myelopathy, chronic inflammatory polyradiculoneuropathy, myasthenia gravis, polymy
Pasi KJ; Hill FG; Department of Haematology, Children's Hospital, Birmingham.
Seventeen previously untreated boys with haemophilia A were treated with high purity heat treated factor VIII concentrate (8Y) for up to 36 months. Liver function tests were assessed monthly. No boy s serum has been shown to contain HIV antibodies and no increases in alanine transaminase activity have been detected. I
To assess the value of single photon emission computed tomography (SPECT) in the differential diagnosis of dementia SPECT and conventional computed tomography were performed in 77 patients (50 men, 27 women, mean age 59 [28-90] years) with dementia diagnosed by a battery of psychom
Lowe J; MacLennan KA; Powe DG; Pound JD; Palmer JB; Department of Histopathology, University of Nottingham Medical; School, Queens Medical Centre, U.K.
The resting human microglia have previously been shown to be cells of dendritic morphology expressing class II MHC antigens and macrophage specific antigens by immunocytochemical techniques. To examine the relationship between the microglia and the family of dendritic antigen presenting cells (APC), normal white matte
Med Hypotheses. 1989 Oct;30(2):105-9. Unique Identifier : AIDSLINE MED/90043323
Gunzler V
The beneficial effects of the teratogenic drug thalidomide on a variety of disorders involving the immune system have been established recently. Comparison of symptoms and immunologic abnormalities of such diseases with the acquired immunodeficiency syndrome, as well as experimentally obtained results suggest that tha
Am J Public Health. 1989 Dec;79(12):1638-42. Unique Identifier : AIDSLINE MED/90053951
Seage GR 3d; Horsburgh CR Jr; Hardy AM; Mayer KH; Barry MA; Groopman JE; Jaffe HW; Lamb GA; Division of Community Medicine, Boston Department of Health and; Hospitals, MA 02118.
To evaluate behavioral and immunologic factors related to transmission of human immunodeficiency virus (HIV) by homosexual intercourse, we studied a population of 329 homosexual/bisexual men (155 partner-pairs) seen in a community health center and medical outpatient clinic. Logistic regression analysis showed that be
Wilmes E; Falser N; Wolf H; Klinik und Poliklinik fur HNO-Kranke der Universitat Munchen.
Experimental and clinical data exist which point at a possible role of herpes virus infections in postnatally acquired inner ear disturbances. The presence of viral DNA in the inner ear and vestibular organ of experimentally infected mice and pigs suggests that not only primary infections but also the reactivation of
From 35 patients infected with Human Immunodeficiency Virus (HIV) and belonging to various risk groups, 60 stool specimens were examined for the presence of Coronavirus-like particles (CVLP) using electron microscopy. CVLP were detected in 5 (8%) stool samples from 5 different patients (14%). Only one of the patients
Busetta B; Laboratoire de cristallographie U.A. 144, Universite de; Bordeaux, Talence, France.
An automatic macromolecular modelling package of unknown protein structures was developed using the intimate correlation which appears between the observed X-ray structures and their associated predicted folding patterns. The method can be considered as a generalization of both the combinatorial [1] and the template i
Blood. 1989 Nov 15;74(7):2486-92. Unique Identifier : AIDSLINE MED/90028793
Fukunaga Y; Evans SS; Yamamoto M; Ueda Y; Tamura K; Takakuwa T; Gebhard D; Allopenna J; Demaria S; Clarkson B; et al; Department of Pediatrics, Nippon Medical School Hospital, Tokyo,; Japan.
Malignant CD4+ T cells in adult T-cell leukemia/lymphoma (ATL) and cutaneous T-cell lymphoma (CTCL) express a number of cell surface molecules that are upregulated on normal T cells activated by foreign antigen. In this report we describe an interesting exception to the parallel phenotypic features of activated T cell
Following emotional head-lines of certain articles in the press, making believe that the cat could be susceptible to the AIDS virus, the authors present elements of comparison between principal feline retroviruses (the feline leucosis virus and the feline immunodeficiency virus) and the two human immunodeficiency viru
Cancer Res. 1989 Nov 15;49(22):6419-24. Unique Identifier : AIDSLINE MED/90030234
Sieweke MH; Stoker AW; Bissell MJ; Division of Cell and Molecular Biology, Lawrence Berkeley; Laboratory, University of California, Berkeley 94720.
Chickens given injections of Rous sarcoma virus form sarcomas at the site of inoculation (primary tumor) and at the site of experimentally introduced wounds (wound tumor). This latter finding provides a model system to study systematically the mechanisms underlying the cocarcinogenic effects of wounding. Our experimen
Cell. 1989 Oct 20;59(2):283-92. Unique Identifier : AIDSLINE MED/90030403
Laspia MF; Rice AP; Mathews MB; Cold Spring Harbor Laboratory, New York 11724.
We studied regulation of human immunodeficiency virus-1 (HIV-1) transcription by Tat and, for comparative purposes, by the adenovirus E1A protein. These two trans-activators exerted different effects. Two classes of HIV-1-promoted cytoplasmic RNA were detected, one class corresponding to full-length transcripts and th
Powell JD; McClure HM; Anderson D; Fultz PN; Sell KW; Ahmed-Ansari A; Department of Pathology and Laboratory Medicine, Emory University; School of Medicine, Atlanta, Georgia 30322.
Greater than 75% of the sooty mangabey monkeys at the Yerkes Regional Primate Research Center are naturally infected with SIV without any apparent clinical symptomology. On the other hand, experimental infection of rhesus macaques with SIV results in a clinical syndrome similar to human AIDS. These differences with re
Kawaguchi T; Fukushima S; Ohmura M; Mishima M; Nakano M
The enzymatic and chemical stability of three 2 ,3 -dideoxy-2 ,3 -didehydropyrimidine nucleosides has been studied. Chemical degradtion of the analogues was measured in the pH range of 1.0-9.0. 2 ,3 -Dideoxy-2 ,3 -didehydrocytidine (DDCN) degraded rapidly under acidic conditions, but the chemical stability was greater
Koffi-Akoua G; Ferly-Therizol M; Kouassi-Beugre MT; Konan A; Timite AM; Assi Adou J; Assale G; Service de Pediatrie, CHU de Cocody.
In a study involving 104 children hospitalized with diarrhoea, 9% were infected with oocyst Cryptosporidium spp. add 56% with such yeast-fungus as Candida (C. Candida 38%). The manifestations noted in cryptosporidiosis infected children are acute diarrhea, vomiting and hyperthermia. One subject out of five who were te
Curr Top Microbiol Immunol. 1989;152:195-9. Unique Identifier : AIDSLINE MED/90031730
Mosier DE; Gulizia RJ; Baird SM; Spector S; Spector D; Kipps TJ; Fox RI; Carson DA; Cooper N; Richman DD; et al
Mice with severe combined immunodeficiency (C.B-17 scid, hereafter SCID) accept xenografts of adult human peripheral blood leukocytes (PBL). The transplanted human PBL expand in number and survive for at least thirteen months and have been shown to reconstitute human immune function at both the T and B cell levels. Hu
Dan Med Bull. 1989 Oct;36(5):503-6. Unique Identifier : AIDSLINE MED/90031804
Lundgren JD; Orholm M; Lundgren B; Nielsen JO; Shelhamer JH; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland.
Pulmonary disease is the most important cause of morbidity and mortality in patients infected with human immunodeficiency virus (HIV). All parts of the hospital system are expected to be involved in the diagnosis and treatment of HIV infected patients in the coming years. Many different processes cause pulmonary disea
FASEB J. 1989 Nov;3(13):2503-11. Unique Identifier : AIDSLINE MED/90033907
Wiley CA; Department of Pathology, University of California, San Diego, La; Jolla 92093.
Neuromuscular diseases are common in acquired immune deficiency syndrome (AIDS). Although the clinical incidence of peripheral neuropathy has not been systematically studied, various reports suggest that up to 40% of AIDS patients have clinical symptoms. Biopsy and au
In view of the changing patterns within the population groups affected with AIDS, the need for preventing transmission of the disease during heterosexual genital intercourse is becoming increasingly important. The problem as to how the woman can protect herself without the help of her partner has so far received littl
Syrjanen SM; von Krogh G; Syrjanen KJ; Department of Pathology, University of Kuopio, Finland.
A series of 128 biopsy specimens from anal condylomas in 73 homosexual or bisexual and 38 heterosexual men (mean (SD) age 31.8 (9.6) years) were subjected to histological assessment and human papillomavirus (HPV) typing by in situ DNA hybridisation with 35S-labelled HPV 6, 11, 16, 18, 31, and 33 probes. Most patients
Int J Cancer Suppl. 1989;4:78-82. Unique Identifier : AIDSLINE MED/90035672
Roncella S; Caretto P; Forni G; Cutrona G; Verde A; Ramarli D; di Celle PF; Foa R; Sessarego M; Pistoia V; et al; Servizio di Immunologia Clinica, Istituto Nazionale per la; Ricerca sul Cancro, IST Genoa, Italy.
Spontaneous lymphoblastoid cell lines (LCLs) were established from the peripheral blood of 10 human immunodeficiency virus (HIV)-seropositive patients in order to investigate whether or not progression of the cells towards a malignant state could be traced. The LCLs studied displayed no differences in their surface ph
Dang CV; Lee WM; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205.
Protein import into the cell nucleus requires specific binding of nuclear proteins to the nuclear pore complex. Based on amino acid sequence motifs of known nuclear targeting signals, we identified peptides within a number of nuclear proteins with likely nuclear targeting potential and tested their function by transfe
J Immunol. 1989 Nov 15;143(10):3343-52. Unique Identifier : AIDSLINE MED/90038492
Dudding L; Haskill S; Clark BD; Auron PE; Sporn S; Huang ES; University of the Witwatersrand, Johannesburg, South Africa.
Monocytes and tissue macrophages play important roles in host defense against virus infections and, in the case of human cytomegalovirus (HCMV) and HIV, may also be the reservoir for latent disease. Because these cells can also rapidly respond to most infections by secretion of inf
J Immunol. 1989 Nov 1;143(9):2996-3000. Unique Identifier : AIDSLINE MED/90038535
Bermudez LE; Stevens P; Kolonoski P; Wu M; Young LS; Kuzell Institute for Arthritis and Infectious Diseases, Medical; Research Institute of San Francisco, Pacific Presbyterian Medical; Center, CA 94115.
Mycobacterium avium complex (MAC) is the most common bloodstream pathogen isolated from patients with AIDS. We have previously shown that TNF alone or in combination with IL-2 can activate human and murine macrophages in vitro to kill MAC strains isolated from dissemin
Toorkey CB; Carrigan DR; Department of Pathology, Medical College of Wisconsin, Milwaukee; 53226.
As a member of the herpesvirus family, human cytomegalovirus (HCMV) induces a life-long latent infection in most individuals infected with it. This latent infection is subject to periodic reactivations that serve as an important source of disease and death in patients with defectiv
Syrjanen S; von Krogh G; Kellokoski J; Syrjanen K; Department of Oral Pathology, University of Kuopio, Finland.
Different types of Human papillomaviruses (HPV) are associated with a variety of oral lesions. So far, HPV types 1, 2, 4, 6, 7, 11, 13, 16, 18, 32 and 57 have been identified in oral lesions. Immunosuppression predisposes oral mucosa to clinical manifestation of different virus infections including HPV. We describe he
Laprevotte I; Laboratoire d'Hematologie Experimentale (CNRS), Centre Hayem,; Hopital Saint-Louis, Paris, France.
The present study is a detailed computer-assisted analysis of the feline leukemia virus gag gene nucleotide sequence together with its flanking sequences (ST-FeLV GAG) that is compared with the aligned sectors of the Moloney strain of murine leukemia virus (Mo-MuLV GAG) and of three strains of feline sarcoma virus. It
We treated 54-year-old Japanese man with a large cell type of Sezary syndrome. He had generalized erythrodermia, superficial lymphadenopathy, atypical lymphocytes in the peripheral blood, anti-HTLV-I antibody negativity and chromosomal abnormality. The patient was a hepatitis B virus carrier, and was complicated with
Life Sci. 1989;45(16):iii-x. Unique Identifier : AIDSLINE MED/90043018
Lake D; Sugano T; Matsumoto Y; Masuho Y; Petersen EA; Feorino P; Hersh EM; Section of Hematology and Oncology, University of Arizona, Tucson; 85724.
A stable hybridoma producing anti-HIV human monoclonal antibody (HMCA) was generated by fusing CD3-depleted human splenic lymphocytes from an HIV sero-positive donor with the mouse myeloma cell line P3x63AgU1. The resultant hybridoma has been secreting IgG1, lambda chain for over nine months at a rate of 2.5 microgram
Birek C; Patterson B; Maximiw WC; Minden MD; Faculty of Dentistry, University of Toronto.
The course of infections with herpes simplex virus and Epstein-Barr virus in an immunosuppressed patient who had undergone bone marrow transplantation and had tested seronegative for human immunodeficiency virus is described. The clinical oral manifestations were unusual, as they included hairy leukoplakia-like lesion
Presse Med. 1989 Oct 14;18(33):1657-62. Unique Identifier : AIDSLINE MED/90046525
Rene E; Service d'Hepato-Gastro-Enterologie et INSERM UIO, Paris.
The high frequency of gastrointestinal manifestations in AIDS raises new diagnostic and therapeutic problems. In this review paper the authors discuss the various clinical presentations and the different types of macroscopic or histological lesions, as well as the diagnostic approaches. This is followed by a descripti
Authors pointed on etiologic connections between particular clinical syndroms in AIDS and microbial, parasitic and viral agents belonging to different taxonomic groups. Participation of viruses in etiologic, immunology, pathology and importance for chemotherapy pointing on proved and probable relations, were analysed.
The chronology of important events in the AIDS/HIV epidemic is presented in Table 2. Nurses are the largest group of health care workers and persons who provide direct care and handle sharp objects regularly. As the number of persons infected with HIV increases and as more infected persons become ill enough to require
The multiplication of iatrogenic factors, nosocomial diseases and acquired immunodeficiency syndrome is responsible for an ever increasing number of deep opportunistic mycoses, namely candidiasis, aspergillosis and cryptococcosis. The advent of a wide variety of rare opportunistic fungi is a fairly recent and worrying
Many viruses, bacteria or parasites can survive in stored blood for varying lengths of time. Recipients are therefore exposed to a risk which depends on the prevalence of pathogens in blood donor populations, the clinical and laboratory controls performed in blood transfusion centres and the efficiency of the patient
Matsuda S; Gidlund M; Chiodi F; Cafaro A; Nygren A; Morein B; Nilsson K; Fenyo EM; Wigzell H; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
Low concentrations of serum obtained from a patient with acquired immunodeficiency syndrome (AIDS) enhanced the replication of human immunodeficiency virus type 1 (HIV-1) in a particular subclone of the CD-4-positive monocytoid cell line U937 clone 2. Cells of this subclone have a high expression of Fc receptors and a
South Med J. 1989 Nov;82(11):1444-5. Unique Identifier : AIDSLINE MED/90049464
Joe L; Ansher AF; Gordin FM; Medical Service, Veterans Administration Medical Center,; Washington, DC 20422.
We have reported a case of pancreatitis caused by CMV in an AIDS patient. Although CMV has caused clinical disease of other gastrointestinal organs, pancreatic involvement has previously been demonstrated only in autopsy specimens. The etiology of idiopathic pan
Sex Transm Dis. 1989 Jul-Sep;16(3):157-60. Unique Identifier : AIDSLINE MED/90049621
Darrow WW; Epidemiology Branch, AIDS Program, Center for Infectious; Diseases, Centers for Disease Control, Atlanta, GA 30333.
In vitro evidence strongly suggests that latex condoms provide an impenetrable barrier for the passage of infectious agents, but few have studied the use-effectiveness of condoms in preventing sexually transmitted diseases. In 1971, a prospective evaluation of the condom failed to demonstrate efficacy against infectio
Luster MI; Germolec DR; White KL Jr; Fuchs BA; Fort MM; Tomaszewski JE; Thompson M; Blair PC; McCay JA; Munson AE; et al; Systemic Toxicology Branch, National Institute of Environmental; Health Sciences, Research Triangle Park, North Carolina 27709.
A number of 2 3 -dideoxynucleosides have been reported to markedly inhibit the in vitro growth of HIV, the causative agent of acquired immunodeficiency syndrome (AIDS). Clinical trials have shown that the continued therapeutic use of these nucleoside derivatives can be associated with adverse side effects. Since these
Pinter A; Honnen WJ; Laboratory of Retroviral Biology, Public Health Research; Institute, New York, New York 10016.
The mature product of the env gene of Friend spleen focus-forming viruses (F-SFFV) is efficiently released from both leukemia cells and infected fibroblasts. Analyses of the kinetics of env protein synthesis and secretion in NRK cells infected with the Lilly-Steeves strain of SFFVp indicated that this product, gp65, w
Singh B; Arlinghaus RB; University of Texas M.D. Anderson Cancer Center, Department of; Molecular Pathology, Houston 77030.
Previous studies have shown that vimentin, an intermediate filament protein, is reduced in amount in cells acutely infected with Moloney mouse sarcoma virus (Mo-MuSV). In this report, we provide evidence for specific alteration of vimentin in Mo-MuSV-transformed cells and demonstrate specific phosphorylation of viment
Federspiel MJ; Crittenden LB; Hughes SH; BRI--Basic Research Program, NCI--Frederick Cancer Research; Facility, Maryland 21701.
We constructed two reticuloendotheliosis virus (REV) envelope gene expression plasmids, one containing the REV-A envelope gene, the other the spleen necrosis virus (SNV) envelope gene. Cell lines were generated by transfecting each of the REV envelope plasmids into D17 cells, a canine cell line. The levels of REV enve
Voytek P; Kozak CA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
HoMuLV is an NB-tropic wild mouse leukemia virus (MuLV) with ecotropic host range which induces lymphoma, erythroleukemia, and myelogenous leukemia in NIH Swiss mice. Although HoMuLV uses the same cell surface receptor as other ecotropic MuLVs, hybridization studies suggested that the HoMuLV envelope glycoprotein diff
Fletcher K; Macnab JC; Medical Research Council, Institute of Virology, University of; Glasgow, Scotland.
We have prepared EMBL3 libraries of DNA extracted from the cervix of a patient with cervical intraepithelial neoplasia (CIN) and isolated seven recombinant clones containing sequences that hybridize to human cytomegalovirus (HCMV) DNA. Restriction analysis of one clone with BamHI a
White AC Jr; Katz BZ; Silbert JA; Department of Medicine, Yale University School of Medicine, New; Haven, Connecticut 06510.
A patient presented with fever, night sweats, generalized lymphadenopathy, cold agglutinin hemolytic anemia, and thrombocytopenia. Lymph node biopsy revealed a lymphoplasmacytic infiltrate sparing the cortical sinuses but associated with arborizing blood vessels. Epstein-Barr virus (EBV) DNA was demonstrated in tissue
Pyle SW; Morein B; Bess JW Jr; Akerblom L; Nara PL; Nigida SM Jr; Lerche NW; Robey WG; Fischinger PJ; Arthur LO; Program Resources, Inc., National Cancer Institute-Frederick; Cancer Research Facility, MD 21701.
In mice, immunostimulatory complexes (ISCOMs) prepared from HIV-1 B external envelope glycoprotein (gp120) induced 10-fold higher antibody titres than gp120 emulsified in depot adjuvant, as measured by enzyme-linked immunosorbent assay (ELISA). Rhesus monkeys immunized with gp120 ISCOMs produced precipitating and viru
Balfour HH Jr; Englund JA; Department of Laboratory Medicine and Pathology, University of; Minnesota Health Sciences Center, Minneapolis 55455.
Pediatricians are made familiar with antiviral drugs and are provided with specific recommendations for treatment of viral diseases. The antiviral drugs in clinical use today are discussed in terms of their doses, routes of administration, mechanisms of action, established and potential efficacies, and toxicities. The
Am J Nephrol. 1989;9(4):316-21. Unique Identifier : AIDSLINE MED/90053725
Deray G; Martinez F; Katlama C; Levaltier B; Beaufils H; Danis M; Rozenheim M; Baumelou A; Dohin E; Gentilini M; et al; Department of Nephrology, Hopital Pitie-Salpetriere, Paris,; France.
Foscarnet is a pyrophosphate analogue that has been successfully used in severe cytomegalovirus ( CMV ) infections. Little is known of the incidence and mechanisms of foscarnet-induced nephrotoxicity as most data comes from rec
Rystedt I; Strannegard IL; Strannegard O; Dept. of Occupational Dermatology, National Board of Occupational; Health, Stockholm, Sweden.
Certain cutaneous viral infections, such as Herpes simplex, vaccinia and varicella infections are known to occasionally run an usually severe course in AD. Patients with AD display increased frequencies of recurrent cold sores and Herpes zoster and they also have increased antibody titers to Epstein-Barr virus. Heavy
Sall RK; Kauffman CL; Levy CS; Department of Infectious Diseases,Washington Hospital Center,; Washington, DC 20010.
We report a case of orofacial herpes simplex virus (HSV) infection that was progressive despite multiple courses of acyclovir sodium in a patient with the acquired immunodeficiency syndrome. The viral isolate was shown to be resistant to acyclovir in vitro, but proved susceptibl
Shibata D; Klatt EC; Department of Pathology, Los Angeles, County-University of; Southern California Medical Center.
Fixed autopsy tissues from nine patients infected with the human immunodeficiency virus (HIV) were assayed for the presence of HIV provirus and/or cytomegalovirus by the polymerase chain reaction. The HIV provirus was detected in lymphoid tissues from all nine patients. With nonlym
Borchelt DR; Perdue ML; United States Department of Agriculture, Southeast Poultry; Research Laboratory, Athens, Georgia.
Two conditions of in vitro translation are described in which the RNA of Rous sarcoma virus is significantly less efficient at protein synthesis than host cellular chick mRNA. In direct competition, addition of increasing amounts of host cell mRNA inhibits synthesis of gag gene products from RSV RNA. When the denatura
Hemming A; Lundberg L; Olofsson S; Department of Clinical Virology, University of Goteborg, Sweden.
By site-directed mutagenesis, two unique restriction sites, surrounding the CD4-binding DNA region of HIV gp 120, were created. The mutations do not cause amino acid substitutions but generate a DNA fragment, which is stable when cloned into M 13 for further mutagenesis and is also easy to reclone.
Magnani M; Bianchi M; Rossi L; Stocchi V; Istituto di Chimica Biologica, Universita degli Studi, Urbino,; Italy.
The mechanism by which 2,3 -dideoxycytidine, an inhibitor of HIV-I infectivity, permeates the cell membrane was investigated. The influx of ddCyd into human erythrocytes was nonconcentrative. The initial velocity of both ddCyd influx and efflux was, in contrast to compounds that permeate the cell membrane via the nucl
Blood. 1989 Nov 1;74(6):1923-8. Unique Identifier : AIDSLINE MED/90028713
Bhalla K; Birkhofer M; Li GR; Grant S; MacLaughlin W; Cole J; Graham G; Volsky DJ; Department of Medicine, Columbia University College of Physicians; and Surgeons, New York, NY.
Bone marrow cytotoxicity of 3 -azido-3 -deoxythymidine ( AZT ), an anti-human immunodeficiency virus (anti-HIV) drug, has been attributed to deoxyribonucleotide pool perturbations that might result in impaired DNA synthesis in normal bone marrow element
Hess G; Rossol S; Voth R; Gerken G; Ramadori G; Drees N; Meyer zum Buschenfelde KH; I. Medical Department, University of Mainz, FRG.
Six patients with chronic type B hepatitis and concurrent infection with the immunodeficiency virus were treated with 600 mg azidothymidine ( AZT )/day and 3 X 10(6) units of interferon-alpha (IFN-alpha) every other day for a total of 4 months. None of
Heagy W; Strom TB; Kelley VE; Collela J; Crumpacker C; Williams JM; Shapiro HM; Laubenstein L; Finberg R; Laboratory of Infectious Diseases, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115.
