Santa Monica, CA : Pyramid Film and Video, 1988 1 videocassette (23 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/8901430A
West KH; Williams GR
(Producer) Infection control procedures for safety and health care professionals, how to minimize the risk of contracting AIDS and other infectious diseases. Includes information on barrier prec autions, needle stick injuries, and Universal Precautions recommended by the Center for Disease Control.
Atlanta, Ga. : U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, [1986] v, 25 p. : ill (Immunology series (Atlanta, Ga.) ; no. 15) Unique Identifier : AIDSLINE CAT/8913730
New York : AMA Membership Publications Division, American Management Association, c1988 160 p (AMA management briefing) Unique Identifier : AIDSLINE CAT/8914792
San Francisco, Calif. : AIDS Health Project, University of California, San Francisco ; Berkeley, Calif. : Distributed to the trade by Celestial Arts, c1989 xi, 400 p Unique Identifier : AIDSLINE CAT/8913750
Pacific and Control of HIV Infection and AIDS Manila, Philippines : World Health Organization, Regional Office for the Western Pacific, [1989] ii, 58 p. : ill., ports Unique Identifier : AIDSLINE CAT/8914738
Berlin ; New York : Springer-Verlag, c1989 vii, 115 p. : ill (Current topics in microbiology and immunology ; 142) Unique Identifier : AIDSLINE CAT/8914657
Radiology of AIDS. Federle MP et al, eds. New York, Raven, 163 p., 1988.. Unique Identifier : AIDSLINE ICDB/89655310
Anonymous; No affiliation given
The number of reported cases of AIDS continues to grow alarmingly, making recognition of the diverse manifestations of this syndrome increasingly important. The present volume is an outgrowth of an extensive interchange of experience and ideas between members of the Departments of Radiology at the San Francisco Genera
Radiology of AIDS. Federle MP et al, eds. New York, Raven, p. 1-20, 1988.. Unique Identifier : AIDSLINE ICDB/89655311
Bessen LJ; Hymes KB; Greene JB; New York Univ. Medical Center, 560 First Ave., New York, NY 10016
Since its first description in 1981, more than 35,000 persons in the United States and as many as 1 million persons worldwide have contracted AIDS. It is estimated that between 1 and 2 million persons in the United States already have been infected with the causative agent, HIV. Epidem
Radiology of AIDS. Federle MP et al, eds. New York, Raven, p. 21-46, 1988.. Unique Identifier : AIDSLINE ICDB/89655312
Olsen WL; Cohen W; San Francisco General Hosp., San Francisco, CA 94110
Neurological signs and symptoms in patients (pts) with HIV infection have become common features of the disease. Neuroimaging studies are frequently requested in these pts. Because AIDS is an ultimately fatal disease, the principal goal is to identify treatable components of HIV infection in order to prolong the time
Radiology of AIDS. Federle MP et al, eds. New York, Raven, p. 47-76, 1988.. Unique Identifier : AIDSLINE ICDB/89655313
Naidich DP; Garay SM; Goodman PC; Rybak BJ; Kramer EL; Bellevue Hosp., New York Univ. Medical Center, 560 First Ave.,; New York, NY 10016
More than 50% of patients (pts) with AIDS develop pulmonary manifestations at some time during the course of their disease. Radiographic evaluation plays an important role in the diagnosis and management of these pts, despite considerable overlap in the clinical and radiographic manifestations of these varied pulmonar
Radiology of AIDS. Federle MP et al, eds. New York, Raven, p. 107-29, 1988.. Unique Identifier : AIDSLINE ICDB/89655315
Federle MP; Nyberg DA; Hulnick DH; Jeffrey RB Jr; San Francisco General Hosp., San Francisco, CA 94110
The clinical manifestations of both Kaposi s sarcoma (KS) and AIDS-related lymphomas (ARLs) are highly variable and difficult to distinguish from other concurrent illnesses. Fever, weight loss, headache, diarrhea, and malaise are common complaints in many patients (pts) with AIDS, whether or not they have KS or lympho
Radiology of AIDS. Federle MP et al, eds. New York, Raven, p. 131-42, 1988.. Unique Identifier : AIDSLINE ICDB/89655316
Genieser NB; Hernanz-Schulman M; Krasinski K; Greco MA; Borkowsky W; New York Univ. Medical Center, 560 First Ave., New York, NY; 10016
By early 1987, at least 450 children under 13 yr of age had been reported to the Centers for Disease Control as having AIDS. This figure probably represents only 20% of children with symptomatic HIV infection; the number of children with asymptomatic infection is unknown. The typical presentation of children with HIV-
World Congress III on Cancers of the Skin. March 7-9, 1988, Houston, TX, M.D. Anderson Hospital and Tumor Institute and The Skin Cancer Foundation, 55 p., 1988.. Unique Identifier : AIDSLINE ICDB/89655583
Anonymous; No affiliation given
Abstracts of papers reported at the World Congress III on Cancers of the Skin, held March 7-9, 1988, in Houston, are presented. The symposium was held in sessions focusing on cutaneous melanoma, basal and squamous cell carcinoma, and miscellaneous skin cancers. Selected topics in the session on cutaneous melanoma incl
Kornstein MJ; Pietra GG; Hoxie JA; Conley ME; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia.
Two infants with AIDS who presented with interstitial pneumonitis, failure to thrive, lymphadenopathy, and hypergammaglobulinemia have been studied. Antibody to human T-lymphotropic retrovirus (HTLV-III) was identified by ELISA and Western blot analysis in serum samples from both patients. The T4/T8 ratios of peripher
Trans R Soc Trop Med Hyg. 1988;82(5):753-7. Unique Identifier : AIDSLINE MED/89299078
Smith PG; Morrow RH; Chin J; UNDP/World Bank/WHO Special Programme for Research and Training; in Tropical Diseases, Geneva, Switzerland.
Infections with the human immunodeficiency virus(es) (HIV) are likely to have a profound impact on the health of those in many parts of Africa over the next several decades. If there are adverse interactions between HIV infections and the endemic tropical diseases the overall impact of the HIV epidemic will be worse t
Simmons PA; Clough SR; Teagle RH; Jaanus SD; Department of Basic and Visual Sciences, Southern California; College of Optometry, Fullerton.
We investigated the effects of the ophthalmic preservatives thimerosal and sorbic acid on the proliferation and survival of rabbit corneal epithelial cells in tissue culture. Normally, explants of corneal epithelium grow vigorously during the first 7 days in culture. With 0.004% thimerosal present in the culture mediu
Moore TC; Spruck CH; Said SI; Department of Surgery, UCLA School of Medicine.
Core pentapeptides and an octapeptide (Peptide T) computer deduced from amino acid sequences from vasoactive intestinal peptide (VIP) and the 120 gp external envelope of the HIV (AIDS) virus and synthesized have been reported to have important in vitro and in vivo activity including inhibition of HIV binding to CD4 su
Trans R Soc Trop Med Hyg. 1988;82(5):761-6. Unique Identifier : AIDSLINE MED/89299081
Woodruff PW; Morrill JC; Burans JP; Hyams KC; Woody JN; US Naval Medical Research Unit No. 3, Cairo, Egypt.
Patients presenting at the Juba Teaching Hospital, either with fever of undetermined origin or with a clinical cause of fever, gave evidence of exposure to a wide range of viral and rickettsial agents. Serological tests showed high antibody levels to flaviviruses (56.9%) and alphaviruses (29.2%), with lesser levels of
Cancer Biochem Biophys. 1988 Nov;10(2):91-106. Unique Identifier : AIDSLINE MED/89303784
Veljkovic V; Metlas R; Laboratory for Multidisciplinary Research RA 180/2, Boris Kidric; Institute, Beograd, Yugoslavia.
The information contained in the primary structure of HIV envelope gp120 determining its biological activity, was analyzed by the use of the informational spectrum method. The parameter determining the interaction between gp120 and T4 cell-surface protein was defined. On the basis of this data in the conserved region
Gerstoft J; Pallesen G; Mathiesen LR; Pedersen C; Gaub J; Lindhardt BO; Department of Infectious Diseases, Rigshospitalet, University of; Copenhagen, Denmark.
Histological changes in lymph nodes were evaluated in a prospective study of 124 homosexual men who presented with generalized lymphadenopathy. The histological changes were classified according to a classification system with three stages. HIV antibodies were present in 88% of the patients. The finding of one of the
Dickson DW; Belman AL; Park YD; Wiley C; Horoupian DS; Llena J; Kure K; Lyman WD; Morecki R; Mitsudo S; et al; Department of Pathology, Albert Einstein College of Medicine,; Bronx, N.Y. 10461.
The neuropathologic findings of brains and spinal cords removed at autopsy from 26 infants and children with AIDS is described; in two cases, only the spinal cords were available. The most common finding in the brains was dystrophic calcification of blood vessels of all calibers in the basal ganglia and deep cerebral
Ost A; Baroni CD; Biberfeld P; Diebold J; Moragas A; Noel H; Pallesen G; Racz P; Schipper M; Tenner-Racz K; et al; Department of Pathology, Karolinska Institute, Stockholm, Sweden.
The histological alterations seen in HIV-related lymphadenopathy have been described with different terms by different authors. In order to facilitate comparisons of results from various laboratories, a group of pathologists of the European Lymphoma Study Group (later the European Association for Haematopathology) hav
Can J Psychiatry. 1989 May;34(4):320-2. Unique Identifier : AIDSLINE MED/89287953
Silva JA; Leong GB; Weinstock R; Ready DJ; School of Medicine, University of California, Los Angeles.
