1990

Too little, too late. [videorecording].: [United States] : Micki Dickoff, c1987 1 videocassette (48 min.) : sd., col. with b&w ; 1/2 in Unique Identifier : AIDSLINE AV/9001259A; Dickoff M; (Producer) For every AIDS patient, according to one authority, the lives of at least eight family members and close friends are profoundly affected. Isolated and frequently shunned, these mothers and fathers, brothers and sisters, lovers and friends can feel as if they have nowhere to turn, and must endure their loss
Care of HIV-infected children. [videorecording]: [Los Angeles, Calif.] : The Network, c1988 1 videocassette (28 min., 30 sec.) : sd., col. ; 1/2 in. + 1 guide Unique Identifier : AIDSLINE AV/9001318A; Boland M; (Producer) Focuses on nursing care of HIV-infected infants and children and a model based on patient and family needs throughout the course of the illness. Illustrates a nursing care plan for HIV-infected children and reviews common problems. Emphasizes observance of Universal Precautions.
Coping with AIDS : some personal experiences of people with AIDS & HIV. [videorecording]: Services Lambeth [England] : Lambeth Council, c1988 1 videocassette (60 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9001322A; (Producer) People with AIDS face an array of physical, psychological, social, and practical problems. These problems are not just limited to dealing with consequences of the illness, but also concern the responses they receive from their families and friends and providers of health care and social services. The aim
AIDS. [slide]: London, UK : Gower, c1989 155 slides : col. with b&w + 1 guide + 1 text (Essential slide collection) Unique Identifier : AIDSLINE AV/9001219A; Williams I; Mindel A; Weller I
Early HIV. [slide]: [Columbus, Ohio] : The Center, [1989] 29 slides : col. + 1 sound cassette (1 7/8 ips) + 1 guide (OMEN ; no. 31) Unique Identifier : AIDSLINE AV/9001231A; Koletar SL; Crane R
The:Acquired immunodeficiency syndrome. [slide].: New York, N.Y. : Gower Medical Pub., c1989 90 slides : col. with b&w + 1 guide (Slide atlas of sexually transmitted diseases ; unit 8) Unique Identifier : AIDSLINE AV/9001263A; Kozarsky PE; Blumberg HM; DuPuis MH
Eyes. [slide].: New York, NY : Gower Medical Pub., c1989 33 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 6) Unique Identifier : AIDSLINE AV/9001287A; Ioachim HL
GI tract, associated organs. [slide].: New York, NY : Gower Medical Pub., c1989 88 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 4) Unique Identifier : AIDSLINE AV/9001289A; Ioachim HL
HIV counseling and testing : the physician's role. [videorecording]: Chicago, Ill. : The Society, c1989 1 videocassette : sd., col. ; 1/2 in. + 1 guide Unique Identifier : AIDSLINE AV/9001292A
Respiratory. [slide].: New York, NY : Gower Medical Pub., c1989 67 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 3) Unique Identifier : AIDSLINE AV/9001301A; Ioachim HL
Skin, hematolymphopoietic, cardiovascular. [slide].: New York, NY : Gower Medical Pub., c1989 94 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 2) Unique Identifier : AIDSLINE AV/9001303A; Ioachim HL
Slide atlas of pathology of AIDS. [slide].: New York, NY : Gower Medical Pub., c1989 453 slides : col. with b&w + 6 guides Unique Identifier : AIDSLINE AV/9001305A; Ioachim HL
Textbook of AIDS pathology. [slide].: New York, NY : Gower Medical Pub., c1989 80 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 1) Unique Identifier : AIDSLINE AV/9001309A; Ioachim HL
Urinary, genital, endocrine, CNS. [slide].: New York, NY : Gower Medical Pub., c1989 91 slides : col. with b&w + 1 guide (Slide atlas of pathology of AIDS ; 5) Unique Identifier : AIDSLINE AV/9001313A; Ioachim HL
[SIDA-AIDS : o que cada um deve saber para a combater.]: Portugal : Publicacoes Europa-America, c1986 171 p (Arte de viver ; 118) Unique Identifier : AIDSLINE CAT/9014591; Bernex R
AIDS in the Sudan : guide lines.: Khartoum : Sudan National AIDS Committee, [1987] 38 p Unique Identifier : AIDSLINE CAT/9013954; El-Tigani A; Eltayeb ES; Elmagzoub A
Acquired immune deficiency syndrome (AIDS) in Massachusetts : workplace issues, rights, and responses : a report of the Senate Committee on Post Audit and Oversight.: and Oversight Bureau [Boston, MA] (Room 314, State House, Boston, 02133) : The Committee, [1987] iv, 56 p Unique Identifier : AIDSLINE CAT/9014646
AIDS/HIV infection policy : ensuring a safe hospital environment : report and recommendations of the Special Committee on AIDS/HIV Infection Policy.: Infection Policy [Washington, D.C.] : American Hospital Association, [1987] viii, 20, 2 p (AHA report) Unique Identifier : AIDSLINE CAT/9014660
Strategies for screening blood for HIV antibody : use of a decision support system.: Philadelphia, Pa. : Leonard Davis Institute of Health Economics, University of Pennsylvania, [1987] 23, [8] leaves : ill (LDI management discussion paper ; no. 63) Unique Identifier : AIDSLINE CAT/9014862; Schwartz JS
Partners in prevention : a media worker's guide to AIDS. 3rd ed., wholly rev.: Carlton South, Vic. : Designer Publications on behalf of the Australian Federation of AIDS Organisations, c1988 49 p Unique Identifier : AIDSLINE CAT/9014094; Carr A
AIDS and development : implications for Australian non-government aid agencies.: Canberra : Australian Council for Overseas Aid, [1988] 50 p (Development dossier, ISSN 0815-9424 ; no. 24) Unique Identifier : AIDSLINE CAT/9014363; Reid E
[AIDS : chega de medo, vamos matar o virus da ignorancia.]: Rio de Janeiro : Associacao Brasileira de Entidades de Planejamento Familiar, 1988 91 p (Cadernos ABEPF ; 6) Unique Identifier : AIDSLINE CAT/9014365
Self-treatment for AIDS : oxygen therapies, etc.: San Francisco, Calif. (1600 Larkin, no. 104, San Francisco 94109) : [Greensward Press], c1988 152 p. : ill., ports Unique Identifier : AIDSLINE CAT/9014574; Russell-Manning B
AIDS and the workplace : a practical approach.: North Ryde, N.S.W. : CCH Australia, c1989 vii, 188 p Unique Identifier : AIDSLINE CAT/9013953; Tillett G
Confronting AIDS on the campus and in the classroom : a guide for higher education.: Washington, D.C. : College and University Personnel Association, c1989 viii, 222 p Unique Identifier : AIDSLINE CAT/9013982; McClain JR; Matteoli TE
[Cronicas do tempo de uma peste : a AIDS : materias educativas e informativas, com posicionamentos pessoais.]: Sao Paulo, SP : Roca, 1989 viii, 91 p Unique Identifier : AIDSLINE CAT/9013985; Amato Neto V
Food programs : assessing and developing community-based nutritional support programs for people with HIV-related illness.: Washington, DC : National AIDS Network (2033 M St., NW, Suite 800, Washington, DC, 20036), c1989 v. : ill (NAN technical assistance series) Unique Identifier : AIDSLINE CAT/9014009; Korda H; Hall CS
Shattered mirrors : our search for identity and community in the AIDS era.: Cambridge, Mass. : Harvard University Press, 1989 159 p Unique Identifier : AIDSLINE CAT/9014135; Price ME
Women and AIDS : a practical guide for those who help others.: New York : Continuum, 1989 xiii, 143 p (The Continuum counseling series) Unique Identifier : AIDSLINE CAT/9014171; Lester B
AIDS, agencies and drug abuse : the Edinburgh experience.: Norwich : Social Work Monographs, 1989 40 leaves (Social work monograph series) Unique Identifier : AIDSLINE CAT/9014203; McRae J
[Atlante di clinica e laboratorio, AIDS = AIDS, clinical and laboratory atlas.]: Pavia : Edizioni Medico-Scientifiche, c1989 vii, 405 p. : ill Unique Identifier : AIDSLINE CAT/9014359; Rondanelli EG
AIDS : sexual behavior and intravenous drug use.: Washington, D.C. : National Academy Press, 1989 (1990 printing) xiii, 589 p. : ill Unique Identifier : AIDSLINE CAT/9014364; Turner CF; Miller HG; Moses LE; the Behavioral, Social, and Statistical Sciences
Guide to planning health promotion for AIDS prevention and control.: Geneva : World Health Organization, 1989 iv, 71 p. : ill (WHO AIDS series, ISSN 1011-5773 ; 5) Unique Identifier : AIDSLINE CAT/9014445
Policing desire : pornography, AIDS, and the media. 2nd ed.: Minneapolis : University of Minnesota Press, 1989 xiii, 167 p. : ill (Media & society) Unique Identifier : AIDSLINE CAT/9014529; Watney S
Pediatric AIDS : report of the Twentieth Ross Roundtable on Critical Approaches to Common Pediatric Problems.: Problems Columbus, Ohio : Ross Laboratories (625 Cleveland Ave., Columbus 43216), c1989 viii, 83 p. : ill (Ross Roundtable report) Unique Identifier : AIDSLINE CAT/9014811
Pharmacia anti-HIV assays : data presented at V International Conference on AIDS, Montreal, 1989.: Uppsala, Sweden ; Columbia, Md., USA : Pharmacia ENI Diagnostics, [1989] 23 p. : ill Unique Identifier : AIDSLINE CAT/9014814
Protocol 1, estimating the use and costs of medical, social, and support services for persons with AIDS and ARC.: Rockville, MD (18-12 Parklawn Bldg., Rockville 20857) : U.S. Dept. of Health and Human Services, Public Health Service, National Center for Health Services Research and Health Care Technology Assessment, [1989] iv, 139 p. : ill (NCHSR program note) Unique Identifier : AIDSLINE CAT/9014829; Scitovsky AA; Technology Assessment (U.S.)
Protocol 3, comparisons of the cost effectiveness of alternative models for organizing services for person with AIDS.: Rockville, MD : The Center ; Springfield, VA : Available from National Technical Information Service, [1989] 88 p (NCHSR program note) Unique Identifier : AIDSLINE CAT/9014285; Knickman J; Benjamin AE; Dunham NC; Technology Assessment (U.S.)
Guidelines on AIDS and first aid in the workplace.: Geneva : World Health Organization, 1990 iii, 12 p (WHO AIDS series, ISSN 1011-5773 ; 7) Unique Identifier : AIDSLINE CAT/9014017
Syphilis as AIDS.: Austin, Tex. : Banned Books, c1990 xx, 128 p Unique Identifier : AIDSLINE CAT/9014149; Mitchell RB
The:AIDS benefits handbook : everything you need to know to get social security, welfare, Medicaid, Medicare, food stamps, housing, drugs, and other benefits.: New Haven : Yale University Press, c1990 xiv, 257 p Unique Identifier : AIDSLINE CAT/9014202; McCormack TP
National AIDS manual. 2nd rev. ed.: London : NAM Publications, 1990- 2 v. (loose-leaf) Unique Identifier : AIDSLINE CAT/9014265; Scott P
Skin manifestations of AIDS.: London : M. Dunitz, 1990 ix, 210 p : ill Unique Identifier : AIDSLINE CAT/9014576; Penneys NS
Vaccines 90 : modern approaches to new vaccines including prevention of AIDS.: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, 1990 xxv, 502 p. : ill Unique Identifier : AIDSLINE CAT/9014619; Brown F
Dancing against the darkness : a journey through America in the age of AIDS.: Lexington, Mass. : Lexington Books, c1990 xxviii, 218 p Unique Identifier : AIDSLINE CAT/9014701; Petrow S
Our responses to a deadly virus : the group-analytic approach.: London : Published by Karnac Books for the Institute of Group Analysis and the Group-Analytic Society, 1990 xix, 220 p. : ill., port Unique Identifier : AIDSLINE CAT/9014805; Molnos A
Report.: Pacific AIDS Manila, Philippines : Printed and distributed by the Regional Office for the Western Pacific of the World Health Organization, [1990] 15 p Unique Identifier : AIDSLINE CAT/9014839
Updated forecasts of the costs of medical care for persons with AIDS, 1989-93.: Rockville, MD (18-12 Parklawn Bldg., Rockville 20857) : U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, [1990] 12 p (AHCPR program note) Unique Identifier : AIDSLINE CAT/9014877; Hellinger FJ
The:Human retroviruses.: San Diego : Academic Press, c1991 xviii, 421 p. : ill Unique Identifier : AIDSLINE CAT/9014034; Gallo RC; Jay G
SECOND ANNUAL MEETING OF THE NATIONAL COOPERATIVE VACCINE DEVELOPMENT GROUPS FOR AIDS, OCTOBER 15-18, 1989, FORT LAUDERDALE, FL: Second Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS. October 15-18, 1989, Fort Lauderdale, FL, Vaccine Research and Development Branch, Division of AIDS, NIAID, 1989.. Unique Identifier : AIDSLINE ICDB/90649240; Anonymous; No affiliation given; The second annual meeting of the National Cooperative Vaccine Development Groups (NCVDGs) for AIDS was held October 15-18, 1989, in Fort Lauderdale, Florida. Topics included the HIV genome: opportunity/obstacles for AIDS vaccine development; the HIV Vaccine Consortium; idiotype-based vaccines for controlling HIV infec
PRINCIPLES OF CARCINOGENESIS: VIRAL: Cancer: Principles and Practice of Oncology. Third Edition. DeVita VT Jr. et al, eds. Philadelphia, Lippincott, p. 149-66, 1989.. Unique Identifier : AIDSLINE ICDB/90666955; Howley PM; Lab. of Tumor Virus Biology, NCI, Bethesda, MD; The observation that cell-free extracts from a sarcoma in chickens could transmit sarcoma to injected animals was made by Peyton Rous in 1911. That this represented viral transmission of cancer was not appreciated for decades. Several human viruses have oncogenic properties, although not all have been demonstrated to
HODGKIN'S DISEASE: Cancer: Principles and Practice of Oncology. Third Edition. DeVita VT Jr. et al, eds. Philadelphia, Lippincott, p. 1696-740, 1989.. Unique Identifier : AIDSLINE ICDB/90666996; Hellman S; Jaffe ES; DeVita VT Jr; Univ. of Chicago, Chicago, IL; Between 7000 and 7500 patients (pts) are diagnosed with Hodgkin s disease (HD) annually in the United States . HD is reviewed under the following headings: etiology and epidemiology; history; pathology (classification, criteria for histologic diagnosis, and cellular origin); natural his
CUTANEOUS LYMPHOMAS: Cancer: Principles and Practice of Oncology. Third Edition. DeVita VT Jr. et al, eds. Philadelphia, Lippincott, p. 1799-808, 1989.. Unique Identifier : AIDSLINE ICDB/90666998; Bunn PA; Fuks Z; Div. of Medical Oncology, Univ. of Colorado, Health Sciences; Center, University Hosp., Denver, CO; T-cell lymphomas are much less common than B-cell lymphomas in patients (pts) in the united States. Cutaneous T-cell lymphoma (CTCL) has an age-adjusted incidence in the United States of 2-3 cases per million persons per year. Acute T-cell leukemia/lymphoma (ATL), which is caused by hu
CANCER IN AIDS AND OTHER IMMUNODEFICIENCY STATES: Cancer: Principles and Practice of Oncology. Third Edition. DeVita VT Jr. et al, eds. Philadelphia, Lippincott, p. 1953-70, 1989.. Unique Identifier : AIDSLINE ICDB/90667004; Groopman JE; Broder S; Div. of Hematology/Oncology, New England Deaconess Hosp., Boston,; MA; In humans, various conditions characterized by impaired immune function are associated with a higher frequency of certain cancers than occur in age-matched controls. Certain immunodeficiency states and their relation to cancer are discussed under the following headings: cancer in allotransplant recipients, cancer in p
MOLECULAR REGULATION OF T LYMPHOCYTE ACTIVATION: Adv Regul Cell Growth; 1:93-118 1989. Unique Identifier : AIDSLINE ICDB/90667930; Edwards CA; Crabtree GR; Molecular Virology Group, Genelabs, Inc., 505 Penobscot Drive,; Redwood City, CA 94063; The interaction of a specific antigen with its cognate antigen receptor in a quiescent T lymphocyte initiates the T-cell immune response. The recognition of antigen at the cell surface triggers second messengers to carry this information to the nucleus and to activate the expression of several genes. Before a T lympho
THE EPIDEMIOLOGY OF AIDS: EXPRESSION, OCCURRENCE, AND CONTROL OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, 359 p., 1989.. Unique Identifier : AIDSLINE ICDB/90668107; Anonymous; No affiliation given; By late 1988, the number of articles cataloged in the National Library of Medicine AIDS Bibliography reached nearly 500 per month. The present volume seeks to assemble the available information on the epidemiology of HIV-1 infection into a coherent framework, accessible to the largest possible number of professionals
THE NERVOUS SYSTEM: PATHOPHYSIOLOGY AND CLINICAL MANIFESTATIONS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 68-83, 1989.. Unique Identifier : AIDSLINE ICDB/90668112; Brew B; Sidtis JJ; Price R; Dept. of Neurology, Memorial Sloan-Kettering Cancer Center, New; York, NY 10021; The course of infection by HIV-1 commonly is complicated by both CNS and peripheral nervous system (PNS) disorders that contribute importantly to its morbidity. The commonest and clinically most important of these disorders are reviewed. Topics include CNS disorders known or suspected to relate to direct HIV-1 infecti
EPIDEMIOLOGY OF AIDS: GENERAL CONSIDERATIONS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 87-116, 1989.. Unique Identifier : AIDSLINE ICDB/90668113; Kaslow RA; Francis DP; NIAID, NIH, Westwood Bldg., Rm. 739, Bethesda, MD 20892; Many epidemiologic features of HIV-1 infection and AIDS are pertinent to the epidemic as a whole rather than peculiar to any of the risk groups individually. General issues common to the HIV-1 epidemic are reviewed, including origins of HIV-1 infection; AIDS occurrence and surveillance; transmission (transmissibility
THE EPIDEMIOLOGY OF AIDS: HETEROSEXUALS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 136-52, 1989.. Unique Identifier : AIDSLINE ICDB/90668115; Haverkos HW; Edelman R; Natl. Inst. on Drug Abuse, Parklawn Bldg, Rm. 10A08, 5600 Fishers; Lane, Rockville, MD 20857; Early in the history of the AIDS epidemic, sexual transmission from men to women was considered unlikely or uncommon. Subsequent records of transmission of HIV-1 from men to women among unmarried women in Africa, spouses of the military, and hemophiliacs rapidly changed this misconception. The epidemiology of HIV-1 in
THE EPIDEMIOLOGY OF AIDS: PARENTERAL DRUG USERS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 153-78, 1989.. Unique Identifier : AIDSLINE ICDB/90668116; Friedland G; Montefiore Medical Center, Albert Einstein Coll. of Medicine, 111; E. 210th St., Bronx, NY 10467; Three features of illicit drug use during the past century have provided a fertile field for the amplification of HIV transmission: (1) an epidemic of drug use; (2) a change to the iv method of administration; and (3) an increase in needle-sharing behavior. The epidemiology of AIDS among parenteral drug users is revie
THE EPIDEMIOLOGY OF AIDS: RECIPIENTS OF BLOOD AND BLOOD PRODUCTS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 179-93, 1989.. Unique Identifier : AIDSLINE ICDB/90668117; Peterman T; Allen J; Center for Prevention Services, Freeway Park, CDC, Atlanta, GA; 30333; Transfusion recipients are exposed to blood from only a few donors, whereas hemophiliacs (ie, clotting-factor recipients) have extensive donor exposure because clotting factor is concentrated from thousands of donors. Recipients of clotting factor have a seroprevalence rate 1,000 times that of transfusion recipients,
HIV-1 INFECTION AND AIDS IN AFRICA: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 194-220, 1989.. Unique Identifier : AIDSLINE ICDB/90668118; Quinn TK; Mann J; Johns Hopkins Hosp., 600 North Wolfe St., Blalock 1111,; Baltimore, MD 21205; As of February 1988, 39 African countries had reported over 10,000 cases of AIDS, but these figures underestimate the true number of AIDS cases because of problems associated with obtaining an accurate diagnosis. Seroprevalence rates in some areas range from 5-15% among pregnant women and blood donors and up to 20-80%
HIV-1 INFECTION AND AIDS IN HAITI: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 221-30, 1989.. Unique Identifier : AIDSLINE ICDB/90668119; Pape JW; Johnson WD Jr; Div. of International Medicine, Cornell Univ. Medical Coll.,; A431, 1300 York Ave., New York, NY 10021; The first cases of AIDS in Haiti were recognized in 1978-1979, a period that coincides with the earliest reports of AIDS in the United States . Current data are consistent with the hypothesis that AIDS originated in Africa, was subsequently brought to
PERINATAL HIV-1 INFECTION: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 231-41, 1989.. Unique Identifier : AIDSLINE ICDB/90668120; Rogers M; Center for Infectious Diseases, Bldg. 6, Rm. 285, CDC, Atlanta,; GA 30333; AIDS in children was first described in 1982 by physicians in New York City, New Jersey, and Miami. As of August 1988, 1142 children under 13 yr of age with AIDS had been reported to the Centers for Disease Control (CDC), accounting for about 2% of all reported AIDS cases. Most (78%) of these children had acquired HIV
HIV-1 INFECTION IN LOW-RISK POPULATIONS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 242-9, 1989.. Unique Identifier : AIDSLINE ICDB/90668121; Saah AJ; Dept. of Epidemiology, Johns Hopkins Univ., Baltimore, MD 21205; Several types of contact with HIV-1-infected persons fall between casual contact and intensive, repeated exposure to blood or secretions. Individuals having contact at this intermediate level are considered at low risk for HIV-1 infection. Such persons include health care workers, correctional facilities personnel, da
THE EPIDEMIOLOGY OF AIDS: CHEMOTHERAPY AND CHEMOPROPHYLAXIS: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 282-308, 1989.. Unique Identifier : AIDSLINE ICDB/90668124; Skowron G; Merigan TC; Div. of Infectious Diseases, Stanford Univ. Sch. of Medicine,; Stanford, CA 94305; Therapeutic agents against HIV-1 can be divided broadly into those that specifically inhibit HIV-1 (antivirals) and those that augment the body s own defenses against HIV-1 infection (immunomodulators); some agents show dual activity. Chemotherapy against HIV-1 is reviewed and attempts at chemoprophylaxis are discusse
THE EPIDEMIOLOGY OF AIDS: IMMUNIZATION: The Epidemiology of AIDS: Expression, Occurrence, and Control of Human Immunodeficiency Virus Type 1 Infection. Kaslow RA and Francis DP, eds. New York, Oxford University Press, p. 309-12, 1989.. Unique Identifier : AIDSLINE ICDB/90668125; Francis DP; Dept. of Health Services, State of California, Berkeley, CA 94704; Immunization against HIV-1 can take three forms: (1) pre-exposure, active immunization; (2) post-exposure, active immunization; and (3) post-exposure, passive immunization. Progress in each of these areas is discussed. Vaccine development has been slowed by the limited understanding of the natural history of HIV-1 inf
EXPRESSION AND FUNCTIONAL DOMAINS OF THE TRANSFORMING PROTEIN OF AVIAN SARCOMA VIRUS UR2: Diss Abstr Int [B]; 51(1):77 1990. Unique Identifier : AIDSLINE ICDB/90667067; Jong SJ; Rockefeller Univ.; In order to study the mechanisms of cell transformation by the avian sarcoma virus UR2 which contains the oncogene ros, antibodies against its product P68gag-ros were developed. They were raised against ros-specific oligo- and poly-peptides. The antibodies were used to monitor the expression of potential c-ros product
SYSTEM DYNAMICS ANALYSIS OF THE IMMUNOLOGICAL RESPONSE TO VIRAL INFECTION, WITH PARTICULAR REFERENCE TO THE PATHOGENESIS OF ACQUIRED IMMUNE DEFICIENCY SYNDROME: Diss Abstr Int [B]; 51(2):654 1990. Unique Identifier : AIDSLINE ICDB/90668480; Whitaker RED; Boston Univ.; The mechanisms essential to the pathogenesis of Human Immunodeficiency Virus (HIV) infection have been extremely difficult to determine to date. The magnitude and breadth of immunological abnormalities and the conundrum of a relatively low viral load in the presence of high titres of HIV-specific anti-viral antibodies
INVOLVEMENT OF G PROTEINS AND CAMP-DEPENDENT PROTEIN KINASES IN THE SIGNAL TRANSDUCTION PATHWAY FOR INTERLEUKIN 1: Diss Abstr Int [B]; 51(2):650 1990. Unique Identifier : AIDSLINE ICDB/90668489; Chedid M; Wake Forest Univ., Bowman Gray Sch. of Medicine; Interleukin 1 (IL1) is a macrophage-derived cytokine that stimulates a broad spectrum of immune and inflammatory responses. The main objective of this thesis is to delineate the steps involved in the signal-transduction pathway for IL1. We characterized the IL1 receptor on human rheumatoid synovial cells. G proteins a
FUNCTIONAL DOMAINS OF THE C-ABL PROTEIN TYROSINE KINASE: Diss Abstr Int [B]; 51(3):1119 1990. Unique Identifier : AIDSLINE ICDB/90668532; Jackson PK; Harvard Univ.; Abelson murine leukemia virus is an oncogenic retrovirus capable of inducing a pre-B cell leukemia. The transforming ability of Abelson virus requires its gene product, pp160v-(abl), a cytoplasmic tyrosine kinase. Abelson virus can transform bone marrow in vitro and cultured cells, notably fibroblasts. The v-abl gene
