CLINICAL MANIFESTATIONS OF KAPOSI'S SARCOMA NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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CLINICAL MANIFESTATIONS OF KAPOSI'S SARCOMA

Aids and Infections of Homosexual Men. Second Edition. Ma P and Armstrong D, eds. Boston, Butterworths, p. 251-64 1989.. Unique Identifier : AIDSLINE ICDB/90659646
Safai B; Cornell Univ. Medical Coll., New York, NY

Abstract: Before the epidemic of AIDS, Kaposi's sarcoma (KS) was considered a rare tumor, occurring in cluster distribution of immune dysfunction, genetic predisposition, and possibly repeated and persistent infections in a given host. In the AIDS epidemic, KS appears to be more aggressive, involving skin, lymph nodes, and gastrointestinal tract, and has a course similar to that seen in African children. The history of the recent KS epidemic, epidemiologic factors (incidence, geographic location and race, age, and sex), clinical manifestations and course of disease, histopathology, classification, associated conditions, laboratory findings, cell of origin, and etiology are reviewed. Available data strongly suggest the involvement of cytomegalovirus (CMV) in KS. Much work is necessary to clarify the role of CMV or other viruses in the etiology of this tumor. The increased incidence of HLADR5 in KS patients is intriguing, but actual HLA association with the development of this disease needs further investigation. To identify the cell of origin and the etiopathogenetic mechanisms of KS, growth of the tumors in tissue cultures and laboratory animals will be necessary. The association of KS with a higher than usual frequency of second primary malignancies of the lymphoreticular system also deserves further investigation. (60 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/PATHOLOGY *Homosexuality Human Male Neoplasms, Multiple Primary/DIAGNOSIS/PATHOLOGY Sarcoma, Kaposi's/*DIAGNOSIS/PATHOLOGY Skin/PATHOLOGY Skin Neoplasms/*DIAGNOSIS/PATHOLOGY MONOGRAPH REVIEW, TUTORIAL REVIEWKWDacquiredimmunodeficiencysyndrome/KWDcomplications/pathologyKWDhomosexualityhumanmaleneoplasms,multipleprimary/diagnosis/pathologysarcoma,kaposi's/KWDdiagnosis/pathologyskin/pathologyskinneoplasms/KWDdiagnosis/pathologymonographreview,tutorialreview
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M9040664

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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