(Producer) Health care professionals and STD clinicians discuss the impact AIDS has had on their work lives and ways to approach the topic of AIDS, health, and human sexuality in a non-threatening manner.
Chapel Hill, NC : Health Sciences Consortium, [1987] 1 computer disk ; 5 1/4 in (Infections in immunocompromised patients) Unique Identifier : AIDSLINE AV/8901260A
Chicago, Ill. : Foundation of the American College of Healthcare Executives, [1988] 1 sound cassette : 1 7/8 ips Unique Identifier : AIDSLINE AV/8901207A
Kangu-Mayumbe, B.Z., Republique du Zaire : Bureau d'etudes et de recherches pour la promotion de la sante, [1987?] 64 p. : ill (Brochure illustree ; no 34) Unique Identifier : AIDSLINE CAT/8912526
Development Infection [Washington, D.C.?] : U.S. Dept. of Health and Human Services, Public Health Service, Health Resources and Services Administration, Bureau of Maternal and Child Health and Resources Development, [1987] 19 p Unique Identifier : AIDSLINE CAT/8912756
London ; New York : Royal Society of Medicine Services, 1988 xi, 86 p. : ill (International congress and symposium series ; no. 145) Unique Identifier : AIDSLINE CAT/8912330
London : GMP Publishers ; Boston, MA : Distributed in North America by Alyson Publications, [1988] 94 p. : ill Unique Identifier : AIDSLINE CAT/8912715
[Copenhagen] : Institute of Criminal Science, University of Copenhagen, 1988 51 p. : ill (Kriminalistisk instituts stencilserie, ISSN 0106-276X ; nr. 46) Unique Identifier : AIDSLINE CAT/8912850
Philadelphia, PA (3641 Locust Walk, Philadelphia 19104-6218) : Trustees of the University of Pennsylvania, c1988 23, [10] leaves Unique Identifier : AIDSLINE CAT/8913161
Principles and Practice of Pediatric Oncology. Pizzo PA, Poplack DG, eds. Philadelphia, Lippincott, p. 477-90, 1989.. Unique Identifier : AIDSLINE ICDB/89655602
Seibel NL; Cossman J; Magrath IT; George Washington Univ. Sch. of Medicine and Health Sciences,; Washington, DC
Lymphoproliferative disorders represent a heterogeneous array of diseases involving B-cell proliferations that range from reactive polyclonal hyperplasias to true monoclonal malignant lymphomas. The present chapter focuses on those lymphoproliferative disorders in which an underlying condition leads to a defect in the
Although just over 1000 cases of pediatric AIDS were reported to the Centers for Disease Control as of June 1988, it is projected that this number will exceed 3000 by 1991, with some estimates projecting upward of 10,000 cases of children infected with the AIDS-associated human immunodeficiency virus (HIV). Many of th
Hamazaki N; Shimizu T; Okamura A; Yamamoto H; Yagi S; Department of Medicine, Dokkyo University School of Medicine,; Tochigi.
The diastolic properties of the left and right ventricles of 17 essential hypertensive patients (HT) without left ventricular hypertrophy and of 12 normotensive subjects were assessed by pulsed Doppler echocardiography during the cold pressor test (CPT) and after administration of nifedipine (10 mg). The results were
Antiviral Res. 1988 Dec 11;10(6):289-98. Unique Identifier : AIDSLINE MED/89271834
Ito M; Sato A; Hirabayashi K; Tanabe F; Shigeta S; Baba M; De Clercq E; Nakashima H; Yamamoto N; Department of Bacteriology, Fukushima Medical College, Japan.
Glycyrrhizin (GL) achieved a dose-dependent inhibition of the replication of human immunodeficiency virus type 1 (HIV-1) in MOLT-4 (clone No. 8) cells within the concentration range of 0.075 to 0.6 mM. Within this concentration range, GL also effected a dose-dependent reduction in the protein kinase C (PKC) activity o
Available is a case of mycobacterial sepsis in patients with immunodeficiency of undetermined origin and presenting morphologically with disseminated Kaposi s sarcoma. The disease ran the course and exhibited morphological manifestations similar in some details to AIDS. The author advocates a differentiated approach t
Aust N Z J Med. 1988 Dec;18(7):854-60. Unique Identifier : AIDSLINE MED/89272962
Lloyd A; Wakefield D; Robertson P; Dwyer JM; Infectious Diseases Department, Prince Henry Hospital, Randwick,; N.S.W., Australia.
Anti-HIV antibodies were found in the cerebrospinal fluid of all 41 subjects tested whose serum contained these antibodies. To ensure that locally produced antibody was being detected, a sensitive assay was used to demonstrate the integrity of the blood-brain barrier. Antibodies to ubiquitous adenovirus group antigens
Wilcock G; Grace S; De Villiers D; Borok MZ; Emmanual J; Downing R; Department of Physiology, University of Zimbabwe, Harare.
Patients with Kaposi s Sarcoma (KS) were grouped according to their clinical symptoms into indolent, locally aggressive, endemic generalised aggressive and epidemic generalised aggressive disease. Only the patients in the epidemic generalised aggressive disease group had serum antibodies to HIV. Complete peripheral bl
Postgrad Med J. 1988 Sep;64(755):699-700. Unique Identifier : AIDSLINE MED/89282671
Panicker R; Bloom AL; Compston DA; Department of Haematology, University Hospital of Wales, Heath; Park, Cardiff, UK.
We describe what we believe to be the first case of chronic inflammatory demyelinating polyneuropathy (CIDP) occurring in a haemophiliac infected with the human immunodeficiency virus (HIV), and the first patient to show a clinical response to treatment with high dose i.v. immunoglobulin. A 55 year old, severe haemoph
Iwaoka T; Umeda T; Naomi S; Ohono M; Miura F; Sasaki M; Inoue J; Hamasaki S; Sato T; Third Department of Internal Medicine, Kumamoto University; Medical School, Japan.
Four lateralizing methods were carried out in 14 patients with primary aldosteronism (PA): ultrasonography, CT scan, adrenal scintiscan and determination of adrenal venous aldosterone levels. In all cases, unilateral aldosterone-producing adenomas were verified by surgery. Of four lateralizing methods, determination o
The spectrum of illness associated with AIDS has been enlarging since its initial description in 1981, and the gastrointaestinal tract continues to be one of the major targets of this devastating disease. The many causative agents are discussed in this article, including bacteria, viruses, fungi, protozoa, helminths,
Dowsett JF; Miller R; Davidson R; Vaira D; Polydorou A; Cairns SR; Weller IV; Dept. of Gastroenterology, University College, London, U.K.
Four patients with acquired immunodeficiency syndrome (AIDS) (CDC group IV) were investigated for biliary disease because of the presence of both severe upper abdominal pain and raised levels of serum alkaline phosphatase. None was clinically jaundiced. Upper abdominal ultrasound was abnormal in three. All had endosco
Chisesi T; Capnist G; Rancan L; Pellizzari G; Vespignani M; Department of Hematology, S. Bortolo Hospital, Vicenza, Italy.
Forty-one patients with Hodgkin s disease staged as IA(4), IIA/B(4/6) IIIA/B(6/9) and IVA/B(3/9) who had had radiotherapy (subtotal nodal irradiation (STNI) or total nodal irradiation (TNI), or combined one (STNI/TNI plus chemotherapy MOPP or MOPP/ABVD) have been enrolled consequently and randomized to receive thymic
Greenspan D; de Villiers EM; Greenspan JS; de Souza YG; zur Hausen H; Department of Stomatology, University of California, San; Francisco 94143-0512.
Human papillomaviruses (HPV) are associated with certain oral soft tissue lesions, such as papillomas, warts, condylomata, and focal epithelial hyperplasia (FEH). HPV types 2, 6, 11, 16, and 18 have been identified in some of these oral lesions, while HPV 13 and 32 are associated with FEH. Little is known about the HP
Jacobson MA; O'Donnell JJ; Porteous D; Brodie HR; Feigal D; Mills J; Department of Medicine, University of California San Francisco.
Of 760 AIDS patients seen at San Francisco General Hospital in 1986, 5.7 per cent had retinitis and 2.2 per cent had gastrointestinal disease caused by cytomegalovirus . We reviewed the records of 44 patients treated with ganciclovir for culture-confirmed cytomegalovirus retinal (31
Howard MR; McVerry BA; Cooper EH; Department of Haematology, St James's University Hospital, Leeds.
Serum beta 2-microglobulin (beta 2-m) levels were measured in 75 adults with haemophilia A. Beta 2-microglobulin was found to be significantly elevated in haemophiliacs compared with the non-haemophiliac population. There was a greater rise in beta 2-m in HIV antibody-positive haemophiliacs. No further significant inc
The nursing care of the patient with AIDS consists of a challenge for the improvement of Nursing in general not only because of the gravity of the disease and the very bad prognosis but also because of the great socioeconomic and psychological effects that accompany it. Nursing care in the hospital consists of facing
Brookmeyer R; Goedert JJ; Department of Biostatistics, Johns Hopkins University, School of; Hygiene and Public Health, Balitmore, Maryland 21205.
In epidemiologic studies of infectious diseases, the times of infection may be known only up to an interval. A two-stage parametric regression model is proposed for the analysis of cohort studies during an epidemic in which the exact times of infection cannot be ascertained. The methods permit joint estimation of the
Motta A; Picone D; Temussi PA; Marastoni M; Tomatis R
The synthetic peptide of sequence H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, termed peptide T, a competitor of the Human Immunodeficiency Virus in the binding to human T cells, and its C-terminal pentapeptide fragment, were studied by 1H-nmr in DMSO solution to determine conformational preferences. The observation of nucle
Despite several decades of contact between health workers and drug misusers and recent publicity aimed at increasing the use of this contact to control HIV infection, there remains a persistent belief that control of drug taking is possible either by medical intervention with substitute drugs or provision of facilitie
Bull Pan Am Health Organ. 1989;23(1-2):1-8. Unique Identifier : AIDSLINE MED/89248193
Adrien A; Hankins C; Remis R
Canada s first AIDS case was diagnosed in 1978, and a total of 2,003 cases had been recorded up to 19 September 1988. Nationwide, 82% of those afflicted have been homosexual or bisexual men, 5% have been immigrants from endemic regions, and 4.6% have been recipients of blood or blood products. Estimates of Canadians i
Bull Pan Am Health Organ. 1989;23(1-2):108-14. Unique Identifier : AIDSLINE MED/89248194
Sepulveda Amor J; de Lourdes Garcia M; Dominguez Torix JL; Valdespino Gomez JL
As of August 1988, 1,628 cases of AIDS had been reported in Mexico , of which 12% were ascribed to transmission through blood. Of the 201 subjects infected by blood, 159 (79%) were infected through transfusions. The relatively high number of such cases was found to be associated wit
Bull Pan Am Health Organ. 1989;23(1-2):115-20. Unique Identifier : AIDSLINE MED/89248195
Clayton AJ; Meltzer AS
Canada s federal AIDS program is orchestrated by the Federal Center for AIDS (FCA), created in 1987. The Center is made up of six bureaus: Program Analysis and Resources, the focal point for policy and program development; AIDS Prevention and Services Program, which focuses on education, liason with health care worker
Bull Pan Am Health Organ. 1989;23(1-2):20-3. Unique Identifier : AIDSLINE MED/89248212
Valdespino JL; Izazola JA; Rico B
The first case of AIDS in Mexico was reported in 1981. Through mid-1988, 1,502 cases had been reported, the incidence of cases having doubled every 7.7 months. Of the cases in adults, 87.6% were sexually transmitted, transfusion with contaminated blood or blood products accounted f
Bull Pan Am Health Organ. 1989;23(1-2):30-4. Unique Identifier : AIDSLINE MED/89248218
Rodrigues LG; Chequer P
AIDS was first identified in Brazil in 1982, and by mid-1988 a total of 3,952 cases had been detected. The highest concentrations of cases have occurred in the Southeast region of the country (81.8%), which includes the States of Rio de Janeiro and Sao Paulo, and in the 25-to-40 ye
Bull Pan Am Health Organ. 1989;23(1-2):35-41. Unique Identifier : AIDSLINE MED/89248219
Diaz Lestrem M; Fainboim H; Mendez N; Boxaca M; Libonatti O; Calello MA; Astarloa L; Weissenbacher M
A serologic study of hepatitis and HIV infections among 99 I.V. drug abusers with hepatitis was conducted between December 1986 and September 1987. The average age of the study subjects was 21 years. Eighty-nine (90%) of the subjects were male, including four whose sexual orientation was homosexual/bisexual. Serologic
Bull Pan Am Health Organ. 1989;23(1-2):42-9. Unique Identifier : AIDSLINE MED/89248220
Narain JP; Hull B; Hospedales CJ; Mahabir S; Bassett DC
A review of surveillance data on AIDS and HIV infection in the 18 English-speaking Caribbean countries and Suriname suggests that the epidemiologic pattern of AIDS in the Caribbean is evolving from an epidemic that began in 1983 among homosexual and bisexual males to one in which
Bull Pan Am Health Organ. 1989;23(1-2):62-7. Unique Identifier : AIDSLINE MED/89248222
Molinert HT; Galban Garcia E; Rodriguez Cruz R
This article describes the National AIDS Prevention and Control Program in Cuba and presents the results of serologic studies of HIV prevalence. As of 30 May 1988 2,224,748 individuals (approximately one-third of the Cuban population plus 32,750 foreigners) of sexually active age fro
Bull Pan Am Health Organ. 1989;23(1-2):76-80. Unique Identifier : AIDSLINE MED/89248224
Bartholomew C; Cleghorn F
Transmission of HIV in many Caribbean countries has followed the pattern of initial predominance among homosexual and bisexual males, with the infection subsequently spreading into the heterosexual community. However, on Saint Lucia
Bull Pan Am Health Organ. 1989;23(1-2):86-94. Unique Identifier : AIDSLINE MED/89248226
Bond LS
Surveys of public knowledge and attitudes regarding AIDS have been conducted in Brazil , Haiti , Mexico, and the Dominican Republic . In Brazil two-thirds of the
Bull Pan Am Health Organ. 1989;23(1-2):9-19. Unique Identifier : AIDSLINE MED/89248227
Quinn TC
As of 13 June 1988 a cumulative total of 64,896 AIDS cases and 36,480 AIDS-related deaths had been reported to the United States Centers for Disease Control (CDC). Of the 63,880 adults afflicted, 63% were homosexual or bisexual men; 19% were intravenous drug users; 7% were homosexual m
Bull Pan Am Health Organ. 1989;23(1-2):95-107. Unique Identifier : AIDSLINE MED/89248228
Connor SS
The first and second epidemics of AIDS are considered to be the spread of HIV infection and subsequent development of AIDS cases; what has been termed the third epidemic is the widespread economic, social, and cultural reaction to the disease, raising crucial social, humanitarian, and legal issues. This article deals
Can Med Assoc J. 1989 Jun 15;140(12):1456-60. Unique Identifier : AIDSLINE MED/89248741
Phillips A; Wainberg MA; Coates R; Klein M; Rachlis A; Read S; Shepherd F; Vellend H; Walmsley S; Halloran P; et al; Department of Medicine, University of Toronto, Ont.
Eight patients with AIDS (acquired immune deficiency syndrome) but free of life-threatening infection were treated with the immunosuppressive drug cyclosporine for a mean of 53.9 days. The serum cyclosporine levels were maintained in the desired therapeutic range. All eight patients experienced severe toxic symptoms,
Cancer. 1989 Jun 1;63(11):2186-91. Unique Identifier : AIDSLINE MED/89248804
Levine PH; Reeves WC; Cuevas M; Arosemena JR; Jaffe ES; Saxinger WC; Altafulla M; De Bernal J; Espino H; Rios B; et al; Environmental Epidemiology Branch, National Cancer Institute,; Bethesda, Maryland 20892.
Serum samples were obtained in a 2-year period (November 1, 1984-December 31, 1986) from 136 Panamanian patients with hematologic malignancies identified by a population-based registry designed for studies investigating human T-cell lymphotropic virus (HTLV)-I. Only three patients had clinical and serologic findings o
Cas Lek Cesk. 1989 Jan 6;128(2):59-61. Unique Identifier : AIDSLINE MED/89249208
Tomsova Z; Juzova Z
Estimation of neopterin in urine has become part of examination in phenylketonuria, malignities, immunodeficiency incl. AIDS and HIV infection. The authors describe a simple chromatographic method for estimation of neopterin which does not call for highly efficient liquid chromatography nor imported kits. The di- and
Oleson D; Grierson H; Goldsmith J; Purtilo DT; Johnson D; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68105.
Natural Killer (NK) activity of lymphocytes from acquired immunodeficiency syndrome (AIDS) patients is frequently below normal and declines as disease progresses. We studied the potential of leucine enkephalin (leu-enkephalin) to restore this immune parameter by incubating nylon wool nonadherent mononuclear cells from
Rickman WJ; Waxdal MJ; Monical C; Damato JD; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850.
With the emergence of the human immunodeficiency virus (HIV) epidemic, lymphocyte immunophenotyping has become the single most important laboratory test for clinical management of HIV-infected subjects. To meet this challenge, the department of Army instituted a multicenter lymphocyte immunophenotyping quality assuran
Bach MC; Division of Infectious Diseases, Maine Medical Center, Portland.
An In-111 leukocyte scan was used to evaluate fever of unknown origin in a patient with the AIDS rather than Ga-67. The scan was normal despite an impressively positive Ga-67 scan performed 48 hours later. In-111 should not be used to evaluate fever in patients with AIDS where mycrobacterium avium-intracellular infect
Klein NC; Duncanson FP; Lenox TH 3d; Pitta A; Cohen SC; Wormser GP; Department of Medicine, Metropolitan Hospital Center, New York,; New York.
Pulmonary tuberculosis in AIDS/ARC patients is an increasing problem. To assess the utility of acid-fast smears of pulmonary secretions in this patient population, we evaluated 38 AIDS/ARC patients with culture-positive pulmonary infection. A control group consisted of 57 non-AIDS/ARC patients, who also did not belong
Woods GL; Goldsmith JC; Department of Pathology and Microbiology, University of Nebraska; Medical Center, Omaha 68105.
A 27-year-old white male homosexual with AIDS presented 19 months after the initial diagnosis with persistent fever, marked dyspnea at rest, and severe substernal pain in the chest. A pericardial friction rub was auscultated, and an effusion was demonstrated echocardiographically. Pericardiocentesis yielded 220 ml of
Stotka JL; Good CB; Downer WR; Kapoor WN; Veterans Administration Medical Center, Pittsburgh.
We describe a 29-year-old homosexual man with acquired immunodeficiency syndrome who developed pericardial effusion and tamponade. Pericardiocentesis resulted in clinical improvement. All diagnostic tests on pericardial fluid were negative. At autopsy, extensive plaques and nodules of Kaposi s sarcoma were found studd
Scheele J; Chirurgische Klinik mit Poliklinik, Universitat; Erlangen-Nurnberg.
Complete surgical resection represents the only treatment for malignant tumors of the liver which offers the chance of long-term tumor-free survival. The segment orientated approach appears to be a fundamental improvement in preventing incomplete tumor removal as well as wastage of non-involved hepatic tissue. This re
EMBO J. 1989 Mar;8(3):765-78. Unique Identifier : AIDSLINE MED/89251608
Garcia JA; Harrich D; Soultanakis E; Wu F; Mitsuyasu R; Gaynor RB; Department of Medicine, UCLA School of Medicine.
The human immunodeficiency virus (HIV) type 1 LTR is regulated at the transcriptional level by both cellular and viral proteins. Using HeLa cell extracts, multiple regions of the HIV LTR were found to serve as binding sites for cellular proteins. An untranslated region binding protein UBP-1 has been purified and fract
Mir N; Costello C; Luckit J; Lindley R; Department of Haematology, St. Stephen's Hospital, London, U.K.
We report our experience of peripheral blood and bone marrow changes in patients with HIV disease. Abnormalities were most commonly seen in patients with advanced disease. In AIDS group IV patients (CDC classification) anaemia (92%) neutropenia (85%) monocytopenia (75%) and thrombocytopenia (61%) have their highest in
Hart CW; Cokely CG; Schupbach J; Dal Canto MC; Coppleson LW; Head & Neck Surgery, Northwestern University Medical School,; Chicago, Illinois.
A Caucasian male contracted acquired immune deficiency syndrome (AIDS) following a blood transfusion during heart surgery. Four years later he developed dizziness, dysequilibrium, and emotional disturbances. Neurotologic evaluation implicated central vestibular and auditory dysfunction. Electronystagmographic findings
Gao RL; Neubauer L; Tang S; Kampik A; Augenklinik der Universitat Munchen, Federal Republic of; Germany.
A total of 42 cases (42 eyes) with silicone oil in the anterior chamber after pars plana vitrectomy (PPV) and after silicone oil injection into the vitreous cavity (SIV) were analyzed. The main complications caused by silicone oil were corneal endothelial cell damage and secondary glaucoma. Specular microscopy showed
Hosp Community Psychiatry. 1989 May;40(5):507-10. Unique Identifier : AIDSLINE MED/89253383
Wallack JJ; Beth Israel Medical Center, New York City, New York.
House staff physicians and nurses at a major New York City teaching hospital completed a 79-item questionnaire designed to assess AIDS anxiety, fear of contagion, and personal attitudes about homosexuality. Sixty-three percent of respondents were skeptical of or did not believe assurances by experts that health care w
Hosp Community Psychiatry. 1989 May;40(5):511-4. Unique Identifier : AIDSLINE MED/89253384
Carlson GA; Greeman M; McClellan TA; Department of Psychiatry, Veterans Administration Medical Center,; Minneapolis, Minnesota 55417.
The authors describe clinical and legal dilemmas faced by staff involved in providing inpatient psychiatric treatment to two HIV carriers who continued to practice high-risk behaviors after learning of their HIV infection. Staff were unsure of their obligation to report the patients under a state law giving the commis
Rosenblum MK; Department of Pathology, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
A 30-year-old homosexual man with the acquired immune deficiency syndrome and a recent history of zoster involving the mandibular division of the right trigeminal nerve was found at autopsy to have a predominantly demyelinating lesion restricted to the ipsilateral spinal trigeminal tract and nucleus. Cowdry A inclusio
Int J Epidemiol. 1989 Mar;18(1):239-41. Unique Identifier : AIDSLINE MED/89254236
Dan M; Rock M; Bar-Shany S; Infectious Diseases Unit, E Wolfson Hospital, Holon, Israel.
A serological survey of 400 Israeli intravenous drug users showed a 2% prevalence of antibodies to human immunodeficiency virus (HIV). No difference was found between seropositive and seronegative subjects regarding mean age, duration of intravenous drug use, and needle sharing. Seropositivity was, however, significan
McLeod GG; Princess Margaret Rose Orthopaedic Hospital, Edinburgh, Scotland.
Surgeons are at risk from both hepatitis B and human immunodeficiency viruses. While vaccines have been developed against the former, barrier methods remain the mainstay of protection. Puncture wounds of the hand are a potential source of contamination; the protection afforded by surgical gloves has been investigated.
Xu JY; Prince AM; Lindsley F. Kimball Research Institute, New York Blood Center, NY; 10021.
A new assay for HIV antigens, the avidin-biotin enhanced reverse passive hemagglutination (AB RPHA) test is described which is suitable for detection of infection in cell culture experiments. This assay is simple to perform and economical, and has sensitivity equal to or greater than that of commercial ELISA assays. T
Gallo P; Piccinno MG; Krzalic L; Tavolato B; Institute of Neurology, University of Padova Medical School,; Italy.
The presence of tumor necrosis factor alpha (TNF alpha)/cachectin was investigated in 180 paired cerebrospinal fluid (CSF) and serum samples from patients with neurological diseases, and in five paired CSF and serum samples of Macaca cynomolgus monkeys with acute monophasic experimental autoimmune encephalomyelitis (A
Ijichi S; Eiraku N; Osame M; Izumo S; Kubota R; Maruyama I; Matsumoto M; Sonoda S; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.
One of the hallmarks of human T-lymphotropic virus type I (HTLV-I) infection is the proliferation in vitro of peripheral blood lymphocytes (PBLs) in the absence of growth factors. This phenomenon, the autologous proliferative response (APR), involves spontaneous growth of HTLV-I-infected T-cells and proliferation of T
A questionnaire designed to measure the application of the dimensions of the Health Belief Model (HBM) to AIDS prevention and to practicing safer sex was administered to 139 undergraduates aged 22 years and under. Students generally had good knowledge about the facts of AIDS, which was consistent with other studies. W
University students from five classes were randomly assigned to seeing either a movie on AIDS or a movie on first aid. Six weeks later, both groups of students filled out a questionnaire measuring their knowledge of AIDS, attitudes toward AIDS, and attitudes toward homosexuals. In general, the differences between the
The effectiveness of four commercial videotape presentations in changing AIDS knowledge and attitudes among 584 college students was evaluated in a pre-post design with control group and follow-up. AIDS knowledge and attitudes were measured prior to, immediately after, and 4 to 6 weeks following presentation of the in
Public health officials have called for increased use of condoms to protect Americans from sexually acquiring human immunodeficiency virus (HIV) infection. To investigate the availability of condoms for sale on college campuses, we asked student union directors and bookstore managers from all 28 public universities in
Weber JN; Banatvala N; Clayden S; McAdam KP; Palmer S; Moulsdale H; Tosswill J; Dilger P; Thorpe R; Amann S; Chester Beatty Laboratories, Department of Virology, St. Thomas's; Hospital Medical School, London, UK.
Serum samples from 557 individuals participating in studies from four separate lowland and highland populations in Papua New Guinea exhibited consistently false-positive results for human T lymphotropic virus (HTLV) type 1 (10%) and
J Ky Med Assoc. 1989 Feb;87(2):66-71. Unique Identifier : AIDSLINE MED/89257086
Frierson RL; Lippmann SB
Mandatory testing for AIDS is controversial. Such screening has been suggested for prisoners, immigrants, prostitutes, military personnel, and persons contemplating marriage or pregnancy. Quarantining and even tatooing have also been recommended for persons with AIDS. The advent of mass testing raises the issues of (1
Tsukada N; Tanaka Y; Yanagisawa N; Department of Medicine, Shinshu University, School of Medicine; (Neurology), Matsumoto, Japan.
We examined the sera of 21 cases of human T-lymphotropic virus type I (HTLV-1)-associated myelopathy (HAM), 30 cases of neuro-Behcet (N-B) syndrome, and 36 cases of multiple sclerosis (MS) for the presence of autoantibodies to brain endothelial cells by enzyme-linked immunosorbent assay (ELISA) using cultured brain en
Piens MA; Garin JP; Departement de Parasitologie et Mycologie, Faculte de; Medicine, Lyon, France.
The usual chemoprophylaxis of toxoplasmosis consists of spiramycin or the combination of pyremethamine-sulfamide. This chemoprophylaxis can be used: 1 - In the pregnant woman: spiramycin avoids or has low fetal damage. In case of maternal contamination after 33 weeks of pregnancy, pyrimethamine-sulfadiazine combinatio
Borkowsky W; Krasinski K; Paul D; Holzman R; Moore T; Bebenroth D; Lawrence R; Chandwani S; Department of Pediatrics, New York University Medical Center, NY; 10016.
Human immunodeficiency virus type 1 (HIV-1) core antigen was assayed in the plasma of children at risk for infection with HIV to determine its usefulness in the diagnosis of infection and to correlate it with the clinical stage of disease. Antigen was detected in the plasma of all children less than 15 months of age w
Hattori T; Koito A; Takatsuki K; Ikematsu S; Matsuda J; Mori H; Fukui M; Akashi K; Matsumoto K; Second Department of Internal Medicine, Faculty of Medicine,; Kumamoto University Medical School, Japan.
Antibody to human T-cell lymphotropic virus type I (HTLV-I) was measured in 49 Japanese patients (48 with hemophilia) infected with human immunodeficiency virus type 1 (HIV-1) and in 18 hemophiliacs who were not infected with HIV-1, by use of an enzyme-linked immunosorbent assay (ELISA). The antigen used was a gag-env
Twu JS; Rosen CA; Haseltine WA; Robinson WS; Department of Medicine, Stanford University School of Medicine,; California 94305.
Hepatitis B virus (HBV) X-gene product activates transcription of the chloramphenicol acetyltransferase (CAT) gene under control of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR). To identify a cis-acting regulatory sequence within the HIV-1 LTR which is responsive to the HBV X-gene trans-a
Furuta Y; Aizawa S; Suda Y; Ikawa Y; Kishimoto H; Asano Y; Tada T; Hikikoshi A; Yoshida M; Seiki M; Laboratory of Molecular Oncology, Tsukuba Life Science Center,; Physical and Chemical Institute (RIKEN), Ibaraki, Japan.
The human T-cell leukemia viruses (HTLV) are associated with T-cell malignancies in humans. The malignant transformation occurs after a long latency in some carriers, and its mechanism appears to be distinct from that of other classes of retroviruses which induce transformation through viral or cellular oncogenes. A w
JAMA. 1989 Jun 23-30;261(24):3567-71. Unique Identifier : AIDSLINE MED/89259261
Selwyn PA; Carter RJ; Schoenbaum EE; Robertson VJ; Klein RS; Rogers MF; Department of Epidemiology, Montefiore Medical Center/Albert; Einstein College of Medicine, Bronx, NY 10467.
We studied decisions to continue or terminate pregnancy among human immunodeficiency virus (HIV)-seropositive (+) and seronegative (-) intravenous drug users informed of HIV antibody status before 24 weeks gestation. Fourteen (50%) of 28 HIV+ vs 16 (44%) of 36 HIV- women chose to terminate their pregnancies. In retro
Fuessl HS; Zoller WG; Kochen MM; Bogner JR; Heinrich B; Matuschke A; Goebel FD; Medizinische Poliklinik der Universitat, Munchen.
We have observed two patients with AIDS suffering from severe watery diarrhea refractory to conventional medical treatment. In the first patient the reason for the diarrhea could not be revealed in spite of extensive investigations; however, the clinical picture suggested cryptosporidia infection. In the second patien
Tunkel DE; Loury MC; Fox CH; Goins MA3d; Johns ME; Department of Otolaryngology/Head and Neck Surgery, Johns Hopkins; Medical Institutions, Baltimore, Md.
Bilateral enlargement of the parotid glands has been noted in five patients who are seropositive for antibody to the human immunodeficiency virus. A characteristic cystic appearance has been noted in these lesions on clinical and radiographic examination. A benign lymphoepithelial infiltrate with cystic degeneration i
Med Trop (Mars). 1989 Jan-Mar;49(1):11-6. Unique Identifier : AIDSLINE MED/89261024
Capdevielle P; Gueziec J; Menager C; Brethes B; Louis F; Desforges S; Daynes C; Calen P; Bobin P; Gras C; Medecin des hopitaux des Armees, service de medecine, Centre; hospitalier territorial, Noumea.
The authors report on 15 HIV seropositive cases detected within 2 years in New Caledonia (150,000 inhabitants). Testing HIV antibodies was systematic among blood donors (9,917 persons) and was carried out in defined samples (1,475 p
Med Trop (Mars). 1989 Jan-Mar;49(1):17-20. Unique Identifier : AIDSLINE MED/89261025
Strobel M; Francois Y; Service de Medecine B, Hopital St Hyacinthe, Basse-Terre.
Guadeloupe is a small Caribbean Island, with racial intermixed population. AIDS prevalence is four time higher than in France . Socio-economical and sanitary levels are similar to those of develop
Med Trop (Mars). 1989 Jan-Mar;49(1):21-8. Unique Identifier : AIDSLINE MED/89261026
Pradinaud R; Sainte-Marie D; Girardeau I; Cassiede P; Service de Dermato-Venereologie, Centre Hospitalier de; Cayenne, Guyane Francaise.
Dermato-venereal manifestations in HIV infection and its severe evolution stage, AIDS, is of particular importance in tropical zones: We may be suspicious of the viral infection and consequently to request serologic tests to confirm it. We get an explanation of the virus transmission during heterosexual relations by t
Med Trop (Mars). 1989 Jan-Mar;49(1):51-7. Unique Identifier : AIDSLINE MED/89261032
Pradinaud R; Sainte-Marie D; Plat JM; Cassiede P; Vienne P; Vigneron-Meleder H; Wojcick L; Wojcick JM; Sankale-Suzanon J; Patient G; et al; Service de Dermato-Venereologie, Centre Hospitalier de; Cayenne.
The French Guyana is an Overseas French Department in South America, with 100,000 inhabitants among them are 20% of Haitian immigrants. At 31 December 1987, 103 AIDS cases have been recorded, 86% by heterosexual transmission. The first case dated May 1979 was retroactively diagnose
Med Trop (Mars). 1989 Jan-Mar;49(1):71-2. Unique Identifier : AIDSLINE MED/89261036
Alandry G; Leguellec A; Flye Sainte-Marie F; Medecin des Hopitaux, Centre Hospitalier Territorial Mamao,; Papeete Tahiti.
HIV case finding tests are performed since three years in French Polynesia . Ratio of seropositivity is 2.4/10,000 inhabitants. The 45 seropositive patients found in three years belong to groups at risk (homosexual males; multi-trans
Med J Aust. 1989 Jun 5;150(11):634-9. Unique Identifier : AIDSLINE MED/89261446
Burcham JL; Tindall B; Marmor M; Cooper DA; Berry G; Penny R; Department of Public Health, University of Sydney, NSW.
By means of prospective cohort data from the Sydney AIDS Project, we report on 55 homosexual or bisexual men who have become infected with human immunodeficiency virus (HIV), as measured by the development of serum HIV antibodies (seroconversion). We have compared the sexual practices, recreational drug abuse, history
Balzarini J; Van Aerschot A; Pauwels R; Baba M; Schols D; Herdewijn P; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
The novel 5-chloro-, 5-bromo-, and 5-iodo-derivatives of 3 -fluoro-2 ,3 -dideoxyuridine (FddUrd), designated FddCIUrd, FddBrUrd, and FddIUrd, respectively, have been synthesized and evaluated for their antiretrovirus activity against human immunodeficiency virus (HIV) and murine Moloney sarcoma virus. All three 5-halo
N Engl J Med. 1989 Jun 15;320(24):1581-5. Unique Identifier : AIDSLINE MED/89261963
McNeil JG; Brundage JF; Wann ZF; Burke DS; Miller RN; Division of Preventive Medicine, Walter Reed Army Institute of; Research, Washington, D.C. 20307-5100.
Direct measurement of the incidence of infection with the human immunodeficiency virus (HIV)--the rate of new HIV infection--is vital if we are to understand better the dynamics of the current epidemic of HIV infection. Because soldiers are periodically and routinely screened for antibody to HIV, it is possible to mea
N Engl J Med. 1989 Jun 22;320(25):1649-54. Unique Identifier : AIDSLINE MED/89261986
Rogers MF; Ou CY; Rayfield M; Thomas PA; Schoenbaum EE; Abrams E; Krasinski K; Selwyn PA; Moore J; Kaul A; et al; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
The early diagnosis of infection with human immunodeficiency virus (HIV) in infants born to infected mothers is essential for early treatment, but current tests cannot detect HIV infection in newborns because of the presence of maternal antibodies. We used the polymerase chain reaction, a new technique that amplifies
Nature. 1989 Jun 1;339(6223):333-4. Unique Identifier : AIDSLINE MED/89262043
Friedman SR; Des Jarlais DC; Neaigus A; Abdul-Quader A; Sotheran JL; Sufian M; Tross S; Goldsmith D; Narcotic and Drug Research Inc., New York, New York 10013.
Saxton EH; Lee H; Swanson P; Chen IS; Ruland C; Chin E; Aboulafia D; Delamarter R; Rosenblatt JD; Department of Neurology, Reed Neurological Research Center, Los; Angeles, CA 90024.
A white man with a progressive spastic paraparesis that began 15 months after sustaining severe trauma in a motor vehicle accident was positive for antibodies to human T-lymphotropic virus type I (HTLV-I) by enzyme-linked immunosorbent assay. Serum antibody to HTLV-I was confirmed by Western blot and radioimmunoprecip
Minerva Chir. 1989 Mar 15;44(5):849-54. Unique Identifier : AIDSLINE MED/89262700
Lemma F; Barbuscia M; Arsena A; Gorgone S; Navarra G; Catalfamo A
After recalling the various therapeutic aids proposed for the treatment of hydatid disease, personal experience in the use of mebendazole in patients suffering from pulmonary hydatidosis is reported. On the basis of the results obtained, it is concluded that mebendazole represents a useful therapeutic approach provide
Nuccetelli F; Assetta M; Di Muzio A; Gambi D; Universita di Chieti, Clinica Neurologica.
Several viruses have been considered in the etiology of Multiple Sclerosis (MS), but definitive proof have not been given so far. Recently, Gallo and Koprowski (1985) pointed out the retroviruses. In our study serum anti-HTLV I and anti-HTLV III antibodies were determined in 31 MS patients. Anti-HTLV I antibodies were
N J Med. 1989 Apr;86(4):295-7. Unique Identifier : AIDSLINE MED/89262825
Szypula G; Sen P; Tan KL; Middleton JR; Kuza M
A case of seminoma is described in a patient with HIV infection. The tumor presented atypically with no lymphocytic infiltrates within the stroma. HIV infection has been reported to be associated with an increased incidence of Kaposi s sarcoma, non-Hodgkin s lymphomas, oropharyngeal carcinoma and pancreatic carcinoma.
A new approach to the treatment of various viral, oncogenic and associated genetic and transmissible immunogenic, for example, infectious DNA or RNA, induced diseases is proposed utilizing amplitude and frequency modulated Jacobson resonance: mc2 = Bvl coulomb, a general expression of Zeeman and cyclotron resonance. O
Le SY; Chen JH; Chatterjee D; Maizel JV; Division of Cancer Biology and Diagnosis, National Cancer; Institute, Frederick, MD 21701.
Genetic variation during the course of infection of an individual is a remarkable feature of the acquired immune deficiency syndrome (AIDS) disease. This variation has been studied for the envelope protein encoding regions of seventeen different sequences from various isolates of human immunodeficiency virus (HIV) usi
Proc Natl Acad Sci U S A. 1989 May;86(10):3857-61. Unique Identifier : AIDSLINE MED/89264522
Terwilliger EF; Godin B; Sodroski JG; Haseltine WA; Laboratory of Biochemical Pharmacology, Dana-Farber Cancer; Institute, Boston, MA 02115.
The construction and properties of an infectious human immunodeficiency virus (HIV) that expresses the bacterial gene chloramphenicol acetyltransferase are described. This virus can be used in vitro to screen for drugs that inhibit HIV infection. The marked virus may also be used to trace the routes of infection from
Proc Natl Acad Sci U S A. 1989 Jun;86(11):3929-33. Unique Identifier : AIDSLINE MED/89264537
Van Roey P; Salerno JM; Chu CK; Schinazi RF; Medical Foundation of Buffalo, Inc., NY 14203.
Analysis of the solid-state conformations of six active and two inactive anti-human immunodeficiency virus nucleoside analogues is used to correlate conformational features with the relative activities of the compounds. Ten of the 11 observations of the active compounds (3 -azido-3 -deoxythymidine, 3 -azido-2 ,3 -dide
Sebag-Montefiore D; Makepeace AR; Spittle MF; Godfrey-Faussett P; Regional Radiotherapy Centre, Mount Vernon Hospital, Northwood,; Middlesex, U.K.
We report a series of five HIV positive patients with histologically proven non-Hodgkin s lymphoma . The paper illustrates the difficulties experienced in both the clinical diagnosis and its histological confirmation. In this series we have confirmed the predominance of aggressive h
Rev Med Panama. 1989 Jan;14(1):48-51. Unique Identifier : AIDSLINE MED/89265838
Arango Durling V
The legal consequences of neglect to advise in cases of AIDS is studied. Marriage with or between persons suffering the illness violates public health and injuries the reputation and integrity of the family.
Rev Mal Respir. 1989;6(2):155-9. Unique Identifier : AIDSLINE MED/89265981
M'Boussa J; Service de Pneumopthisiologie, Hopital general, Brazzaville,; Congo.
To understand the change in disease encountered since the appearance of the epidemic of AIDS, two enquiries have been carried out in the only service for pulmonary tuberculosis in Brazzaville which previously had exclusively treated cases of tuberculosis. The first enquiry showed that amongst 104 patients hospitalised
Slow virus diseases are characterized by a long asymptomatic period, often months or years in duration, between the introduction of the infectious agent and the appearance of clinical illness. Two distinct groups cause serious degenerative diseases of the brain and spinal cord. The first to be identified are those cau
Stat Med. 1989 May;8(5):619-31. Unique Identifier : AIDSLINE MED/89266291
Makuch RW; Rosenberg PS; Scott G; Yale University School of Medicine, Division of Biostatistics,; New Haven, Connecticut 06510.
We examine Goodman and Kruskal s lambda using Efron s approach to regression and analysis of variance (ANOVA) for zero-one outcome data. For a binary response cross-classified by a single nominal predictor, we present a computationally simple ANOVA table in which lambda is analogous to Pearson s R-square. We character
One of the possible pathways into heterosexual population is the transfer of HIV-virus from bisexual men to their female partners. Therefore sexual behaviour of HIV-positive and -negative bisexual men (n = 31) before and after Aids-disease was analysed. Prior to the Aids-epidemic promiscuous behavior towards male part
Vaillant JM; Chomette G; Talbi M; Labrousse F; Szpirglas H; Raphael B; Gentilini M; Auriol M; Guilbert F; Institut de Stomatologie et de Chirurgie maxillo-faciale,; Hopital de la Pitie-Salpetriere, Paris.
Cystic lymphoid hyperplasia of the parotid, a rare disease, was recently described in patients with acquired immunodeficiency syndrome. We reported here 2 new cases of this illness. The 2 HIV+ patients showed an enlargement of parotid gland. A superficial parotidectomy was performed. The histological and immunohistoch
Bratt G; Waldenlind L; Von Krogh G; Karlsson A; Moberg L; Biberfeld G; Sandstrom E; Department of Dermatology and Venereology, Sodersjukhuset,; Stockholm, Sweden.
Changes in IgG levels and patterns in association with human immunodeficiency virus, (HIV) infection were characterized in a prospective investigation by studying serum electrophoresis and antibodies to HIV at least once a year in 144 homo/bisexual (HS) men during a 4-year period. Initially, 25 men (17.4%) were HIV-po
Arendrup M; Ulrich K; Nielsen JO; Lindhardt BO; Kusk P; Mathiesen LR; Pedersen C; Krogsgaard K; Laboratory of Tumor Virology, Fibiger Institute, Danish Cancer; Society, Copenhagen.
Serum neutralization was measured in 72 sera collected during a 5.5-year period from 10 HIV infected individuals. Neutralizing antibodies (NA) were present in all sera. NA titers ranging from greater than 40 to greater than 640 were detected in sera from 4 patients, who all remained healthy and further an increase wit
Guthrie TH Jr; Oral A; Section of Hematology, Medical Oncology, Medical College of; Georgia, Augusta 30912.
Idiopathic thrombocytopenia purpura (ITP) is a primary immune thrombocytopenia that is typically manifested in adults by acute bleeding, severe thrombocytopenia, and normal to increased megakaryocytes in the bone marrow. Labeling studies suggest that most patients with ITP have an IgG antibody directed against the pla
Hoballah JJ; Kim EH; Dumont AE; Department of Surgery, New York University Medical Center, New; York 10016.
Twenty heterosexual men considered to be at risk for developing the acquired immunodeficiency syndrome because of parenteral drug abuse underwent splenectomy for steroid resistant thrombocytopenia during a recent 34 month period. Increased bruising, ecchymoses petechiae and occasional epistaxis, together with markedly
Todays OR Nurse. 1989 May;11(5):21-8. Unique Identifier : AIDSLINE MED/89267883
Fay MF
1. Under a new directive, employers have been advised that they have a legal responsibility of protecting workers who may come in contact with blood or body fluids contaminated with AIDS. 2. Formal policies and procedures ensure that high-risk tasks are properly identified, standard operating procedures are developed,
Kamihira S; Sohda H; Oyakawa N; Moriuti Y; Momita S; Ikeda S; Yamada Y; Ichimaru M; Kinosita K; Okuda H; et al; Blood Transfusion Service, Nagasaki University Hospital, Japan.
Healthy blood donors, patients with adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy (HAM) and recipients of unscreened blood (SR) who had seroconverted and were followed-up for more than 2 years were examined for HTLV-I antibodies of immunoglobulin G (IgG) and M(IgM) classes. The overall infection rate in
West Indian Med J. 1989 Mar;38(1):39-41. Unique Identifier : AIDSLINE MED/89268639
Panditrao M; Panditrao MS; Homi J
This report describes the anaesthetic management of an HIV-positive patient and proposes a protocol for the management that is suitable for the present working conditions in Jamaica .
Heinrich J; Sporkmann C; Frauenklinik des Bezirkskrankenhauses, Stralsund.
Various graphic diagrams of obstetrical and perinatological quality assessment between 1984-1986 in the district of Rostock are demonstrated. The advantages of centralization of premature labors are visible. The prenatal diagnosis of intrauterine growth retardation is still insufficient. With an upper cesarean section
Am J Cardiol. 1989 Jun 15;63(20):1489-97. Unique Identifier : AIDSLINE MED/89270251
Lipshultz SE; Chanock S; Sanders SP; Colan SD; Perez-Atayde A; McIntosh K; Department of Cardiology, Children's Hospital, Boston,; Massachusetts 02115.
Thirty-one pediatric patients with human immunodeficiency virus infection were prospectively evaluated using 2-dimensional and M-mode echocardiography, Doppler cardiography, electrocardiography and Holter monitoring. Left ventricular shape, wall motion and valve morphology were evaluated with 2-dimensional echocardiog
Am J Law Med. 1989;14(4):377-430. Unique Identifier : AIDSLINE MED/89270506
MacFarlane MA
Within the past few years a number of children have been excluded from attending public school because they are linked to AIDS. School boards have justified their decisions to exclude these children on the basis that protecting the public s health, safety and welfare outweighs the rights of these children. Most courts
Ruef C; Dickey P; Schable CA; Griffith B; Williams AE; D'Aquila RT; Department of Internal Medicine, Yale University School of; Medicine, New Haven, Connecticut.
Carpenter CC; Mayer KH; Fisher A; Desai MB; Durand L; Brown University AIDS Program, Providence, Rhode Island 02906.
PURPOSE: Current recommendations for treatment of human immunodeficiency virus (HIV) infection and for prophylaxis against associated opportunistic infections in North America are largely based on observations of HIV infection in males. In an effort to determine whether the natural history and clinical course may be d
Krumholz HM; Sande MA; Lo B; Department of Medicine, San Francisco General Hospital,; University of California 94110.
PURPOSE: Community-acquired bacteremia is an easily treatable infection occurring in patients with acquired immunodeficiency syndrome (AIDS). Although other studies have reported bacterial infections in AIDS patients, none have clearly described the clinical presentation of these patients. In this survey, we sought to
Raviglione MC; Battan R; Pablos-Mendez A; Aceves-Casillas P; Mullen MP; Taranta A; Department of Medicine, Cabrini Medical Center, New York, New; York 10003.
PURPOSE: Hickman catheters are frequently used as convenient long-term venous access in patients with acquired immunodeficiency syndrome (AIDS). These patients seem to be at increased risk for bacterial infections of intravenous devices. The aim of our study was to determine the frequency of Hickman catheter infection
Dressler R; Peters AT; Lynn RI; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York 10461.
PURPOSE: To our knowledge, there has been no report documenting the spectrum of peritonitis in human immunodeficiency virus (HIV)-infected persons. We therefore analyzed our records to confirm our previous observation of a higher incidence of pseudomonal and fungal peritonitis in a group of HIV antibody-positive (HIV+
Gertner E; Thurn JR; Williams DN; Simpson M; Balfour HH Jr; Rhame F; Henry K; Department of Internal Medicine, St. Paul-Ramsey Medical Center,; Minnesota.
Kossoy LR; Hill GA; Parker RA; Rogers BJ; Dalglish CS; Herbert GM 3d; Wentz AC; Department of Obstetrics and Gynecology, Vanderbilt University; Medical Center North, Nashville, TN 37232.
A series of 110 therapeutic donor insemination cycles was analyzed to determine the impact on fecundity when a urinary luteinizing hormone detection kit was used to plan inseminations. To prevent the transmission of human immunodeficiency virus, frozen semen, thawed after a 90-day quarantine, was used. The minimum sta
Am J Psychiatry. 1989 Jun;146(6):782-4. Unique Identifier : AIDSLINE MED/89270762
Schaerf FW; Miller RR; Lipsey JR; McPherson RW; Department of Psychiatry and Behavioral Sciences, Johns Hopkins; Hospital, Baltimore, MD 21205.
The authors describe four individuals infected with the human immunodeficiency virus type I (HIV) whose severe depressions were successfully treated with ECT.
A photoactivatable reagent for introducing haptens onto DNA probes has been prepared using a commercially available bifunctional linker arm reagent and amino-derivatized 2,4-dinitrophenyl (DNP). The resulting compound (photo-DNP) couples efficiently to DNA using an ordinary sunlamp. Under optimum conditions, about 7-2
Ann Emerg Med. 1989 Jun;18(6):654-7. Unique Identifier : AIDSLINE MED/89271196
Baraff LJ; Talan DA; Emergency Medicine Center, UCLA Medical Center 90024-1777.
We investigated the compliance of emergency department health care workers with barrier precaution policies adapted from the Centers for Disease Control s Recommendations for Prevention of HIV Transmission in Health-Care Settings. One hundred sixty-nine health care worker encounters with 97 patients were observed. One
Leff DR; Leff AR; Center for Urban Affairs and Policy Research, Northwestern; University, Evanston, IL 60201.
Twenty-eight metropolitan health departments reporting greater than 250 cases annually in 1978 were surveyed to determine the standard of practice in the control of pulmonary tuberculosis and the factors affecting treatment policy. The results were compared to previous surveys in 1978, 1980, and 1984 to determine the
Morse GD; Olson J; Portmore A; Taylor C; Plank C; Reichman RC; University of Rochester AIDS Clinical Trial Group, State; University of New York, Buffalo, New York.
Zidovudine (formerly azidothymidine, AZT ) is used to treat certain patients infected with the human immunodeficiency virus (HIV). However, the clinical use of zidovudine (ZDV) in hemophilia patients may be complicated by the high incidence of chronic
Reeder JM; University of Maryland School of Nursing, Baltimore.
Ethical issues surrounding the care of HIV-infected patients continue to be a source of discussion, controversy, and difficult decisions. New information and new policies concerning AIDS are emerging frequently. In the final report of the Presidential Commission, we are reminded that the responsibility of the health c
Nadal D; Hunziker UA; Schupbach J; Wetzel JC; Tomasik Z; Jendis JB; Fanconi A; Seger RA; Department of Pediatrics, University of Zurich, Switzerland.
A longitudinal evaluation was carried out of the clinical, infective, and immunological progress of 34 children (who were aged 6 to 68 months--mean 25 months at the time of writing) born to 31 mothers infected with human immunodeficiency virus (HIV), over a mean observation period of 13.4 months. Clinical symptoms, no
Rieder HL; Cauthen GM; Bloch AB; Cole CH; Holtzman D; Snider DE Jr; Bigler WJ; Witte JJ; Division of Tuberculosis Control, Centers for Disease Control,; Atlanta, Ga 30333.
Florida reported 1858 cases of the acquired immunodeficiency syndrome (AIDS) and 8455 cases of tuberculosis from January 1, 1981, through October 31, 1986. Of the patients with AIDS, 159 (8.6%) also had tuberculosis, and 154 (1.8%) of the patients with tuberculosis also had AIDS. Among patients with both diagnoses, tu
Martin CM; Matlow AG; Chew E; Sutton D; Pruzanski W; Department of Medicine, Wellesley Hospital, Toronto, Canada.
The hyperviscosity syndrome is most commonly seen in association with monoclonal gammopathies and has only rarely been described in association with polyclonal hypergammaglobulinemia. We have recently seen a patient with known acquired immunodeficiency syndrome who presented with the hyperviscosity syndrome in the set
Schlossberg D; Morad Y; Krouse TB; Wear DJ; English CK; Littman M; Department of Medicine, Episcopal Hospital, Philadelphia, PA; 19125.
A male homosexual (positive for the human immunodeficiency virus) with a recent cat scratch developed fever, epitrochlear and axillary lymphadenopathy, and retinitis. Subsequently, he developed skin (epitheloid hemangioma) and mucosal lesions (Kaposi s sarcoma), multiple liver abscesses, and pleural effusion. Warthin-
Aust Dent J. 1989 Apr;34(2):101-5. Unique Identifier : AIDSLINE MED/89272856
Daly CG; Allan BP; Bhagwandeen SB; Sutherland DC
Kaposi s sarcoma formerly a rare tumour in the western world, is now found frequently in homosexual patients with the Acquired Immune Deficiency Syndrome. A common site of occurrence is the mouth. The characteristic intra-oral appearance of the lesion is of a flat or raised pigmented lesion. An intra-oral Kaposi s sar
AIDS Res Hum Retroviruses. 1989 Jun;5(3):303-10. Unique Identifier : AIDSLINE MED/89274039
Dorries R; Kaiser R; ter Meulen V; Institut fur Virologie der Universitat, Wurzburg, Federal; Republic of Germany.
An affinity-mediated immunoblot (AMI) is introduced, able to identify virus-specific, oligoclonal IgG in unconcentrated cerebrospinal fluid (CSF) of patients infected by HIV. CSF specimens are isoelectrically focused in agarose gels and blotted to nitrocellulose (NC) strips coated with E. coli recombinant HIV-specific
AIDS Res Hum Retroviruses. 1989 Jun;5(3):321-6. Unique Identifier : AIDSLINE MED/89274041
Ranki A; Zheng Y; Kirjarinta M; Karvonen J; Saxinger C; Ashorn P; Safai B; Krohn K; Department of Dermatology, Helsinki University Central Hospital,; Finland.
Previous seroepidemiologic studies have suggested that in addition to certain subtropical and tropical parts of the world, human T cell leukemia virus type I (HTLV-I) may be endemic in the arctic regions, too. We studied 111 sera collected from original inhabitants of Finnish Lapland with ELISA and Western blot analys
AIDS Res Hum Retroviruses. 1989 Jun;5(3):345-54. Unique Identifier : AIDSLINE MED/89274044
Kumar R; Goedert JJ; Hughes SH; NCI-Frederick Cancer Research Facility, BRI-Basic Research; Program, MD 21701.
In theory, screening directly for the human immunodeficiency virus (HIV) DNA has advantages over screening for HIV-related antibodies; however, the HIV genome appears to be present only in a small fraction of peripheral blood cells from infected individuals. The polymerase chain reaction (PCR) specifically amplifies d
Rubin J; University of Mississippi Medical Center, Department of Medicine,; Jackson 39216.
It is unclear whether patients should be tested for the presence of HIV antibody. This test has taken upon itself a significance beyond a simple hemoglobin. Extreme views on testing are prevalent, both from the Centers for Disease Control, which does not recommend routine testing, to physicians advocating screening. T
Ledoux S; Libman I; Robert F; Just N; Department of Neurology, Jewish General Hospital, McGill; University, Montreal, P.Q., Canada.
An unusual case of Progressive Multifocal Leukoencephalopathy (PML) in a Haitian man with AIDS is reported. The lesions involving both white and gray matter are described radiologically and at post-mortem. The implications regarding neuroradiological differential diagnosis in AIDS as well as PML virulence in this type
Ozsoylu S; Irken G; Karabent A; Hacettepe University Faculty of Medicine, Department of; Pediatrics, Ankara, Turkey.
49 children with acute idiopathic thrombocytopenic purpura (ITP) were divided into non-treatment, oral prednisone (2 mg/kg), and high-dose intravenous methylprednisolone (HIVMP) treatment groups which consisted of 17, 16 and 16 children respectively. Platelet counts rose above 150,000/microliters over a 2-week period
Hicsonmez G; Ozsoylu S; Gurgey A; Zamani VP; Irken G; Department of Pediatrics, Hacettepe University Faculty of; Medicine, Hacettepe Children's Hospital, Ankara, Turkey.
The effectiveness of high-dose intravenous methylprednisolone (HIVMP) in inducing an initial remission was examined in a child with acute nonlymphoblastic leukemia (ANLL). Dramatic clinical and hematological improvement with 7% marrow blasts was obtained in 3 weeks with HIVMP treatment without giving any other antileu
Breustedt W; Krause H; Leonhard T; Porstmann T; Volk D
In HIV-infected people the course of syphilis is altered and aggressive. Besides seronegativity Neurosyphilis can manifest premature and as a outcome of failed penicillin-therapy in secondary syphilis. Two cases of neurosyphilis are reported and discussed. The usefulness of sp
Int J Cancer. 1989 Jun 15;43(6):1061-4. Unique Identifier : AIDSLINE MED/89277582
Kondo T; Kono H; Miyamoto N; Yoshida R; Toki H; Matsumoto I; Hara M; Inoue H; Inatsuki A; Funatsu T; et al; Ehime ATLL Study Group, Japan.
We have surveyed the incidence of adult T-cell leukemia/lymphoma (ATLL) in an endemic area of 290,464 inhabitants for 7 years. We now revise our previous results on the basis of additional findings and estimate the age- and sex-specific cumulative rate for HTLV-I carriers, the adoption of which is recommended by curre
Int J Cancer. 1989 Jun 15;43(6):979-85. Unique Identifier : AIDSLINE MED/89277604
Biggar RJ; Burnett W; Mikl J; Nasca P; Viral Epidemiology Section, National Cancer Institute, Bethesda,; MD 20892.
In the United States , New York City has had the greatest number of subjects at risk of AIDS for the longest period of time. This population therefore serves as an indicator of changes in cancer risk which may emerge among persons at risk from AIDS. Using a proportional incidence method
Rickert VI; Jay MS; Gottlieb A; Bridges C; Department of Pediatrics, University of Arkansas for Medical; Sciences, Little Rock.
Condom use has been advocated as a method to prevent human immunodeficiency virus (HIV) transmission. Although condoms are not uniformly popular with adolescent males, adolescent females beliefs about condom use are unclear. To assess the specific health attitudes and behaviors as they relate to condom purchase by ad
Slade HB; Pica RV; Pahwa SG; Department of Pediatrics, North Shore University Hospital,; Manhasset, New York 11030.
Asymptomatic congenital HIV infection cannot be diagnosed in infants less than 15 mo by routine serologic techniques because of the presence of passively acquired maternal antibody in the infants circulation. Possibly, infants who synthesize antibody to highly conserved HIV proteins may be recognized by the detection
Berkley SF; Widy-Wirski R; Okware SI; Downing R; Linnan MJ; White KE; Sempala S; Ministry of Health Epidemiology Unit, AIDS Control Programme,; Entebbe, Uganda.
Risk factor data were collected in 1,328 inpatients and outpatients in 1987 in 15 hospitals throughout Uganda ; 42% were positive for HIV antibodies by ELISA. Seropositivity was associated with urban residence, sexually transmitted diseases (STD), number of sex partners, and sex for
Tristem M; Mansinho K; Champalimaud JL; Ayres L; Karpas A; Department of Haematological Medicine, University of Cambridge; Clinical School, U.K.
We report the isolation of human immunodeficiency virus type 2 (HIV-2) from each of six West Africans with AIDS-related complex or AIDS. One isolate (HIV-2CAM2) was molecularly cloned and shown by restriction mapping to differ in seven out of 22 sites from the prototype HIV-2ROD. Nevertheless, by a number of serologic
J N Y State Nurses Assoc. 1989 Mar;20(1):4-7. Unique Identifier : AIDSLINE MED/89279484
Gould EJ
Concern for quality, cost, and access dominate the health care system in the eighties. State and national actions, demographic changes, and technological advances are converging to create many changes in the home care delivery system. Knowledgeable nurses can influence the evolution of home care services to assure tha
Miller PJ; Farr BM; Department of Medicine, University of Virginia Medical Center,; Charlottesville 22908.
Multiple authorities have recommended that human immunodeficiency virus (HIV) testing should be performed only with consent of the patient. After institution of a policy requiring written consent for testing patients and employees after blood/body fluid exposures, we prospectively studied incidents in which employees
Narkewicz MR; Janoff EN; Sokol RJ; Levin MJ; Department of Pediatrics, University of Colorado School of; Medicine, Denver 80262.
Blastocystis hominis is an enteric protozoan that has occasionally been associated with gastrointestinal illness in man but is not considered an opportunistic pathogen. We describe a 16-year-old hemophiliac with acquired immune deficiency-related complex in whom upper gastrointestinal symptoms in conjunction with high
Diagnostic bone marrow aspiration, biopsy, and culture are useful procedures in the evaluation of patients with suspected or proven acquired immunodeficiency syndrome (AIDS) who are febrile. In as many as one fourth of these patients, the information provided by the bone marrow examination may establish a diagnosis of
Palmer MC; Mador DR; Venner PM; Department of Medicine, Cross Cancer Institute, Edmonton,; Alberta, Canada.
Two homosexual men positive for human immunodeficiency virus with evidence of acquired cellular immunodeficiency were diagnosed recently to have seminoma of the testis. One man has the acquired immunodeficiency syndrome with lymphopenia, a low CD4:CD8 ratio, condylomata accuminata, pneumocystis carinii and cerebral to
Stramer SL; Heller JS; Coombs RW; Parry JV; Ho DD; Allain JP; Diagnostic Division, Abbott Laboratories, North Chicago, Ill; 60064.
During a 1-year period of study at two plasma collection centers, 7 of 35,000 plasma donors seroconverted to the human immunodeficiency virus (HIV) and had stored plasma samples that predated or antedated the seroconversion period. From each donor, three to eight plasma samples that had been collected at 2- to 7-day i
Ikehara O; Endo K; Hakamada K; Department of Internal Medicine, Okinawa Chubu Hospital.
Listeriosis occurred in two patients with hematological malignancies, one with adult T-cell leukemia (ATL) (Case 1) and the other with chronic granulocytic leukemia (CGL) (Case 2). In Case 1, listeriosis was the initial manifestation of ATL, while it occurred in Case 2 after prolonged treatment with an alkylating agen
Ohba N; Matsumoto M; Sameshima M; Kabayama Y; Nakao K; Unoki K; Uehara F; Kawano K; Maruyama I; Osame M; Department of Ophthalmology, Kagoshima University, Faculty of; Medicine, Japan.
Ocular manifestations in patients infected with human T-lymphotropic retrovirus type I (HTLV-I) consisted of a wide range of neoplastic, infectious and noninfectious vascular or inflammatory lesions. These disorders were associated with two distinct HTLV-I-induced systemic diseases, ie, adult T-cell leukemia/lymphoma
Forty HIV-1-sero-positive and 15 HIV-1 antibody negative homosexual or bisexual men were examined by means of magnetic resonance imaging (MRI) and 20 neuropsychological tests. Subcortical, mainly frontal cerebral pathological aberrations were detected in 75 per cent of the patients on examination with ultra low field
Kloft WJ; Institut fur Angewandte Zoologie der Universitat, Bonn.
The question whether the possibility exists of transmission of HIV by hematophagous insects from infected to uninfected persons is a point of very intensive discussion. The solution of this problem could help to explain the spreading of the disease in human populations and could contribute to an understanding of the e
Seltzer VL; Rabin J; Benjamin F; Department of Obstetrics and Gynecology, Queens Hospital Center,; Jamaica, NY 11432.
One hundred female teenagers attending a teenage pregnancy program were studied to determine the extent of their awareness about acquired immunodeficiency syndrome (AIDS) and the impact of such knowledge on their sexual behavior. Ninety-eight knew that AIDS is a disease, 45 stated that it is fatal, and all knew that i
Children with HIV infection have highly specialized physical and psychosocial needs. Appropriately applied, standard and creative nursing interventions can greatly improve the quality of life.
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4644-8. Unique Identifier : AIDSLINE MED/89282827
Layne SP; Spouge JL; Dembo M; Theoretical Division, Los Alamos National Laboratory, NM 87545.
We have developed a mathematical model that quantifies lymphocyte infection by human immunodeficiency virus (HIV) and lymphocyte protection by blocking agents such as soluble CD4. We use this model to suggest standardized parameters for quantifying viral infectivity and to suggest techniques for calculating these para
Peters UH; Karenberg A; Diederich N; Nervenklinik der Universitat zu Koln.
3 case histories of patients with acquired immune deficiency syndrome and acute organic psychoses are reported. Their psychoses can be classified as benefaction or blissfulness psychoses. A handfull of previous reports classify similar acute organic psychoses as symptomatic manias. The respective descriptions make obv
There is still a lack of interest in problems emerging in the institutional treatment of the psychiatric AIDS-patient. The small number of articles dealing with the treatment of the acute ill is reported. None of them regards the risk of HIV-infection for chronic mental ill or mental retarded persons in greater instit
The authors give a brief review over papers presented on the International Symposion on Autogenic Training in Berlin, March 1988. A study based on empirical data from 48 managers was presented, showing how Autogenic Training (AT) could reduce cardiovascular riskfactors, e.g. cardiac-functions and levels of bloodcholes
The Texas Department of Health reports that as of March 31, 1989, Texas ranked fifth in the nation for AIDS cases, with a total of 6,312 cases and 3,829 deaths. Cited in a report from the Texas Legislative Task Force on AIDS, TDH estimates that 100,000 Texans are infected with human immunodeficiency virus (HIV), with
Rawal BD; Busch MP; Endow R; Garcia-de-Lomas J; Perkins HA; Schwadron R; Vyas GN; Irwin Memorial Blood Center, San Francisco, CA.
Several filters for leukocyte removal were evaluated in terms of their ability to reduce the cell-associated human immunodeficiency virus (HIV) load in units of blood either inoculated in vitro with lymphocytes from a chronically infected cell line or collected directly from seropositive donors. Filtration of the expe
Versicherungsmedizin. 1989 May 1;41(3):97-102. Unique Identifier : AIDSLINE MED/89284453
Frohlich EM
The health condition of man has changed considerably since life insurance companies have been established. The initial problem of the companies was the fact that many young persons died from tuberculosis. For many decades persons from families with tuberculosis cases or with underweight were not accepted for insurance
A seroepidemiologic survey for antibodies to the human T-cell lymphotropic virus type I (HTLV-I) was carried out in two Hawaiian hematologic-oncologic practices. Specimens of serum or plasma from 215 donors were assayed using the ELISA technique, followed by the Western blot technique to confirm antibody specificity t
It has been reported that the acquired immune deficiency syndrome can present neuropsychiatric symptoms of major depressive disorders, adjustment disorder with depressed mood and organic brain syndromes with affective, delusional and demented features. The aim of the present study was to determine deficits in performa
Am J Public Health. 1989 Jul;79(7):832-5. Unique Identifier : AIDSLINE MED/89285515
Stehr-Green JK; Holman RC; Mahoney MA; Division of Host Factors, Center for Infectious Diseases,; Atlanta, GA 30333.
Using national hemophilia-associated AIDS (acquired immunodeficiency syndrome) surveillance data and the life table method of survival analysis, the median length of survival of hemophilic patients in the United States after the diagnosis of AIDS was 11.7 months; the cumulative probabi
Am J Public Health. 1989 Jul;79(7):836-9. Unique Identifier : AIDSLINE MED/89285516
Selik RM; Castro KG; Pappaioanou M; Buehler JW; AIDS Program, Centers for Disease Control, Atlanta, GA 30333.
To extend previous work showing that the risk of AIDS (acquired immunodeficiency syndrome) is higher in US Hispanics than in Whites who are not Hispanic, we compared US residents born in different Latin American countries. We computed the cumulative incidence (CI) of AIDS and the distribution of cases by mode of expos
Am J Public Health. 1989 Jul;79(7):840-2. Unique Identifier : AIDSLINE MED/89285517
Andrus JK; Fleming DW; Knox C; McAlister RO; Skeels MR; Conrad RE; Horan JM; Foster LR; Division of Field Services, Center for Disease Control, Atlanta,; Georgia 30333.
We studied 977 newly incarcerated Oregon inmates to compare voluntary versus mandatory human immunodeficiency virus antibody (HIVAb) testing in the prison setting. All inmates were offered HIVAb counseling and testing. Blood drawn for routine syphilis serology from those who declined this offer was also tested for HIV
Am J Public Health. 1989 Jul;79(7):871-4. Unique Identifier : AIDSLINE MED/89285525
Cates W Jr; Bowen GS; Centers for Disease Control, Atlanta, GA 30333.
Authorities frequently state that education is the only method we have to stop the AIDS (acquired immunodeficiency syndrome) epidemic until a vaccine and/or curative therapy is available. We suggest that education, while critically important to our efforts to stop transmission of the human immunodeficiency virus (HIV)
Am J Public Health. 1989 Jul;79(7):874-6. Unique Identifier : AIDSLINE MED/89285526
Potterat JJ; Spencer NE; Woodhouse DE; Muth JB; El Paso County Health Department, Colorado Springs.
Partner notification should be standard public health practice in the control of human immunodeficiency virus (HIV) infection. A universal partner notification program for the United States is affordable, operationally manageable, and can effectively reach high-risk persons. Such a foc
Am J Public Health. 1989 Jul;79(7):876-8. Unique Identifier : AIDSLINE MED/89285527
Archer VE
The well known psychological defenses of avoidance, repression, and denial against the knowledge that one has, or might have, a fatal disease used by a high percentage of individuals, must be considered in control programs for the human immunodeficiency virus (HIV). Current programs of education, voluntary testing, an
Am J Public Health. 1989 Jul;79(7):883-5. Unique Identifier : AIDSLINE MED/89285529
Darney PD; Myhra W; Atkinson ES; Meier J; Department of Obstetrics, Gynecology and Reproductive Sciences,; San Francisco General Hospital, University of California 94110.
To determine the seroprevalence of human immunodeficiency virus (HIV) in contracepting women, 1,308 consecutive attendees at an inner-city family planning clinic completed a risk factor questionnaire and were then asked to have an HIV test. None of the 1,000 women tested was seropositive. Preventive efforts in family
Am J Public Health. 1989 Jul;79(7):885-7. Unique Identifier : AIDSLINE MED/89285530
Coates TJ; McKusick L; Kuno R; Stites DP; Division of General Internal Medicine, University of California,; San Francisco 94105.
We tested the impact of stress management training on sexual behavior and immune functioning in 64 gay men infected with human immunodeficiency virus (HIV). Subjects randomized to the stress management group met for eight two-hour sessions and one all day retreat to learn systematic relaxation, health behavior change,
Lane HC; Falloon J; Walker RE; Deyton L; Kovacs JA; Masur H; Banks S; Kirk LE; Baseler MW; Salzman NP; et al; National Institutes of Health, Bethesda, Maryland.
STUDY OBJECTIVE: To evaluate the toxicity, effects on immune function, antitumor effects, antiretroviral effects, and pharmacokinetics of zidovudine therapy in patients with early human immunodeficiency virus (HIV) infection and Kaposi sarcoma. DESIGN: Randomized, double-blind, placebo-controlled trial. SETTING: Natio
Biochem Biophys Res Commun. 1989 Jun 15;161(2):910-6. Unique Identifier : AIDSLINE MED/89286603
Neidle S; Urpi L; Serafinowski P; Whitby D; Cancer Research Campaign Biomolecular Structure Unit, Institute; of Cancer Research, Sutton, Surrey, U.K.
The crystal structure of the nucleoside 2 ,3 -dideoxyformycin A has been determined. The structure shows a syn conformation about the glycosidic bond, stabilised by an intramolecular hydrogen bond between the 05 and N3 atoms. HIV activity was examined in a syncytium inhibition assay. In contrast to the marked decreas
Bull Pan Am Health Organ. 1989;23(1-2):68-75. Unique Identifier : AIDSLINE MED/89248223
Echeverria de Perez G; Deibis L; Silvia Garcia C; Olaria T; Marquez M; Blanca I; Bianco NE
A study of the immunopathogenic characteristics of HIV infection was begun in 1984 at the National Reference Center on Clinical Immunology (CNRIC) in Caracas, Venezuela , on 240 individuals with a variety of clinical manifestations. The most important findings were depletion of t
Margolick JB; Carey V; Munoz A; Polk BF; Giorgi JV; Bauer KD; Kaslow R; Rinaldo C; Department of Environmental Health Sciences, Johns Hopkins School; of Public Health, Baltimore, Maryland 21205.
This study investigated whether seroconversion with respect to human immunodeficiency virus, type 1 (HIV-1) was associated with an increase in lymphocytes expressing the CD3+CD4-CD8- phenotype. Proportions and absolute numbers of CD3+, CD4+, and CD8+ lymphocytes were determined prospectively over a 2.5-year period on
The AIDS Clinical Trial Group s (ACTG) Immunology Committee was charged with initiating a quality control program for all laboratories participating in the ACTG program reporting flow cytometry data. Forty-one laboratories were evaluated. This report defines the goals of this program and the subsequent findings after
Stites DP; Moss AR; Bacchetti P; Osmond D; McHugh TM; Wang YJ; Hebert S; Colfer B; Department of Laboratory Medicine, University of California, San; Francisco 94143.
A group of 10 leukocyte and lymphocyte subsets were measured by simultaneous dual immunofluorescence and flow cytometry in a group of homosexual men from the San Francisco General cohort. Absolute numbers and percentages of lymphocytes were determined in 30 individuals who progressed to AIDS and 29 who did not over a
Fleury-Feith J; Van Nhieu JT; Picard C; Escudier E; Bernaudin JF; Service d'histologie, Hopital Henri Mondor, Creteil, France.
Lower pulmonary tract cell populations collected by bronchoalveolar lavages (BAL) were evaluated in three groups of immunocompromised patients: HIV infected patients with Pneumocystis carinii (PC) pneumonitis (n = 22), or pneumonitis not related to PC (n = 29), and non-HIV-infected, immunocompromised patients with a P
Chechani V; Zaman MK; Finch PJ; Pulmonary Section, Brooklyn VA Medical Center, NY.
A 39-year-old man with AIDS presented with cough, chest pain, dyspnea on exertion, fever, and a cavitary lesion in the upper lobe of the left lung. The cavity increased in size over the next five months with disease involvement limited to the left upper lobe. Pneumocystis carinii infection was then diagnosed. Symptoms
EMBO J. 1989 Mar;8(3):757-64. Unique Identifier : AIDSLINE GENBANK/X77585
Tagaya Y; Maeda Y; Mitsui A; Kondo N; Matsui H; Hamuro J; Brown N; Arai K; Yokota T; Wakasugi H; et al; Institute for Immunology, Faculty of Medicine, Kyoto University,; Japan.
HTLV-I transformed T cells not only express a large number of interleukin-2 receptors [IL-2R/p55(Tac)], but also produce a factor named ATL-derived factor (ADF) that augments the expression of IL-2R/p55(Tac). Based on a partial N-terminal amino acid sequence, complementary DNA (cDNA) clones for human and mouse ADF wer
Gowda SD; Stein BS; Engleman EG; Department of Pathology, Stanford University School of Medicine,; California 94305.
We have used a recombinant vaccinia virus (VV) which expresses high levels of human immunodeficiency virus-1 (HIV-1) gag proteins to analyze the processing pathway of the gag p55 precursor. HIV-1 gag proteins were isolated from [3H]leucine-labeled VV:gag-infected H9 T lymphocytes by immunoprecipitation with either ant
J Immunol. 1989 Jun 15;142(12):4493-9. Unique Identifier : AIDSLINE MED/89256707
Koga Y; Oh-Hori N; Sato H; Yamamoto N; Kimura G; Nomoto K; Department of Virology, Kyushu University, Fukuoka, Japan.
The expression of lck gene (lymphocyte specific protein tyrosine kinase) in the human system was examined by Northern blot analysis in human T cell leukemia virus type I (HTLV-I)-positive T cell lines, HTLV-I-T cell lines, normal T cell population, and a T cell line infected with human immunodeficiency virus. In the c
Ishibashi K; Hanada S; Uozumi K; Otsuka M; Sakurami T; Hashimoto S; Second Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.
A sandwich enzyme-linked immunosorbent assay (ELISA) for immune complexes of human T cell leukemia virus type I (HTLV-I) was developed using monoclonal antibody (MoAb) 3G1 which recognizes a different epitope on HTLV-I to that with which natural human anti-HTLV-I antibody binds. The assay was capable of titrating arti
The presence of anti-human immunodeficiency virus 1 antibodies was tested in 5,565 serum samples from Ethiopia of which 5,265 were collected from military recruits in the framework of a hepatitis B (HBV) seroepidemiological study performed on a national scale in 1985-1986; the re
Vlahov D; Brewer F; Munoz A; Hall D; Taylor E; Polk BF; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland 21205.
Acquired immune deficiency syndrome (AIDS) became the leading cause of death among Maryland State prisoners in 1985. To identify the prevalence, risk factors, and temporal trends for infection with the human immunodeficiency virus type 1 (HIV-1) in the statewide prison system, excess sera were obtained from incoming m
Davis P; Stein M; Latif A; Emmanuel J; Department of Medicine, University of Zimbabwe, Harare.
The clinical features of an acute arthritis in 20 Zimbabwean patients, 17 of whom fulfilled criteria for the diagnosis of complete or incomplete Reiter s syndrome, are described. Fourteen of 19 patients tested were positive for human immunodeficiency virus (HIV) antibodies and most had features of the AIDS related com
Harouse JM; Kunsch C; Hartle HT; Laughlin MA; Hoxie JA; Wigdahl B; Gonzalez-Scarano F; Department of Neurology, University of Pennsylvania Medical; Center, Philadelphia 19104-6076.
A number of studies have indicated that central nervous system-derived cells can be infected with human immunodeficiency virus type 1 (HIV-1). To determine whether CD4, the receptor for HIV-1 in lymphoid cells, was responsible for infection of neural cells, we characterized infectable human central nervous system tumo
Pinter A; Honnen WJ; Tilley SA; Bona C; Zaghouani H; Gorny MK; Zolla-Pazner S; Public Health Research Institute of the City of New York, New; York 10016.
We characterized the structural forms of the human immunodeficiency virus env-encoded proteins with a panel of monoclonal and polyclonal antibodies. Western blot (immunoblot) assays with antibodies specific for gp41 invariably recognized a major component of 160 kilodaltons and a less intense component of 120 kilodalt
Radonovich M; Jeang KT; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.
One potent transcriptional activator of human T-cell leukemia virus type I (HTLV-I) is virally encoded protein Tax (p40x). p40x trans-activates HTLV-I through the long terminal repeat (LTR) by using a triply repeated 21-base-pair sequence as the target. In this report we have characterized the induction of the HTLV-I
Kitado H; Fan H; Department of Molecular Biology and Biochemistry, University of; California, Irvine 92717.
Human T-cell lymphotropic virus types I and II (HTLV-I and HTLV-II) are replication-competent retroviruses which contain two additional regulatory proteins, tax and rex. tax is a transcriptional transactivator of the HTLV-I or HTLV-II long terminal repeat (LTR) and also of some heterologous promoters. To investigate t
Goto H; Oka S; Mohri H; Kimura S; Mitamura K; Shimada K; Department of Infectious Diseases, University of Tokyo, Japan.
Two cases of Pneumocystis carinii pneumonia occurred in human immunodeficiency virus infected patients who were diagnosed by the aspiration-lung-biopsy. They were treated with 4 mg/kg of pentamidine isethionate intravenously administered followed by pentamidine aerosol inhalation. Although clinical and laboratory find
Med Clin (Barc). 1989 Mar 25;92(11):405-8. Unique Identifier : AIDSLINE MED/89260584
Navarro MD; Flores JM; Wichmann I; Rey C; Velardo MA; Pineda JA; Leal M; Lissen E
In a cohort of 30 randomly selected hemophiliacs who were prospectively controlled for four years the predictive value of AIDS development was evaluated for serum markers of HIV infection and for lymphocytic subpopulations in peripheral blood. The patients were evaluated with a mean of 15.79 +/- 5.74 months, and overa
Tan TH; Horikoshi M; Roeder RG; Laboratory of Biochemistry and Molecular Biology, Rockefeller; University, New York, New York 10021.
Within the human T-cell leukemia virus type I promoter, there are three copies of a 21-base-pair repeat (hereafter called the tax-responsive element [TRE]) that both contributes to basal promoter activity and mediates induction by the viral activator TAX. We have identified and separated three nuclear proteins that in
N Engl J Med. 1989 Jun 22;320(25):1637-42. Unique Identifier : AIDSLINE MED/89261984
Ryder RW; Nsa W; Hassig SE; Behets F; Rayfield M; Ekungola B; Nelson AM; Mulenda U; Francis H; Mwandagalirwa K; et al; Projet SIDA, Department of Public Health, Kinshasa, Zaire.
To examine perinatal transmission of the human immunodeficiency virus type 1 (HIV-1) in Zaire , we screened 8108 women who gave birth at one of two Kinshasa hospitals that serve populations of markedly different socioeconomic status. For up to one year, we followed the 475 infants
Nature. 1989 Jun 1;339(6223):389-92. Unique Identifier : AIDSLINE GENBANK/X14307
Hirsch VM; Olmsted RA; Murphey-Corb M; Purcell RH; Johnson PR; Department of Microbiology, Georgetown University, NIH/Twinbrook; II, Rockville, Maryland 20852.
The ancestors of the human immunodeficiency viruses (HIV-1 and HIV-2) may have evolved from a reservoir of African nonhuman primate lentiviruses, termed simian immunodeficiency viruses (SIV). None of the SIV strains characterized so far are closely related to HIV-1. HIV-2, however, is closely related to SIV (SIVmac) i
van Griensven GJ; de Vroome EM; Goudsmit J; Coutinho RA
Prevalence and incidence of HIV were studied in two cohorts of homosexual men in Amsterdam between 1980 and 1987. The cumulative incidence of HIV infection increased from a weighted 2.2% in 1980 to 39% in 1987. In that year the observed incidence was less than 1%. The estimated annual HIV incidence was 3% in 1981, ros
Molgaard CA; Eisenman PA; Ryden LA; Golbeck AL; Division of Epidemiology and Biostatistics, Graduate School of; Public Health, San Diego State University, Calif.
Tropical spastic paraparesis (TSP) is a chronic neurological syndrome of gradual onset involving the pyramidal tracts and upper motor neurons, resulting in weakness and stiffness of the lower extremities, hyperactive tendon reflexes, spasticity, low back pain, and urinary disturbances. Clusters of endemic TSP have bee
Shibasaki H; Tokudome S; Kuroda Y; Yanagawa T; Yoshihara M; Department of Internal Medicine, Saga Medical School, Japan.
Surveying the disease by sending questionnaires to all physicians of the Saga Medical Association, we tabulated 19 definite cases of HTLV-I-associated myelopathy (7 males and 12 females) as of January 31, 1988. The population at risk of HTLV-I carriers was estimated by applying sex- and age-specific anti-HTLV-I antibo
Gross FJ; Waxman JS; Rosenblatt MA; Tabibzadeh SS; Solodnik P; Department of Ophthalmology, Mount Sinai Medical Center, New; York.
A 35-year-old HIV-positive woman with painful ophthalmoplegia, sensory loss extending to all branches of the trigeminal nerve, and progressive optic neuropathy was found to have eosinophilic granuloma of the cavernous sinus, superior orbital fissure, and orbital apex. There was no radiologic evidence of a lytic bone l
Kaugars GE; Burns JC; Department of Oral Pathology, School of Dentistry, Medical; College of Virginia, Virginia Commonwealth University, Richmond,; Va.
A 34-year-old homosexual man had a large mass of the left side of the hard palate; alveolar bone resorption was observed in the area of the tumor. Microscopically, the lesion was interpreted as non-Hodgkin s lymphoma , and immunocytochemical marker studies were consistent with a B-l
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4287-90. Unique Identifier : AIDSLINE MED/89264604
Tateno M; Gonzalez-Scarano F; Levy JA; Cancer Research Institute, University of California, School of; Medicine, San Francisco 94143.
Certain human immunodeficiency virus (HIV) strains were shown to infect human fibroblastoid cells. Replication was demonstrated only by coculturing normal peripheral blood mononuclear cells or human T-lymphotropic virus type 1-transformed T-cell lines with the infected human cells. This infection of human fibroblastoi
HIV antigenemia was found in 52/243 HIV antibody positive individuals attending 2 AIDS-screening clinics, giving a prevalence of 13, 25 and 76% in CDC groups II, III and IV, respectively. No correlation was found to decreased CD4 lymphocyte values in the individual groups. HIV antigen therefore identified a separate s
Sugimoto M; Nakashima H; Matsumoto M; Uyama E; Ando M; Araki S; First Department of Internal Medicine, Kumamoto University; Medical School, Japan.
A chronic spastic myelopathy associated with HTLV-I infection (HTLV-I-associated myelopathy: HAM) shows subclinical pulmonary involvement with bronchoalveolar T lymphocytosis. In the present study, we investigated 18 patients with HAM: five HTLV-I carriers without myelopathy and 13 normal control subjects seronegative
Mason GR; Hashimoto CH; Dickman PS; Foutty LF; Cobb CJ; Department of Medicine, Harbor-UCLA Medical Center, Torrance; 90509.
The clinical records and bronchoalveolar lavage (BAL) cell differential counts were analyzed in 96 patients at risk for Pneumocystis carinii pneumonia (PCP) from human immunodeficiency virus (HIV) infection to determine if this information may be prognostically useful and to identify possible mechanisms of BAL neutrop
Gan To Kagaku Ryoho. 1989 Apr;16(4 Pt 2-1):880-5. Unique Identifier : AIDSLINE MED/89271982
Takatsuki K; Kumamoto University Medical School.
Adult T-cell leukemia (ATL) was first discovered and reported in Japan , where it has a high incidence in the southwest region. The retrovirus HTLV-I (human T-cell lymphotropic virus type I) is considered to be related to its etiology. In ATL endemic areas, HTLV-I carriers are found
Freeman WR; Gross JG; Labelle J; Oteken K; Katz B; Wiley CA; Department of Ophthalmology, University of California San Diego,; School of Medicine, La Jolla 92093.
A 43-year-old black woman with acquired immunodeficiency syndrome developed bilateral multifocal choroidopathy characterized by slowly enlarging round to oval lesions in the posterior pole and midperiphery. Systemic evaluation revealed no evidence of mycobacterial, fungal, or spirochetal disease. Fluorescein angiograp
AIDS Res Hum Retroviruses. 1989 Jun;5(3):279-91. Unique Identifier : AIDSLINE MED/89274037
Ameisen JC; Guy B; Chamaret S; Loche M; Mouton Y; Neyrinck JL; Khalife J; Leprevost C; Beaucaire G; Boutillon C; et al; Centre d'Immunologie et de Biologie Parasitaire, INSERM U; 167-CNRS 624, Institut Pasteur, Lille, France.
The silent period that follows infection by the human immunodeficiency virus (HIV-1) and precedes seroconversion remains a problem for the screening of blood supply, and knowledge about the mechanism involved in the maintenance of latency is only fragmentary. Using purified nef recombinant protein and six synthetic ne
Ruff P; Bagg A; Papadopoulos K; Department of Medicine, Hillbrow Hospital, Johannesburg, South; Africa.
The majority of lymphomas that develop in human immunodeficiency virus type 1 (HIV-1) positive patients have a B-cell phenotype, with few reported cases of T-cell lymphoma. Within the latter group, those that have been comprehensively phenotyped had a mature helper T-cell phenotype (CD4+). We report, for the first tim
Harefuah. 1989 Mar 15;116(6):311-2. Unique Identifier : AIDSLINE MED/89277026
Pines A; Giladi M; Moshkowitz M; Finkelstein A; Levo Y
Pneumocystis carinii pneumonia (PCP) is the major cause of death in AIDS. The use of standard drugs for PCP is associated with a remarkably high rate of adverse reactions in AIDS patients. We treated a 35-year-old homosexual with a first episode of PCP with intravenous trimethoprim, 20 mg/kg, and sulfamethoxazole, 100
Int J Cancer. 1989 Jun 15;43(6):970-4. Unique Identifier : AIDSLINE MED/89277602
Yokota T; Cho MJ; Tachibana N; McLane MF; Takatsuki K; Lee TH; Mueller N; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115.
A gene product (p42) of the long open reading frame, now termed tax, of the viral genome of human T-cell leukemia virus type I (HTLV-I) may be related to the transformation of T cells in adult T-cell leukemia-lymphoma (ATLL). To evaluate its association with the disease, we compared the prevalence of antibody to p42 i
Mathews WC; Ferdon E; Bennett C; Kanouse D; Department of Medicine, University of California, San Diego.
Mortality during hospital care of AIDS-associated Pneumocystis carinii pneumonia (PCP) varies as much as 3-fold among reporting institutions. Prognostic factors for death during an episode of PCP have been identified that may be useful risk adjustors for quality-of-care studies. We illustrate a risk adjustment approac
Science. 1989 Jun 16;244(4910):1357-60. Unique Identifier : AIDSLINE MED/89283721
Homsy J; Meyer M; Tateno M; Clarkson S; Levy JA; Department of Medicine, School of Medicine, University of; California, San Francisco 94143.
Antibodies that enhance human immunodeficiency virus (HIV) infectivity have been found in the blood of infected individuals and in infected or immunized animals. These findings raise serious concern for the development of a safe vaccine against acquired immunodeficiency syndrome. To address the in vivo relevance and m
Barton JJ; O'Connor TM; Cannon MJ; Weldon-Linne CM; Department of Obstetrics and Gynecology, Illinois Masonic Medical; Center, Chicago 60657.
Controversy surrounds the issue of screening for the human immunodeficiency virus in pregnancy. The question remains: Which pregnant women should be tested? To answer this question, it is clear that local prevalence data of seropositivity must be known. At present, these figures are unavailable for midwestern metropol
JAMA. 1989 Jun 16;261(23):3415-8. Unique Identifier : AIDSLINE MED/89259235
Turnock BJ; Kelly CJ; Illinois Department of Public Health, Chicago 60601.
During the first 6 months of legislatively mandated premarital testing for human immunodeficiency virus in Illinois, 8 of 70,846 applicants for marriage licenses were found to be seropositive, yielding a seroprevalence of 0.011%. The total cost of the testing program for 6 months is estimated at $2.5 million or $312,0
AIDS Res Hum Retroviruses. 1989 Feb;5(1):87-95. Unique Identifier : AIDSLINE MED/89247172
Bell J; Ratner L; Division of Hematology and Oncology, Washington University, St.; Louis, MO 63110.
The polymerase chain amplification reaction (PCR) is a sensitive, specific, and quantitative assay of human immunodeficiency virus type 1 (HIV-1). The assay was performed with polymerases from Escherichia coli or Thermus aquaticus (Taq). A single pair of oligonucleotide primers within the long terminal repeat (LTR) se
Bull Pan Am Health Organ. 1989;23(1-2):24-9. Unique Identifier : AIDSLINE MED/89248217
Boshell J; Gacharna MG; Garcia M; Jaramillo LS; Marquez G; Fergusson MM; Gonzalez S; Prada EY; de Rangel R; de Cabas R
Between January 1984 and December 1987 a total of 178 AIDS cases were reported to the Colombian Ministry of Health. The location of these cases suggests that the human immunodeficiency virus (HIV) is widely distributed in Colombia. Most of those afflicted (97%) have been adult males. HIV seroprevalence studies of sele
Bull Pan Am Health Organ. 1989;23(1-2):50-61. Unique Identifier : AIDSLINE MED/89248221
Pape JW; Johnson W Jr
Vertical transmission of human immunodeficiency virus (HIV) from an infected mother to her fetus or infant can occur in utero and probably during labor and delivery. Transmission via breast milk has also been documented. Because of limitations of conventional HIV testing in infants, it is difficult to determine the ra
Bull Pan Am Health Organ. 1989;23(1-2):81-5. Unique Identifier : AIDSLINE MED/89248225
Ivo-dos-Santos J; Galvao-Castro B
The established method of purifying human immunodeficiency virus (HIV) involves centrifuging the lysates of infected cells onto a sucrose gradient. This article reports an alternative methodology for purifying large amounts of HIV antigens that avoids the need for expensive equipment such as an ultracentrifuge and req
Consideration of immunologic consequences of aging coupled with the potential for infectious disease and the relatively new recognition of HIV infection will continue to present challenges to nurses in acute care settings. Knowledge of these issues can provide the basis for effective approaches to the problems.
Can Med Assoc J. 1989 Jun 1;140(11):1281-7. Unique Identifier : AIDSLINE MED/89248718
Edelson JD; Hyland RH; Department of Medicine, St. Michael's hospitals.
Infectious and noninfectious forms of pulmonary disease are the most common complications of acquired immune deficiency syndrome (AIDS), and many are amenable to treatment. We describe the clinical and radiologic features of the most common causes of lung disease in AIDS patients and review the drugs available for tre
Giorgi JV; Detels R; Department of Medicine, UCLA School of Medicine.
Immunologic changes in HIV-infected homosexual men without AIDS were studied using flow cytometry and monoclonal antibodies. A decline in CD4 cells occurred after anti-HIV antibodies detectable by ELISA developed. CD4 T-cell levels dropped to an average of 60% of their original level within 12-18 months after seroconv
Koepke JA; Landay AL; Department of Hospital Laboratories, Duke University Medical; Center Durham, North Carolina 27710.
A critique of leukocyte counting using automated hematology instruments is presented. Important preanalytical variables include the anticoagulant and specimen assay delays. The precision of counts is directly related to the number of leukocytes counted. Criteria for the selection of an acceptable hematology laboratory
Fletcher MA; Azen SP; Adelsberg B; Gjerset G; Hassett J; Kaplan J; Niland JC; Odom-Maryon T; Parker JW; Stites DP; et al; University of Miami School of Medicine, Florida 33101.
The Transfusion Safety Study (TSS) is a cooperative investigation of factors that determine the occurrence of and modify the expression of transfusion-transmitted infections. A major component of its data is derived from lymphocyte immunophenotyping using a large panel of monoclonal antibodies and two-color flow cytom
Hospital transfusion services and blood centers still use manual hemagglutination tests for most of their serological procedures. Automation of hemagglutination reactions has proven to be difficult, primarily because hemagglutination lacks an objective endpoint which can be easily interpreted by inexpensive instrument
Strigle SM; Gal AA; Department of Pathology, Los Angeles County-University of; Southern California Medical Center.
Over the past 6 yr, we have observed an increase in cytologic specimens from the respiratory tract in patients suspected or known to have AIDS, from 7 of 81,031 cases in 1982 to 1,231 of 55,333 in 1987. Based on our experience with 1,140 patients, this article reviews the technical and morphologic evaluation of pulmon
In approximately 10-16% of the cases, diseases of the peripheral nerves occur in the fully developed stage of AIDS, more seldom, however, in the stage of ARC. Some cases have been described in the stage of seroconversion or lymphadenopathy. At this stage cranial neuropathies can show up in connection with aseptic meni
Hosp Community Psychiatry. 1989 May;40(5):502-6. Unique Identifier : AIDSLINE MED/89253382
Horwath E; Kramer M; Cournos F; Empfield M; Gewirtz G; New York State Psychiatric Institute, New York 10032.
The epidemiologic, neuropsychiatric, and medical data on AIDS and HIV infection that are relevant to state psychiatric facilities are reviewed. The epidemiologic data suggest that a larger than expected number of AIDS patients may be seen in these facilities. Patients who are severely disturbed and psychotic may prese
De Paepe ME; Vuletin JC; Lee MH; Rojas-Corona RR; Waxman M; Department of Pathology, Montefiore Medical Center, Bronx, NY.
An immunopathologic analysis of the testes of 20 homosexual acquired immune deficiency syndrome (AIDS) patients was performed to investigate the hypothesis that the testicular atrophy of these patients represents an immune-mediated process. The findings were compared to those in a control group of heterosexual men wit
Freedman B; McGill Centre for Medicine, Montreal, Canada.
As more AIDS patients seek access to nonvalidated therapies, Authorized Investigational Units can preserve the integrity of clinical trials, protect patients interests, and enhance clinicians flexibility.
Gallo P; Frei K; Rordorf C; Lazdins J; Tavolato B; Fontana A; Institute of Neurology, University of Padova, Italy.
Cytokines play an important role not only for initiation of immune reactivity but also for development of tissue injury. Of 38 patients infected with human immunodeficiency virus type 1 (HIV-1) interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) were identified in cerebrospinal fluid (CSF) of 22 (58%) and 16 (42%)
Nakayama J; Higuchi R; Kabemura M; Kiryu H; Takenaka A; Hori Y
We have carried out in vitro studies of hyperthermic effects on the viability, blastogenesis, and ultrastructural changes of atypical lymphocytes isolated from the peripheral blood of three patients with malignant lymphoma/leukemia. One was lymphocytic lymphoma/leukemia (T-cell origin), and the others were adult T-cel
J Ky Med Assoc. 1989 Feb;87(2):75-7. Unique Identifier : AIDSLINE MED/89257087
Haist SA
The peripheral and central nervous systems are commonly affected in patients with acquired immunodeficiency syndrome (AIDS). Primary infection with human immunodeficiency virus (HIV) can cause an acute encephalitis, meningitis, or an acute polyneuropathy. Spinal cord involvement can result in a progressive spastic par
Inagi K; Takahashi H; Okamoto M; Yao K; Furukawa K
Adult T cell leukemia (ATL) is one of malignant tumors originated from T-cell system, first described by Takatsuki in 1976. Most cases of ATL have been diagnosed in department of internal medicine and dermatology, because they usually show lymphoadenopathy and skin rash. However, it is rare that ATL has symptoms of ot
The number of pediatric AIDS cases are increasing. This disease, with its social and political ramifications, as well as its biological consequences, presents a number of unique issues for psychologists. Some of the areas that present opportunities and problems for psychologists are briefly identified. These areas inc
Adams M; Toy PT; Reid ME; Blood Bank, San Francisco General Hospital Medical Center,; California.
Patients with acquired immune deficiency syndrome (AIDS) or AIDS-related complex (ARC) are subject to recurrent and severe infections due to organisms known to cause red blood cell membrane modifications. These red cell modifications include the exposure of novel carbohydrate cryptantigens that can react with naturall
Moseson M; Zeleniuch-Jacquotte A; Belsito DV; Shore RE; Marmor M; Pasternack B; Institute of Environmental Medicine, New York University Medical; Center, New York City 10010.
The literature is briefly summarized as to how several nutrients affect immune function, susceptibility to infection, and cancer susceptibility or progression. Nutritional deficiencies can impair immunity and so influence susceptibility to infectious agents, including ones that are common and relatively virulent in ac
Perkins A; Cochrane AW; Ruben SM; Rosen CA; Department of Molecular Oncology, Roche Institute of Molecular; Biology, Roche Research Center, Nutley, New Jersey 07110.
Expression of the human immunodeficiency virus (HIV) rev protein is required for expression of virus structural proteins. Site-directed mutagenesis was used to localize regions important for Rev function. We found that proteins with single amino acid substitution mutations concentrated within the amino termini and mid
Peng C; Ho BK; Chang TW; Chang NT; Division of Molecular Virology, Baylor College of Medicine,; Houston, Texas 77030.
It is generally believed that the gag gene product of human immunodeficiency virus type 1 (HIV-1) is processed into several core proteins by a virus-specific protease. We used deletion mutation analysis to study the role of HIV-specific protease in the processing of core proteins and its requirement for viral infectiv
Harrich D; Garcia J; Wu F; Mitsuyasu R; Gonazalez J; Gaynor R; Department of Medicine, School of Medicine, University of; California, Los Angeles 90024.
Five regions of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) have been shown to be important in the transcriptional regulation of HIV in HeLa cells. These include the negative regulatory, enhancer, SP1, TATA, and TAR regions. Previous studies in which purified SP1 was used showed that the
Bathurst IC; Chester N; Gibson HL; Dennis AF; Steimer KS; Barr PJ; Chiron Corporation, Emeryville, California 94608-2916.
A semisynthetic gene precisely encoding the 502 amino acids of the human immunodeficiency virus type 1 gag precursor (Pr53gag) was expressed in the yeast Saccharomyces cerevisiae. Amino acid sequence analysis of the recombinant Pr53gag showed that the amino terminus was fully blocked. Labeling of Pr53gag with [3H]myri
Med Oncol Tumor Pharmacother. 1989;6(1):55-8. Unique Identifier : AIDSLINE MED/89260575
Hermans P; Clumeck N; Division of Infectious Diseases, St Pierre University Hospital,; Brussels, Belgium.
The human immunodeficiency virus (HIV) is the newly recognized agent of the acquired immunodeficiency syndrome (AIDS). Global defects of the immune functions, including T- and B-cell immunity, macrophage functions and cytokine production, are commonly observed among patients with HIV infection. Many studies have shown
Med Oncol Tumor Pharmacother. 1989;6(1):59-61. Unique Identifier : AIDSLINE MED/89260576
Touraine JL; Transplantation and Immunobiology Unit, Pav. P, Hopital Edouard; Herriot, Lyon, France.
LF 1695, a synthetic immunomodulator with a low mol. wt, has been shown to exert its activity on T-lymphocytes and macrophages. It induced T-cell differentiation of bone marrow precursor cells which acquired the expression of CD3, CD4 and/or CD8. It increased lymphocyte proliferative responses to mitogens, antigens an
Med Clin (Barc). 1989 Feb 11;92(5):161-3. Unique Identifier : AIDSLINE MED/89260597
Soriano V; Tor J; Muga R; Fernandez JL; Ribera A; Balanzo X; Foz M
We have studied retrospectively the presence of serologic markers of type 1 and type 2 human immunodeficiency virus infection in 102 subjects coming from West Africa and living in Catalonia. We have proven the presence of specific antibodies to type 2 human immunodeficiency virus in three asymptomatic subjects among w
N Engl J Med. 1989 Jun 22;320(25):1643-8. Unique Identifier : AIDSLINE MED/89261985
Blanche S; Rouzioux C; Moscato ML; Veber F; Mayaux MJ; Jacomet C; Tricoire J; Deville A; Vial M; Firtion G; et al; Immunology and Hematology Unit, Hopital Necker, Paris, France.
Assessment of the risks of transmission of infection with human immunodeficiency virus type 1 (HIV-1) from mother to newborn is difficult, partly because of the persistence for up to a year of maternal antibodies transmitted passively to the infant. To determine the frequency of perinatal transmission of HIV infection
Brew BJ; Bhalla RB; Fleisher M; Paul M; Khan A; Schwartz MK; Price RW; Department of Neurology, Memorial Sloan Kettering Cancer Center,; New York, NY.
We prospectively evaluated CSF concentrations of beta 2 microglobulin (beta 2M) in 65 human immunodeficiency virus type 1 seropositive patients. The highest concentrations occurred in those with lymphoma, neurologic opportunistic infections, and acquired immune deficiency syndrome deme
Lubbert M; Miller CW; Kahan J; Koeffler HP; UCLA Department of Medicine, Division of Hematology/Oncology; 90024.
p53 is a nuclear protein associated with cellular transformation and normal cellular proliferation. Some transformed cells have been found to have one or several quantitative or qualitative abnormalities of p53. We studied expression, kinetics, phosphorylation, DNA methylation and chromatin structure of p53 in resting
Chanock SJ; McIntosh K; Department of Pediatrics, Harvard Medical School, Children's; Hospital, Boston, Massachusetts.
Pediatric HIV infection is increasing at a rapid rate. It has many features that distinguish it from the adult forms of the disease. An understanding of the epidemiology and pathophysiology of HIV infection in children is necessary for the clinician to accurately diagnose and effectively treat infected children. Parti
Grady C; National Institutes of Health, Bethesda, Maryland.
During the past few years, an incredible body of knowledge about HIV infection and all of its ramifications has been accumulated. As we consider whether or not our conduct toward persons who are HIV infected is right, however, many unanswered questions still exist. All health care professionals must be involved in ref
Mod Pathol. 1989 Mar;2(2):125-8. Unique Identifier : AIDSLINE MED/89264433
Cohen AH; Sun NC; Shapshak P; Imagawa DT; Department of Pathology, Harbor-UCLA Medical Center, Torrance.
HIV-associated nephropathy (HIVAN) is a renal disease characterized clinically by heavy proteinuria and renal failure and morphologically by severe and rapidly evolving focal and segmental glomerulosclerosis, tubular necrosis, interstitial edema, and ultrastructural cellular inclusions. In an attempt to elucidate its
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4152-5. Unique Identifier : AIDSLINE GENBANK/M23167
Slabaugh MB; Roseman NA; Department of Biochemistry and Biophysics, Oregon State; University, Corvallis 97331-6503.
The retroviral protease-encoding region, PR, situated between the gag and pol genes, underwent gene duplication in the lineage now represented by simian retrovirus type 1; the sequence of the duplicated segment has diverged considerably from the present PR sequence [Power, M.D., Marx, P.A., Bryant, M.L., Gardner, M.B.
Jones B; Fishman EK; Russell H. Morgan Department of Radiology and Radiological; Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
The spread of the acquired immunodeficiency syndrome, the increasing popularity of bone marrow, renal, and other organ transplants, and the development of potent immunosuppressive drugs have produced a large population of immunocompromised hosts. These patients are at great risk for developing both opportunistic infec
Calabrese LH; Department of Rheumatic and Immunologic Disease, Cleveland Clinic; Foundation 44195-5028.
The recognized clinical spectrum of disease associated with HIV infection is rapidly expanding and now includes a variety of rheumatic syndromes. The laboratory features of HIV infection closely resemble those found in many connective tissue diseases and thus alter the predictive value of these tests in the evaluation
Mittelman A; Bertram J; Henry DH; Snyder HW Jr; Messerschmidt GL; Ciavarella D; Ainsworth S; Kiprov D; Arlin Z; New York Medical College, Valhalla 10595.
Both antibodies and circulating immune complexes (CIC), which bind to platelets and induce the destruction and clearance of platelets by the reticuloendothelial system, are found in patients with human immunodeficiency virus (HIV) and immune thrombocytopenic purpura (ITP). IgG and CIC were removed from patients plasm
Kasper CK; Graham JB; Kernoff PB; Larrieu MJ; Rickard KA; Mannucci PM; Hemophilia and Thrombosis Center, Milan, Italy.
Since 1982, when the World Federation of Hemophilia first published a document on the state of the art of hemophilia diagnosis and care, there have been lights and shadows in this field. Although the widespread infection of hemophiliacs with the human immunodeficiency virus (HIV) contaminating clotting factor concentr
Hoffman DM; Caruso RF; Mirando T; University Hospital, State University of New York, Stony Brook; 11794.
Thrombocytopenia has emerged as a major hematological manifestation associated with AIDS (acquired immunodeficiency syndrome) and human immunodeficiency virus (HIV)-positive patients. A study of homosexual patients with thrombocytopenia indicates 93 percent had serological evidence of HIV exposure whereas only 33 perc
Berkelman RL; Heyward WL; Stehr-Green JK; Curran JW; AIDS Program, Centers for Disease Control, Atlanta, Georgia; 30333.
As of December 31, 1988, 82,764 cases of acquired immunodeficiency syndrome (AIDS) and more than 46,000 AIDS-related deaths had been reported in the United States . In 1987, AIDS deaths accounted for 9% of the total mortality among men 25 to 34 years of age. Projections suggest that the
Am J Ophthalmol. 1989 Jun 15;107(6):613-23. Unique Identifier : AIDSLINE MED/89270698
Davis JL; Nussenblatt RB; Bachman DM; Chan CC; Palestine AG; National Eye Institute, Laboratory of Immunology, Bethesda,; Maryland 20892.
We studied two patients, one with histologically confirmed endogenous bacterial retinitis associated with the acquired immunodeficiency syndrome and a second with ophthalmoscopically identical findings who also responded to antibiotic treatment. Both patients had focal, discrete patches of retinitis that enlarged slow
Am J Psychiatry. 1989 Jun;146(6):737-42. Unique Identifier : AIDSLINE MED/89270752
Ostrow DG; Monjan A; Joseph J; VanRaden M; Fox R; Kingsley L; Dudley J; Phair J; Midwest AIDS Biobehavioral Research Center, University of; Michigan, Ann Arbor 48109.
The authors administered the Center for Epidemiological Studies Depression (CES-D) Scale to 4,954 homosexual men in the Multicenter AIDS Cohort Study. HIV antibody status at enrollment was a less important predictor of psychological distress than were reported physical symptoms. Multivariate analysis showed an associa
Stover DE; Greeno RA; Gagliardi AJ; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York.
Because Pneumocystis carinii pneumonia (PCP) is so common among patients infected with the human immunodeficiency virus-1 (HIV-1), a quick, simple test to evaluate for its presence or absence would be helpful. We report our results on the role of an exercise blood gas test as a useful procedure for the detection of Pn
Ann Intern Med. 1989 Jun 15;110(12):1001-16. Unique Identifier : AIDSLINE MED/89271445
Gottesdiener KM; Brigham and Women's Hospital, Boston, Massachusetts.
PURPOSE: To evaluate the transmission of infectious agents from organ donors to transplant recipients, and to assess risk factors for transmission, primarily in recipients of kidney, cornea, and heart allografts. DATA IDENTIFICATION: Computerized literature searches of MEDLINE and PAPERCHASE through January 1988, exte
Ragni MV; Nimorwicz P; Department of Medicine, University of Pittsburgh School of; Medicine, PA.
Heterosexual transmission of human immunodeficiency virus (HIV) accounts for only a small percentage of the cases of acquired immunodeficiency syndrome in the United States , but it is a major public health care issue. However, despite intensive education and counseling regarding HIV tr
Chiang CS; Grove T; Cooper M; Cuan J; Kowalski A; Parcells K; Tsunokawa M; Rosenberg M; Arcuri E; Franklin S; et al; SmithKline Bio-Science Laboratories, Van Nuys, CA 91405.
We subcloned six discrete protein-coding regions representing the gag (Kp24 and Kp55), env (Kp41, Kp120N, and Kp120CC), and pol (Kp66/31) gene products of the human immunodeficiency virus type 1 (HIV-1) and expressed them in Escherichia coli as fusion proteins with the first 56 residues of galactokinase. An enzyme-lin
Buesching WJ; Neff JC; Sharma HM; Ohio State University, Columbus.
The increasing risk of exposure to blood-borne pathogens in the health care setting makes the development of effective infection control programs in the laboratory workplace critical. Central to such programs is the concept of universal precautions. The program described here relates the level of protection or precaut
Recent data suggest that the pathogenicity of HIV is mediated by the production of metabolised viral components which act as hormones. In particular the replication and maturation of T-lymphocytes, and the cellular interaction of immunocompetent cells and nerve cells are affected. The recognition of HIV by the immune
More than 50% of HIV-infected patients develop gastrointestinal symptoms. The HIV-induced damage of the mucosa-associated immune system (reduction of CD4-positive cells in the lamina propria) leads to an increased risk of opportunistic infections (Candida, Herpes simplex virus, Cytomegalovirus, Cryptosporidia, Isospor
Maekawa I; Kawamura T; Miyake T; Nakamura M; Kurosawa M; Department of Internal Medicine, Asahikawa Municipal Hospital,; Hokkaido, Japan.
Although determination of the presence of antibodies to HTLV-1 in cerebro-spinal fluid (CSF) is very important for the diagnosis of HTLV-1-associated myelopathy (HAM), these antibodies in CSF have not yet been completely investigated so far in patients without overt HAM. We examined antibodies to HTLV-1 in CSF of leuk
Holmberg SD; Horsburgh CR Jr; Ward JW; Jaffe HW; AIDS Program, Centers for Disease Control, Atlanta, Georgia; 30333.
The probability that any single episode of genital-genital or anogenital sexual intercourse will result in transmission of HIV may be determined by multiple biologic factors of the infectious person, the virus itself, and the exposed susceptible person. Some of these factors are known or suspected (figure 1), and they
Brenner BG; Dascal A; Margolese RG; Wainberg MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.
This review describes current knowledge of changes in natural killer (NK) cell function in acquired immunodeficiency syndrome (AIDS)-related disorders, vis-a-vis associated abnormalities in NK cytolytic function, NK cell subset distribution, NK cytopathology, and lymphokine regulation. NK cells, which are closely asso
Vilgrain V; Frija J; Yana C; Couderc LJ; David M; Clauvel JP; Laval-Jeantet M; Service de Radiologie, Hopital Saint-Louis, Paris.
Three patients with lymphoid interstitial pneumonia (two HIV 1+ patients with chronic lymphadenopathic syndromes and one with a not-characterized autoimmune disease) have been studied with high-resolution computed tomography (HR-CT). This technique reveals septal lines, small reticulonodular opacities, polyhedral micr
J Natl Cancer Inst. 1989 Jun 21;81(12):914-23. Unique Identifier : AIDSLINE MED/89279941
Waldmann TA; Metabolism Branch, National Cancer Institute, Bethesda, MD 20892.
Activation of resting T cells induces synthesis of interleukin-2 ( IL-2 ) and expression of its specific high-affinity receptor. We proposed a multichain model for the high-affinity IL-2 receptor in which both a 55-kilodalton IL-2-binding peptide identified by the anti-T
Nimer SD; Gasson JC; Hu K; Smalberg I; Williams JL; Chen IS; Rosenblatt JD; Department of Medicine, UCLA School of Medicine 90024-1678.
Production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by normal T lymphocytes requires activation by antigen, mitogen or lectin, whereas T-cell lines transformed by human T-cell leukemia virus type I (HTLV-I) or type II (HTLV-II) constitutively produce high levels of GM-CSF. Using transient cotransfe
Vernant JC; Roman GC; Service de Neurologie, Hopital La Meynard, Fort de France,; Martinique.
Human T-Cell Leukaemia Virus (HTLV) has been found to be endemic in the Caribbean Islands. So-called spastic paraplegia of unknown origin, described in Martinique (named tropical spastic paraplegia in other countries) was found to b
Rushton JP; Bogaert AF; Department of Psychology, University of Western Ontario, London,; Canada.
Previously we have reported population differences in sexual restraint such that, higher socio-economic status greater than lower socio-economic status, and Mongoloids greater than Caucasoids greater than Negroids. This ordering was predicted from a gene-based evolutionary theory of r/K reproductive strategies in whic
South Med J. 1989 Jun;82(6):711-4, 718. Unique Identifier : AIDSLINE MED/89283800
Amundson DE; Murray KM; Brodine S; Oldfield EC; Department of Internal Medicine (Division of Pulmonary Medicine; and Infectious Disease) Naval Hospital, San Diego, Calif.
Overwhelming Pneumocystis carinii pneumonia (PCP) in patients with acquired immunodeficiency syndrome (AIDS) carries a poor prognosis. Patients who require mechanical ventilation have up to a 90% mortality rate despite vigorous treatment. Although there are theoretic contraindications to steroid use in severely immuno
Stary A; Ambulatorium fur Pilzinfektionen und andere infektiose; venero-dermatologische Erkrankungen, Wien.
Zoster is the clinical manifestation of the endogenous reactivation of the varicella-zoster virus. Current observations of viral reactivation emphasize the role of cellular immunity and show an inverse correlation between the specific cellular immune response of the host and the incidence of zoster. Thus, immunocompro
Am J Public Health. 1989 Jul;79(7):878-82. Unique Identifier : AIDSLINE MED/89285528
Judson FN; Denver Public Health, CO 80204-4507.
For the near term, control of the AIDS epidemic depends entirely upon altering the human behavior which results in HIV transmission. How best to achieve the required changes has been controversial with approaches ranging from education/information only, to a vast array of largely unproven voluntary behavior modificati
The authors tried in this article to review the principal aspects of deep mycoses. A special attention was paid to the clinical aspects of candidiasis, aspergillosis and cryptococcosis. The incidence of these diseases is now growing owing to the increasing use of immunosuppressives drugs and to AIDS. The difficulty of
Although research is underway to answer the many unknown questions about AIDS/HIV, there are many myths that continue to plague the public as well as health care and education workers. In this report, the ASHA Committee on Quality Assurance provides factual information about what is known about AIDS/HIV and delineates
AIDS Res Hum Retroviruses. 1989 Feb;5(1):97-106. Unique Identifier : AIDSLINE MED/89247173
Cory JM; Ohlsson-Wilhelm BM; Steck ME; Smithgall MD; Rozday V; Eyster ME; Rapp F; Department of Microbiology and Immunology, Milton S. Hershey; Medical Center, Pennsylvania State University, Hershey 17033.
In order to optimize detection of human immunodeficiency virus-1 (HIV-1)-infected cells, the temporal appearance of virus antigens in newly infected H9 cell cultures was examined. Analyses were accomplished by indirect immunofluorescence labeling with each of 10 monoclonal antibodies and evaluation by flow cytometry.
Arvinte T; Schulz B; Cudd A; Nicolau C; Biophor Corporation, Texas A & M University Research Park,; College Station 77840.
Glycophorin and CD4 proteins are tightly associated with intact human erythrocyte membranes after a short-time incubation at low pH (1-2 min, pH lower than 5, 37 degrees C). Flow cytometry and epifluorescence microscope observations showed that after incubation of red cells with fluorescein isothiocyanate (FITC) label
De Gruttola V; Lagakos SW; Harvard University, Boston, Massachusetts.
This paper proposes nonparametric and weakly structured parametric methods for analyzing survival data in which both the time origin and the failure event can be right- or interval-censored. Such data arise in clinical investigations of the human immunodeficiency virus (HIV) when the infection and clinical status of p
To assess whether alcohol and glutaraldehyde are effective disinfectants against dried HIV the virucidal effects of 70% alcohol (ethanol and industrial methylated spirit) and 1% and 2% alkaline glutaraldehyde were tested against cell associated and cell free HIV dried on to a surface. Virus stock (100 microliters) or
Darby SC; Rizza CR; Doll R; Spooner RJ; Stratton IM; Thakrar B; Imperial Cancer Research Fund Cancer Epidemiology and Clinical; Trials Unit, University of Oxford, Radcliffe Infirmary.
