CONTROVERSIES IN HIV-RELATED CENTRAL NERVOUS SYSTEM DISEASE: NEUROPSYCHOLOGICAL ASPECTS OF HIV-1 INFECTION

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

CONTROVERSIES IN HIV-RELATED CENTRAL NERVOUS SYSTEM DISEASE: NEUROPSYCHOLOGICAL ASPECTS OF HIV-1 INFECTION

AIDS Clinical Review 1989. Volberding P and Jacobson MA, eds. New York, Marcel Dekker, p. 151-91, 1989.. Unique Identifier : AIDSLINE ICDB/90659413
Levy RM; Bredesen DE; Northwestern Univ. Medical Sch., Chicago, IL

Abstract: Neurologic illness can arise not only from opportunistic infections and neoplasms but also from primary HIV-1 infection of the nervous system. Research on HIV-1-related cognitive dysfunction relative to clinical stages of HIV-1 infection is reviewed, including phases of CNS infection and cognitive dysfunction in patients with AIDS (AIDS-dementia complex, neurobehavioral abnormalities), AIDS-related opportunistic infections or neoplasms, AIDS-related complex (ARC), persistent lymphadenopathy, or asymptomatic HIV-1 infection. Published and ongoing studies on the neuropsychologic complications of HIV-1 infection are summarized. Although it is premature to make conclusions based on these studies, the data are strongly weighted toward supporting the hypothesis that cognitive deficits do not occur with any significantly increased frequency in HIV-1-seropositive, otherwise asymptomatic people, as compared to seronegative controls. The data support the conclusion that cognitive dysfunction can occur as a complication of ARC or AIDS, and this dysfunction may correlate with the onset of immunosuppression. Methodologic issues pertinent to future research are discussed, including selection of study populations, control groups, and test instruments; collection and reporting of data; and implication of test outcomes. (50 Refs)

Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS AIDS Dementia Complex/*DIAGNOSIS/PSYCHOLOGY AIDS-Related Complex/COMPLICATIONS Brain Neoplasms/DIAGNOSIS Cognition Disorders/DIAGNOSIS Human HIV/*PATHOGENICITY HIV Infections/*COMPLICATIONS HIV Seropositivity/COMPLICATIONS *Neuropsychological Tests Opportunistic Infections/DIAGNOSIS MONOGRAPH REVIEW REVIEW, TUTORIAL
900430
M9040674

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