Decreased responses to antigens and lectins are a characteristic feature of peripheral blood lymphocytes isolated from patients with the acquired immunodeficiency syndrome (AIDS). The in vitro addition of recombinant gamma interferon (IFN-gamma) to cultures of peripheral blood lymphocytes obtained from patients with A
Langhoff E; McElrath J; Bos HJ; Pruett J; Granelli-Piperno A; Cohn ZA; Steinman RM; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York, New York 10021.
We have addressed the capacity of HIV-1 infection to alter the growth of primary CD4+ T cells, but at the clonal level. Single T cells were expanded in the presence of PHA, IL-2 , and small numbers of accessory dendritic cells. We report two new findings. First, T cells
J Immunol. 1989 Nov 1;143(9):2858-66. Unique Identifier : AIDSLINE MED/90038515
Scheppler JA; Nicholson JK; Swan DC; Ahmed-Ansari A; McDougal JS; Immunology Branch, United States Department of Health and Human; Services, Atlanta, GA 30333.
HIV-1 is capable of infecting many different cell types that express the CD4 molecule. In vivo and in vitro this infection is associated with profound immunologic defects. We have examined the effect of HIV-1 infection on the expression of MHC class I (MHC-I) molecules to explore the possibility that this important im
Klein RS; Selwyn PA; Maude D; Pollard C; Freeman K; Schiffman G; Department of Medicine, Montefiore Medical Center, Bronx, NY; 10467.
Antibody responses to pneumococcal vaccine were studied in asymptomatic heterosexual partners of persons with AIDS and intravenous drug users seropositive for human immunodeficiency virus (HIV). Serum antibodies to 12 pneumococcal capsular antigens were measured by radioimmunoassay. Eleven intravenous drug users serop
A 22-year-old, female patient came to see the allergists because of a 10-year history of chronic urticaria. Widespread pruritic, urticarial papules developed at times of stress and exercise, each papule being surrounded by a striking blanched vasoconstricted halo. The halo hives could be replicated with an intradermal
Lancet. 1989 Oct 28;2(8670):1023-5. Unique Identifier : AIDSLINE MED/90042712
Genesca J; Shih JW; Jett BW; Hewlett IK; Epstein JS; Alter HJ; Department of Transfusion Medicine, Warren G. Magnuson Clinical; Center, National Institutes of Health, Bethesda, Maryland.
To investigate the specificity of western blot indeterminate (WBi) patterns for antibodies to the human immunodeficiency virus type 1 (HIV-1), 100 enzyme immunoassay (EIA) negative donors from whom prospectively obtained recipient sera were available were tested by WB. 20 were WBi, with p24 being the predominant (70%)
Lancet. 1989 Nov 4;2(8671):1069-71. Unique Identifier : AIDSLINE MED/90042764
Brisson-Noel A; Gicquel B; Lecossier D; Levy-Frebault V; Nassif X; Hance AJ; Unite de Genie Microbiologique, Institut Pasteur, Paris.
A method based on DNA amplification and hybridisation for the rapid detection of Mycobacterium tuberculosis was used to test 35 clinical specimens (sputum, gastric aspirate, abscess aspirate, biopsy sample) from 34 patients in whom tuberculosis was suspected. M tuberculosis was detected in 15 specimens, 2 of which wer
Lancet. 1989 Nov 18;2(8673):1184-7. Unique Identifier : AIDSLINE MED/90042871
Morgan OS; Rodgers-Johnson P; Mora C; Char G; Department of Medicine, University of the West Indies, Kingston,; Jamaica.
IgG antibodies to human T-cell lymphotropic virus (HTLV-1) were found in 11 of 13 (85%) Jamaican patients with idiopathic adult polymyositis. The association was first observed in 7 patients with polymyositis who were included in a control group of 100 patients with neurological and neuromuscular diseases in a serolog
Regarding the staging of HIV infection, there are several classification systems, but neither of them has universally been accepted. We tested a new staging system with 4 parameters: HIV antibodies, CD4/CD8 ratio, absolute count of CD4 + lymphocytes, and absolute count of leukocytes. This classification indicates a re
Am J Hematol. 1989 Dec;32(4):262-72. Unique Identifier : AIDSLINE MED/90053542
Teitel JM; Freedman JJ; Garvey MB; Kardish M; Toronto and Central Ontario Comprehensive Hemophilia Program,; Department of Medicine, St. Michael's Hospital, Canada.
Fifty-nine HIV-1 antibody positive and 58 antibody negative hemophiliacs were evaluated over a 2 year study period to gain insight into the natural history and prognosis of HIV-1 disease in members of this risk group. Mean CD4 (Leu 3+) cell counts calculated at 6 month intervals decreased gradually in seropositive pat
Am J Pathol. 1989 Nov;135(5):793-800. Unique Identifier : AIDSLINE MED/90053801
Nickoloff BJ; Griffiths CE; Department of Pathology, University of Michigan Medical Center,; Ann Arbor 48109-0602.