OBJECTIVE--To estimate the cumulative incidence of AIDS by time since seroconversion in haemophiliacs positive for HIV and to examine the evidence for excess mortality associated with HIV in those who had not yet been diagnosed as having AIDS. DESIGN--Analysis of data from ongoing national surveys. SETTING--Haemophili
Hart GJ; Sonnex C; Petherick A; Johnson AM; Feinmann C; Adler MW; Academic Department of Genitourinary Medicine, University; College, London.
To study a range of possible risk factors for HIV among injecting drug user patients attending a clinic in London were interviewed from November 1986 to November 1987. Serum samples were tested for viral markers. Of 116 patients, 101 had shared injecting equipment, 75 on the first occasion of injecting and 76 during t
EMBO J. 1989 Mar;8(3):779-85. Unique Identifier : AIDSLINE MED/89251609
Argos P; European Molecular Biology Laboratory, Heidelberg, FRG.
With the use of a sensitive sequence comparison algorithm, a homology has been suggested between the primary structures of simian immunodeficiency virus (SIV) p24 core protein and foot-and-mouth disease virus (FMD) VP2 coat protein. Since the FMD sequence is homologous to picornaviral VP2 sequences with known three-di
Chave JP; Bille J; Glauser MP; Francioli P; Department of Internal Medicine, Centre Hospitalier Universitaire; Vaudois, Lausanne, Switzerland.
Over a three-year period, 54 episodes of pneumonia were diagnosed in 45 adults infected with the human immunodeficiency virus (HIV). These episodes were reviewed in order to assess the distribution of pathogens and their clinical presentation. Thirty-six episodes were due to an opportunistic pathogen (Pneumocystis car
In this paper we review our experience with HIV-related thrombocytopenic purpura (TP) in 24 patients seen from October, 1985 through April, 1988: the median follow-up was 16 months (range 3-32). All patients belonged to risk groups for AIDS and intravenous drug abusers represented 83% of the entire cohort. The male/fe
Hatanaka K; Yoshida T; Uryu T; Yoshida O; Nakashima H; Yamamoto N; Mimura T; Kaneko Y; Institute of Industrial Science, University of Tokyo.
Anti-HIV effects of lentinan sulfate were investigated by using an HTLV-I-carrying cell line, MT-4, in vitro. Lentinan, a fungal branched (1----3)-beta-D-glucan, was sulfated to various degrees by means of two kinds of procedures using piperidine N-sulfonic acid in dimethyl sulfoxide or chlorosulfonic acid in pyridine
Okamoto T; Ohno Y; Tsugane S; Watanabe S; Shimoyama M; Tajima K; Miwa M; Shimotohno K; Virology Division, National Cancer Center, Tokyo.
The age-specific occurrence of adult T-cell leukemia (ATL) was analyzed using 357 cases collected during nationwide surveys carried out between 1982 and 1985 in Japan . A simple Weibull distribution function fitted well as a model. The mode of ATL onset was log-linear in this model a
Eng RH; Bishburg E; Smith SM; Mangia A; Infectious Disease Section, Veterans Administration Medical; Center, East Orange, New Jersey 07019.
Thirty acquired immunodeficiency syndrome patients with mycobacterial bacteremia documented by Du Pont Isolator (Du Pont Co., Wilmington, Del.) blood cultures underwent microscopic examination of buffy coat blood smears. Of 30 patients, 14 were culture positive for Mycobacterium avium-Mycobacterium intracellulare comp
J Immunol. 1989 Jun 15;142(12):4241-7. Unique Identifier : AIDSLINE MED/89256671
Halloran PF; Urmson J; Van der Meide PH; Autenried P; Department of Medicine, University of Alberta, Edmonton, Canada.
We examined the effect of type I IFN inducers and rIFN-alpha on MHC expression in mouse tissues in vivo. MHC expression was assessed in a radiolabeled mAb binding assay and by indirect immunoperoxidase staining of tissue sections. polyI:C, an inducer of IFN-alpha/beta, induced large increases in class I MHC in many ti
Sonnerborg A; Nybom R; Britton S; Ehrnst A; Forsgren M; Larsson PH; Strannegard O; Andersson J; Department of Infectious Diseases, Roslagstull Hospital,; Karolinska Institute, Stockholm, Sweden.
The cerebrospinal fluid of 52 patients with human immunodeficiency virus type 1 (HIV-1) infection was incubated with polystyrene microspheres coated with monoclonal antibodies specific for HIV-1 core or envelope antigens. The beads were then collected on a filter surface and inspected by scanning electron microscopy (
J Med Virol. 1989 Mar;27(3):258-63. Unique Identifier : AIDSLINE MED/89257299
Sonnerborg A; Ehrnst A; Strannegard O; Department of Virology, Central Microbiological Laboratory of; Stockholm County Council, Sweden.
Attempts to isolate human immunodeficiency virus type 1 (HIV-1) were carried out on cerebrospinal fluid (CSF) and blood plasma samples from 111 HIV-1 infected subjects in various stages of infection. HIV-1 was recovered at a low rate from CSF of persons with normal immunological parameters but frequently from patients
Kahn JO; Kaplan LD; Volberding PA; Ziegler JL; Crowe S; Saks SR; Abrams DI; Department of Medicine, University of California Medical Center,; San Francisco.
The effect of recombinant tumor necrosis factor-alpha (rTNF), injected directly into the tumor, was evaluated in a Phase I/II study of 27 patients with AIDS-associated Kaposi s sarcoma (KS). The maximally tolerated intralesional dose was less than 100 micrograms/m2 and the recommended intralesional dose was 25 microgr
JAMA. 1989 Jun 16;261(23):3434-8. Unique Identifier : AIDSLINE MED/89259239
Pierce GF; Lusher JM; Brownstein AP; Goldsmith JC; Kessler CM; Department of Pathology, Washington University Medical Center, St; Louis, Mo.
Treatment of hemophilia, although greatly improved in recent years, continues to be problematic owing to infectious complications of blood product replacement therapy. This report examines the therapeutic options presently available for the treatment of hemophilia, focusing on the potential for repeated viral exposure
N Engl J Med. 1989 Jun 15;320(24):1598-603. Unique Identifier : AIDSLINE MED/89261966
Winkenwerder W; Kessler AR; Stolec RM; Southeast Permanente Medical Group, Atlanta, GA 30326.
Is the federal government devoting sufficient resources to fighting the epidemic of human immunodeficiency virus (HIV) infection, and are these resources being spent appropriately? Some observers contend that the amounts have been inadequate, but until now there has been no overall accounting of federal activities and
Mil Med. 1989 Jun;154(6):315-8. Unique Identifier : AIDSLINE MED/89262671
Huber MA; Hall EH; Rathbun WA
A case report of an AIDS patient afflicted with disseminated histoplasmosis is presented. Characteristic granulomatous-appearing lesions on the tongue were observed during the patient s initial workup, but the patient became unavailable for a scheduled biopsy. Consequently, the diagnosis of a histoplasmosis infection
Tufveson G; Geelings W; Broyer M; Brunner FP; Brynger H; Dykes SR; Ehrich JH; Fassbinder W; Rizzoni G; Selwood NH; et al; Transplantation Unit, University Hospital, Uppsala, Sweden.
This paper summarises the information given on the 1986 EDTA Registry centre questionnaire which was returned by 82% of the 2,065 known dialysis and transplant centres in 33 European countries. Information is given on the number of patients alive on haemodialysis according to the type of dialysis facilities available
Crocker KS; New England Critical Care, Marlborough, Massachusetts.
AIDS-related gastrointestinal disease is common, presenting a challenge to all nutritional support clinicians. Patients frequently suffer from weight loss, diarrhea, malabsorption, and cachexia. Many factors complicate the course of AIDS-related gastrointestinal disease, including decreased food intake (resulting from
Public Health Rep. 1989 May-Jun;104(3):231-40. Unique Identifier : AIDSLINE MED/89265497
Magura S; Grossman JI; Lipton DS; Amann KR; Koger J; Gehan K; Narcotic and Drug Research, Inc., New York, NY 10013.
The authors examined the factors associated with methadone patients decisions about participating in a clinic-based AIDS prevention protocol. Despite the offer of incentives, only 27 percent attended AIDS education and only 12 percent obtained voluntary HIV antibody (ab) testing. However, AIDS education was attended
Settergren B; Burman LA; Gustafsson A; Juto P; Li QG; Wadell G; Department of Virology, Umea University, Sweden.
HIV-Western blot (WB) testing of sequential sera from a blood donor revealed identical bands in the p24 and p55 positions. Additional testing using indirect immunofluorescence antibody technique, radioimmunoprecipitation assay and an HIV p24 antigen immunoassay were negative. During a 5-year follow-up period the blood
Matsuda S; Urata Y; Shiota T; Yamada M; Yoshikawa H; Tegoshi T; Okada M; Nakamura H; Kitaoka T; Ashihara T; et al; Department of Medical Zoology, Kyoto Prefectural University of; Medicine, Japan.
This report describes the histopathology of a disseminated Pneumocystis carinii infection in a 24-year-old Japanese male haemophiliac diagnosed as having the acquired immunodeficiency syndrome. He developed respiratory symptoms, and Pneumocystis carinii pneumonia was confirmed by transbronchial lung biopsy. On the 70t
Ikuta K; Morita C; Miyake S; Ito T; Okabayashi M; Sano K; Nakai M; Hirai K; Kato S; Department of Pathology, Osaka University, Japan.
MT-4 cells persistently infected with human immunodeficiency virus type 1 (HIV-1) (MT-4/HIV-1) were recently isolated (K. Ikuta, C. Morita, M. Nakai, N. Yamamoto, and S. Kato, Japan . J. Cancer Res. (Gann), 79, 418-423, 1988). Mouse hybridoma cell clones producing monoclonal antibodi
Biochem Biophys Res Commun. 1989 May 15;160(3):1250-6. Unique Identifier : AIDSLINE GENBANK/M26463
Larrick JW; Danielsson L; Brenner CA; Abrahamson M; Fry KE; Borrebaeck CA; Genelabs Incorporated, Redwood City, CA 94063.
A general method to directly obtain the DNA sequence of the variable regions of any immunoglobulin chain using a mixture of oligomer primers and the polymerase chain reaction (PCR) is described. Mixed oligonucleotide primers corresponding to the 5 signal peptide and a conserved 3 constant region primer were used for
MacAskill SG; Hastings GB; McNeill RE; Gillon J; Department of Marketing, University of Strathclyde, Glasgow.
OBJECTIVE--To see whether the issue of AIDS has influenced the observed decline in blood donation in Scotland. DESIGN--Two methods: a quantitative survey using personal interviews based on a questionnaire and a qualitative survey based on group discussions. SETTING--Interviews based on the questionnaire were conducted
C R Acad Sci III. 1989;308(16):431-6. Unique Identifier : AIDSLINE MED/89274851
Bourin P; Mansour I; Levi F; Villette JM; Roue R; Fiet J; Rouger P; Doinel C; (I.N.S.E.R.M. n. U 76), Paris.
Circadian rhythms in circulating B and T (CD3, CD4, CD8) lymphocyte subsets and in plasma cortisol were studied in 13 HIV-infected men and 14 healthy male controls. The circadian maximum (acrophase) of plasma cortisol was similar in both groups, approximately 8.00 A.M., however, a statistically significant increase wa
Tauris P; Moller B; Petersen CM; Black FT; University Department of Clinical Immunology, University of; Arhus, Denmark.
Although an optimal dose-regimen has still not been established, the antiviral drug 3 -azido-3 -deoxythymidine is known to improve the clinical condition of patients suffering from acquired immunodeficiency syndrome and acquired immunodeficiency syndrome-related complex. The drug effect has mainly been assessed in ter
28 HIV-infected persons (19 stadium II, 5 stadium III, 4 stadium IV) were investigated for CD4+ lymphocytes, HIV p24 core antigen and urinary neopterin. Monitoring the course of infection repeated estimations were done. Urinary neopterin was found elevated in 26 out of 28 infected people (p less than 0.001). There is
As first step for the development of a programme of haemophilia care, the disease was diagnosed locally in 5 bleeders. These patients were all affected by severe haemophilia A. They were treated with fresh frozen plasma for bleedings. All of them were negative for antibodies to HIV. The potentialities of the Blood Tra
South Med J. 1989 Jun;82(6):719-22. Unique Identifier : AIDSLINE MED/89283802
Farrior J
Osteomyelitis of the temporal bone often begins with minor trauma and results in a persistent external otitis. I report my experience with ten patients managed with combined medical and surgical therapy, and discuss the progression of the disease process and how it affects the duration of antibiotic therapy and the in
Ragni MV; Bontempo FA; Lewis JH; Department of Medicine, University of Pittsburgh School of; Medicine, Pennsylvania.
The spontaneous disappearance of the inhibitor to factor VIII (FVIII) was observed in two human immunodeficiency virus (HIV)-infected men with hemophilia A. Both men had end-stage HIV infection, one with acquired immune deficiency syndrome (AIDS) and one with severe AIDS-related complex (ARC). Loss of the inhibitor wa
Caruso A; Foresti I; Gribaudo G; Bonfanti C; Pollara P; Dolei A; Landolfo S; Turano A; Institute of Microbiology, University of Brescia, Italy.
High serum levels of antibodies to interferon-gamma (IFN-gamma) have been found in patients infected with human immunodeficiency virus (HIV). A radioimmunoassay (RIA) with a recombinant IFN-gamma protein or an affinity purified IFN-gamma preparation as antigens, was developed to detect the specific anti-IFN-gamma anti
Ullrich R; Zeitz M; Heise W; L'age M; Hoffken G; Riecken EO; Free University of Berlin, Federal Republic of Germany.
STUDY OBJECTIVE: To determine small intestinal mucosal structure and function in patients with human immunodeficiency virus (HIV) infection. DESIGN: Prospective, consecutive sample study. SETTING: Referral-based medical clinics at a municipal and a university medical center. PATIENTS: Forty-five HIV-infected patients
Steinberg JP; Spear JB; Murphy RL; Wallemark CB; Benson CA; Kessler HA; Pottage JC Jr; Phair JP; Department of Medicine, Northwestern University School of; Medicine, Chicago, IL 60611.
Fifty-eight AIDS patients who previously had Pneumocystis carinii pneumonia (PCP) were enrolled in an open trial of zidovudine therapy. We analyzed baseline clinical and laboratory parameters to identify predictors of outcome. Fifty-eight patients were followed for a mean of 26.5 weeks. There were 17 deaths; the proba
Jason J; Gomperts E; Lawrence DN; Holman RC; Bouhasin JD; Miller R; Evatt BL; Division of Host Factors, Centers for Disease Control, Atlanta,; Georgia 30333.
The acquired immune deficiency syndrome (AIDS) often has profound effects on growth; however, the effects of human immunodeficiency virus (HIV) on asymptomatic children s growth are unknown. Before heat inactivation/HIV donor screening of factor concentrates, many hemophilic children became infected with HIV. We evalu
Dedera D; Hu W; Vander Heyden N; Ratner L; Department of Medicine, Washington University, St. Louis,; Missouri 63110.
Viral protein R (VPR) is conserved in human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). To assess its function, we have constructed mutations within the vpr coding regions of HIV-1 and HIV-2 predicted to express truncated VPR products. Infectious virus was produced by each proviral clone and showed similar
JAMA. 1989 Jun 16;261(23):3424-9. Unique Identifier : AIDSLINE MED/89259237
Kaslow RA; Blackwelder WC; Ostrow DG; Yerg D; Palenicek J; Coulson AH; Valdiserri RO; National Institute of Allergy and Infectious Diseases, Bethesda,; MD 20892.
In a multicenter cohort study of homosexual men, the proportion of seropositives at enrollment who developed the acquired immunodeficiency syndrome (AIDS) during the following 18 months ranged from 5.5% to 8.2% in 1597 alcohol drinkers vs 9.2% in 109 nondrinkers with no clear trend according to use, and from 6.3% to 9
Pneumocystis carinii pneumonia (PCP), the most common presenting manifestation of the acquired immunodeficiency syndrome (AIDS), is a major and recurring cause of morbidity and mortality for persons infected with the human immunodeficiency virus (HIV). In recent years, important advances have been made in understandin
Nature. 1989 Jun 1;339(6223):383-5. Unique Identifier : AIDSLINE MED/89262051
Clerici M; Stocks NI; Zajac RA; Boswell RN; Bernstein DC; Mann DL; Shearer GM; Berzofsky JA; Experimental Immunology Branch, National Cancer Institute,; Bethesda, Maryland 20892.
T lymphocytes from mice and healthy humans immunized against the human immunodeficiency virus (HIV) envelope have recently been shown to recognize two antigenic regions of the gp160 HIV-envelope protein which have been located on the basis of amphipathicity. In HIV-infected humans, T-cell proliferative responses are l
Roos MT; Miedema F; Eeftinck Schattenkerk JK; de Wolf F; Goudsmit J; Lange JM; Danner SA; Out TA; Schellekens PT
The relationship between infection with human immunodeficiency virus (HIV) and various immunological parameters was studied in: (a) healthy controls; (b) homosexual individuals from the AIDS risk group without anti-HIV antibodies; (c) idem, but with anti-HIV antibodies; (d) patients with persistent generalized lymphad
Expertising on HIV-infected patients will become more frequent in future. These can be suffering - besides already existing mental disturbances - from further health disturbances of reactive and cerebro-organic origin caused by the HIV infection. Expertising requires extensive diagnostic exploration especially for cle
The epidemic became apparent in Tanzania in 1983. Ever since, case reporting seems to point at a dynamic progression of HIV-spread. In Tanzania HIV seems to be transmitted predominantly by heterosexual contact, transplacentally, by blood transfusions and possibly by traditional r
A high percentage of intravenous drug addicts was found among HIV-infected individuals who had been detected by anonymous testing from May, 1985, to October, 1988, at the AIDS Counselling Service of the Municipal Health Department in Stuttgart. Among the subjects being seropositive for HIV-1 antibodies, 36.6% were dru
Federal German Land legislation on the prevention of blood contact infections (legislation on hygiene) now also enforced in the Rhineland-palatinate (Rheinland-Pfalz) deals with relevant hygienic prerequisities for instalations and equipment that can be involved in spreading diseases which can be transmitted by blood.
MacPhail LA; Greenspan D; Schiodt M; Drennan DP; Mills J; University of California, San Francisco.
We report the case of an immunocompromised patient with AIDS in whom developed a perioral and several intraoral HSV 2 lesions that persisted for more than 1 year. The virus was resistant to acyclovir but was sensitive to foscarnet. Viral isolates were thymidine kinase negative.
Presse Med. 1989 May 20;18(20):1010-13. Unique Identifier : AIDSLINE MED/89264333
Adjrad L; Amara A; Rouabhi F; Girot R; Labie D; Benabadji M; Centre de Transfusion sanguine, CHU Sidi M'Hamed, Alger,; Algerie.
During the years 1982-1987, 66 patients with homozygous beta-thalassaemia were treated at the blood transfusion centre of Algiers. The patients, aged from 1 to 23 years in 1982, came from 48 families, 30 of which were issued from consanguinous unions. The patients fell into three groups according to the early institut
Mannucci PM; Zanetti AR; Gringeri A; Tanzi E; Morfini M; Messori A; Tirindelli MC; de Biasi R; Ciavarella N; Colombo M; Study Group of the Fondazione dell'Emofilia, Milan, Italy.
Short-term studies indicate that hepatitis B vaccines are safe and satisfactorily immunogenic in hemophiliacs. The duration of immunity in these immunocompromised patients, however, is not known. To determine this, we studied 78 hemophiliacs prospectively 2, 3, and 4 years after the initial vaccination with a plasma-d
Aust Paediatr J. 1989 Apr;25(2):86-8. Unique Identifier : AIDSLINE MED/89286511
Henry RL; Hankin RG; Abramson R; University of Newcastle, Newcastle Mater Hospital, Waratah, New; South Wales, Australia.
A double-blind crossover study was performed on 33 children with asthma to compare the effectiveness of nebulized solutions of preservative-containing and preservative-free ipratropium bromide. Both solutions produced bronchodilation. No significant differences were found between the two solutions at any time after ne
Jensen OA; Klinken L; Eye Pathology Institute, University of Copenhagen, Denmark.
During the years 1984-1987, a consecutive Danish autopsy material of 43 AIDS cases was analysed in order to investigate a possible coincidence of pathological changes in brain and eye. In the brain, nodular gliosis/encephalitis was most frequent, followed by cytomegalovirus infecti
AIDS Res Hum Retroviruses. 1989 Feb;5(1):23-32. Unique Identifier : AIDSLINE MED/89247163
Earl PL; Robert-Guroff M; Matthews TJ; Krohn K; London WT; Moss B; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
The immune responses produced by four macaques inoculated intradermally with a recombinant vaccinia virus that expresses the envelope gene of human immunodeficiency virus (HIV) were analyzed. Antibody capable of immunoprecipitating the glycosylated envelope protein precursor gp160 was detected in all animals within 3
AIDS Res Hum Retroviruses. 1989 Feb;5(1):33-9. Unique Identifier : AIDSLINE MED/89247164
Shafferman A; Lennox J; Grosfeld H; Sadoff J; Redfield RR; Burke DS; Department of Virus Diseases, Walter Reed Army Institute of; Research, Washington, D.C. 20307.
A total of six amino acid sequences encoded in conserved regions of the HIV-env (three from gp120 and three from gp41) were selected as potential antigenic domains. These sequences (11-20 amino acids) were fused to the NH2 terminus of beta-galactosidase by recombinant DNA techniques, and the purified chimeric proteins
AIDS Res Hum Retroviruses. 1989 Feb;5(1):7-22. Unique Identifier : AIDSLINE MED/89247169
Venable RM; Pastor RW; Brooks BR; Carson FW; Biophysics Laboratory, Food and Drug Administration, Bethesda, MD; 20892.
Three-dimensional computer models for two segments of the C terminus of gp41, the transmembrane AIDS envelope protein, which may form amphipathic alpha-helices, have been generated using structure prediction techniques combined with energy minimization and molecular dynamics simulations. Regions gp41(772-790) and gp41
AIDS Res Hum Retroviruses. 1989 Feb;5(1):73-8. Unique Identifier : AIDSLINE MED/89247170
Amadori A; Ciminale V; Calabro ML; Tessarollo L; Francavilla E; Chieco-Bianchi L; Institute of Oncology, University of Padua, Italy.
An EBV-transformed lymphoblastoid B cell clone (A12) derived from peripheral blood lymphocytes of an HIV-1-infected individual is described. The immunoglobulin isotype produced by this clone was IgM, and Southern blot analysis of immunoglobulin gene rearrangement showed a monoclonal pattern. The A12 monoclonal antibod
AIDS Res Hum Retroviruses. 1989 Feb;5(1):79-85. Unique Identifier : AIDSLINE MED/89247171
McDonald JF; Josephs SF; Wong-Staal F; Strand DJ; Department of Genetics, University of Georgia, Athens 30602.
The long terminal repeats (LTRs) of the human immunodeficiency virus (HIV) the Rous sarcoma virus (RSV) and the copia Drosophila retrotransposon were compared in their capacity to direct expression of the bacterial cat (chloramphenicol acetyltransferase) gene in human, murine, and Drosophila cell lines. The results in
Norley SG; Kurth R; Paul-Ehrlich-Institut, Frankfurt, Federal Republic of Germany.
