The value of lymph node histology in human immunodeficiency virus related persistent generalized lymphadenopathy. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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The value of lymph node histology in human immunodeficiency virus related persistent generalized lymphadenopathy.

APMIS Suppl. 1989;8:24-7. Unique Identifier : AIDSLINE MED/89287145
Gerstoft J; Pallesen G; Mathiesen LR; Pedersen C; Gaub J; Lindhardt BO; Department of Infectious Diseases, Rigshospitalet, University of; Copenhagen, Denmark.

Abstract: Histological changes in lymph nodes were evaluated in a prospective study of 124 homosexual men who presented with generalized lymphadenopathy. The histological changes were classified according to a classification system with three stages. HIV antibodies were present in 88% of the patients. The finding of one of the three histopathological stages was highly indicative--although not absolutely pathognomonic--for HIV infection. The subsequent course of HIV infection after biopsy was significantly correlated to the histopathological changes, but it was not possible to evaluate if the biopsy added new information to that already available. Among the group of HIV infected, immediate clinical consequences of lymph node biopsy were not observed (95% confidence limits 0-3.3%). In a retrospective investigation of 123 consecutive AIDS patients, it was found that lymph node histopathology had been able to identify secondary infections and neoplasms among 10%. It is concluded that lymph node biopsy is indicated in the HIV infected patients with unexplained generalized symptoms or with atypical enlargement of the lymph nodes. The prognostic significance of lymph node histology compared to other prognostic parameters of HIV infection, remains to be determined.
Keywords: Adult Aged AIDS-Related Complex/CLASSIFICATION/*PATHOLOGY Biopsy Follow-Up Studies Homosexuality Human HIV-1 Lymph Nodes/*PATHOLOGY Male Middle Age Predictive Value of Tests Prognosis Prospective Studies Retrospective Studies JOURNAL ARTICLE

KWDadultagedaids-relatedcomplex/classification/KWDpathologybiopsyfollow-upstudieshomosexualityhumanhiv-1lymphnodes/KWDpathologymalemiddleagepredictivevalueoftestsprognosisprospectivestudiesretrospectivestudiesjournalarticle
891030
M89A0585

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