Nucleotide composition bias and CpG dinucleotide content in the genomes of HIV and HTLV 1/2. NLM AIDSLINE Important note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.

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Nucleotide composition bias and CpG dinucleotide content in the genomes of HIV and HTLV 1/2.

Biochim Biophys Acta. 1989 Dec 22;1009(3):280-2. Unique Identifier : AIDSLINE MED/90089402
Kypr J; Mrazek J; Reich J; Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.

Abstract: Nucleotide compositions of the HIV subfamily and HTLV 1/2 genomes are strongly biased in a remarkably opposite way; HIV is adenine-rich and cytosine-poor while HTLV 1/2 is cytosine-rich and adenine-poor. In addition, the CpG dinucleotides are underrepresented in HIV but abundant in HTLV 1/2. By these two properties the genomes of HIV and HTLV 1/2 mimic an (A + T)-rich and (G + C)-rich segment of the host genome, respectively. These dramatic differences between the two human retroviruses might have evolved to direct integration of the retroviral genomes into specific segments of the human chromosomes.
Keywords: Adenine/ANALYSIS Base Composition Cytidine/*ANALYSIS Cytosine/ANALYSIS HIV/*GENETICS HTLV-I/*GENETICS HTLV-II/*GENETICS Nucleotides/*ANALYSIS JOURNAL ARTICLEKWDadenine/analysisbasecompositioncytidine/KWDanalysiscytosine/analysishiv/KWDgeneticshtlv-i/KWDgeneticshtlv-ii/KWDgeneticsnucleotides/KWDanalysisjournalarticle
900430
M9040630

Copyright © 1990 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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