Synthesis and biological activity of a cyclic hexapeptide related to peptide T. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Synthesis and biological activity of a cyclic hexapeptide related to peptide T.

Farmaco. 1989 Dec;44(12):1233-7. Unique Identifier : AIDSLINE MED/90234131
Bianchi S; Scaranari V; Tomatis R; Dipartimento Scienze Farmaceutiche, Universita di Ferrara,; Italy.

Abstract: The cyclo [Thr-Thr-Thr-Tyr-Asn-Thr] hexapeptide related to peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, competitor of the Human Immunodeficiency Virus in the binding to human T cells, was synthesized and tested for its ability to stimulate monocyte migration (chemotaxis). The new cyclic derivative showed negligible biological activity.
Keywords: Amino Acid Sequence Chemistry Chemotaxis, Leukocyte/DRUG EFFECTS Human In Vitro Molecular Sequence Data Monocytes/DRUG EFFECTS Peptide T/ANALOGS & DERIVATIVES/*CHEMICAL SYNTHESIS/PHARMACOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLEKWDaminoacidsequencechemistrychemotaxis,leukocyte/drugeffectshumaninvitromolecularsequencedatamonocytes/drugeffectspeptidet/analogs&derivatives/KWDchemicalsynthesis/pharmacologysupport,non-uKWDsKWDgov'tjournalarticle
900830
M9080745

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1990. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1990. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .