Mononuclear phagocytes and the human immunodeficiency virus. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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Mononuclear phagocytes and the human immunodeficiency virus.

Curr Opin Immunol. 1989-90 Feb;2(3):414-9. Unique Identifier : AIDSLINE MED/90234252
Gendelman HE; Meltzer MS; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland.

Abstract: Macrophages are an important in vivo reservoir for HIV. Conclusive evidence that CNS, pulmonary, lymph node and blood-derived mononuclear phagocytes harbor and support HIV replication is supported by numerous independent studies. HIV variants which preferentially replicate in macrophages have been recovered from infected individuals, suggesting that these cells and variant viruses are involved in the establishment and progression of HIV-related disease.
Keywords: Biological Factors/PHYSIOLOGY Cells, Cultured Gene Expression Regulation, Viral Human HIV/GENETICS/ISOLATION & PURIF/*PHYSIOLOGY HIV Infections/PATHOLOGY Macrophage Activation Macrophages/*MICROBIOLOGY/PATHOLOGY Monocytes/MICROBIOLOGY/PATHOLOGY Support, Non-U.S. Gov't Virus Cultivation *Virus Replication JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDbiologicalfactors/physiologycells,culturedgeneexpressionregulation,viralhumanhiv/genetics/isolation&purif/KWDphysiologyhivinfections/pathologymacrophageactivationmacrophages/KWDmicrobiology/pathologymonocytes/microbiology/pathologysupport,non-uKWDsKWDgov'tviruscultivationKWDvirusreplicationjournalarticlereviewreview,tutorial
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Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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