MOLECULAR GENETIC ANALYSES OF THREE LEUKOCYTE SURFACE GLYCOPROTEINS: CD4, LEU-8 AND CD27: Diss Abstr Int [B]; 51(3):1113 1990. Unique Identifier : AIDSLINE ICDB/90668533; Camerini DPJ; Harvard Univ.; We have studied three molecules found on the surface of cells in the human immune system. CD4, Leu-8/TQ1 and CD27 are glycoproteins found on T lymphocytes, the cells which in large part regulate the body s immune defenses. Each of these molecules participates in a different aspect of T cell function. CD4 is part of th
A NOVEL SYSTEM FOR GENERATING PRIMATE RECOMBINANT HYBRID VIRIONS: Diss Abstr Int [B]; 51(3):1129 1990. Unique Identifier : AIDSLINE ICDB/90668550; Wilson CA; George Washington Univ.; The host range of a retrovirus, as determined by the cell types and species that it may infect, is a critical component of viral pathogenicity. The interaction of a retrovirus, via the envelope, with a specific cellular receptor is one of the key factors which determine the viral host range. Retroviral gene transfer t
DEATH WORK: STAFF PERSPECTIVES ON THE CARE OF TERMINALLY ILL PATIENTS IN AN ACUTE CARE HOSPITAL: Diss Abstr Int [A]; 51(3):1002 1990. Unique Identifier : AIDSLINE ICDB/90668578; Goodman HG; City Univ. of New York; This dissertation is a qualitative study of the perspectives of doctors, nurses, and social workers on terminally ill patients (pts) in their care. The methods used for this study were participant observation and focused interviews with professionals about dying pts whom they identified as difficult to manage. Fifteen
PAIN AND HIV INFECTION IN CHILDREN (MEETING ABSTRACT): J Pain Symptom Manage; 4(4):S5 1989. Unique Identifier : AIDSLINE ICDB/90666517; Veber F; Halpern-Weil F; Blanche S; Griscelli C; Hopital des Enfants Malades, Paris, France; Babies and children infected by HIV virus may have symptoms evocative of pain. The causes are diverse, including etiologies other than the classical ones such Candida esophagitis causing pain during deglutition or infectious diarrhea provoking abdominal pain for which cause and reliability of the pain are recognized a
Control of acute and chronic HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):134 (abstract no. Th.A.1). Unique Identifier : AIDSLINE ICA6/10000190; Martin MA; Laboratory of Molecular Microbiology, NIAID, National Institutes; of Health, Bethesda, MD, USA
Regulatory genes of HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):134 (abstract no. Th.A.2). Unique Identifier : AIDSLINE ICA6/10000290; Pavlakis GN; National Cancer Institute, National Institutes of Health,; Bethesda, MD, USA
Mechanism of HIV tat and HTLV tax.: Int Conf AIDS. 1990 Jun 20-23;6(1):134 (abstract no. Th.A.3). Unique Identifier : AIDSLINE ICA6/10000390; Jeang KT; Laboratory of Molecular Biology, National Institute of Allergy; and Infectious Diseases, NIH, Bethesda, MD, USA
Cellular factors affecting HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):134 (abstract no. Th.A.4). Unique Identifier : AIDSLINE ICA6/10000490; Gaynor R; UCLA, CA, USA
Structure and function of HIV envelope.: Int Conf AIDS. 1990 Jun 20-23;6(1):135 (abstract no. Th.A.5). Unique Identifier : AIDSLINE ICA6/10000590; Sodroski J; Dana-Farber Cancer Institute, Boston, MA, USA
Accessory genes in HIV replication.: Int Conf AIDS. 1990 Jun 20-23;6(1):135 (abstract no. Th.A.6). Unique Identifier : AIDSLINE ICA6/10000690; Haseltine W; Dana-Farber Cancer Institute, Boston, MA, USA
The use of PCR in HIV research.: Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.9). Unique Identifier : AIDSLINE ICA6/10000990; Sninsky J; Emeryville, CA, USA
A rapid method for detection and differentiation of amplified HIV-1 and HIV-2 DNA using a sensitive chemiluminescent DNA probe system (HPA).: Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.10). Unique Identifier : AIDSLINE ICA6/10001090; McDonough S; Brown V; Ryder T; Ou CY; Schochetman G; Gen-Probe, Inc., San Diego, California, USA; OBJECTIVE: As the occurrence of HIV-2 infection increases among the population, the need for differentiation of HIV-1 and HIV-2 becomes more important. The objective of this work was to apply the Hybridization Protection Assay (HPA) to the differentiation of amplified HIV-1 and HIV-2 DNA. METHODS: HPA using DNA probes
Silent HIV infection: a rare occurrence in a high risk heterosexual population.: Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.11). Unique Identifier : AIDSLINE ICA6/10001190; Sullivan JL; Brettler DB; Somasundaran M; Koup RA; Forsberg A; Brewster F; Byron KS; Chattopadyay B; University of Massachusetts Medical School and Medical Center of; Central Massachusetts-Memorial, Worcester, MA, USA; OBJECTIVE: To study the natural history of HIV infection in high-risk sexual partners of HIV infected hemophiliac men. METHOD: Sixty female spouses and/or sexual partners of HIV infected hemophiliac men have been followed for one year to five years following seroconversion in the infected male. Assessment for HIV infe
Resolution of western blot-indeterminate and high risk seronegative blood donors by PCR.: Int Conf AIDS. 1990 Jun 20-23;6(1):136 (abstract no. Th.A.12). Unique Identifier : AIDSLINE ICA6/10001290; Eble B; Busch M; Hurt M; Nason M; Garner J; Guiltinan A; Vyas G; Khayam-Bashi H; University of California, San Francisco, California, USA; OBJECTIVE: Employ polymerase chain reaction amplification (PCR) as a confirmatory assay in order to resolve HIV or HTLV western blot-indeterminate serological results and as a means of screening high-risk seronegative individuals for occult HIV infection. METHODS: Peripheral blood mononuclear cell preparations from se
Detection of HIV-1 infected individuals in a seronegative high-risk population by polyclonal B cell activation in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):137 (abstract no. Th.A.13). Unique Identifier : AIDSLINE ICA6/10001390; Sell K; Yehuda-Cohen T; Slade B; Powell J; Villinger F; McClure H; Ansari A; Emory University Sch. of Med., Atlanta, GA, USA; OBJECTIVE: To determine if polyclonal activation of B cells in vitro leads to the secretion of anti HIV-1 reactive antibodies. METHODS: PBMC from a total of 215 individuals from a high-risk patient population at Grady Memorial Hospital were cultured in vitro with pokeweed mitogen (PWM) for 5 days. Serum and supernatan
Early detection of HIV infection by PCR before seroconversion in multitransfused seronegative hemophiliacs and sexual partners.: Int Conf AIDS. 1990 Jun 20-23;6(1):137 (abstract no. Th.A.14). Unique Identifier : AIDSLINE ICA6/10001490; Moncany ML; Berthier A; Ferris S; Montagnier L; Unite d'Oncologie Virale, Institut Pasteur, Paris, France; Limitations of the available serological tests led us to study by PCR a heterogenous at risk population composed of paradoxical seronegative hemophiliacs and of seronegative partners of seropositive patients. We designed a complete set of primers covering the entire genomes of the HIV1 and of the HIV2. They were teste
Enzyme-linked immunospot (ELISPOT) and PCR for the diagnosis of HIV infection in infants.: Int Conf AIDS. 1990 Jun 20-23;6(1):137 (abstract no. Th.A.15). Unique Identifier : AIDSLINE ICA6/10001590; Lee FK; Ou CY; Nesheim SR; Jones D; Schochetman G; Nahmias AJ; Emory University School of Medicine, Atlanta, GA, USA; OBJECTIVE: To evaluate and compare ELISPOT, a new immunological technique, and polymerase chain reaction (PCR) for the early diagnosis of HIV infection in infants. METHODS: Peripheral blood mononuclear cells (PBMC) from 62 infants born to seropositive mothers were prospectively tested for HIV antibody-secreting cells
Mixed HIV-1/HIV-2 infection in Brazil confirmed by PCR analysis.: Int Conf AIDS. 1990 Jun 20-23;6(1):137 (abstract no. Th.A.16). Unique Identifier : AIDSLINE ICA6/10001690; Peralta JM; Ferreira JA; Pieniazek D; Krebs JW; Sion FS; Ferrera Ramos Filho C; Morais de Sa CA; Weniger BG; Heyward WL; Ou CY; et al; Fundacao Oswaldo Cruz, Rio de Janeiro (RJ), Brazil; OBJECTIVE: Analysis of sera from Brazil in 1989 suggested the presence of HIV-1, -2, and mixed infections within the populace. To further evaluate these observations HIV-1 and -2 PCR analysis was performed on selected sero-reactive persons. METHODS: Peripheral blood mononuclear cel
Zidovudine therapy of asymptomatic HIV infected persons with less than 500 CD4+ cells/mm3 - ACTG protocol 019.: Int Conf AIDS. 1990 Jun 20-23;6(1):138 (abstract no. Th.B.17). Unique Identifier : AIDSLINE ICA6/10001790; Volberding P; Lagakos S; Koch M; Pettinelli C; Myers M; Booth D; University of California, San Francisco, California, USA; OBJECTIVES: Determine the safety and efficacy of zidovudine (ZDV) in asymptomatic HIV-infected subjects with CD4+ cell counts below 500/mm3. METHODS: Randomized trial of 1338 HIV-infected asymptomatic subjects with fewer than 500 CD4+ cells/mm3 comparing two dosages of ZDV (500 mg daily, 1500 mg daily in 5 doses) to p
Long term effects of zidovudine therapy in early HIV disease. Results from the Multicentre Canadian Azidothymidine Trial (MCAT).: Int Conf AIDS. 1990 Jun 20-23;6(1):138 (abstract no. Th.B.18). Unique Identifier : AIDSLINE ICA6/10001890; Ruedy J; Montaner JS; Schechter MT; Le T; Fanning M; Tsoukas C; Falutz J; Wells G; Child S; O'Shaughnessy M; et al; Canada; OBJECTIVE: To describe the long term effects of zidovudine (ZDV) therapy in early HIV infection. METHODS: Design: Multicentre, prospective, dose range finding study. Subjects: 74 HIV positive homosexual men (CDC groups IIB, III and IVC2; CD4 counts greater than 270). Intervention: Following a 3 weeks observation, volu
Functional status and well-being in a placebo-controlled trial of zidovudine in early ARC.: Int Conf AIDS. 1990 Jun 20-23;6(1):138 (abstract no. Th.B.19). Unique Identifier : AIDSLINE ICA6/10001990; Wu AW; Rubin HR; Mathews WC; Brysk LM; Hardy WD; Bozzette SA; Atkinson JH; Grant I; Richman DR; University of California, San Francisco, CA, USA; OBJECTIVE: To examine the impact of zidovudine (ZDV) on functional status and well-being in persons with early ARC. METHODS: Seventy-one subjects were randomized to ZDV 200 mg (n = 35) or placebo (n = 36) as part of ACTG Protocol 016. We measured health status at baseline, 1 month, and every 3 months thereafter. Our i
The efficacy and safety of a lower dose of zidovudine in the treatment of patients with AIDS-associated PCP.: Int Conf AIDS. 1990 Jun 20-23;6(1):138 (abstract no. Th.B.20). Unique Identifier : AIDSLINE ICA6/10002090; Fischl M; Parker CB; Pettinelli C; Wulfsohn M; Rasheed S; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland, USA; OBJECTIVES: To evaluate the efficacy and safety of a lower daily dose of zidovudine (ZVD) in the treatment of advanced HIV disease. METHODS: A randomized controlled trial was conducted in 524 subjects with a first episode of P. carinii pneumonia. 262 subjects received ZVD at an oral dose of 250 mg every 4 hrs (standar
Randomized prospective trial of two regimens of zidovudine (ZDV) in AIDS and ARC patients: 1200 mg/day vs 600 mg/day.: Int Conf AIDS. 1990 Jun 20-23;6(1):139 (abstract no. Th.B.21). Unique Identifier : AIDSLINE ICA6/10002190; Salmon D; Detruchis P; Matheron S; Bouvet E; Levacher M; Leport C; Hopital Claude Bernard - Bichat, Paris, France; OBJECTIVES: To compare tolerance and efficacy of two regimens of ZDV: full dose (FD) 200 mg every 4 hours and half dose (HD) 200 mg every 8 hours in AIDS and ARC patients (pts). METHODS: From 4/88 to 6/89, 76 pts were randomly assigned to receive either FD, or HD of ZDV. Inclusion criteria were Karnovsky index greater
A randomized trial comparing zidovudine, alpha interferon, or the combination in early HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):139 (abstract no. Th.B.22). Unique Identifier : AIDSLINE ICA6/10002290; Davey V; Cefali F; Metcalf JA; Masur H; Fauci AS; Lane HC; National Institutes of Health, Bethesda, Maryland, USA; OBJECTIVES: To compare tolerance and toxicity of administration of zidovudine (Z), alpha interferon (IFN), and the combination of both (Z + IFN) and to determine relative efficacy in delaying progression of HIV disease. METHODS: HIV-infected patients with greater than or equal to 500 CD4 cell/mm3, were randomized to o
Phase II trial of alternating and intermittent regimens of zidovudine (ZDV) and 2',3'-dideoxycytidine (ddC) in ARC and AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):139 (abstract no. Th.B.23). Unique Identifier : AIDSLINE ICA6/10002390; Skowron G; Merigan TC; Roger Williams General Hospital, Providence, RI, USA; OBJECTIVE: To determine the efficacy and toxicity of alternating and intermittent regimens of ZDV 200 mg q4h and low dose (0.01 mg/kg q4h) or high dose (0.03 mg/kg q4h) ddC compared with continuous ZDV alone in ARC and AIDS. METHODS: Patients were str
Decreased HIV plasma titer in response to combined low-dose zidovudine and acyclovir therapy in CDC class IVA patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):139 (abstract no. Th.B.24). Unique Identifier : AIDSLINE ICA6/10002490; Coombs RW; Collier AC; Chaloupka K; Corey L; University of Washington, Seattle, Washington, USA; OBJECTIVE: To measure the virologic response of low-dose zidovudine (300 versus 600 mg/day) with or without acyclovir (4800 mg/day) in CDC class IVA disease. METHODS: Twenty-two CDC class IVA patients enrolled in ACTG protocol 010 received zidovudine Q4H po at either 50mg (N=5)
Coping responses and psychological adjustment in gay men with AIDS: a longitudinal analysis.: Int Conf AIDS. 1990 Jun 20-23;6(1):140 (abstract no. Th.B.25). Unique Identifier : AIDSLINE ICA6/10002590; Reed GM; Kemeny ME; Taylor SE; University of Washington, Seattle, Washington, USA; OBJECTIVE: This study examined the relationship between coping responses of gay men diagnosed with AIDS and psychological adjustment, both cross-sectionally and longitudinally. METHODS: Fifty men with AIDS, recruited from the UCLA Multicenter AIDS Cohort Study (MACS), participated at Time 1. A subset of 24 men partici
Psychological adjustment to HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):140 (abstract no. Th.B.26). Unique Identifier : AIDSLINE ICA6/10002690; Kelly B; Raphael B; Zournazi A; Dunne M; Smith S; University of Queensland, Brisbane, Australia; OBJECTIVE: The preliminary phase of a multicentre prospective study of the correlates of psychiatric morbidity, psychological adjustment to disease and sexual behaviour in homosexual/bisexual HIV positive men is described. METHOD: To date 24 asymptomatic HIV+ (CDC II) homosexual/bisexual males have been recruited thro
Relationships between CD4 lymphocytes and psychosocial variables among HIV seropositive adults.: Int Conf AIDS. 1990 Jun 20-23;6(1):140 (abstract no. Th.B.27). Unique Identifier : AIDSLINE ICA6/10002790; Perry S; Jacobsberg L; Fishman B; Cornell University Medical College, NY, USA; OBJECTIVE: Determine if psychosocial factors correlate with total CD4, currently the best predictor of disease progression among HIV-infected individuals (HIV+). METHODS: Among 108 males and 8 females (CDC II/III), Pearson correlations were obtained between entry measures of total CD4 and standardized measures of psyc
Psychosocial adjustment to HIV infection: efficacy of different group interventions in gay and bisexual men.: Int Conf AIDS. 1990 Jun 20-23;6(1):140 (abstract no. Th.B.28). Unique Identifier : AIDSLINE ICA6/10002890; Earl W; Flinders R; Flahive M; Flinders T; Bartholow B; Kobayashi J; Cohn D; Denver Health and Hospitals, Denver, CO, USA; OBJECTIVE: To establish the level of distress experienced by HIV-infected gay and bisexual men and to assess the efficacy of psychosocial interventions in preventing maladaptive adjustment to living with HIV infection and AIDS. METHODS: Psychosocial inventories were administered to 4 groups of HIV-infected men: (1) pa
AIDS inpatients and psychiatric disturbances: diagnostical and therapeutical aspects.: Int Conf AIDS. 1990 Jun 20-23;6(1):141 (abstract no. Th.B.29). Unique Identifier : AIDSLINE ICA6/10002990; Tempesta E; Di Giannantonio M; Mattioni T; Persico AM; Lestingi L; Ortona L; Dept. of Psychiatry, Catholic University of S. Heart, Rome, Italy; A psychodiagnostical and psychopharmacotherapeutical study was conducted on a population of 40 IVDA and 10 homosexuals, affected by AIDS (CDC: 80% IV group) and hospitalized in the Infectious Diseases Ward. Hamilton Rating Scale for Anxiety (HRSA), Hamilton Rating Scale for Depression (HRDS) and Brief Psychiatric Rati
A comparison of self reported suicidal behaviors in different stages of HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):141 (abstract no. Th.B.30). Unique Identifier : AIDSLINE ICA6/10003090; Orr D; O'Dowd MA; McKegney FP; Natali C; Montefiore Medical Center, Albert Einstein College of Medicine,; Bronx, NY USA; OBJECTIVE: To examine the incidence of suicidal behaviors in patients at different stages of HIV infection. METHOD: 155 patients attending a psychiatric outpatient clinic for HIV related problems were surveyed regarding past and present suicidal behaviors. The population surveyed was predominantly Hispanic (54%) and 5
Pharmacologic management of delirium in medically hospitalized AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):141 (abstract no. Th.B.31). Unique Identifier : AIDSLINE ICA6/10003190; Marotta R; Breitbart W; Platt M; Corbera K; Weisman H; Cancellieri F; St. Luke's/Roosevelt Hospital Center, New York, New York, USA; OBJECTIVE: To compare the efficacy of three drug interventions in the treatment of delirium in medically hospitalized AIDS patients, i.e. Haloperidol (a high potency neuroleptic) vs. Chlorpromazine (a low potency neuroleptic), vs. Lorazepam (a benzodiazipene). METHODS: Patients admitted to two AIDS units were screened
The efficacy of imipramine in the treatment of HIV-related depression.: Int Conf AIDS. 1990 Jun 20-23;6(1):141 (abstract no. Th.B.32). Unique Identifier : AIDSLINE ICA6/10003290; Manning D; Jacobsberg L; Erhart S; Perry S; Frances A; Department of Psychiatry, The New York Hospital-Cornell Medical; Center, NY, USA; OBJECTIVE: To test the efficacy of antidepressant medication in the treatment of depressed HIV positive patients. Subsidiary objectives of this study are to determine how improvement in HIV related depression impacts on medical status and rate of progression of illness, suicide risk and other psychiatric morbidity, ov
Natural history of HIV infection in a cohort of homosexual and bisexual men: clinical and immunologic outcome, 1977-1990.: Int Conf AIDS. 1990 Jun 20-23;6(1):142 (abstract no. Th.C.33). Unique Identifier : AIDSLINE ICA6/10003390; Lifson AR; Hessol N; Rutherford G; O'Malley P; Barnhart L; Buchbinder S; Cannon L; Bodecker T; Holmberg S; Harrison J; et al; Dept. Public Health, San Francisco CA, USA; OBJECTIVE: To determine the relationship between duration of HIV infection and clinical and immunologic status in a cohort of homosexual and bisexual men. METHODS: From 1978 to 1980, we recruited 6,706 homosexual and bisexual men for studies of hepatitis B; men included in this analysis had well characterized dates of
Natural history of HIV infection, a prospective study in a cohort of 162 HIV seroconverters.: Int Conf AIDS. 1990 Jun 20-23;6(1):142 (abstract no. Th.C.34). Unique Identifier : AIDSLINE ICA6/10003490; Pedersen C; Gerstoft J; Lindhardt B:O; Lundgren JD; Jensen BL; Dickmeiss E; University of Copenhagen, Copenhagen, Denmark; OBJECTIVE: To examine the natural history of HIV infection, and to delineate factors of importance for disease progression. METHODS: 162 HIV seroconverters (less than 12 months between last seronegative and first seropositive sample) were followed for a median of 37 (range 1-131) months. All were healthy (CDC groups I
AIDS incidence trends over 5 years in the Multicenter AIDS Cohort Study (MACS).: Int Conf AIDS. 1990 Jun 20-23;6(1):142 (abstract no. Th.C.35). Unique Identifier : AIDSLINE ICA6/10003590; Visscher B; Munoz A; Jacobson L; Dudley JP; Chmiel J; Zhou S; Graham N; Vermund S; Detels R; UCLA Sch of Public Hlth, CA, USA; OBJECTIVE: To model the incidence of AIDS over calendar time in a cohort of infected men. METHODS: In 1984-85, 1809 HIV seropositive AIDS-free men were enrolled in the MACS. Data from 6 month visits and continuous reports of CDC-defined AIDS were used to determine the observed incidence by semester, starting in July,
Cessation of intravenous drug use reduces progression of HIV-infection in HIV+ drug users.: Int Conf AIDS. 1990 Jun 20-23;6(1):142 (abstract no. Th.C.36). Unique Identifier : AIDSLINE ICA6/10003690; Weber R; Ledergerber B; Opravil M; Luthy R; University of Zurich, Zurich, Switzerland; OBJECTIVE: To determine if cessation of drug use and methadone maintenance treatment programs reduce risk of progression of HIV infection in intravenous drug users (IVDU). METHODS: IVDU without antiretroviral therapy, categorized into 1. those remaining enrolled in a methadone program during observation period, 2. for
The rate of development of HIV-1 related illness in women with a known duration of infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):143 (abstract no. Th.C.37). Unique Identifier : AIDSLINE ICA6/10003790; Anzala A; Wambugu P; Bosire M; Ngugi EN; Waiyaki P; Plummer FA; University of Nairobi, Nairobi, Kenya; OBJECTIVE: To determine the rate and risk factors for the development of symptomatic HIV-1 related disease in women with a known duration of infection. METHODS: A cohort of 123 women working as prostitutes in Nairobi have been followed from the time of seroconversion to HIV-1. Women were evaluated at 3-6 month interva
The progression to AIDS in the Italian hemophilia population over a six-year period.: Int Conf AIDS. 1990 Jun 20-23;6(1):143 (abstract no. Th.C.38). Unique Identifier : AIDSLINE ICA6/10003890; Schinaia N; Chiarotti F; Istituto Superiore de Sanita, Rome, Italy; OBJECTIVE: To estimate the progression to AIDS in the Italian hemophilia population and to correlate the outcome with different clinical features. METHODS: Study subjects: all HIV-positive individuals already recruited at the on-going National Registry of Patients with Blood Clotting Disorders. Statistical analysis: t
Cigarette smoking and incidence of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):143 (abstract no. Th.C.39). Unique Identifier : AIDSLINE ICA6/10003990; Royce RA; Winkelstein W; Bacchetti P; University of California, Berkeley, California, USA; OBJECTIVE: Investigate cigarette smoking as a cofactor for incidence of AIDS. METHODS: Smoking status and other covariates were determined at entry for members of the San Francisco Men s Health Study, a population based cohort of single men ages 25-54 observed biennially since 1984. Using the Cox proportional hazards
Survival in adults AIDS cases, Brazil, 1980-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):143 (abstract no. Th.C.40). Unique Identifier : AIDSLINE ICA6/10004090; Chequer P; Hearst N; Castilho E; Loures LA; Rodrigues L; Rutherford G; Division of DST/AIDS, Ministry of Health, Brasilia-Brasil; OBJECTIVE: To assess the extent to which the survival of adults AIDS cases in Brazil has been influenced by clinical and epidemiological features. METHODS: Using data from the Brazilian National AIDS registry, analyses were conducted to assess survival as a function of gender, risk
Routine vs. targeted prenatal testing for HIV.: Int Conf AIDS. 1990 Jun 20-23;6(1):144 (abstract no. Th.C.41). Unique Identifier : AIDSLINE ICA6/10004190; Barbacci M; Chaisson RE; Johns Hopkins University School of Medicine, Baltimore, Maryland,; USA; OBJECTIVE: To compare Centers for Disease Control (CDC) HIV screening guidelines to routine HIV screening of pregnant women. METHODS: Women attending the Johns Hopkins Obstetrics clinic between 2/87 and 8/88 who acknowledged risk factors for HIV infection were targeted for HIV screening, following recommended CDC scre
Perinatal outcome in HIV-infected women in Uganda.: Int Conf AIDS. 1990 Jun 20-23;6(1):144 (abstract no. Th.C.42). Unique Identifier : AIDSLINE ICA6/10004290; Guay L; Mmiro F; Ndugwa C; Kataha P; Mugisha K; Goldfarb J; Hom D; Friesen H; Toltzis P; Coulter B; et al; Case Western Reserve Univ., Cleveland, Ohio, USA; OBJECTIVE: To determine the effect of maternal HIV infection upon the course and outcome of pregnancy. METHODS: Women of unknown HIV-serological status were sequentially enrolled in the prenatal clinic at Mulago Hospital, Kampala. Maternal serological status was determined, and compared to the frequency of complicatio
Mother to child transmission of HIV: first immunologic and serologic features from an ongoing cohort study in Kigali, Rwanda.: Int Conf AIDS. 1990 Jun 20-23;6(1):144 (abstract no. Th.C.43). Unique Identifier : AIDSLINE ICA6/10004390; Van de Perre P; Simonon A; Hitimana DG; Msellati P; Dabis F; Baganizi E; Van Goethem C; Bazubagira A; Stevens AM; Lepage P; AIDS Reference Laboratory (National AIDS Control Program),; Kigali, Rwanda; OBJECTIVE: To evaluate immunologic and serologic parameters associated with Mother (M) to Child (C) transmission of HIV. METHODS: Two cohorts of 218 infants born of HIV seropositive (HIV +) M and 218 infants of HIV seronegative (HIV -) M were enrolled at delivery. A blood sample was available from the M and C at 0, 3,
Risk for HIV 1 perinatal transmission varies with the mother's stage of HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):144 (abstract no. Th.C.44). Unique Identifier : AIDSLINE ICA6/10004490; Boue F; Pons JC; Keros L; Chambrin V; Papiernik E; Henrion R; Delfraissy JF; Service de Medecine Interne et de Gynecologie-Hopital Antoine; Beclere-Clamart-92 141-France; OBJECTIVE: Recent European studies have shown an observed incidence of transmission of 30%. However, most of the women belong to CDC groups II and III and they are conflicting results concerning the relationship between mother s status and rate of perinatal transmission. METHODS: Between October 1985 and December 1989
Elevated maternal total and neutralizing anti-HIV1 antibody does not prevent perinatal HIV1.: Int Conf AIDS. 1990 Jun 20-23;6(1):145 (abstract no. Th.C.45). Unique Identifier : AIDSLINE ICA6/10004590; Krasinski K; Cao YZ; Friedman-Kien A; Borkowsky W; Fidelia A; Bebenroth D; NYU Med. Ctr., NY, NY, USA; OBJECTIVE: To determine if total and neutralizing anti-HIV1 maternal antibody protects children from HIV1 infection. METHODS: HIV1 infected mothers blood collected at delivery was titrated for: anti-HIV1 using EIA and neutralizing antibody. Neutralization was determined by 90% reduction of p24 antigen production in H
IgA specific antibody to HIV in infants.: Int Conf AIDS. 1990 Jun 20-23;6(1):145 (abstract no. Th.C.46). Unique Identifier : AIDSLINE ICA6/10004690; Martin N; Wara D; Levy J; Crombleholme W; Hourtane M; Legg H; Cowan M; Weintrub P; Dept. of Pediatrics, University of CA. San Fran., San Francisco,; CA 94143 USA; OBJECTIVE: The early serological diagnosis of HIV infection in infants and the determination of the sequence of development of antibodies to envelope and core proteins. METHODS: We developed an IgA Western Blot method using recombinant antigens (gp160, gp120, gp41, p25). Serum samples were obtained from 23 infants at
Lack of proviral sequences in children who have lost maternal antibody following birth to HIV (+) mothers.: Int Conf AIDS. 1990 Jun 20-23;6(1):145 (abstract no. Th.C.47). Unique Identifier : AIDSLINE ICA6/10004790; Rogers M; Ou C; Abrams E; Nesheim S; Mayers M; Conner E; Centers for Disease Control (CDC), Atlanta, GA. USA; OBJECTIVE: To determine whether children who have lost maternal antibody following birth to an HIV (+) mother are infected with HIV. METHODS: Children born to HIV (+) mothers are followed from birth at 4 sites. Those children who have lost maternal antibody were tested for proviral sequences by polymerase chain reacti
Transmission of HIV-infection from an infected infant to his mother by breast-feeding.: Int Conf AIDS. 1990 Jun 20-23;6(1):145 (abstract no. Th.C.48). Unique Identifier : AIDSLINE ICA6/10004890; Pokrovsky VV; Kuznetsova I; Eramova I; Central Research Institute of Epidemiology, 3-a,; Novogyreyevskaya, Moscow, USSR; During the existence of nosocomial focuses of HIV-infection in Elista, Rostov-on-Don, Volgograd there were 152 children and 12 mothers found to be seropositive. The children were infected due to using the same syringe on multiple patients. As far as the women were concerned, 2 of them had seropositive sexual partners,
Homosexually and nonhomosexually identified male blood donors who have sex with men: a behavioral comparison.: Int Conf AIDS. 1990 Jun 20-23;6(1):146 (abstract no. Th.D.49). Unique Identifier : AIDSLINE ICA6/10004990; Doll L; Centers for Disease Control, Atlanta, GA, USA; OBJECTIVE: Describe nonhomosexually identified men who have sex with men. METHODS: From June 1988-September 1989, 200 seropositive male blood donors who had sex with men were interviewed regarding HIV-related risk behaviors. Self-reported sexual identity was measured on a 7-pt. Kinsey scale. Perception of HIV risk was
AIDS-related health behavior and sexual practices of gay men in Japan.: Int Conf AIDS. 1990 Jun 20-23;6(1):146 (abstract no. Th.D.50). Unique Identifier : AIDSLINE ICA6/10005090; Sawazaki Y; Kehoe J; Department of Health Sociology, Graduate School of Medical; Science, University of Tokyo, Tokyo, Japan; OBJECTIVE: Though the majority of HIV patients in Japan are Haemophiliacs, the sexual transmission of HIV is increasing. To date, there has been no social research carried out on the sexual transmission of AIDS in Japan. This study looks specifically at Gay Men, exploring their know
Profile of the female prostitution in Mexico and HIV risk factors.: Int Conf AIDS. 1990 Jun 20-23;6(1):146 (abstract no. Th.D.51). Unique Identifier : AIDSLINE ICA6/10005190; Valdespino JL; Loo E; Izazola JA; Garcia ML; Magis C; Sepulveda J; General Directorate of Epidemiology, Ministry of Health, Mexico; OBJECTIVES: To analyze the socio-demographic profile, sexual practices, knowledge and attitudes on AIDS, condom use, and risk factors in female sex workers (FSW). METHODS: Results of KAB surveys and pilot studies are analyzed in a group of 3,612 FSW in 20 cities in Mexico ; studied
KAP-study and HIV-seroprevalence among prostitutes in rural Burkina Faso.: Int Conf AIDS. 1990 Jun 20-23;6(1):146 (abstract no. Th.D.52). Unique Identifier : AIDSLINE ICA6/10005290; Didier B; Lorenz N; Ouedraogo LH; Zina Y; Barth P; Rehle T; Ministere de la Sante et de l'Action Sociale, Ouagadougou,; Burkina Faso; OBJECTIVE: To obtain baseline data and to planify HIV education programs an HIV-seroprevalence-study combined with a KAP-Study were carried out among prostitutes working at a gold prospecting site in the North of Burkina Faso . METHODS: All 38 known prostitutes on the site were int
Psychosocial predictors of intended condom use among Zimbabwean schoolpupils.: Int Conf AIDS. 1990 Jun 20-23;6(1):147 (abstract no. Th.D.53). Unique Identifier : AIDSLINE ICA6/10005390; Wilson D; Lavelle S; University of Zimbabwe, Harare, Zimbabwe; OBJECTIVE: To identify psychosocial predictors of intended condom use among adolescents to develop optimally effective AIDS education approaches for this group. METHOD: Respondents were a purposive sample of 635 (388 male, 247 female) volunteers (mean age=18.2, SD=2.2) from urban and rural secondary schools in all Zim
Preferred strategies for safe sex: relation to past and actual behaviour among sexually active men and women.: Int Conf AIDS. 1990 Jun 20-23;6(1):147 (abstract no. Th.D.54). Unique Identifier : AIDSLINE ICA6/10005490; Gallois C; Kashima Y; Hills R; McCamish M; University of Queensland, St. Lucia (Brisbane), Queensland,; Australia; OBJECTIVES: To determine the preferred sexual strategies for reducing risk of HIV infection among sexually active heterosexual men and women and homosexual men. To compare these preferences to past behaviour, intentions and behaviour at the next sexual encounter, using recent revisions of the Theory of Reasoned Action
Serostatus and relationship formation in the gay community: the AIDS Behavioral Research Project.: Int Conf AIDS. 1990 Jun 20-23;6(1):147 (abstract no. Th.D.55). Unique Identifier : AIDSLINE ICA6/10005590; Hoff CC; McKusick L; Coates T; Hilliard B; Center for AIDS Prevention Studies, University of California, San; Francisco California USA; OBJECTIVE: As more gay men are tested for HIV antibody, it is becoming evident that serostatus will influence the nature of formation of primary partner bonds in this community. To investigate this question we compared tested seropositives, tested seronegatives, and those who did not know their serostatus or had not b
Sex and power: young women's sexuality in the shadow of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):147 (abstract no. Th.D.56). Unique Identifier : AIDSLINE ICA6/10005690; Holland J; Ramazanoglu C; Scott S; Sharpe S; Thomson R; Institute of Education, London University, UK; This paper reports a qualitative investigation of the sexual practices, beliefs and understanding of young women, including their ideas and experience of risk, danger and control in sexual encounters. The implications of this information for the spread of HIV infection and sex and AIDS education are examined. We have
Access to clinical trials: the ACTU without walls concept.: Int Conf AIDS. 1990 Jun 20-23;6(1):148 (abstract no. Th.D.57). Unique Identifier : AIDSLINE ICA6/10005790; Kramer AS; Brownstein AP; The National Hemophilia Foundation, New York, NY USA; OBJECTIVE: To provide access to government-sponsored clinical trials for HIV-infected persons with hemophilia at the comprehensive hemophilia treatment centers (HTC) where approximately 50% of hemophilia patients in the U.S. receive care. METHOD: Of the 10 geographic regions (designated by the Department of Health and
Feasibility of early intervention, counseling and follow up of HIV positives in the Haitian community.: Int Conf AIDS. 1990 Jun 20-23;6(1):148 (abstract no. Th.D.58). Unique Identifier : AIDSLINE ICA6/10005890; Marcel AJ; Charles C; Pierre-Louis E; Romulus JR; Michel C; Landesman SH; SUNY Health Science Ctr./Kings County Hosp Ctr., Brooklyn, NY,; USA; OBJECTIVE: Are early intervention, adequate counseling and follow up feasible in a population reluctant to seek medical care? METHODS: From 4/88 to 12/89 50 persons (22M, 28F) testing HIV+ for immigration purposes were referred to a Haitian physician. All underwent counseling in Creole, a brief physical exam and lab e
Access, equity, and survival: use of ZVD and pentamidine by persons with AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):148 (abstract no. Th.D.59). Unique Identifier : AIDSLINE ICA6/10005990; Hidalgo J; Sugland B; Moore R; Chaisson RE; Department of Health and Mental Hygiene, AIDS Administration,; Baltimore, Maryland, USA; OBJECTIVE: Earlier studies have concluded that zidovudine (ZVD) and pentamidine produce significant increases in survival among PWAs. Despite the historically high cost and limited availability of ZVD and pentamidine, researchers have not adequately investigated the impact of access to these treatments on survival. Th
Medical care for intravenous drug users with AIDS and ARC: delivering services at a methadone treatment program.: Int Conf AIDS. 1990 Jun 20-23;6(1):148 (abstract no. Th.D.60). Unique Identifier : AIDSLINE ICA6/10006090; Batki SL; London J; Goosby E; Clement M; Wolfe R; Ryan C; French D; Young M; Miller D; Christmas R; et al; University of California, San Francisco, Department of; Psychiatry, San Francisco General Hospital, San Francisco, CA,; USA; OBJECTIVE: To examine the utilization of medical services provided for HIV-infected intravenous drug users (IVDUs) on-site at a methadone maintenance treatment (MMT) program. METHOD: On-site primary medical care was provided to serve 175 IVDUs in an MMT program at San Francisco General Hospital. Services were provided
A study of six home-care programmes for persons with HIV-infection in Africa.: Int Conf AIDS. 1990 Jun 20-23;6(1):149 (abstract no. Th.D.61). Unique Identifier : AIDSLINE ICA6/10006190; Westphal Victor B; Widdus R; Schietinger H; The Nordic School of Public Health, Goteborg, Sweden; OBJECTIVES: To analyze and compare selected home care programmes for persons with HIV-infection and their families in Africa; to discuss the programmes in the context of national AIDS policies and strategies and WHO s Health for All strategy and WHO policy documents; to suggest ways of learning from and sharing the kn
Insurance coverage for investigational drugs.: Int Conf AIDS. 1990 Jun 20-23;6(1):149 (abstract no. Th.D.62). Unique Identifier : AIDSLINE ICA6/10006290; Austein C; Walkover M; Hadley E; U.S. Department of Health and Human Services, Washington, D.C.,; USA; OBJECTIVE: To study the possibility of providing insurance coverage for investigational drugs to treat life-threatening diseases. METHODS: The study includes an analysis of the various types of investigational drugs available for patients with AIDS or other life-threatening illnesses. These include treatment INDs, gro
Buyers' clubs and the legitimization of the AIDS treatment underground -- the PWA (people with AIDS) Health Group as case study.: Int Conf AIDS. 1990 Jun 20-23;6(1):149 (abstract no. Th.D.63). Unique Identifier : AIDSLINE ICA6/10006390; Hodel D; Wilkinson SD; The PWA Health Group, New York, NY, USA; OBJECTIVE: To examine the history and development of the AIDS treatment substratum in the context of inferior treatment access systems in the United States . METHODS: The case history of the PWA Health Group (New York City) is documented and investigated in detail, via questionnaire, cl
Access to health care for HIV infection: a consumers perspective.: Int Conf AIDS. 1990 Jun 20-23;6(1):149 (abstract no. Th.D.64). Unique Identifier : AIDSLINE ICA6/10006490; Ludington P; American Association of Physicians for Human Rights, San; Francisco, CA, USA
HIV pathogenesis.: Int Conf AIDS. 1990 Jun 20-23;6(1):150 (abstract no. Th.A.65). Unique Identifier : AIDSLINE ICA6/10006590; Montagnier L; Institut Pasteur, Paris, France
Neutralising monoclonal antibody and rCD4 selected HIV-1 variants.: Int Conf AIDS. 1990 Jun 20-23;6(1):150 (abstract no. Th.A.66). Unique Identifier : AIDSLINE ICA6/10006690; McKeating JA; Clapham PR; Moore J; Ferguson M; Balfe P; Almond J; Evans; Weiss RA; Institute of Cancer Research, London, England; OBJECTIVE: Analysis of epitopes important for virus envelope-CD4 binding and antibody-mediated neutralisation. METHODS: Molecular cloned HIV was propagated in the presence of saturating levels of rCD4 or neutralising monoclonal antibodies (mab) specific for the epitopes on gp120 amino-acid (aa) residues 305-321, 430-4
HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure.: Int Conf AIDS. 1990 Jun 20-23;6(1):150 (abstract no. Th.A.67). Unique Identifier : AIDSLINE ICA6/10006790; Zack J; Arrigo S; Chen IS; University of California, Los Angeles, USA; OBJECTIVE: HIV-1 can infect quiescent human T-lymphocytes and remain in an inactive state until subsequent mitogenic stimulation of the cell. Studies were undertaken to identify the molecular nature of HIV-1 in quiescent primary lymphocytes. METHODS: Quiescent and dividing human peripheral blood lymphocytes were infec
Physical mapping of replicative and cytopathic properties of HIV-1.: Int Conf AIDS. 1990 Jun 20-23;6(1):150 (abstract no. Th.A.68). Unique Identifier : AIDSLINE ICA6/10006890; Cheng-Mayer C; Shioda T; Seto D; Levy JA; University of California, School of Medicine, San Francisco, USA; OBJECTIVE: To map viral genes that control in vitro biologic properties of HIV-1. METHODS: HIV-1 isolates (HIV-1SF2, HIVV-1SF13) obtained over-time from the same individual as he progressed from a relatively healthy state to disease were molecularly cloned. Biologically active recombinant viruses were generated betwee
Biological characterization of a highly cytopathic variant of an attenuated HIV-2.: Int Conf AIDS. 1990 Jun 20-23;6(1):151 (abstract no. Th.A.69). Unique Identifier : AIDSLINE ICA6/10006990; Hoxie JA; Haggarty B; Pletcher C; Sweet R; Chaikin M; Kappes JC; Hahn BH; Univ. of Penn, Philadelphia, PA, USA; OBJECTIVE: Naturally occurring and molecularly-derived isolates of HIV-2 have been described which are markedly attenuated in their ability to cause cytopathic effects in vitro, to downmodulate CD4 and to establish superinfection interference with cytopathic strains of HIV-1 and HIV-2. In order to determine the basis
Anti-HIV enhancing antibodies do not allow infection of a CD4-negative IgG Fc receptor-positive monocytic cell line.: Int Conf AIDS. 1990 Jun 20-23;6(1):151 (abstract no. Th.A.70). Unique Identifier : AIDSLINE ICA6/10007090; Grangette C; Ameisen JC; Maniez M; Tourvieille B; Antolin S; Vampouille N; Capron A; CIBP, Unite INSERM 167-CNRS 624, Institut Pasteur, Lille, France; OBJECTIVE: To investigate whether FcR-mediated antibody enhancement of HIV infection in the U937 monocytic cell line represents an additional mechanism of HIV infection that does not require CD4. METHODS: A CD4-negative IgG FcR-positive U937 cell line was derived from a CD4-positive IgG FcR-positive U937 cell line. Ab
Inhibition of HIV infection in vitro by anti-carbohydrate monoclonal antibodies.: Int Conf AIDS. 1990 Jun 20-23;6(1):151 (abstract no. Th.A.71). Unique Identifier : AIDSLINE ICA6/10007190; Hansen JE; Clausen H; Nielsen C; Teglbjaerg LS; Nielsen CM; Mathiesen L; Hakomori S; Nielsen JO; Dept. of Infectious Diseases, Hvidovre Hospital, Denmark; OBJECTIVE: To examine whether oligosaccharides of HIV could be targets for neutralizing antibodies in vitro. METHODS: Twenty anti-carbohydrate monoclonal antibodies (MAbs) were tested for their ability to inhibit in vitro HIV infection of peripheral blood mononuclear cells, and cell-lines MT4 (lymphocytic) and U937 (m
In vitro infection and generation of chronically HIV-1 infected CD3+CD8+ T cells from peripheral blood lymphocytes of healthy donors. Anti-CD2(2+3) mediated reactivation is associated with virus replication and cell death.: Int Conf AIDS. 1990 Jun 20-23;6(1):151 (abstract no. Th.A.72). Unique Identifier : AIDSLINE ICA6/10007290; DeMaria A; Pantaleo G; Schnittman SM; Fauci AS; NIAID, NIH, Bethesda, Maryland, USA; OBJECTIVE: To study infection status and virus replication in T-cell survivor populations of HIV-1 infected peripheral blood mononuclear cells (PBMC) after T-cell activation. METHODS: PBMC obtained from healthy HIV seronegative donors by Ficoll-Hypaque separation were cultured in the presence of PHA for 72 hours and s
Relationship between HIV-1 disease stage, titer of anti-P24 antibody (a-P24), and P24 antigen: a multicenter AIDS cohort study (MACS).: Int Conf AIDS. 1990 Jun 20-23;6(1):152 (abstract no. Th.A.73). Unique Identifier : AIDSLINE ICA6/10007390; Farzadegan H; Chmiel J; Saah A; Allain JP; Hardy W; Phair J; The Johns Hopkins University, Balitmore, MD, USA; OBJECTIVE: To investigate the serum levels of antigen/antibody for HIV-1 P24 viral component among HIV-1 infected/diseased homosexual men. METHOD: Anti-P24 Titration: A competitive ELISA using recombinant HIV-1 P24 antigen (Abbott Labs) was used and titers were expressed as the reciprocal of endpoint dilutions. P24 An
Antibody responses to selected peptides of HIV-1 gp160 in immunized or HIV-1 infected individuals.: Int Conf AIDS. 1990 Jun 20-23;6(1):152 (abstract no. Th.A.74). Unique Identifier : AIDSLINE ICA6/10007490; Buchanan T; Coombs R; Hu SL; Smith G; McCullough D; Jasman R; Corey L; University of Washington, Seattle, WA., USA; Peptides were synthesized to represent HIV-1 gp160: the V3 region (AA approximately 306-320, 14 sequence variant peptides) reactive with neutralizing and syncytium-inhibiting antibodies, the CD4 binding region (AA approximately 414-453, 30 peptides), and the immunodominant region (AA approximately 595-609, 2 peptides)
Production of human monoclonal antibodies against the V3 loop of gp120.: Int Conf AIDS. 1990 Jun 20-23;6(1):152 (abstract no. Th.A.75). Unique Identifier : AIDSLINE ICA6/10007590; Zolla-Pazner S; Gianakakos V; Williams C; Sharpe S; Gorny MK; Veterans Administration Medical Center, New York, New York, USA; OBJECTIVE: To generate human monoclonal antibodies (HumAb) against a neutralizing epitope of HIV-1 (MN) gp120. METHODS: Peripheral blood lymphocytes (PBL) were transformed by Epstein-Barr virus (EBV) as per PNAS, 86, 1624, 1989. Cultures were screened for antibody to a synthetic 24-mer peptide from the V3 region of MN
A neutralizing human monoclonal antibody (HMab) identifies an epitope within the putative CD4-binding domain (CD4-BD) of HIV-1 gp120.: Int Conf AIDS. 1990 Jun 20-23;6(1):152 (abstract no. Th.A.76). Unique Identifier : AIDSLINE ICA6/10007690; Ho DD; Li XL; Daar ES; Moudgil T; Sun NC; Holton D; Robinson JE; UCLA School of Medicine, Los Angeles, CA, USA; OBJECTIVE: To use HMabs to characterize epitopes of HIV-1 gp120 that are immunogenic during natural infection and are functionally important. METHODS: N70-1.5e is one of three IgG1 gp120-specific HMabs produced by EBV transformed cell lines derived from an HIV-1-infected patient. Antibody specificity was determined by
Development of an IgG-1 human monoclonal antibody that neutralizes HIV1 infectivity and binding and reacts with a cell surface antigen expressed by HIV1 infected cells.: Int Conf AIDS. 1990 Jun 20-23;6(1):153 (abstract no. Th.A.77). Unique Identifier : AIDSLINE ICA6/10007790; Posner M; Mukherjee M; Hideshima T; Cannon TC; Mayer K; Brown University Medical School, Providence, RI, USA; OBJECTIVE: Production of human monoclonal antibodies (HuMoAbs) reactive with HIV1 antigens to study and treat the disease caused by the virus. METHODS: Patient PBM transformed by Epstein Barr Virus (EBV) in oligoclonal cultures. Indirect immunofluorescence (IF) was used to screen for IgG antibodies reactive with HIV-I
Two immunodominant domains of the HIV-1 transmembrane glycoprotein, GP41, bind antibodies which enhance HIV-1 infection in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):153 (abstract no. Th.A.78). Unique Identifier : AIDSLINE ICA6/10007890; Robinson WE Jr; Lake D; Gorny MK; Horton L; Montefiori DC; Zolla-Pazner S; Hersh E; Mitchell WM; Vanderbilt University, Nashville, TN, USA; OBJECTIVE: To identify and map human monoclonal antibodies to HIV-1 which enhance HIV-1 infection in vitro. METHODS: Human monoclonal antibodies (huMAb) were made by either fusion with a murine myeloma cell line P36x36 AgV1 or transformation of human PBMC with Epstein-Barr Virus. The ability of antibodies to enhance H
Identification of GP41 determinants recognized by antibodies in cytolytic assays.: Int Conf AIDS. 1990 Jun 20-23;6(1):153 (abstract no. Th.A.79). Unique Identifier : AIDSLINE ICA6/10007990; Wood L; Koenig S; Wood R; Fuerst T; Newell A; Brewah A; Fauci AS; NIH, NIAID, Bethesda, MD, USA; OBJECTIVE: To identify sequences within HIV-envelope recognized by antibody from HIV seropositive donors and to demonstrate lysis of target cells bearing these sequences by CD16+ cells from HIV seropositive donors. METHODS: MHC-mismatched lymphoblastoid cells (LCL) pulsed with synthesized peptides from gp41 were added
Biological properties of CD4 immunoadhesins.: Int Conf AIDS. 1990 Jun 20-23;6(1):153 (abstract no. Th.A.80). Unique Identifier : AIDSLINE ICA6/10008090; Capon DJ; Byrn RA; Mordenti J; Smith D; Lucas C; Marsters SA; Chamow SM; Wurm FM; Gregory T; Groopman JE; Genentech, Inc., 460 Point San Bruno Boulevard, South San; Francisco, California 94080, USA; Molecular fusions of CD4, the receptor for HIV, with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4 (rCD4) and certain properties of IgG, notably long plasma half-life and Fc receptor binding. We show that a CD4 immunoadhesin can mediate
Clinical studies with ddI.: Int Conf AIDS. 1990 Jun 20-23;6(1):154 (abstract no. Th.B.81). Unique Identifier : AIDSLINE ICA6/10008190; Dolin R; Infectious Disease Unit, University of Rochester Medical Center,; Rochester, NY, USA
Clinical studies with ddC.: Int Conf AIDS. 1990 Jun 20-23;6(1):154 (abstract no. Th.B.82). Unique Identifier : AIDSLINE ICA6/10008290; Merigan T; School of Medicine, Stanford University Medical Center, Stanford,; CA, USA
Anti-retroviral drugs as single agents and in combination therapy.: Int Conf AIDS. 1990 Jun 20-23;6(1):154 (abstract no. Th.B.83). Unique Identifier : AIDSLINE ICA6/10008390; Yarchoan R; National Cancer Institute, National Institutes of Health,; Bethesda, MD, USA
Recombinant soluable CD4 and derivatives.: Int Conf AIDS. 1990 Jun 20-23;6(1):154 (abstract no. Th.B.84). Unique Identifier : AIDSLINE ICA6/10008490; Corey L; University of Washington, Seattle, WA, USA
Interferons.: Int Conf AIDS. 1990 Jun 20-23;6(1):155 (abstract no. Th.B.85). Unique Identifier : AIDSLINE ICA6/10008590; Lane HC; Laboratory of Immuno regulation, National Institutes of Health,; Bethesda, MD, USA
Immune based therapies for HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):155 (abstract no. Th.B.86). Unique Identifier : AIDSLINE ICA6/10008690; Schooley R; Massachusetts General Hospital, Boston, MA, USA
Significance and management of immune thrombocytopenia in HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):156 (abstract no. Th.B.89). Unique Identifier : AIDSLINE ICA6/10008990; Oksenhendler E; Department of Clinical Immunology and Hematology, Hopital; Saint-Louis, Paris, France
Use of hemapoeotic growth factors.: Int Conf AIDS. 1990 Jun 20-23;6(1):156 (abstract no. Th.B.90). Unique Identifier : AIDSLINE ICA6/10009090; Mitsuyasu R; UCLA Medical Center, Los Angeles, CA, USA
Kaposi's sarcoma as a sexually transmitted disease.: Int Conf AIDS. 1990 Jun 20-23;6(1):156 (abstract no. Th.B.91). Unique Identifier : AIDSLINE ICA6/10009190; Peterman T; Centers for Disease Controls, Atlanta, GA, USA
Presentation and management of Kaposi's sarcoma in Central Africa.: Int Conf AIDS. 1990 Jun 20-23;6(1):156 (abstract no. Th.B.92). Unique Identifier : AIDSLINE ICA6/10009290; Bayley AC; University of Zambia, Lusaka, Zambia
New directions in the treatment of HIV-related non-Hodgkin's lymphoma.: Int Conf AIDS. 1990 Jun 20-23;6(1):157 (abstract no. Th.B.93). Unique Identifier : AIDSLINE ICA6/10009390; Kaplan LD; San Francisco General Hospital, University of California, San; Francisco, CA, USA
Premalignant and malignant lesions associated with human papillomavirus infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):157 (abstract no. Th.B.94). Unique Identifier : AIDSLINE ICA6/10009490; Palefsky J; University of California, San Francisco, CA, USA
Non ulcerative sexually transmitted diseases (STD) as risk factors for HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):158 (abstract no. Th.C.97). Unique Identifier : AIDSLINE ICA6/10009790; Laga M; Nzila N; Manoka AT; Malele M; Bush TJ; Behets F; Heyward WL; Piot P; Ryder R; CDC, Atlanta, GA, USA; OBJECTIVES: To identify risk factors associated with HIV infection among prostitutes in Kinshasa, Zaire . METHODS: Among 493 HIV (-) prostitutes followed prospectively for a mean duration of 11 months (with monthly STD checkups and HIV testing every 3 months), a case control study
Risk factors for HIV-1 infection in pregnant women in Malawi.: Int Conf AIDS. 1990 Jun 20-23;6(1):158 (abstract no. Th.C.98). Unique Identifier : AIDSLINE ICA6/10009890; Chiphangwi J; Dallabetta G; Saah A; Liomba G; Miotti P; Ministry of Health, Malawi; OBJECTIVE: To assess the prevalence and associated risk factors for HIV-1 infection in pregnant women attending an antenatal clinic. METHODS: 1482 pregnant women presenting for routine care to the antenatal clinic of a large urban hospital in Malawi were interviewed to assess risk
Contraceptive use and HIV infection among women attending family planning clinics in Nairobi, Kenya.: Int Conf AIDS. 1990 Jun 20-23;6(1):158 (abstract no. Th.C.99). Unique Identifier : AIDSLINE ICA6/10009990; Mati J; Maggwa A; Chewe D; Solomon M; Mbugua S; Bhullar V; Tukei P; Hunter D; Achola P; University of Nairobi, Kenya; OBJECTIVES: To investigate the relationship between HIV infection and contraceptive use among women not believed to be at high risk for HIV. METHODS: Between Oct. 1989 and Jan. 1990, consenting women attending two Nairobi family planning (FP) clinics were screened for HIV and other sexually transmitted diseases (STD),
Heterosexual transmission of HIV: follow-up of a European cohort of couples.: Int Conf AIDS. 1990 Jun 20-23;6(1):158 (abstract no. Th.C.100). Unique Identifier : AIDSLINE ICA6/10010090; De Vincenzi I; Ancelle-Park R; WHO Collaborating Centre on AIDS, Paris, France; OBJECTIVE: To assess acceptability and evaluate efficacy of safe-sex counselling in serologically discordant couples. METHODS: Since March 1987, 403 couples were recruited from 7 European countries. Data for HIV+ subjects (Index Case) and their heterosexual partners are collected every 6 months and counselling was off
The relative efficiency of female-to-male HIV sexual transmission.: Int Conf AIDS. 1990 Jun 20-23;6(1):159 (abstract no. Th.C.101). Unique Identifier : AIDSLINE ICA6/10010190; Padian N; Shiboski S; Jewell N; University of California, San Francisco, California, USA; OBJECTIVE: To examine the relative efficiency of female-to-male heterosexual transmission of HIV among couples in San Francisco. METHODS: We enrolled 41 male sexual partners of 38 HIV-infected women in 1985-1989. HIV serological tests and detailed risk factor interviews were administered to both partners. Transmission
HIV recovery from semen: minimal impact of clinical stage of infection and minimal effect on semen analysis parameters.: Int Conf AIDS. 1990 Jun 20-23;6(1):159 (abstract no. Th.C.102). Unique Identifier : AIDSLINE ICA6/10010290; Krieger J; Coombs R; Collier A; Ross S; Chaloupka K; Cummings D; Corey L; University of Washington School of Medicine, Seattle, WA, USA; OBJECTIVE: We investigated the role of stage of infection on presence of culturable HIV in semen. METHODS: Specimens from 18 asymptomatic patients and 18 patients with AIDS were separated into seminal cells and plasma, then co-cultured with phytohemagglutinin-stimulated lymphocytes. RESULTS: HIV was isolated from peri
Crack use predicts incident HIV seroconversion.: Int Conf AIDS. 1990 Jun 20-23;6(1):159 (abstract no. Th.C.103). Unique Identifier : AIDSLINE ICA6/10010390; Schoenbaum EE; Hartel D; Friedland GH; Montefiore Medical Center, Bronx, New York City, NY, USA; OBJECTIVE: To examine the relation of CRACK use to HIV risk factors and HIV seroconversion among seropositive (SP) and seronegative (SN) intravenous drug users (IVDUs) in New York City. METHODS: From 6/85 - 12/88 576 methadone maintained IVDUs enrolled in a prospective study of HIV infection had serial interviews rega
Nosocomial transmission of HIV in Romania.: Int Conf AIDS. 1990 Jun 20-23;6(1):159 (abstract no. Th.C.104). Unique Identifier : AIDSLINE ICA6/10010490; Beldescu N; Apetrei R; Calumfirescu A; National AIDS Committee, Ministry of Health, Bucharest, Romania; OBJECTIVE: To determine the risk factors and geographic spread of HIV infection among children in Romania . METHODS: Collection of serum for HIV testing from representative samples of children under 7 years of age with history of recent hospitalization, collection of serum from mot
Distribution and determinants for risk behaviors of HIV infection among young adults in Zaire, a KAP study.: Int Conf AIDS. 1990 Jun 20-23;6(1):160 (abstract no. Th.C.105). Unique Identifier : AIDSLINE ICA6/10010590; Moore M; Bomboko B; Bertrand WE; Adjou Moumouni; Kashala TD; Centers for Disease Control, Atlanta, GA, USA; OBJECTIVE: The purpose of the study was to determine the distribution and the determinants for risks behaviors of HIV infection among young adults in Zaire . METHODS: A self-administered questionnaire was given to randomly selected College students in Kinshasa. The selection was me
HIV transmission knowledge, beliefs about personal risk of AIDS and condom use in the U.S., France, and U.K.: Int Conf AIDS. 1990 Jun 20-23;6(1):160 (abstract no. Th.C.106). Unique Identifier : AIDSLINE ICA6/10010690; Wells JA; Will A; Sell R; Valleron AJ; Cohen M; DeFilippes P; Project HOPE Center for Health Affairs, Chevy Chase, Maryland,; USA; OBJECTIVE: To compare patterns and levels of transmission knowledge and beliefs about AIDS risk in three countries and compare associations of knowledge and belief with condom use during vaginal intercourse, anal intercourse among men, and initiation of condom use. METHODS: Interviews with national probability samples
HIV-1 behavioral and sociological risks and condom use in gay men in Mexico.: Int Conf AIDS. 1990 Jun 20-23;6(1):160 (abstract no. Th.C.107). Unique Identifier : AIDSLINE ICA6/10010790; Izazola JA; Valdespino JL; Sepulveda J; Gortmaker SL; Townsend J; Palacios M; Mueller N; Becker J; Ministry of Health, Mexico; OBJECTIVE: To estimate behavioral and sociological risk factors for HIV seropositivity and condom use in gay and bisexual men in Mexico . METHODS: Data about knowledge, attitudes and practices (KAP) about AIDS were collected for 715 men; interviews took place in gay gathering places
Relapse from safer sex: the AIDS behavioral research project.: Int Conf AIDS. 1990 Jun 20-23;6(1):160 (abstract no. Th.C.108). Unique Identifier : AIDSLINE ICA6/10010890; Stall R; Ekstrand M; Pollack L; Coates TJ; UC-SF Center for AIDS Prevention Studies, (CAPS), San Francisco,; CA, USA; OBJECTIVE: To determine the extent and correlates of relapse from safe sex. METHODS: This reports data from a 5-year prospective study of gay men in San Francisco. In the 1988 wave of data collection, 71% (n=575) of the original cohort continued to respond to the survey. Independent variables included psychosocial mea
