THE EPIDEMIOLOGY OF AIDS: IMMUNIZATION

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

THE EPIDEMIOLOGY OF AIDS: IMMUNIZATION

The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 309-12, 1989.. Unique Identifier : AIDSLINE ICDB/90668125
Francis DP; Dept. of Health Services, State of California, Berkeley, CA 94704

Abstract: Immunization against HIV-1 can take three forms: (1) pre-exposure, active immunization; (2) post-exposure, active immunization; and (3) post-exposure, passive immunization. Progress in each of these areas is discussed. Vaccine development has been slowed by the limited understanding of the natural history of HIV-1 infection. The first attempts at a pre-exposure vaccine involved attempted induction of protective immunity based on surface components of the virus within the gp 120 (envelope) and/or gp 41 (transmembrane) proteins. Various antigens were prepared and four had completed chimpanzee challenge studies by early 1988. Two additional prototype vaccines were used directly in humans. Although much knowledge was gained in developing these vaccines, the first-generation prototypes have not proven effective. Questions about the immunologic correlates of HIV-1 infection and the similarity between the human and the chimpanzee need to be resolved. Unless there is a remarkable breakthrough, an AIDS vaccine does not appear to be on the horizon. Although there is no reason to believe that an HIV-1 vaccine is not feasible, the road toward its production appears complex and may take several years to negotiate. (9 Refs)

Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*PREVENTION & CONTROL Animal Human HIV Antigens/IMMUNOLOGY HIV Infections/IMMUNOLOGY/*PREVENTION & CONTROL HIV-1/*IMMUNOLOGY Vaccines, Synthetic/ADMINISTRATION & DOSAGE Viral Vaccines/*ADMINISTRATION & DOSAGE/IMMUNOLOGY MONOGRAPH REVIEW REVIEW, TUTORIAL
901230
M90C3724

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