[Treatment of mycobacteriosis] NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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[Treatment of mycobacteriosis]

Medicina (Firenze). 1989 Oct-Dec;9(4):375-9. Unique Identifier : AIDSLINE MED/90231059
Covi M; Velluti G; Bisetti A

Abstract: At present the increased incidence of infections with mycobacteria other than tuberculosis and leprae bacilli seems to be correlated with several causes: improved diagnostic techniques, prolonged life expectancy, immunodepression. Rational chemotherapy depends upon the identification of the etiologic mycobacterium and the determination of its drug susceptibility. Besides the classic treatment with 3 or 4 antituberculous and, sometimes, nonantituberculous chemotherapics, clinical trials are in progress to assess the effectiveness of new molecules: rifamycin derivatives, fluorinated quinolones, anti-lepromatous drugs, and the latest macrolides. Yet at present, national and international data do not permit to define a standard treatment for every mycobacteriosis; in fact, the drug resistance is high and varies not only between different strains but also within the same strain; moreover, there are discrepancies between in vitro and in vivo results. When possible, appropriated surgery for circumscribed disease is recommended.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Antitubercular Agents/*THERAPEUTIC USE Drug Therapy, Combination English Abstract Human Mycobacterium avium-intracellulare Infection/COMPLICATIONS/DRUG THERAPY Mycobacterium Infections/*DRUG THERAPY Mycobacterium Infections, Atypical/COMPLICATIONS/*DRUG THERAPY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDacquiredimmunodeficiencysyndrome/complicationsantitubercularagents/KWDtherapeuticusedrugtherapy,combinationenglishabstracthumanmycobacteriumavium-intracellulareinfection/complications/drugtherapymycobacteriuminfections/KWDdrugtherapymycobacteriuminfections,atypical/complications/KWDdrugtherapyjournalarticlereviewreview,tutorial
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Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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