[Immunologic changes associated with human immunodeficiency virus (HIV)] NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


[Immunologic changes associated with human immunodeficiency virus (HIV)]

AMB Rev Assoc Med Bras. 1989 May-Jun;35(3):111-6. Unique Identifier : AIDSLINE MED/90232181
Brigido LF; Duarte AJ

Abstract: Infection by HIV usually leads to dysfunction of the immune system which, facilitates the development of opportunistic infections or neoplasia in which almost always are fatal. The pathological process associated with this infection involves, characteristically, the destruction or malfunction of helper T lymphocytes (CD4+), due to, besides other factors, direct parasitism of the virus or to the secondary immune response, which seems to include autoimmune mechanisms. These pathological changes, along with the action of the virus on other components of the immune system, disturb the production of trophic factors and also the proliferation, differentiation and effector ability of different cells of the immune system. The long latent period, when a large number of infected individuals remain asymptomatic or with only minor clinical and/or laboratory disturbances suggest the possible role of some as yet uncharacterized cofactors, either inherent to the host or to other environmental agents; these cofactors may play a role in the modulation of the progression to this syndrome (AIDS).
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY English Abstract Human HIV/*PHYSIOLOGY HIV Infections/*IMMUNOLOGY Lymphocyte Transformation T-Lymphocytes, Helper-Inducer/*IMMUNOLOGY/MICROBIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDacquiredimmunodeficiencysyndrome/immunologyenglishabstracthumanhiv/KWDphysiologyhivinfections/KWDimmunologylymphocytetransformationt-lymphocytes,helper-inducer/KWDimmunology/microbiologyjournalarticlereviewreview,tutorial
900830
M9080713

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1990. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1990. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .