In vivo depression of lymphocyte traffic in sheep by VIP and HIV (AIDS)-related peptides. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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In vivo depression of lymphocyte traffic in sheep by VIP and HIV (AIDS)-related peptides.

Immunopharmacology. 1988 Nov-Dec;16(3):181-9. Unique Identifier : AIDSLINE MED/89307926
Moore TC; Spruck CH; Said SI; Department of Surgery, UCLA School of Medicine.

Abstract: Core pentapeptides and an octapeptide (Peptide T) computer deduced from amino acid sequences from vasoactive intestinal peptide (VIP) and the 120 gp external envelope of the HIV (AIDS) virus and synthesized have been reported to have important in vitro and in vivo activity including inhibition of HIV binding to CD4 surface antigens of brain cells and lymphocytes and limitation of HIV infectivity. Two of these core pentapeptides, peptide TTNYT (Peptide T [4-8]) and peptide TDNYT (VIP [7-11]), are reported here, on acute infusion into cannulated afferent popliteal lymphatics of sheep, to produce prompt and marked depressions in the output of both small recirculating and blast lymphocytes into popliteal lymph node efferent lymph. As with a prior VIP infusion study, there appeared to be a selective effect on T4 (CD4) lymphocytes, with a marked predominance of T4 (CD4) lymphocytes in the lymphocyte depleted efferent lymph.
Keywords: Animal Antigens, Differentiation, T-Lymphocyte/ANALYSIS *HIV Lymph Nodes/IMMUNOLOGY *Lymphocyte Depletion Lymphocytes/*DRUG EFFECTS/IMMUNOLOGY Oligopeptides/*PHARMACOLOGY Retroviridae Proteins/*PHARMACOLOGY Sheep Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Vasoactive Intestinal Peptide/*PHARMACOLOGY JOURNAL ARTICLE

KWDanimalantigens,differentiation,t-lymphocyte/analysisKWDhivlymphnodes/immunologyKWDlymphocytedepletionlymphocytes/KWDdrugeffects/immunologyoligopeptides/KWDpharmacologyretroviridaeproteins/KWDpharmacologysheepsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDvasoactiveintestinalpeptide/KWDpharmacologyjournalarticle
891030
M89A0608

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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