Retroviruses are single stranded RNA viruses that possess a unique enzyme, reverse transcriptase. This enzyme facilitates the synthesis of double stranded DNA intermediates able to integrate into the genome of the host cell. Although primarily a means of remaining latent, this integration can have the effect of transf
C R Acad Sci III. 1989;308(14):401-6. Unique Identifier : AIDSLINE MED/89248611
Clement JM; Szmelcman S; Jehanno M; Martineau P; Schwartz O; Hofnung M; Unite de Programmation moleculaire et Toxicologie genetique; C.N.R.S.-U.A. n degrees 271, I.N.S.E.R.M. n degrees U 163.
Genetic fusions allowing the expression in E. coli of hybrid proteins between a bacterial periplasmic maltose binding protein (MalE) and the CD4 molecule (the receptor of the HIV virus) have been constructed. One of them has kept most of the properties of each constituent: it is exported, can be purified in one step o
Cell. 1989 May 5;57(3):469-81. Unique Identifier : AIDSLINE MED/89249309
Arthos J; Deen KC; Chaikin MA; Fornwald JA; Sathe G; Sattentau QJ; Clapham PR; Weiss RA; McDougal JS; Pietropaolo C; et al; Smith Kline and French Laboratories, King of Prussia,; Pennsylvania 19406.
The CD4 molecule is a T cell surface glycoprotein that interacts with high affinity with the envelope glycoprotein of the human immunodeficiency virus, HIV, thus serving as a cellular receptor for this virus. To define the sites on CD4 essential for binding to gp120, we produced several truncated, soluble derivatives
Nicholson JK; Jones BM; Division of Host Factors, Centers for Disease Control, Atlanta,; Georgia 30333.
Lymphocyte immunophenotyping has been done at the Centers for Disease Control since 1981. The technology is constantly evolving, and changes have been instituted to keep up with and improve this technology. In the last 7 years we have analyzed approximately 8300 specimens from patients and persons at risk in projects
Qavi HB; Green MT; SeGall GK; Font RL; Division of Molecular Virology, Baylor College of Medicine,; Houston, TX 77030.
Using an immunohistochemical technique and monoclonal antisera, HIV-1 and CMV antigens were demonstrated in lesioned areas of retinal tissues from selected AIDS patients. Polymerase chain reaction (PCR) was utilized to detect HIV-1 and HHV-6 DNA sequences in tot
Landini MP; Mirolo G; Re MC; Ripalti A; La Placa M; Institute of Microbiology, Medical Faculty, St. Orsola General; Hospital, Bologna, Italy.
A total of 56 sera from asymptomatic HIV-seropositive subjects and patients with symptomatic HIV infection were studied by immunoblotting for IgM, IgG and IgG subclass reactivity against cytomegalovirus structural polypeptides. The results showed a high percentage of IgM-positive s
Toohey MG; Jones KA; Molecular Biology and Virology Laboratory, Salk Institute, La; Jolla, California 92037.
Trans-activation of HIV-1 transcription by the viral regulatory protein Tat has been proposed recently to overcome a block to RNA polymerase II elongation in vivo imposed by 5 -untranslated leader sequences. Interestingly, however, only full-length transcripts, rather than prematurely terminated HIV RNAs, are synthesi
De Paepe ME; Waxman M; Department of Pathology, St. Vincent's Hospital and Medical; Center, New York.
The pertinent clinical data and histologic features of the testes in 57 autopsied acquired immunodeficiency syndrome (AIDS) patients were analyzed and compared with those of 55 age-matched control patients without AIDS. The testes of the AIDS patients showed a significantly lower degree of spermatogenesis (determined
Pal R; Kalyanaraman VS; Hoke GM; Sarngadharan MG; Department of Cell Biology, Bionetics Research Inc., Rockville,; Md 20850.
The processing and secretion of the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) were studied in chronically infected cells treated with the trimming glucosidase inhibitor deoxynojirimycin (DNM). In Molt3 cells infected with human T-lymphotropic virus type III (HTLV-IIIB), DNM inhibited the int
Bardy B; Morinet F; Perol Y; Department of Virology, University of Helsinki, Finland.
The occurrence of Epstein-Barr virus (EBV) specific DNase antibodies was measured in the sera of 400 patients. Three hundred sera were positive (greater than or equal to 20) for early antigen diffuse component (EA-D) antibodies, as measured by indirect immunofluorescence (IF). One hundred sera were EA-D antibody-negat
Dewar RL; Vasudevachari MB; Natarajan V; Salzman NP; Division of Molecular Virology and Immunology, Georgetown; University School of Medicine, D.C. 20007.
When human immunodeficiency virus type 1 envelope glycoproteins were expressed in 293 cells by using a recombinant adenovirus expression vector, the envelope precursor (gp160) was initially glycosylated by cotranslational addition of N-linked high-mannose oligosaccharide units to the protein backbone and then cleaved
Hiscott J; Alper D; Cohen L; Leblanc JF; Sportza L; Wong A; Xanthoudakis S; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis-Jewish General Hospital, Montreal, Quebec, Canada.
The relationship between transcription of alpha and beta interferon (IFN-alpha and IFN-beta) genes and the interaction of IFN promoter-binding transcription factors has been examined in monoblastoid U937 cells following priming with recombinant IFN-alpha 2 (rIFN-alpha 2) and Sendai virus induction. Pretreatment of U93
Chaunu MP; Ratinahirana H; Raphael M; Henin D; Leport C; Brun-Vezinet F; Leger JM; Brunet P; Hauw JJ; Laboratoire de Neuropathologie R. Escourolle, Hopital de La; Salpetriere, Paris, France.
Nerve and muscle biopsies were performed on 20 patients with HIV infection and peripheral neuropathy . Nine patients had distal symmetrical peripheral neuropathy (DSPN) (six ARC and three AIDS), six had inflammatory demyelinating polyneuropathy (IDP) (three ARC, one AI
Nature. 1989 Jun 1;339(6223):385-8, 340. Unique Identifier : AIDSLINE MED/89262052
Evans DJ; McKeating J; Meredith JM; Burke KL; Katrak K; John A; Ferguson M; Minor PD; Weiss RA; Almond JW; Department of Microbiology, University of Reading, UK.
The Sabin type 1 vaccine strain of poliovirus is probably the safest and most successful live-attenuated vaccine virus used in humans. Its widespread use since the early 1960s has contributed significantly to the virtual eradication of poliomyelitis in developed countries. We have reported previously the construction
Cook HW; Spence MW; Atlantic Research Centre for Mental Retardation, Department of; Pediatrics, Dalhousie University, Halifax, NS, Canada.
Dideoxycytidine (ddCyd), an inhibitor of AIDS-related HIV, has been examined for effects on cell proliferation and phosphatidylcholine synthesis in tumor lines of nervous system origin. Uptake and metabolism of [3H]ddCyd, observed in all cells, was greatest in one human neuroblastoma line, HTB-10. Growth of the HTB-10
Greenspan JS; Greenspan D; Division of Oral Biology, University of California, San Francisco; 94143-0512.
Oral hairy leukoplakia (HL) is a remarkable lesion associated with Epstein-Barr virus (EBV) found in persons infected with the human immunodeficiency virus. The clinical and histologic features of HL are characteristic and distinctive. However, none of these features are entirely specific for HL, and we consider that
Sciubba J; Brandsma J; Schwartz M; Barrezueta N; Department of Dentistry, Long Island Jewish Medical Center, New; Hyde Park, NY 11042.
Hairy leukoplakia has been defined and confirmed as a specific oral mucosal marker for human immunodeficiency virus infection. Light microscopic findings include alteration of spinous layer cells, which contain nuclear chromatin abnormalities. Enlargement of spinous cells with ballooning degeneration is also character
Kabani S; Greenspan D; deSouza Y; Greenspan JS; Cataldo E; Tufts University School of Dental Medicine, Boston, MA 02111.
Oral hairy leukoplakia (HL) is a lesion that occurs predominantly on the tongue in HIV-infected persons. Evidence strongly indicates that HL is related to the presence of Epstein-Barr virus in the epithelial cells. The lesion appears on the lateral border of the tongue as a painless, white plaque varying in size from
Green TL; Greenspan JS; Greenspan D; De Souza YG; School of Dentistry, Department of Stomatology and Oral AIDS; Center, University of California, San Francisco.
Oral hairy leukoplakia is seen in immunosuppressed persons infected with the human immunodeficiency virus and is a predictor of the development of acquired immunodeficiency syndrome in that population. Over the past 3 years we have seen 16 examples of a lesion that histologically resembles hairy leukoplakia but is fou
Green TL; Eversole LR; Department of Stomatology, University of California, San; Francisco.
Nine instances of oral non-Hodgkin s lymphoma occurring in homosexual male patients infected with the human immunodeficiency virus were evaluated for clinical features, histopathologic features, lymphocyte phenotypic markers, and Epstein-Barr virus (EBV) DNA. Histologically, the tu
Benabbou L; Verdier M; Leonard G; Sangare A; Gershy-Damet GM; Mounier M; Rey JL; Terrot C; Denis F; Service de Bacteriologie-Virologie, CHU Dupuytren, Limoges,; France.
Chlamydial serum antibodies were screened in more than 1,000 persons by immunofluorescence test. C. trachomatis antibodies (greater than or equal to 1/16 for males, greater than or equal to 1/64 for females) were found more frequently in risk group (prostitutes: 64.7%, prisoners: 64.0%) than in control groups (pregnan
Vega-Alvarez M; Garbarg-Chenon A; Goulin J; Nicolas JC; Bricout F; Laboratoire de Virologie, Hopital Trousseau, Paris, France.
Cytomegalovirus is frequently isolated from immunosuppressed patients or from patients with acquired immunodeficiency syndrome. Twelve patients were studied for several months. In 7 patients more than 1 Cytomegalovirus was isolated; in one of these patients three viruses were isolated, two of them show small differenc
Manoff SB; Gayle HD; Mays MA; Rogers MF; AIDS Program, Center for Infectious Diseases, United States; Department of Health and Human Services, Atlanta, GA 30333.
Kuppuswamy M; Subramanian T; Srinivasan A; Chinnadurai G; Institute for Molecular Virology, St Louis University School of; Medicine, MO 63110.
The tat gene of HIV-1 is a potent trans-activator of gene expression from the HIV long terminal repeat (LTR). To define the functionally important regions of the product of the tat gene (Tat) of HIV-1, deletion, linker insertion and single amino acid substitution mutants within the Tat coding region of strain SF2 were
Proc Natl Acad Sci U S A. 1989 May;86(10):3842-6. Unique Identifier : AIDSLINE MED/89264519
Szebeni J; Wahl SM; Popovic M; Wahl LM; Gartner S; Fine RL; Skaleric U; Friedmann RM; Weinstein JN; Theoretical Immunology Section, National Cancer Institute,; Bethesda, MD 20892.
Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory effects of 3 -azido-3 -deoxythymidine ( AZT ) and 2 ,3 -d
Proc Natl Acad Sci U S A. 1989 May;86(10):3862-6. Unique Identifier : AIDSLINE MED/89264523
Chattopadhyay SK; Morse HC 3d; Makino M; Ruscetti SK; Hartley JW; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
C57BL/6 mice infected with a mixture of murine leukemia viruses (MuLV) develop a syndrome characterized by lymphoproliferation and profound immunodeficiency. Analyses of this viral mixture (LP-BM5 MuLV) showed that it includes replication-competent ecotropic and mink cell focus-inducing MuLV and defective viruses with
Science. 1989 Jun 2;244(4908):1075-8. Unique Identifier : AIDSLINE MED/89266919
Hildreth JE; Orentas RJ; Department of Pharmacology and Molecular Sciences, Johns Hopkins; University School of Medicine, Baltimore, MD 21205.
Cell fusion (syncytium formation) is a major cytopathic effect of infection by human immunodeficiency virus (HIV) and may also represent an important mechanism of CD4+ T-cell depletion in individuals infected with HIV. Syncytium formation requires the interaction of CD4 on the surface of uninfected cells with HIV enve
Science. 1989 Jun 9;244(4909):1186-9. Unique Identifier : AIDSLINE MED/89266943
Laumann EO; Gagnon JH; Michaels S; Michael RT; Coleman JS; Department of Sociology, University of Chicago, IL 60637.
Respondents in the 1988 General Social Survey (GSS) were asked to scan their acquaintance networks to identify all those who had been a victim of a homicide or had acquired immunodeficiency syndrome (AIDS). Estimates of the sex, race, age, and regional breakdowns for homicides in the last year and for people with AIDS
Felser JM; Klimkait T; Silver J; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
We describe a syncytia assay that utilizes a noninfectious plasmid (pEVd1443) derived from human immunodeficiency virus type I (HIV-I). This plasmid carries a large deletion of gag-pol sequences but expresses HIV-I envelope proteins and induces syncytia following transfection into HeLa-CD4 cells. This plasmid was used
Inoue T; Tsushita K; Itoh T; Ogura M; Hotta T; Saneyoshi M; Yoshida S; Saitoh H; Tomoda Y; Nagai Y; Department of Obstetrics and Gynecology, Nagoya University School; of Medicine, Japan.
3 -Azido-2 ,3 -dideoxythymidine is known to cause severe anemia and neutropenia. Although these are rare for 2 ,3 -dideoxycytidine, it frequently impairs thrombocytogenesis. These differential myelossuppressive features correlated well with the in vitro toxicities of the drugs for a megakaryoblastic cell line and for
Shanley JD; Debs RJ; University of Connecticut VA Medical Center, Newington.
Cytomegalovirus ( CMV ) is a major source of morbidity for immunocompromised patients, such as AIDS patients. The folic acid antagonists have not been explored as potential antiviral agents against CMV. We examined the effects of methotrexate, compared to
Guyer DR; Jabs DA; Brant AM; Beschorner WE; Green WR; Uveitis and Clinical Immunology Service, Wilmer Ophthalmological; Institute, Johns Hopkins Hospital, Baltimore, MD 21205.
A 55-year-old man with the acquired immunodeficiency syndrome had cytomegalovirus ( CMV ) retinitis develop in his left eye. The patient declined treatment with ganciclovir but elected to be treated with zidovudine. Two months
Biochem Biophys Res Commun. 1989 May 15;160(3):1429-37. Unique Identifier : AIDSLINE GENBANK/M25955
Ferguson BQ; Friedland BK; Hendrickson E; Strehl L; Petteway SR; Jonak GJ; Medical Products Department, E.I. du Pont de Nemours & Co., Inc.,; Wilmington, DE 19880.
A gene encoding the human immunodeficiency virus-1 (HIV-1) TAT protein was chemically synthesized and expressed in HeLa cells and in a cell-free system. To facilitate both the assembly of the synthetic gene and further mutagenesis and gene fusion studies, several unique restriction endonuclease cleavage sites were inc
Biochem Biophys Res Commun. 1989 May 30;161(1):134-42. Unique Identifier : AIDSLINE GENBANK/M26709
Gama Sosa MA; Hall JC; Schneider KE; Lukaszewicz GC; Ruprecht RM; Division of Cancer Pharmacology, Dana-Farber Cancer Institute,; Boston, MA.
Supercoiled pHXBc2 DNA (containing the genome of the human immunodeficiency virus type 1 and human sequences) migrated more slowly than linear DNA in native and ethidium bromide agarose gel electrophoresis at 4.5 volts/cm, suggesting the presence of unusual DNA structures. S1 nuclease analysis of pHXBc2 revealed two S
Biochem Biophys Res Commun. 1989 May 30;161(1):305-11. Unique Identifier : AIDSLINE MED/89273653
Sosa MA; DeGasperi R; Fazely F; Ruprecht RM; Dana-Farber Cancer Institute, Boston, MA.
A DNA fragment containing the tat, rev and env genes of the human immunodeficiency virus type 1 was inserted into the retroviral vector pZIPneoAU3. The resulting plasmid penvAU3 was transfected into HeLa and psi CRIP cells. Resulting recombinant retroviruses were used to infect HeLa and Jurkat cells. Immunoprecipitati
AIDS Res Hum Retroviruses. 1989 Jun;5(3):259-68. Unique Identifier : AIDSLINE MED/89274034
Bu M; Oroszlan S; Luftig RB; Department of Microbiology, Immunology and Parasitology, LSU; Medical Center, New Orleans.
HIV protease is a virally coded enzyme that cleaves gag as well as gag-pol precursor polyproteins into functional products needed for virus assembly. A pUC plasmid containing an HIV insert starting at the 5 end of the pol gene and ending just inside the intergrase coding sequence was expressed in E. coli. It provided
AIDS Res Hum Retroviruses. 1989 Jun;5(3):275-8. Unique Identifier : AIDSLINE MED/89274036
Bacheler LT; Strehl LL; Neubauer RH; Petteway SR Jr; Ferguson BQ; Medical Products Department, E.I. du Pont de Nemours & Co., Inc.,; Wilmington, DE 19880-0400.
Since HIV tat function is essential for the HIV infectious cycle, it represents an important possible target of therapeutic intervention for HIV infection. Stable human cell lines were derived that express high levels of beta-galactosidase under the combined control of the transacting HIV-1 tat gene product and the ci
AIDS Res Hum Retroviruses. 1989 Jun;5(3):311-9. Unique Identifier : AIDSLINE MED/89274040
Cao YZ; Hosein B; Borkowsky W; Mirabile M; Baker L; Baldwin D; Poiesz BJ; Friedman-Kien AE; New York University Medical Center, Department of Microbiology,; NY 10016.
Specific antibodies to human immunodeficiency virus type 1 (HIV-1) were detected in 200-fold concentrated urine samples, but none were detected in unconcentrated urine specimens, from 100 randomly selected HIV-1--seropositive individuals by enzyme-linked immunosorbent assay (ELISA) and Western blot techniques using th
AIDS Res Hum Retroviruses. 1989 Jun;5(3):327-36. Unique Identifier : AIDSLINE MED/89274042
Shafferman A; Layne A; Sadoff J; Burke DS; Morton WR; Benveniste RE; Department of Virus Diseases, Walter Reed Army Institute of; Research, Washington, D.C. 20307.
Four stretches of amino acid sequences encoded in conserved HIV-1 env domains and four parallel regions of the SIVmac env (two from gp120 and two from gp41/p32E) were fused to the NH2 terminus of beta-galactosidase by recombinant DNA techniques and used to analyze sera from three macaque species experimentally infecte
AIDS Res Hum Retroviruses. 1989 Jun;5(3):337-43. Unique Identifier : AIDSLINE MED/89274043
Kodama T; Silva DP; Daniel MD; Phillips-Conroy JE; Jolly CJ; Rogers J; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.
We have documented rare infection of baboons in their native habitat with simian immunodeficiency virus (SIV). Of 124 sera collected from yellow baboons in central Tanzania , two gave high readings by SIVagm ELISA (greater than 1.0) and moderate by SIVmac ELISA (0.5-1.0). These tw
AIDS Res Hum Retroviruses. 1989 Jun;5(3):355-66. Unique Identifier : AIDSLINE MED/89274045
Spickett G; Beattie R; Farrant J; Bryant A; Dalgleish A; Webster D; Division of Immunological Medicine, Clinical Research Centre,; Harrow, Middlesex, United Kingdom.
The effect of different HIV-1 isolates on normal human B lymphocyte function has been studied in vitro. Production of IgM and IgG was measured by ELISA using a standard non-T preparation of B cells depleted of macrophages and T cells (but not of low-density accessory cells, LDC). Only one (H9/CBL-4) of five different
Harris ML; Mathalone MB; St Stephen's Hospital, London.
A case is reported of a 35-year-old male with established acquired immune deficiency syndrome who developed cytomegalovirus retinitis. When intravenous treatment with ganciclovir had to be withdrawn because of toxicity, one eye was treated successfully by intravitreal injections of
Langerhans cells (LC) are epidermal dendritic cells which express several surface antigens among them the CD4 antigens. We investigated the fate of HIV envelope glycoproteins (gp 120 and gp 160) incubated with healthy human trypsinized LC in suspension. After trypsin treatment only the epitope for OKT4 appeared to be
Int J Cancer. 1989 Jun 15;43(6):1017-21. Unique Identifier : AIDSLINE MED/89277574
Masucci G; Mellstedt H; Henle G; Henle W; Rymo L; Masucci MG; Ernberg I; Klein G; Dept. of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Non-Hodgkin lymphoma (NHL) patients with centroblastic (Cb) or centroblastic-centrocytic (Cb/Cc)-diffuse lymphomas, immunocytoma (IC) and chronic lymphocytic leukemia (CLL) in clinical stages III-IV and with active disease (highly malignant group) were compared to NHL patients with CLL, IC, and centrocytic (Cc) or cen
Int J Cancer. 1989 Jun 15;43(6):1104-11. Unique Identifier : AIDSLINE MED/89277589
Lai PK; Li X; Volsky DJ; Department of Virology, Showa University Research Institute, St.; Petersburg, FL 33716.
Individuals infected with the human immunodeficiency virus (HIV), the etiologic agent of acquired immunodeficiency syndrome (AIDS), often show symptoms associated with reactivation of Epstein-Barr virus (EBV). In this study, we show that exposure of EBV-positive B lymphocytes to HIV-1 in vitro induced the EBV replicat
We have established 40 cell cultures from biopsies of 5 patients with sporadic Kaposi s sarcoma (KS) and compared them with cell cultures derived from KS biopsies of AIDS patients. Immunocytochemical staining of sporadic KS cells revealed the same endothelial cell markers as those expressed on AIDS-KS cells, indicatin
Tremblay M; Wainberg MA; Lady Davis Institute for Medical Research, Sir Mortimer B.; Davis--Jewish General Hospital, Montreal, Quebec, Canada.
How 3 -azido-3 -deoxythymidine ( AZT ) affects the ability of three different variants of HIV-1 to infect a line of EBV-transformed B cells was studied. Susceptible cells were pretreated with three different concentrations of AZT (1, 5, and 10 microM) f
Saito I; Servenius B; Compton T; Fox RI; Department of Basic and Clinical Research, Scripps Clinic, La; Jolla, California 92037.
Polymerase chain reaction has been used to detect increased levels of EBV DNA in salivary gland (SG) biopsies and PBL from patients with Sjogren s syndrome (SS). These results suggest that EBV, which has a normal site of latency in a small number of SG epithelial cells, may be reactivated in SS patients and provide a
Walker DG; Itagaki S; Berry K; McGeer PL; Kinsmen Laboratory of Neurological Research, Department of; Psychiatry, Vancouver, BC, Canada.
The role of direct virus infection as a determining factor in acquired immunodeficiency syndrome (AIDS) dementia was investigated using in situ hybridisation for human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV). Four of the fi
Nature. 1989 Jun 15;339(6225):548-51. Unique Identifier : AIDSLINE MED/89281717
Clayton LK; Sieh M; Pious DA; Reinherz EL; Laboratory of Immunobiology, Dana-Farber Cancer Institute,; Boston, Massachusetts.
Interactions of CD4 with the class II major histocompatibility complex (MHC) are crucial during thymic ontogeny and subsequently for helper and cytotoxic functions of CD4+CD8- T lymphocytes. CD4 is the receptor for the T-lymphotropic human immunodeficiency virus and binds its envelope glycoprotein, gp120. The residues
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4793-7. Unique Identifier : AIDSLINE MED/89282857
Colgate SA; Stanley EA; Hyman JM; Layne SP; Qualls C; Theoretical Division, Los Alamos National Laboratory, NM 87545.
The cumulative number of cases of acquired immunodeficiency syndrome (AIDS) in the United States has grown as the cube of time rather than exponentially. We explain this by interactions involving partner choice and sexual frequency in a risk-behavior model with biased mixing. This lead
Oberg B; Department of Antiviral Chemotherapy, Research & Development; Laboratories, Astra Alab AB, Sodertalje, Sweden.
This article describes the antiviral properties of foscarnet (trisodium phosphonoformate) at the enzyme level as well as in cell cultures and in vivo. The mechanism of action against herpesvirus DNA polymerases and reverse transcriptases is outlined. Clinical studies using topical foscarnet against mucocutaneous herpe
Barcena Marugan R; Perez Hernandez F; Capelo Jaramillo L; Rodriguez Medal J; Milicua Salmeron JM; Quereda Rodriguez-Navarro C
The authors report and HIV positive patient whose first manifestation of AIDS was the appearance of a giant esophageal ulcer due to cytomegalovirus . We comment on the frequency, clinical manifestations, diagnosis and endoscopic aspects of esophageal cytomegalovirus affectation.
Zeidner NS; Strobel JD; Perigo NA; Hill DL; Mullins JI; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523.
2 ,3 -dideoxycytidine ( ddC ) inhibits replication of the immunodeficiency inducing strain of feline leukemia virus (FeLV-FAIDS) in vitro at concentrations ranging from 1-10 micrograms/ml. Additive antiviral effect is achieved when ddC is combined with
AIDS Res Hum Retroviruses. 1989 Feb;5(1):107-14. Unique Identifier : AIDSLINE MED/89247162
Desportes I; Bonnet D; Nicol I; Snart R; Sarin P; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.
HIV antigens were detected by immunoelectron microscopy at the surface of human and simian T4 lymphocytes that had been infected in vitro. HIV antigens were detected at the surface of cells exhibiting viral particles but also at the surface of cells before the release of virions. The latter cells may be considered imm
Ito M; Baba M; Hirabayashi K; Matsumoto T; Suzuki M; Suzuki S; Shigeta S; De Clercq E; Department of Bacteriology, Fukushima Medical College, Japan.
Mannan sulfate, a novel sulfated polysaccharide, was prepared and investigated for its activity against human immunodeficiency virus type 1 (HIV-1) in vitro. Mannan sulfate completely inhibited HIV-1-induced cell destruction and viral antigen expression in HIV-1-infected Molt-4 (clone 8) cells at a concentration of 4
Specificity of autoantibodies against lymphocyte antigens was assayed in sera of patients with autoimmune hematologic diseases, leukemias, secondary immunodeficiencies as well as in sera of persons seropositive to antibodies against retroviruses HTLV-I and HTLV-III. Autoantigens of the lysates of stimulated peripheral
Ito S; Yamamoto N; Nomoto K; Sasaki K; Onodera K; Shin-Etsu Chemical Co., Ltd., Tokyo.
n-Pentyl ether of damavaricin Fc (n-pentyl DvFc) preferentially killed human T-cell lymphotropic virus type I (HTLV-I)-transformed cell lines. The mechanism of action of the drug was investigated using MT-4 cells. Cytotoxic action was diminished by the removal of n-pentyl DvFc from the culture or by the addition of su
J Immunol. 1989 Jun 15;142(12):4248-55. Unique Identifier : AIDSLINE MED/89256672
Honda M; Kitamura K; Matsuda K; Yokota Y; Yamamoto N; Mitsuyasu R; Chermann JC; Tokunaga T; Department of Cellular Immunology, National Institute of Health,; Tokyo, Japan.
By using a fluorescence sandwich ELISA, elevated IL-2R levels were detected in the sera from both HIV-infected hemophiliacs and other HIV-infected patients. The serum IL-2R levels were reflective of the classification of HIV-induced diseases by the Centers for Disease Control. Moreover, the IL-2R levels were negativel
Jacobson MA; Abrams DI; Volberding PA; Bacchetti P; Wilber J; Chaisson RE; Crowe S; Howard W; Moss A; Department of Medicine, University of California, San Francisco.
Abnormally elevated serum beta 2-microglobulin has been associated with progression of human immunodeficiency virus (HIV) disease and could reflect in vivo HIV activity. We prospectively studied the effect of azidothymidine therapy on serum beta 2-microglobulin concentration in 41 patients with AIDS or AIDS-related co
Kramer A; Wiktor SZ; Fuchs D; Milstien S; Gail MH; Yellin FJ; Biggar RJ; Wachter H; Kaufman S; Blattner WA; et al; National Cancer Institute, Rockville, MD 20852.
In 79 homosexual men infected with human immunodeficiency virus (HIV), urinary neopterin was significantly higher as compared with 70 HIV-seronegative men in the same cohort (p less than 0.0001). This highly significant association was found both for naturally occurring oxidized (native) neopterin and for total neopte
Med J Aust. 1989 Jan 16;150(2):87-92. Unique Identifier : AIDSLINE MED/89261478
Tindall B; Swanson C; Whyte BM; Perdices M; Cooper DA; NHMRC Special Unit in AIDS Epidemiology and Clinical Research,; University of New South Wales, Surry Hills.
van der Poel CL; Lelie PN; Reesink HW; van Exel-Oehlers PJ; Tersmette M; van den Akker R; Gonzalves M; Huisman JG; Red Cross Blood Bank Amsterdam, The Netherlands.
During a follow-up period of 23-40 months, 7 regular blood donors had persistently, and 4 had intermittently indeterminate anti-p24gag reactivity in human immunodeficiency virus (HIV)-1 Western Blot. Serological testing and viral cultures revealed that these donors had no signs of infection for HIV-1, HIV-2, human T-c
Ann Intern Med. 1989 Jun 15;110(12):963-9. Unique Identifier : AIDSLINE MED/89271461
Eyster ME; Ballard JO; Gail MH; Drummond JE; Goedert JJ; Pennsylvania State University School of Medicine, Hershey.
STUDY OBJECTIVE: To investigate the predictive value of assays for human immunodeficiency virus (HIV) p24 antigen, p24 antibody, and gp120 antibody compared with T4 cell counts. DESIGN: Prospective cohort selected from persons who had HIV-antibody seroconversion. PATIENTS: Eighty-seven persons with hemophilia with an
Ann Intern Med. 1989 Jun 15;110(12):970-5. Unique Identifier : AIDSLINE MED/89271462
LoPresti JS; Fried JC; Spencer CA; Nicoloff JT; University of Southern California School of Medicine, Los; Angeles.
STUDY OBJECTIVE: To determine alterations in serum thyroid hormone indices in patients with human immunodeficiency virus (HIV) infection. DESIGN: Prospective, single-blind study. SETTING: Large metropolitan hospital where 20% of all patients with the acquired immunodeficiency syndrome (AIDS) in Los Angeles are treated
Terpstra FG; Al BJ; Roos MT; De Wolf F; Goudsmit J; Schellekens PT; Miedema F; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
The early effects of infection with human immunodeficiency virus (HIV) were investigated in homosexual men who had seroconverted for anti-HIV antibodies. Leukocyte functional activities were determined in longitudinally collected peripheral blood mononuclear cell samples. During the first 10 months following seroconve
Lancet. 1989 Jun 17;1(8651):1348-53. Unique Identifier : AIDSLINE MED/89280865
Girard PM; Landman R; Gaudebout C; Lepretre A; Lottin P; Michon C; De Truchis P; Matheron S; Camus F; Farinotti R; et al; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Claude Bernard, Paris, France.
To examine the efficacy and tolerance of pentamidine aerosol in the prevention of Pneumocystis carinii pneumonia (PCP) relapse in patients with the acquired immunodeficiency syndrome (AIDS) being treated with zidovudine, 51 patients who had had an episode of PCP in the previous 5 months were enrolled in a randomised c
AIDS Res Hum Retroviruses. 1989 Feb;5(1):41-50. Unique Identifier : AIDSLINE MED/89247165
Van Eendenburg JP; Yagello M; Girard M; Kieny MP; Lecocq JP; Muchmore E; Fultz PN; Riviere Y; Montagnier L; Gluckman JC; UER Pitie-Salpetriere, Paris, France.
The only animal that can be reproducibly infected with HIV, and that thus provides an experimental system for testing the effectiveness of prototype vaccines, is the chimpanzee. We compared proliferative responses to HIV and to vaccinia virus (VV) antigens of lymphocytes taken at various times from chimpanzees vaccina
We have raised a rabbit monospecific antibody against a synthetic peptide derived from a sequence within the COOH-terminal portion of the reverse transcriptase (RT) of HIV-1. This sequence was also found to be conserved in the predicted amino acid sequence of HIV-2. The antibody, designated C2003, cross-reacted with H
AIDS Res Hum Retroviruses. 1989 Feb;5(1):61-71. Unique Identifier : AIDSLINE MED/89247168
Padberg C; Nowlan S; Mermer B; Department of Molecular Biology, Baxter Healthcare Corporation,; Cambridge, MA 02139.
Eight fragments derived from the HIV-1 pol gene were expressed as recombinant polypeptides in Escherichia coli. The fragments were from the portion of the pol gene that encodes the reverse transcriptase. The expressed peptides were analyzed immunologically with sera from HIV-1-infected individuals. Three distinct immu
Stringer SL; Stringer JR; Blase MA; Walzer PD; Cushion MT; University of Cincinnati College of Medicine, Department of; Microbiology and Molecular Genetics, Ohio 45267-0524.
Pneumocystis carinii is the etiologic agent of a lethal pneumonia which occurs in patients with the acquired immune deficiency syndrome (AIDS) and other immunocompromised hosts. The basic biochemical and genetic characteristics of P. carinii are poorly understood and its taxonomic classification as a protozoan is unce
FEBS Lett. 1989 May 8;248(1-2):48-52. Unique Identifier : AIDSLINE MED/89252050
Hattori T; Koito A; Takatsuki K; Kido H; Katunuma N; Second Department of Internal Medicine, Kumamoto University; Medical School, Japan.
Trypstatin, a new cellular Kunitz-type protease inhibitor purified from rat mast cells, inhibited syncytium formation in human immunodeficiency virus type 1 (HIV-1)-infected CCRF-CEM and uninfected Molt-4 clone 8 at a concentration of 1 microM. Anti-rat tongue mast cell tryptase antibodies reacted with Molt-4 clone 8
Selby MJ; Bain ES; Luciw PA; Peterlin BM; Howard Hughes Medical Institute, Department of Medicine,; University of California, San Francisco 94143.
The human immunodeficiency virus (HIV-1)-encoded trans-activator (tat) increases HIV gene expression and replication. Previously, we demonstrated that tat facilitates elongation of transcription through the HIV-1 long terminal repeat (LTR) and that short transcripts corresponding to prematurely terminated RNA are rele
Ajito K; Atsumi S; Ikeda D; Kondo S; Takeuchi T; Umezawa K; Institute of Microbial Chemistry, Tokyo, Japan.
It was reported that doxorubicin inhibited virus reverse transcriptase. We have synthesized various new 14-O-acyladriamycins. The derivatives having a 17-O-benzoyl group with hydrophobic aliphatic side chains showed stronger inhibitory activity on human immunodeficiency virus reverse transcriptase and lower cytotoxici
Basu A; Tirumalai RS; Modak MJ; Department of Biochemistry and Molecular Biology, University of; Medicine and Dentistry of New Jersey-New Jersey Medical School,; Newark 07103-2757.
Human immunodeficiency virus reverse transcriptase (HIV-RT) exhibits a strong sensitivity to pyridoxal 5 -phosphate (PLP), a substrate-binding site directed reagent for DNA polymerases (Modak, M. J. (1976) Biochemistry 15, 3620-3626). Treatment of HIV-RT with PLP followed by sodium borohydride reduction of the enzyme-
Laurence J; Friedman SM; Chartash EK; Crow MK; Posnett DN; Laboratory for Acquired Immunodeficiency Syndrome (AIDS) Virus; Research, Hospital for Special Surgery, New York.
HIV selectively inhibited the proliferative response of clonal CD4+ T lymphocytes to alloantigen while other alloantigen-dependent responses were unperturbed. Specifically, impaired blastogenesis could be dissociated from alloantigen-specific induction of the B cell activation molecule CD23, IL-4 release, and inositol
J Med Virol. 1989 Mar;27(3):188-95. Unique Identifier : AIDSLINE MED/89257289
Chrystie IL; Almeida JD; Department of Virology, United Medical and Dental School of; Guys', Hospital London, England.
Negative staining studies of human immunodeficiency virus (HIV) have been hampered by the fragile nature of the particles. Although detergent treatment is capable of releasing cores from HIV-2 particles, these are unstable and do not retain morphological integrity. Addition of glutaraldehyde will stabilise these struc
Baba M; Schols D; Nakashima H; Pauwels R; Parmentier G; Meijer DK; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Several cholic acid derivatives such as taurolithocholic acid, lithocholic acid 3-sulfate, taurolithocholic acid 3-sulfate, and glycolithocholic acid 3-sulfate were shown to inhibit selectively the replication of human immunodeficiency virus type 1 (HIV-1) in vitro. These compounds completely protected MT-4 cells agai
Matsuyama T; Hamamoto Y; Soma G; Mizuno D; Yamamoto N; Kobayashi N; Department of Virology and Parasitology, Yamaguchi University,; Japan.
Tumor necrosis factor (TNF), a monokine initially described as a tumoricidal agent, facilitated the replication of human immunodeficiency virus (HIV) in vitro. The viability of human T-cell line MOLT-4/HIV, chronically infected with HIV, was affected by the addition of a low dose (10 ng/ml) of recombinant TNF-alpha (r
Med Oncol Tumor Pharmacother. 1989;6(1):63-7. Unique Identifier : AIDSLINE MED/89260577
De Simone C; Albertini F; Almaviva M; Angarano G; Chiodo F; Costigliola P; Delia S; Ferlini A; Gritti F; Mazzarello G; et al; Insegnamento Malattie Infettive, Universita, L'Aquila, Italia.
Inosine-pranobex (methisoprinol, isoprinosine; INPX) is the p-acetamidobenzoic salt of N,N-dimethylamino-2-propanol and inosine in a 3:1 molar ratio. In early studies, INPX was found to partially inhibit human immunodeficiency virus (HIV) and to increase the immunocompetence of HIV-infected subjects in vitro. We repor
Bashir RM; Harris NL; Hochberg FH; Singer RM; Division of Neurology, University of Nebraska Medical Center,; Omaha 68105.
We used an optimized in-situ hybridization technique employing a biotinylated Epstein-Barr (EB) virus sequence, BamH1V (3.1 kb), to detect this sequence in 2 EB virus-infected cell lines (B95-8 and Namalwa) and 8 CNS lymphomas. We obtained a good hybridization signal from cytospins of B95-8 (EB virus productively infe
Corso B; Eversole LR; Hutt-Fletcher L; University of Florida, Gainesville 32610.
Hairy leukoplakia (HL) is an oral white lesion associated with, and probably caused by, the Epstein-Barr virus (EBV) among persons who are seropositive for infection with human immunodeficiency virus. A unique feature of HL is its localization to the lateral portion of the tongue. To determine site differences for EBV
Proc Natl Acad Sci U S A. 1989 May;86(10):3539-43. Unique Identifier : AIDSLINE MED/89264459
Krug MS; Berger SL; Division of Cancer Biology and Diagnosis, National Cancer; Institute, Bethesda, MD 20892.
A series of test substrates have been synthesized to establish the effect of termini on the putative exoribonuclease H activity of reverse transcriptase. Recombinant reverse transcriptase from human immunodeficiency virus, natural enzyme from avian myeloblastosis virus, and a known endonuclease, Escherichia coli ribon
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4205-9. Unique Identifier : AIDSLINE MED/89264586
Lederman MM; Purvis SF; Walter EI; Carey JT; Medof ME; Department of Medicine, Case Western Reserve University,; Cleveland, OH 44106.
Although the human immunodeficiency virus can induce cytopathic changes in human lymphocytes in vitro, the mechanism(s) underlying progressive lymphopenia in patients with AIDS and AIDS-related complex has not been elucidated. To investigate this issue, peripheral blood lymphocytes of AIDS and AIDS-related complex pat
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4244-8. Unique Identifier : AIDSLINE MED/89264595
Matsukura M; Zon G; Shinozuka K; Robert-Guroff M; Shimada T; Stein CA; Mitsuya H; Wong-Staal F; Cohen JS; Broder S; Division of Cancer Treatment, National Cancer Institute,; Bethesda, MD 20892.
In this report, we demonstrate the sequence-specific suppression of viral expression in T cells chronically infected with human immunodeficiency virus 1 (HIV-1), using antisense phosphorothioate oligodeoxynucleotides. As a target for antisense intervention, we used the HIV-1 gene rev, which is essential for viral repl
S D J Med. 1989 Apr;42(4):15-7. Unique Identifier : AIDSLINE MED/89266856
Lang E; Humphreys DW; Jaqua-Stewart MJ
Crusted (Norwegian) scabies, a highly contagious variant of classical scabies, has traditionally been associated with mentally retarded and physically debilitated patients. Recent reports have increasingly linked scabies with immunosuppression, as in acquired immunodeficiency syndrome (AIDS) and in transplant recipien
Treatment of AIDS is a complicated problem since there is a limited set of preparations tested and most of them appear to be ineffective. Their main target is HIV reverse transcriptase. The data presented show that proteolysis inhibitors are able to inhibit HIV reproduction in cell culture. The compounds used in this
A total of 177 children seen at two hospitals in Kampala are described who were strongly suspected of having acquired immunodeficiency syndrome (AIDS), either on clinical grounds or because they fulfilled the World Health Organization (WHO) case-definition criteria for diagnosis of pae
Shuler JD; Holland GN; Miles SA; Miller BJ; Grossman I; AIDS Unit of UCLA Uveitis Center.
Three studies were performed to assess more accurately the prevalence, natural history, and appropriate treatment of acquired immunodeficiency syndrome (AIDS)-related Kaposi sarcoma involving ocular structures. The first study was a prospective examination of 100 male homosexuals with AIDS-related Kaposi sarcoma for s
Biochem Biophys Res Commun. 1989 May 15;160(3):982-7. Unique Identifier : AIDSLINE MED/89273615
Ono K; Nakane H; Fukushima M; Chermann JC; Barre-Sinoussi F; Laboratory of Viral Oncology, Aichi Cancer Center Research; Institute, Nagoya, Japan.
5,6,7-Trihydroxyflavone (baicalein) is a potent inhibitor of the activities of reverse transcriptases from murine leukemia viruses (MLV) (Rauscher and Moloney strains) and human immunodeficiency virus (HIV). Under the reaction conditions specified for each of the MLV- and HIV-reverse transcriptases, both enzyme activi
AIDS Res Hum Retroviruses. 1989 Jun;5(3):269-74. Unique Identifier : AIDSLINE MED/89274035
Grinde B; Hungnes O; Tjotta E; Department of Virology, National Institute of Public Health,; Oslo, Norway.
Retroviruses depend on a virus-encoded proteinase. As this enzyme is an interesting target for antiviral therapy, we examined the effect of various low-molecular-weight proteinase inhibitors, as well as a few oligopeptides related to the proteolytic cleavage sites, on the replication of HIV-1 in H9 cells. The increase
AIDS Res Hum Retroviruses. 1989 Jun;5(3):293-302. Unique Identifier : AIDSLINE MED/89274038
Kanitakis J; Marchand C; Su H; Thivolet J; Zambruno G; Schmitt D; Gazzolo L; INSERM U 209, Clinique Dermatologique, Hopital Edouard Herriot,; Lyon, France.
Langerhans cells (LC) are dendritic epidermal antigen-presenting cells expressing the surface molecule CD4, which renders them theoretical cellular targets for direct infection by the human immunodeficiency virus (HIV). To date, somewhat conflicting results have been reported concerning the in vivo infection of LC by
Hall JC; Brewer JH; Appl BA; Department of Dermatology, St. Luke's Hospital, Kansas City,; Missouri.
A rare, severe form of scabies called Norwegian or keratotic scabies is described in a patient with acquired immune deficiency syndrome (AIDS). This is the first known description of this disease in an AIDS patient. The occurrence of secondary staphylococcal sepsis illustrates the importance of early correct diagnosis
Pope JH; Bisshop F; McRandle B; Blok J; Schmidt CW; Kemp RJ; Sir Albert Sakzewski Virus Research Laboratory, Royal Children's; Hospital, Brisbane, Qld., Australia.
Human immunodeficiency virus (HIV) was readily isolated by co-cultivation of patients cells with phytohaemagglutinin-stimulated mononuclear cells from umbilical cord blood in 2 ml cultures in 24-well plates. Fluids from cultures of the MLA 144 cell line acted as an excellent source of interleukin-2, and promoted earl
Taylor GM; Morten JE; Morten H; Dodge AB; Ridway JC; Jones PM; Harris R; Department of Medical Genetics, St Mary's Hospital, Manchester,; UK.
Two hybrid cell lines expressing human CD4 were prepared by fusing human B-lymphoid cells with the mouse T-lymphoma BW5147. Hybrid TF42 was derived from a human B-lymphoblastoid line and TF53.1 from a human B-ALL. Variants of these hybrids expressing or lacking CD4 were isolated by sorting cells stained with the monoc
Meloen RH; Liskamp RM; Goudsmit J; Central Veterinary Institute, Lelystad, The Netherlands.
An important antigenic determinant of human immunodeficiency virus type 1 that induces neutralizing activity in infected humans and chimpanzees was previously mapped with nonapeptides between amino acids 307 and 320 on the external envelope glycoprotein (gp 120) of strain HTLV-IIIB (molecular clone BH10) and amino aci
Gillespie D; Thompson J; Solomon R; Hahnemann University, Department of Neoplastic Diseases,; Philadelphia, PA 19102.
A set of probes was designed for the quantitation of HIV-1 RNA in infected cells by a molecular hybridization procedure called reversible target capture. Reversible target capture is analogous to sandwich hybridization, except that the link between hybrid complexes and the affinity support was reversible, allowing for
Proc Natl Acad Sci U S A. 1989 Jun;86(12):4710-4. Unique Identifier : AIDSLINE MED/89282840
Robinson WE Jr; Montefiori DC; Mitchell WM; Prince AM; Alter HJ; Dreesman GR; Eichberg JW; Department of Pathology, Vanderbilt University, Nashville, TN; 37232.
Based on recent reports of antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection in vitro by serum from HIV-1-infected humans, sera from HIV-1 antibody-positive chimpanzees (Pan troglodytes) was evaluated for enhancing activity in an in vitro infection assay that uses MT-2 cells (a hu
Pontani DR; Sun D; Brown JW; Shahied SI; Plescia OJ; Schaffner CP; Lopez-Berestein G; Sarin PS; New Jersey Department of Health, Trenton 08625.
This report shows the potential of using a liposomal encapsulated preparation of amphotericin B (a polyene macrolide antibiotic) for the in vitro inhibition of HIV. There was no significant difference between the effective doses of the free form of drug when compared to the liposomal encapsulated preparation in inhibi
Montefiori DC; Robinson WE Jr; Mitchell WM; Department of Pathology, Vanderbilt University, School of; Medicine, Nashville, TN 37232.
Human immunodeficiency virus type 1 (HIV-1) infectivity and cytopathic effect require proper maturation of the viral envelope glycoprotein carbohydrate moieties. We have found that fresh human serum enhances the infectivity of HIV-1 in MT-2 cell infection assays when virus is synthesized in the presence of the mannosi
Biochem Biophys Res Commun. 1989 Jun 15;161(2):393-8. Unique Identifier : AIDSLINE MED/89286529
White EL; Parker WB; Macy LJ; Shaddix SC; McCaleb G; Secrist JA 3d; Vince R; Shannon WM; Kettering-Meyer Laboratory, Southern Research Institute,; Birmingham, AL 35255.
Carbocylic 2 ,3 -didehydro-2 ,3 -dideoxyguanosine (Carbovir; NSC 614846) is an antiretroviral agent which may be useful in the treatment of AIDS. We have synthesized the 5 -triphosphate of Carbovir and examined its ability to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (EC 2.7.7.49) and o
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