Silent HIV infection: a rare occurrence in a high risk heterosexual population.

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

Silent HIV infection: a rare occurrence in a high risk heterosexual population.

Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.11). Unique Identifier : AIDSLINE ICA6/10001190
Sullivan JL; Brettler DB; Somasundaran M; Koup RA; Forsberg A; Brewster F; Byron KS; Chattopadyay B; University of Massachusetts Medical School and Medical Center of; Central Massachusetts-Memorial, Worcester, MA, USA

Abstract: OBJECTIVE: To study the natural history of HIV infection in high-risk sexual partners of HIV infected hemophiliac men. METHOD: Sixty female spouses and/or sexual partners of HIV infected hemophiliac men have been followed for one year to five years following seroconversion in the infected male. Assessment for HIV infection has included viral culture and PCR using env and gag primers, whole virus western blot and recombinant env, gag and nef immunoblot, evaluation of T cell subsets. RESULTS: Of sixty subjects evaluated repeatedly three have demonstrated HIV seroconversion which was accompanied by virus isolation. Thirteen pregnancies have resulted in one infected infant born to a seropositive isolation positive female. In twenty female spouses with more than five years of sexual exposure to an HIV infected male one seronegative female was found to be PCR positive, virus culture negative and nef antibody negative. In no instance was antibody to recombinant nef protein predictive of PCR positivity in the absence of virus isolation. T cell subset evaluations were normal with the exception of those individuals who seroconverted and from whom HIV was isolated. CONCLUSION: In a population of sixty high risk female spouses of HIV infected men, silent or latent HIV infection is a rare occurrence. Heterosexual transmission of HIV infection is accompanied by a diagnostic serum antibody response and the ability to isolate HIV.

Keywords: Female Hemophilia/COMPLICATIONS Human HIV/ISOLATION & PURIF HIV Antibodies/BIOSYNTHESIS HIV Infections/COMPLICATIONS/*TRANSMISSION *HIV Seropositivity Infant, Newborn Male Pregnancy Pregnancy Complications, Infectious/*ETIOLOGY Risk Factors *Sexual Partners ABSTRACT
901230
M90C3707

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