Recent changes in behaviour and practices in relation to the HIV epidemic in Rakai, Uganda.: Int Conf AIDS. 1990 Jun 20-23;6(1):161 (abstract no. Th.C.109). Unique Identifier : AIDSLINE ICA6/10010990; Musagara M; Konde-Lule J; Mugrave S; Serwadda D; Wawer MJ; Sewankambo N; AIDS Control Programme/Rakai Project, Uganda; OBJECTIVE: To define changes in behaviour and practices made in response to knowledge of the HIV epidemic. METHODS: 21 clusters of 40 households each were randomly selected, (9 trading center clusters and 12 rural). All consenting adults answered a Knowledge, Attitudes and Behaviours (KAB) interview (n=1304). In addit
Condom use and sexually transmitted diseases (STDs) among commercial sex workers (CSWs) undergoing a health education (HE)/intervention program on AIDS in the Philippines.: Int Conf AIDS. 1990 Jun 20-23;6(1):161 (abstract no. Th.C.110). Unique Identifier : AIDSLINE ICA6/10011090; Monzon OT; Santana RT; Paladin FJ; Bautista AN; Bagasao TM; Giannone P; Department of Health Research Institute for Tropical Medicine,; Metro Manila, Philippines; OBJECTIVES: 1) To obtain baseline information on prevalence of HIV and other STDs among CSWs. 2) To correlate condom use and STD prevalence. METHODS: Baseline information on STD prevalence and condom use were obtained on a cohort of 680 female CSWs prior to initiation of an ongoing 2-year HE/intervention program on AI
Incidence of heterosexual pairings associated with risk of secondary HIV transmission: population-based estimates.: Int Conf AIDS. 1990 Jun 20-23;6(1):161 (abstract no. Th.C.111). Unique Identifier : AIDSLINE ICA6/10011190; Capell FJ; Schiller G; California Department of Health Services, Sacramento, California,; USA; OBJECTIVE: To assess the potential in California (CA) for sexual transmission of HIV from intravenous drug users (IVDU) and male bisexuals (MB) to segments of the heterosexual population with no other risks for infection. METHODS: We used probability sample telephone survey methods to select and interview 6,673 CA adu
Heterogeneity and fluctuations in homosexual behavior: implications for modeling the AIDS epidemic.: Int Conf AIDS. 1990 Jun 20-23;6(1):161 (abstract no. Th.C.112). Unique Identifier : AIDSLINE ICA6/10011290; Van Griensven G; De Vroome E; Veugelers P; Coutinho RA; Municipal Health Service, Amsterdam, The Netherlands; OBJECTIVE: Heterogeneity in mathematical models is mostly restricted to variation in sexual partner change. Less attention is paid to variation in sexual role behavior. We assume the existence of 4 sexual subgroups based on the preference for: 1) no anal intercourse; 2) anal insertive only; 3) anal receptive only; 4)
The UK declaration of the rights of people with HIV and AIDS: voluntary organisations join to defend human rights.: Int Conf AIDS. 1990 Jun 20-23;6(1):162 (abstract no. Th.D.113). Unique Identifier : AIDSLINE ICA6/10011390; Grimshaw J; Jay M; Kelmanson A; National AIDS Trust (NAT), London, England; OBJECTIVE: A group of voluntary organisations concerned with AIDS and HIV is seeking to raise awareness of the human rights dimensions of the treatment of people with AIDS and HIV in the UK and internationally. METHODS: A working group, convened by the NAT, established a list of shared concerns which have been related
AIDS and human rights in Czechoslovakia.: Int Conf AIDS. 1990 Jun 20-23;6(1):162 (abstract no. Th.D.114). Unique Identifier : AIDSLINE ICA6/10011490; Machala L; Infections House, Bulovka Hospital, Prague, Czechoslovakia
AIDS, human rights and discrimination in Mexico.: Int Conf AIDS. 1990 Jun 20-23;6(1):162 (abstract no. Th.D.115). Unique Identifier : AIDSLINE ICA6/10011590; Galvan F; de la Pena R; Gonzalez R; Universidad Autonoma Metropolitana, GIS-SIDA, AC, Mexico; OBJECTIVE: To describe what kind of human rights are frequently violated in AIDS related conditions. Explain the function of sociopolitical, legal and cultural factors in shaping such aggravating. METHODOLOGY: In-depth interviewing, opinion polls in-live research, documentary testimonial and subject analysis. RESULTS:
HIV seropositivity in Spanish prisons.: Int Conf AIDS. 1990 Jun 20-23;6(1):162 (abstract no. Th.D.116). Unique Identifier : AIDSLINE ICA6/10011690; Granados A; Miranda MJ; Martin L; Ministerio Justicia, Madrid, Espana; OBJECTIVE: is to know the prevalence of HIV, hepatitis B and syphilis infection among the Spanish prison population, so as the risk factors which do determine it. In order to administer preventive or curative treatment. METHODOLOGY: A transversal study has been performed all over the Spanish prison population, in Marc
Issues in AIDS related legislation: health control versus human rights.: Int Conf AIDS. 1990 Jun 20-23;6(1):163 (abstract no. Th.D.117). Unique Identifier : AIDSLINE ICA6/10011790; Bhimani GV; Gilada IS; Thakur V; Indian Health Organisation, J.J. Hospital, Bombay, India; OBJECTIVE: Legislation is likely to be the most conflictual area of sociopolitical response to AIDS. The need for international consensus was highlighted by the experience of a case study. METHOD: As a test case we were involved in countermanding a legislation in one of the states in In
The impact of HIV infection on homophobia in the U.S.: Int Conf AIDS. 1990 Jun 20-23;6(1):163 (abstract no. Th.D.118). Unique Identifier : AIDSLINE ICA6/10011890; Coles M; ACLU--San Francisco, CA, USA
Poor sustainability of birth control utilization and consequent high fertility rates in a cohort of 249 HIV(+) Zairian women aware of their serostatus and followed for 30 months post-partum.: Int Conf AIDS. 1990 Jun 20-23;6(1):164 (abstract no. Th.D.121). Unique Identifier : AIDSLINE ICA6/10012190; Badi N; Nsuami M; Mundele L; Utshudi M; Matela B; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVE: To measure the use and effect on fertility rates (FR) of BC techniques freely provided to a cohort of HIV(+) and HIV(-) mothers informed of their HIV serostatus during the immediate post-partum period. METHODS: 249 HIV(+) and 310 age-matched HIV(-) women were enrolled shortly before delivery in 1986-87. Fol
Community impact of maternal HIV-1 infections on infant and childhood survival in a Haitian slum 1976-1989.: Int Conf AIDS. 1990 Jun 20-23;6(1):164 (abstract no. Th.D.122). Unique Identifier : AIDSLINE ICA6/10012290; Boulos R; Halsey N; Coberly J; Holt E; Kissinger P; Brutus JR; Quinn T; Ruff A; Boulos C; The Centers for Development and Health, Port-au-Prince, Haiti; OBJECTIVE: To evaluate trends in seroprevalence of HIV-1 in pregnant women and the community impact of maternal HIV infection on survival of children. METHODS: From 1986-1989 women attending prenatal clinics in Cite Soleil were screened for antibodies to HIV-1. Infant mortality was estimated by conducting fertility an
Treating the non-infected sibling: an AIDS dilemma.: Int Conf AIDS. 1990 Jun 20-23;6(1):164 (abstract no. Th.D.123). Unique Identifier : AIDSLINE ICA6/10012390; Harris A; Nozyce M; Caffrey B; Wiznia A; Caspe W; Bronx-Lebanon Hospital Center, Albert Einstein College of; Medicine, Bronx, New York, USA; OBJECTIVE: To assess the entire family dynamics and to offer individualized services to the non-infected siblings. METHODS: The clinic is currently following 90 children: 29 are in foster care, 20 with relatives and 31 are living with their biological mothers. Seven families have relocated and three have been lost to
Adult children of persons with AIDS: issues and treatment.: Int Conf AIDS. 1990 Jun 20-23;6(1):164 (abstract no. Th.D.124). Unique Identifier : AIDSLINE ICA6/10012490; Greene D; McVinney D; Gay Men's Health Crisis, New York, New York, USA; OBJECTIVE: The objective of this paper is to: 1) identify psychological themes and behaviors expressed by adult children of Persons With AIDS (PWA s) and 2) to identify counseling strategies specific to this population. METHOD: Information presented will be based upon descriptive data collected through five years of c
Clinicians' attitudes about the aggressiveness of treatment for newborns at risk for AIDS: an ethical issue in the NICU.: Int Conf AIDS. 1990 Jun 20-23;6(1):165 (abstract no. Th.D.125). Unique Identifier : AIDSLINE ICA6/10012590; Levin BW; Driscoll JM; Fleischman AR; Brooklyn College, Brooklyn, NY, USA; OBJECTIVE: To investigate attitudes about treatment for newborns in neonatal intensive care units (NICUs) who are at risk for AIDS. METHODS: Questionnaires were distributed to physicians, nurses, and ethics committee members in NICUs at six hospitals in New York City; 247 responded. Treatment recommendations were elic
Pediatric AIDS hospitalizations in New Jersey.: Int Conf AIDS. 1990 Jun 20-23;6(1):165 (abstract no. Th.D.126). Unique Identifier : AIDSLINE ICA6/10012690; Conviser R; Grant C; Coye M; Children's Hospital AIDS Program, Newark, NJ, USA; OBJECTIVE: To determine correlates of inpatient utilization for all children with AIDS hospitalized in New Jersey during 1987. METHODS: All New Jersey hospital discharge abstracts from 1987 were scanned for AIDS diagnoses and matched to the state AIDS Registry to find those corresponding to children under 13 with AIDS
AIDS orphans in Kinshasa, Zaire.: Int Conf AIDS. 1990 Jun 20-23;6(1):165 (abstract no. Th.D.127). Unique Identifier : AIDSLINE ICA6/10012790; Kamenga M; DaSilva M; Muniaka K; Matela B; Batter V; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVES: To determine the impact premature maternal mortality has had on children whose mothers have died of HIV/AIDS (AIDS orphans). METHODS: Since 1986 475 newborn infants of 466 HIV(+) women and 616 newborn infants of 606 matched HIV(-) women have been followed. Within this cohort, a nested case-control study ha
Adoption as a life plan for HIV-positive children.: Int Conf AIDS. 1990 Jun 20-23;6(1):165 (abstract no. Th.D.128). Unique Identifier : AIDSLINE ICA6/10012890; Gurdin P; Wiznia A; Canepa L; Leake and Watts Children's Home Inc., Yonkers, NY, USA; OBJECTIVE: To demonstrate that, by means of innovative recruitment and supportive services strategies, families can be identified which will adopt HIV-positive children. METHODS: A historical data base describing the HIV-positive children placed with foster families by Leake and Watts pioneering AIDS specialized fost
Nutritional status of HIV+ patients during the early stages of disease.: Int Conf AIDS. 1990 Jun 20-23;6(1):168 (abstract no. Th.B.200). Unique Identifier : AIDSLINE ICA6/10020090; Coulston A; McCorkindale C; Dybevik K; Merigan T; Stanford University, Stanford, CA, USA; OBJECTIVE: To improve our understanding of the malnutrition of AIDS patients, monthly nutritional assessment (NA) has been determined on HIV+ patients early in the disease. METHODS: Twenty-six HIV+ men from ACTU studies were recruited. Group I had 19 men (13 CDC Group II and 6 CDC Group IVA) and were followed for 16 m
Dietary intake in AIDS, AIDS-related complex and asymptomatic seropositive HIV patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):168 (abstract no. Th.B.201). Unique Identifier : AIDSLINE ICA6/10020190; Seaton T; Dworkin B; Wormser G; New York Medical College, Valhalla, New York, USA; A major manifestation of AIDS is the development of cachexia. This likely results from a multifactorial interplay of poor diet, malabsorption and altered metabolism. To assess the role of nutrient intake, we performed an analysis of a 72 hour diet record in clinically stable patients with AIDS (N=18), ARC (N=12) and a
Dietary intake, nutritional status, and immunologic function in patients with HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):168 (abstract no. Th.B.202). Unique Identifier : AIDSLINE ICA6/10020290; Chlebowski R; Grosvenor M; Kruger S; Tai V; Beall G; Harbor-UCLA Medical Center, Department of Medicine, Torrance, CA,; USA; Nutritional status is a major determinant of HIV survival (Am J Gastro 84:1288, 1989). To investigate etiologic factors, relationships among dietary intake, nutritional status, and immunologic function were determined using food records obtained for 537 patient days at 89 intervals from 55 favorable performance status
Evaluation and therapy of malnutrition in enteropathogenic AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):168 (abstract no. Th.B.203). Unique Identifier : AIDSLINE ICA6/10020390; Scevola D; Barbarini G; Zambelli A; Bottari G; Guanziroli A; Franchini A; Inst. Infect. Dis., University of Pavia, IRCCS Policlinico S.; Matteo, Pavia, Italy; OBJECTIVE: The high frequency of gastrointestinal pathology depicts so called enteropathogenic AIDS in which malnutrition may influence the course of disease. This study defines microbiological, biochemical, immunological and anthropometric aspects of malnutrition that require nutritional therapy. METHODS: Actual and
Increased energy expenditure and lean body mass in HIV infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):169 (abstract no. Th.B.204). Unique Identifier : AIDSLINE ICA6/10020490; Melchior JD; Salmon D; Rigaud D; Leport C; Vilde JL; Apfelbaum M; Hopital Bichat - Claude Bernard, Paris, France; OBJECTIVE: Is body weight loss in stable HIV-infected patients caused by increased Resting Energy Expenditure (REE)? METHODS: REE was measured by indirect calorimetry in 29 malnourished HIV patients: 9 ARC, 20 AIDS (28 men, 1 woman). Patients with fever or uncontrolled opportunistic infections were excluded. Lean Body
Hypovitaminemia B-12 in HIV infected patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):169 (abstract no. Th.B.205). Unique Identifier : AIDSLINE ICA6/10020590; Riera A; Remacha A; Cadafalch J; Gimferrer E; Serveis de Medicina Interna i Hematologia. Seccio Patologia; Organica. Unitat Toxicomanies. Programa Sant Pau-CITRAN.; Hospital de la Santa Creu i Sant Pau. UAB. Barcelona. Spain.; It has been reported that some HIV infected patients have low vitamin B-12 (B-12) levels. OBJECTIVE: To assess the changes in B-12 and folic acid status in HIV infected patients. MATERIAL AND METHODS: We have studied 60 HIV infected patients, admitted in the Internal Medicine Department during a period of 4 months. 44
Trace metal and vitamin deficiencies in AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):169 (abstract no. Th.B.206). Unique Identifier : AIDSLINE ICA6/10020690; Malcolm JA; Tynan PF; Sutherland DC; Dobson P; Kelson K; Carlton J; Department of Clinical Immunology, Royal Newcastle Hospital,; Newcastle, Australia; OBJECTIVE: To examine the prevalence and significance of trace metal and vitamin deficiencies in AIDS. METHODS: Twenty nine patients were studied, 6 with ARC and 23 with AIDS. Mean age was 36 years (SD=12.0, range 21 to 69 years). Vitamin and trace metal levels and a range of other biochemical variables were examined.
