[Serum and lacrimal proteins in acquired immunodeficiency syndrome] NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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[Serum and lacrimal proteins in acquired immunodeficiency syndrome]

J Fr Ophtalmol. 1989;12(8-9):499-502. Unique Identifier : AIDSLINE MED/90244044
Meillet D; Glomaud J; Unanue F; Diemert MC; Galli A; Le Hoang P; Rousselie F; Galli J; Laboratoire d'Immunochimie, Groupe hospitalier; Pitie-Salpetriere, Paris.

Abstract: The concentrations of seven proteins [albumin (Alb), immunoglobulins (IgG, A, M), lactoferrin (Lf), lysozyme (Lzm) and beta 2-microglobulin (beta 2 m)] were measured in the tears and serum of 10 patients with acquired immune deficiency syndrome (AIDS) and in 13 normal subjects. In the AIDS group, alteration of the blood-lacrimal barrier was revealed by the high Alb clearance. In this group also, the significantly high IgG, IgA, IgM and beta 2 m concentrations indicated a systemic and local immune response, with passive transfer of these proteins from serum to tears. However, Lf and Lzm concentrations were normal, showing that the secretory activity of the lacrimal gland remained unchanged.
Keywords: Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY Adult English Abstract Eye/IMMUNOLOGY Female Human *Immunodiffusion Immunoenzyme Techniques Lacrimal Apparatus/IMMUNOLOGY Male Middle Age Proteins/*ANALYSIS Reproducibility of Results Tears/*ANALYSIS JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDblood/immunologyadultenglishabstracteye/immunologyfemalehumanKWDimmunodiffusionimmunoenzymetechniqueslacrimalapparatus/immunologymalemiddleageproteins/KWDanalysisreproducibilityofresultstears/KWDanalysisjournalarticle
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M9080716

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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