Cerebral spinal fluid IgG production in HIV-positive patients. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Cerebral spinal fluid IgG production in HIV-positive patients.

Recenti Prog Med. 1989 Mar;80(3):150-2. Unique Identifier : AIDSLINE MED/89297731
Cirelli A; Ciardi M; Rossi F

Abstract: A brief characterization of 27 neurologic syndromes occurring in 44 AIDS patients during two years is presented. In 4 out of 7, intrathecal Ig synthesis was demonstrated without the CSF cell count and blood brain barrier values being within a normal range. Ig intrathecal formation was also observed in 2 LAS patients without neurological symptoms. Similar changes in CSF findings occur in other subacute encephalitis, particularly in multiple sclerosis. Activation of CSF B-cells or their depression due to impairment of CD8 T-lymphocytes was indicated as the cause of this phenomenon. In the Authors' opinion this explanation is somewhat general. The possibility of an immune response in CNS was clearly demonstrated, but in the CSF neither B-cells nor Ig producing plasma cells are evident. In addition, it should be noted that the reliability of blood brain barrier and Ig intrathecal assessment procedures is doubtful in ADC disease, because of the severe alterations in serum albumin and Ig concentrations seen in these patients.
Keywords: Acquired Immunodeficiency Syndrome/*CEREBROSPINAL FLUID/ COMPLICATIONS/IMMUNOLOGY Adult Aged AIDS-Related Complex/*CEREBROSPINAL FLUID/COMPLICATIONS/ IMMUNOLOGY Central Nervous System Diseases/*CEREBROSPINAL FLUID/ COMPLICATIONS/IMMUNOLOGY Female Human IgG/*CEREBROSPINAL FLUID Male Middle Age JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDcerebrospinalfluid/complications/immunologyadultagedaids-relatedcomplex/KWDcerebrospinalfluid/complications/immunologycentralnervoussystemdiseases/KWDcerebrospinalfluid/complications/immunologyfemalehumanigg/KWDcerebrospinalfluidmalemiddleagejournalarticle
891030
M89A0495

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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