Lipid abnormalities in HIV infection.: Int Conf AIDS. 1990 Jun 20-23;6(1):169 (abstract no. Th.B.207). Unique Identifier : AIDSLINE ICA6/10020790; Blatt S; Zajac R; Lucey D; Hendrix C; Abbadessa S; Melcher G; Boswell R; Wilford Hall USAF Medical Center, Lackland Air Force Base, Texas,; USA; OBJECTIVE: AIDS is characterized by a chronic wasting process resulting in severe cachexia. Non-HIV related cachexia is associated with serum hypertriglyceridemia and variable decreases in serum cholesterol. Animal models suggest these lipid abnormalities are mediated by Tumor Necrosis Factor (TNF) alpha. To understan
Three month evaluation of a controlled high calorie/protein intake in AIDS patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):170 (abstract no. Th.B.208). Unique Identifier : AIDSLINE ICA6/10020890; Johnston S; Clotet B; Biosca C; Abad E; Alcalde C; Castro T; Pont M; Dietetic Dept. Hospital Germans Trias i Pujol - Badalona -; Barcelona - Spain; OBJECTIVE: Since malnutrition is widespread in AIDS patients, this study aimed to evaluate the efficacy of a high calorie/protein intake in HIV seropositive patients with 5-10% weight loss and poor appetite over a 3 month period. METHOD: We introduced 23 male patients fulfilling the AIDS criteria with a mean age of 31
Metabolic disturbances in AIDS: the role of circulating interferon alpha (IFNa) and tumor necrosis factor (TNF) in the hypertriglyceridemia of AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):170 (abstract no. Th.B.209). Unique Identifier : AIDSLINE ICA6/10020990; Grunfeld C; Pang MY; Doerrler W; Shigenaga JK; Kotler DP; Feingold KR; University of California, San Francisco, CA, USA; AIDS is characterized by increased serum triglycerides (TG), elevated circulating levels of cytokines and depletion of body cell mass (wasting). It is thought that cytokines mediate the metabolic disturbances of infection. We measured triglyceride and cytokine levels, triglyceride clearance and lean body mass in patie
Evaluation of the effectiveness of megestrol acetate as inducer of appetite, weight gain and improved nutrition in ARC patients.: Int Conf AIDS. 1990 Jun 20-23;6(1):170 (abstract no. Th.B.210). Unique Identifier : AIDSLINE ICA6/10021090; Viteri FE; Kahn J; Mudie H; Conroy A; Abrams D; Hellerstein M; University of California, Berkeley, CA, USA; OBJECTIVE: To determine the changes in nutritional, immunological and clinical status induced by an 8 week course of 800 mg/day Megestrol Acetate (MA) in ARC patients with weight loss greater than 5% whether or not patients are on AZT . METHODS: Commun
A retrospective study on the effect of Megace on body weight in HIV patients, who had lost more than 5% body weight: its efficacy and its limitation as a form of treatment for weight loss.: Int Conf AIDS. 1990 Jun 20-23;6(1):170 (abstract no. Th.B.211). Unique Identifier : AIDSLINE ICA6/10021190; Chen W; Brown S; Gazzard B; Howard L; Westminster Hospital, London, UK; OBJECTIVE: To evaluate the effect of Megace on body weight in HIV patients with or without gastrointestinal disturbance. METHOD: Twenty-five patients, who had lost more than 5% body weight, given Megace (40-169mg) were weighted and reviewed 3 months prior to treatment and monthly thereafter. RESULT: 3 patterns of weig
AIDS-education and prevention in the workplace in Uganda.: Int Conf AIDS. 1990 Jun 20-23;6(1):171 (abstract no. Th.D.212). Unique Identifier : AIDSLINE ICA6/10021290; Rwakagiri F; Okware S; Federation of Uganda Employers, Uganda.; OBJECTIVE: The available data show that 85% of AIDS cases in Uganda is between 15 years to 55 years. This is the age that is in meaningful employment. In the absence of the drug nor vaccine against AIDS, in an effort to curtail the spread of AIDS, the employer has to devise means o
HIV infectivity program on Tap Air Portugal.: Int Conf AIDS. 1990 Jun 20-23;6(1):171 (abstract no. Th.D.213). Unique Identifier : AIDSLINE ICA6/10021390; Alves-Sa J; Sousa-Ura A; Sa-Leal A; Health Department, Tap Air Portugal, Lisboa, Portugal; At present, HIV infectivity in workplace is not only a medical problem since it concerns as well social, political, cultural, ethical and legal aspects. Any approach of workplace HIV infectivity must involve an increase in preventive measures in order to avoid new seropositives and protect against discrimination. The
Why do persons with HIV-related illness stop working?: Int Conf AIDS. 1990 Jun 20-23;6(1):171 (abstract no. Th.D.214). Unique Identifier : AIDSLINE ICA6/10021490; Yelin EH; Greenblatt R; Hollander H; McMaster J; University of California, San Francisco, USA; OBJECTIVE: To determine the risk factors (RF) for work disability (WD) among persons with HIV-related illness (HIV). WD is defined as total cessation of employment among those working at onset of illness. The RF analyzed include: symptoms and diagnoses of HIV, demographics, and the physical requirements and flexibilit
Training managers and supervisors on the law of AIDS in the United States.: Int Conf AIDS. 1990 Jun 20-23;6(1):171 (abstract no. Th.D.215). Unique Identifier : AIDSLINE ICA6/10021590; Nau CJ; Syntex Corporation, Palo Alto, California, USA; A key factor in the American civil rights revolution of the sixties and early seventies was not just the passage of federal and state anti-discrimination legislation but corporate America s response to those legal mandates and proscriptions. To properly recognize the rights of HIV-infected employees, as well as to pre
An evaluation of a workplace AIDS education intervention program focusing on HIV knowledge levels and attitudes toward gay men and people with AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):172 (abstract no. Th.D.216). Unique Identifier : AIDSLINE ICA6/10021690; Cowen E; Maddix J; DC Area Resource Center of Mid-Atlantic AIDS Education & Training; Center, Georgetown U., Washington, DC, USA; OBJECTIVE: The effectiveness of the Whitman-Walker Clinic s AIDS in the Workplace intervention program was evaluated. METHODS: Prior to attending the AIDS in the Workplace workshop developed and presented by staff members of the Whitman-Walker Clinic (D.C. s primary community-based AIDS service agency), 289 federal an
Large increase in health care utilization by HIV infected employees at a commercial bank in Kinshasa, Zaire.: Int Conf AIDS. 1990 Jun 20-23;6(1):172 (abstract no. Th.D.218). Unique Identifier : AIDSLINE ICA6/10021890; Mposo N; Bertozzi S; Kamenga M; Doppagne A; Engele B; Ryder R; Projet SIDA, Kinshasa, Zaire; OBJECTIVE: To evaluate the impact of HIV infection on health care utilization at large service corporation in Zaire . METHODS: We used a previously identified cohort of HIV positive (ELISA/Western Blot) employees (n=90) at a large bank in Kinshasa and selected a seronegative contro
AIDS prevention in Brazilian enterprises.: Int Conf AIDS. 1990 Jun 20-23;6(1):172 (abstract no. Th.D.219). Unique Identifier : AIDSLINE ICA6/10021990; Moreira Lima MD; Rodrigues LG; Rodrigues JF Jr; National Division of Sexually Transmitted Diseases/AIDS-Ministry; of Health-Brazil; CONTEXT: Nearly 20 million individuals work in the approximately 3 million enterprises in Brazil . These individuals are predominantly in the age group 18-48, in which the majority of AIDS cases in the country falls. This fact led the STD/AIDS Division of the Ministry of Health in B
The impact of workplace AIDS education on attitudes toward people with HIV/AIDS.: Int Conf AIDS. 1990 Jun 20-23;6(1):173 (abstract no. Th.D.220). Unique Identifier : AIDSLINE ICA6/10022090; Leonard J; Hartfield K; Smith K; Seattle-King County Department of Public Health, Seattle,; Washington, USA; OBJECTIVE: To measure the impact of workplace AIDS education on employee knowledge and attitudes about people with AIDS and people at risk for HIV infection. METHODS: We developed a two-hour curriculum, augmenting our standard AIDS 101 curriculum with additional materials on AIDS-related prejudice, discrimination, and
The open-box condom policy in the workplace in Africa: effects on attitudes and practices.: Int Conf AIDS. 1990 Jun 20-23;6(1):173 (abstract no. Th.D.221). Unique Identifier : AIDSLINE ICA6/10022190; Tavrow PA; USAID, Dar es Salaam, Tanzania; OBJECTIVE: To test whether making condoms easily, reliably, and anonymously available to employees in workplaces in Dar es Salaam, in the absence of active promotion or counseling, leads to changed attitudes and practices in regard to sexual behavior of urban African men and women. METHODS: Starting in mid-1988, sever
Still on the job; the Army's experience with the workplace management of the HIV+ soldier.: Int Conf AIDS. 1990 Jun 20-23;6(1):173 (abstract no. Th.D.222). Unique Identifier : AIDSLINE ICA6/10022290; Vernon DM; Walter Reed Retrovirology Research Working Group, Walter Reed; Army Institute of Research, USA; OBJECTIVE: Examines the effect of the Army s AIDS policy on the military worksite. METHODS: Thirteen HIV+ soldiers were followed from diagnosis (late 1986, early 1987) until late November 1988. Initially diagnosed in Europe, these male soldiers and their commanders were interviewed pre-transfer to a US post (T1), one
Workplace training in an international non-governmental organisation.: Int Conf AIDS. 1990 Jun 20-23;6(1):173 (abstract no. Th.D.223). Unique Identifier : AIDSLINE ICA6/10022390; Couteau P; Wallace B; Michael L; Brever N; League of Red Cross and Red Crescent Societies, Geneva,; Switzerland; OBJECTIVE: To describe AIDS workplace training in a multicultural international organisation, including policy development, in which non-discrimination and integration of AIDS activities into staff s on-going work are stressed. METHODS: Using extensive interviews and consultation with staff members from all regions of
Molecular dynamics simulations of HIV-1 protease monomer and binding of inhibitors to the dimer in solution.: Int Conf AIDS. 1990 Jun 20-23;6(1):176 (abstract no. Th.A.225). Unique Identifier : AIDSLINE ICA6/10022590; Venable RM; Brooks BR; Carson FW; CBER, FDA, Bethesda, MD 20892, USA; OBJECTIVES: The goals of this investigation were to simulate motions of one of the 99-residue subunits of the HIV-1 protease homodimer and to analyze binding of inhibitors to the active dimeric enzyme. METHODS: The X-ray crystallographic structure of HIV-1 protease determined by Wlodawer et al. [Science, 245, 616-621
Inhibitors of HIV protease.: Int Conf AIDS. 1990 Jun 20-23;6(1):176 (abstract no. Th.A.226). Unique Identifier : AIDSLINE ICA6/10022690; Martin JA; Broadhurst AV; Galpin S; Handa BK; Kinchington D; Krohn A; Lambert RW; Machin PJ; Merrett JH; Parkes KE; et al; Roche Products Ltd., Welwyn Garden City, Hertfordshire, England; OBJECTIVE: Design, synthesis and biological evaluation of protease inhibitors as potential therapeutic agents for the treatment of HIV infection. METHODS: An analysis of the primary cleavage sites in gag and gag-pol suggested a series of small synthetic substrat
A fluoroquinolone (DR-3355) protects human lymphocyte cell lines from HIV-1-mediated cytotoxicity.: Int Conf AIDS. 1990 Jun 20-23;6(1):176 (abstract no. Th.A.227). Unique Identifier : AIDSLINE ICA6/10022790; Furusawa M; Renard J; Iino T; Sato Y; Marumoto Y; Ohta G; Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan; OBJECTIVE: To analyze the function of the 1-isomer of ofloxacin (DR-3355) to protect HIV-1-infected human lymphocyte cell lines. METHODS: The d-isomer (DR-3354) or l-isomer (DR-3355) of ofloxacin was added to the medium in which HIV-1-infected CEM cells were inoculated. Viable cell number, viability, HIV antigen-posit
Inhibition of HIV replication and cytopathicity in vitro by synthetic soluble melanins.: Int Conf AIDS. 1990 Jun 20-23;6(1):177 (abstract no. Th.A.228). Unique Identifier : AIDSLINE ICA6/10022890; Candia AF; Modliszewski M; Shaff DI; Montefiori DC; Department of Pathology, Vanderbilt University Medical School,; Nashville, TN, USA; OBJECTIVE: To study the antiviral activity of a variety of synthetic soluble melanins against HIV-1 and HIV-2 in vitro. METHODS: Soluble melanins were synthesized by spontaneous oxidation of L-dopa, L-dopamine, norepinephrine and 5-hydroxytryptamine, and by chemical oxidation of L-tyrosine. Their antiviral activities
Anti-HIV activity of porphyrins and phthalocyanines in vitro.: Int Conf AIDS. 1990 Jun 20-23;6(1):177 (abstract no. Th.A.229). Unique Identifier : AIDSLINE ICA6/10022990; Kato A; Higuchi H; Kaji H; Jefferson Medical College, Philadelphia, PA, USA; OBJECTIVE: To assess the anti-HIV effect of porphyrin and phthalocyanine derivatives for development of poss