Kaposi s sarcoma is a neoplasm that develops as multifocal lesions, often involving the skin, characterized by a complex histologic picture including numerous vascular spaces, perivascular and interstitial spindle-shaped cells, and extravasated erythrocytes, lymphocytes, and plasma cells. Using an antibody against fac
Ann Intern Med. 1989 Dec 1;111(11):871-5. Unique Identifier : AIDSLINE MED/90054709
Shibata D; Brynes RK; Rabinowitz A; Hanson CA; Slovak ML; Spira TJ; Gill P; University of Southern California School of Medicine, Los; Angeles.
A patient had adult T-cell leukemia-lymphoma in the unusual setting of coinfection with human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus type I (HTLV-I). The leukemic cells were CD4 positive and showed clonal genetic rearrangement of the T-cell receptor complex. Cytogenetic analysis show
Arch Environ Health. 1989 Sep-Oct;44(5):323-30. Unique Identifier : AIDSLINE MED/90055320
Lynn WS; Mathews D; Cloyd M; Wallwork JC; Thompson A; Sachs C Jr; Department of Preventive Medicine and Community Health,; University of Texas Medical Branch, Galveston.
Following injury or activation in some immune cell lines, elevation of intracellular Ca2+ concentration (Cai2+) is an early and major event that precedes cell death. Agents shown to elevate Cai2+ and to result subsequently in the death of some cells include human immunodeficiency virus (HIV) (in T4+ cells), 25-hydroxy
Calabrese LH; Wilke WS; Perkins AD; Tubbs RR; Department of Rheumatic and Immunologic Disease, Cleveland Clinic; Foundation, OH 44195-5028.
A patient with seropositive rheumatoid arthritis became infected with the human immunodeficiency virus (HIV) through heterosexual transmission. After the primary phase of the HIV infection, persistent lymphadenopathy, leukopenia, and thrombocytopenia developed. Over the ensuing 3 years, the signs and symptoms of infla
Chieco-Bianchi L; Calabro ML; Panozzo M; De Rossi A; Amadori A; Callegaro L; Siccardi A; Istituto di Oncologia, Universita di Padova, Italy.
The addition of monosialoganglioside GM1 to serum-free culture medium efficiently and specifically inhibited CD4 antigen expression on normal T lymphocytes from peripheral blood or thymus as well as on cells from H9 and Molt-3 lines; other molecules such as CD3, CD2 and CD8 were not affected. Subsequent addition of fe
Cell. 1989 Oct 20;59(2):273-82. Unique Identifier : AIDSLINE MED/90030402
Berkhout B; Silverman RH; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Expression of the human immunodeficiency virus type 1 (HIV-1) genome is greatly dependent on the viral trans-activator protein Tat. Tat functions through the TAR element, which is represented in both viral DNA and RNA. At present, there is no definitive evidence that determines whether Tat acts through a DNA or RNA fo
Experientia. 1989 Oct 15;45(10):996-8. Unique Identifier : AIDSLINE MED/90033157
Sugawara I; Itoh W; Kimura S; Mori S; Shimada K; Department of Pathology, University of Tokyo, Japan.
Fucoidan and dextran sulfate showed anti-HIV activities against mononuclear cells from AIDS patients, and they abrogated HIV reverse transcriptase (RT) activity by interacting with the HIV envelope in the membranes of target cells. Furthermore, they showed a synergistic effect with azidothymidine (
Yoshiyama H; Kobayashi S; Tanabe A; Kajii T; Shimada K; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Ube, Japan.
Three different assay systems for monitoring the production of human immunodeficiency virus (HIV) in infected cells were compared. These were (1) a reverse transcriptase assay (RTA), (2) an indirect immunofluorescence assay (IFA), and (3) an enzyme immunoassay (EIA) for detecting HIV antigen in vitro. MOLT-4 subclone
Berkower I; Smith GE; Giri C; Murphy D; Division of Biochemistry and Biophysics, Food and Drug; Administration, Bethesda, Maryland 20892.
HIV-1 is known to show a high degree of genetic diversity, which may have major implications for disease pathogenesis and prevention. If every divergent isolate represented a distinct serotype, then effective vaccination might be impossible. However, using a sensitive new plaque-forming assay for HIV-1, we have found
Nishizawa M; Yamagishi T; Dutschman GE; Parker WB; Bodner AJ; Kilkuskie RE; Cheng YC; Lee KH; Natural Products Laboratory, School of Pharmacy, University of; North Carolina, Chapel Hill 27599.
Four new tetragalloylquinic acids, 3,5-di-O-galloyl-4-O-digalloylquinic acid, 3,4-di-O-galloyl-5-O-digalloylquinic acid, 3-O-digalloyl-4,5-di-O-galloylquinic acid, and 1,3,4,5-tetra-O-galloylquinic acid, were isolated and characterized from a commercial tannic acid as a new class of human immunodeficiency virus (HIV)
A micromethod for assaying HIV reverse transcriptase was developed. Accuracy, and sensitivity of the micromethod were comparable to those of the traditional macromethod. The micromethod is easy to perform and can be used in non specialised laboratories.
Hakansson B; Linder C; Ohlsson K; Tegner H; Toremalm NG; Department of Otorhinolaryngology, University of Lund, Malmo; General Hospital, Sweden.
The effect of two decongestive substances and two preservatives used in nasal drops on phagocytosis by human granulocytes was studied. The vasoactive substances oxymetazoline chloride and zylometazoline chloride incubated with human granulocytes during 20 min. gave a reduction of phagocytosis to almost zero when using
Protein Eng. 1989 Oct;3(1):13-21. Unique Identifier : AIDSLINE MED/90046625
Bates PA; McGregor MJ; Islam SA; Sattentau QJ; Sternberg MJ; Biomolecular Modelling Laboratory, Imperial Cancer Research Fund,; London, UK.
A predicted three-dimensional structure of the two N-terminal extracellular domains of human CD4 antigen, a cell surface glycoprotein, is reported. This region of CD4, particularly the first domain, has been identified as containing the binding region for the envelope gp120 protein of the human immunodeficiency virus.
Proc Natl Acad Sci U S A. 1989 Oct;86(20):8055-8. Unique Identifier : AIDSLINE MED/90046736
Rossi P; Moschese V; Broliden PA; Fundaro C; Quinti I; Plebani A; Giaquinto C; Tovo PA; Ljunggren K; Rosen J; et al; Department of Immunology, Karolinska Institutet, Stockholm,; Sweden.
The present study demonstrates that maternal antibodies to certain epitopes of human immunodeficiency virus 1 (HIV-1) proteins are associated with a defined outcome for at-risk pregnancies of HIV-infected women. An initial retrospective analysis of antibodies to synthetic peptides and recombinant proteins representing
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8343-7. Unique Identifier : AIDSLINE MED/90046793
Perrino FW; Preston BD; Sandell LL; Loeb LA; Joseph Gottstein Memorial Cancer Research Laboratory, Department; of Pathology University of Washington, Seattle 98195.
The unusually high error rate of human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) suggests that polymerization errors by this enzyme contribute to the genetic variability of the AIDS virus. We have analyzed the mechanism for HIV-1 RT infidelity by studying two distinct steps that might lead to base
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8492-6. Unique Identifier : AIDSLINE GENBANK/M27913
Maul GG; Jimenez SA; Riggs E; Ziemnicka-Kotula D; Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
The possibility that viruses play a role in the etiology of various autoimmune diseases has been proposed. One approach to the search for these agents involves identifying potential crossreactive epitopes in viruses that infect cells of the immune system or of the target tissues. Antibodies to DNA topoisomerase I are
Proc Natl Acad Sci U S A. 1989 Nov;86(22):8964-7. Unique Identifier : AIDSLINE MED/90046910
Karacostas V; Nagashima K; Gonda MA; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
Infectious retrovirus particles consist of a core structure containing RNA and gag-pol polypeptides surrounded by a lipid membrane studded with env proteins. A recombinant vaccinia virus was designed to express the entire gag-pol precursor protein of the human immunodeficiency virus type 1. Synthesis and processing of
Beaussoleil S; Bosgiraud C; Nicolas JA; Laboratoire de Microbiologie, U.F.R. de Pharmacie de Limoges,; France.
We summarize the pathogenesis of animal lentiviruses (visna-maedi virus, caprine arthritis and encephalitis virus, and equine infectious anemia virus), which have raised considerable interest since the discovery of human lentiviruses. The human lentiviruses possess structural, genetic, and clinical properties similar
Pozsgay JM; Klyczek KK; Blank KJ; Molecular Biology Graduate Group, University of Pennsylvania,; Philadelphia 19104.
Inoculation of adult BALB/c-H-2k (BALB.K) mice with both Gross murine leukemia virus (GV) and a biological clone derived from this virus resulted in the recovery of variant viruses which differ from GV with respect to the expression of specific epitopes associated with the env gene product, gp70. The loss of these epi
Pedersen M; Permin H; Norn S; Skov PS; University Clinic for Infectious Diseases M, Rigshospitalet,; Copenhagen, Denmark.
AIDS patients in contrast to healthy individuals show basophil histamine release by stimulation in vitro of their blood leukocytes with Candida albicans (CA) and Herpes simplex virus Type I (HSV-I). Passive sensitization of cells from healthy individuals with the patient serum or surface immunoglobulins (Ig) derived f
Smith MS; Brian EL; De Clercq E; Pagano JS; Lineberger Cancer Research Center, University of North Carolina,; Chapel Hill 27599.
The replication of human immunodeficiency virus in vitro is inhibited by some acyclic adenosine derivatives, such as 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-2,6-diaminopurine [(S)-HPMPDAP], as well as by 3 -azido-3 -deoxythymidine (
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