ANALYSIS OF MECHANISMS OF IMMUNE SUPPRESSION IN AIDS

Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

ANALYSIS OF MECHANISMS OF IMMUNE SUPPRESSION IN AIDS

Aids and Infections of Homosexual Men. Second Edition. Ma P and Armstrong D, eds. Boston, Butterworths, p. 373-82 1989.. Unique Identifier : AIDSLINE ICDB/90659650
Cunningham-Rundles S; Dept. of Pediatrics, The New York Hosp., Cornell Univ. Medical; Center, New York, NY

Abstract: A number of questions remain concerning the differences among patients (pts) with AIDS in relation to (1) the time required for development of frank AIDS in persons infected with the virus, (2) disease course, (3) potential response to therapy, and (4) whether a balanced carrier state can occur naturally or be achieved through therapeutic intervention. Immunologic studies are described, including relative effect of multiple infecting agents on the immune response in vitro in AIDS and HIV infection; longitudinal study of immune response in AIDS pts with opportunistic infections and cryptosporidiosis; comparison of helper/inducer to cytotoxic/suppressor ratio in pts with AIDS; modulation of proliferative response in vitro by alpha interferon (alpha-IFN); acid-labile, alpha-IFN-induced natural killer activity; effect of IFN treatment on proliferative response to B-cell activators in AIDS pts with Kaposi's sarcoma (AIDS-KS); and the effects of NPT-15392 (erythro-9-[2-hydroxy-3-nonyl]-c-hydroxypurine) on peripheral blood mononuclear cells from a pt with AIDS-KS cultured with Candida albicans or Escherichia coli. Analysis of the immune response in AIDS suggests that immune deregulation evolves differently in different subgroups of pts infected with HIV. Since reception of soluble signals as well as lymphocyte subpopulation balances affect signal transduction, study of these factors and the conditions in which they are produced is essential to meaningful analysis. Furthermore, different pts have varied capacities for modulation in vitro, and the study of intrinsic modulatory function may well prove essential to future assessment of immune response in AIDS. (19 Refs)

Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/THERAPY *Homosexuality Human HIV/*IMMUNOLOGY Interferon Alfa, Recombinant/THERAPEUTIC USE Longitudinal Studies Lymphocyte Transformation/DRUG EFFECTS Male Opportunistic Infections/IMMUNOLOGY Sarcoma, Kaposi's/IMMUNOLOGY Skin Neoplasms/IMMUNOLOGY T-Lymphocytes, Helper-Inducer/IMMUNOLOGY MONOGRAPH REVIEW REVIEW, TUTORIAL
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M9040660

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