Cervical ectopy and lack of male circumcision as risk factors for heterosexual transmission of HIV in stable sexual partnerships in Kenya.

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

Cervical ectopy and lack of male circumcision as risk factors for heterosexual transmission of HIV in stable sexual partnerships in Kenya.

Int Conf AIDS. 1990 Jun 20-23;6(1):267 (abstract no. Th.C.570). Unique Identifier : AIDSLINE ICA6/10057090
Moss GB; D'Costa LJ; Ndinya-Achola JO; Plummer FA; Reilly MP; Kreiss JK; University of Washington, Seattle, Washington, USA

Abstract: OBJECTIVE: To determine the frequency of and risk factors for heterosexual transmission of HIV within couples. METHODS: HIV+ individuals attending a Nairobi STD clinic were enrolled in a prospective study along with their spouses. RESULTS: Of 90 couples, 39 (43%) were concordant (CON) for HIV infection. Of 51 discordant (DIS) couples, in 31 the index case was male (DIM), and in 20 the index case was a female (DIF). In a stepwise logistic regression analysis HIV+ women were more likely than HIV- women to have cervical ectopy (OR=4.1, p=0.02); HIV+ men were more likely to have a positive H. Ducreyi IgG (OR=6.9, p=0.002) and a history of prostitute contact since 1980 (OR=4.4, p=0.02). CON and DIS couples were similar with respect to age, length of partnership, frequency of sex, sex during menses, CDC stage of HIV disease, history of genital ulcers, and STD diagnosis at study entry. Compared to DIS couples, the presence of cervical ectopy in women (27/37 vs 19/49, OR=4.3, p=0.003) and the lack of circumcision in men (23/39 vs 19/50, OR=2.3, p=0.08) were more common in CON couples. In a stepwise logistic regression analysis controlling for age, oral contraceptive use, and pregnancy, the presence of cervical ectopy (OR=4.3, p=0.01) and lack of male circumcision (OR=3.3, p=0.04) were predictors of concordance. CONCLUSION: The presence of cervical ectopy in women and lack of male circumcision were predictive of HIV seroconcordance among couples in stable sexual partnerships in Nairobi, Kenya.

Keywords: Cervix Uteri/*ABNORMALITIES *Circumcision Female Human HIV Infections/*TRANSMISSION Kenya/EPIDEMIOLOGY Male Prospective Studies Regression Analysis Risk Factors *Sexual Partners ABSTRACT
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M90C3228

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