This article reports the case of a 28 year-old female presenting to a psychiatric inpatient unit with depression and a history of acquired immune deficiency syndrome (AIDS). Although medical assessment was negative for AIDS, psychiatric evaluation and psychological testing were consistent with a presentation of factit
Cell. 1989 Jun 30;57(7):1155-65. Unique Identifier : AIDSLINE MED/89288317
Emerman M; Vazeux R; Peden K; Unite d'Oncologie Virale, Institut Pasteur, CNRS UA1157, Paris,; France.
By in situ hybridization analysis and immunoprecipitations following transfection of COS cells, we show that the Rev protein of the human immunodeficiency virus is necessary for envelope protein expression, which is correlated with the appearance in the cytoplasm of envelope-specific RNA. In the absence of cotransfect
Sato Y; Shiroma Y; Department of Parasitology, School of Medicine, University of the; Ryukyus, Okinawa, Japan.
Sera from 91 patients with strongyloidiasis in Okinawa prefecture, Japan , were examined for the presence of the concurrent infection with adult T-cell leukemia (ATL) virus by detecting the antibody to ATL-associated virus antigen (anti-ATLA). As high as 73.6% of the patients were fo
Allen JN; Wewers MD; Ohio State University, Columbus.
A man with serologic evidence of HIV infection and a depressed T-helper:suppressor ratio developed fever, pulmonary infiltrates, and respiratory failure. Bronchoalveolar lavage and transbronchial biopsy failed to reveal an infectious cause; however, an open lung biopsy demonstrated classic bronchiolitis obliterans org
Mehle ME; Adamo JP; Mehta AC; Wiedemann HP; Keys T; Longworth DL; Department of Pulmonary Disease, Cleveland Clinic Foundation.
The pulmonary manifestations of AIDS are well described in the medical literature; however, MAI infection presenting as an endobronchial lesion has not, to our knowledge, been reported in a patient with AIDS. We report a unique case of an AIDS patient who developed endobronchial polypoid lesions secondary to MAI infec
A 29-year-old black man with HIV infection had an abnormal chest x-ray film with bilateral hilar adenopathy. Sarcoidosis was suspected, but a thorough and comprehensive evaluation was completed to differentiate the multiple infectious and noninfectious causes of these findings. Biopsy of a hilar node and pulmonary tis
Health Psychol. 1989;8(2):255-66. Unique Identifier : AIDSLINE MED/89289660
Hogan T; Department of Psychology, Agnes Scott College, Decatur, GA 30030.
Psychophysical methods were applied to measure and analyze attitudes toward the threat and control of acquired immune deficiency syndrome (AIDS). Participants rated and gave magnitude estimations for the amount of social restriction in 12 possibilities for controlling AIDS. The relation between ratings and magnitude e
Goddard C; Aquino A; Glazer RI; Felsted RL; Division of Cancer Treatment, National Cancer Institute,; Bethesda, MD 20892.
The N-terminal p17gag protein of the human immunodeficiency virus has been shown to incorporate radioactivity following labelling of infected cell lines with [3H]myristic acid. We investigated p17gag to determine whether the incorporated radioactivity was the consequence of N-terminal myristoylation. The virus was pur
Fillit H; Fruchtman S; Sell L; Rosen N; Mount Sinai Medical Center, New York.
Although acquired immunodeficiency syndrome (AIDS) remains relatively uncommon in the elderly, there are serious and unique implications associated with the diagnosis of AIDS in this age group. The most common mode of transmission is transfusion. With the growing number of elderly, an increase in AIDS in the elderly w
Paroni R; Del Puppo M; Borghi C; Sirtori CR; Galli Kienle M; Istituto Scientifico H. S. Raffaele, Milan, Italy.
Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a broad spectrum antiviral agent, with a primary indication in human immunodeficiency virus (HIV) infection, but with significant activity against more common viral pathogens. Since the available kinetic data are only in HIV patients, a study was carri
Issues Law Med. 1989 Spring;4(4):427-54. Unique Identifier : AIDSLINE MED/89291353
In 1988, the United States Supreme Court determined that primary alcoholism is willful misconduct that disqualifies veterans for an extension of time for educational benefits eligibility based on disability. The Civil Rights Restoration Act, passed in 1988, broadened the scope of progr
Maayan S; Engelhard D; Boger S; Ganer A; Morag A; Shapiro M; Sacks T; Department of Clinical Microbiology, Hadassah University; Hospital, Jerusalem, Israel.
Of the first 395 attendees at the AIDS clinic in Jerusalem, 32% were homo/bisexuals, 4% i.v. drug abusers (IVDAs), 24% persons with minimal risk for AIDS and 38% were persons having no risk. Human immunodeficiency virus (HIV) antibody rates were 7% for homosexuals, 29% for IVDAs, 1% for persons with minimal risk and 0
Hawaii Med J. 1989 Apr;48(4):125-6. Unique Identifier : AIDSLINE MED/89291410
Milbourne A; Nakamura S; Nakamura JM
The advent of recombinant DNA technology has brought us many new techniques for the detection of genetic defects. With these methods it has become possible to do prenatal screening of the DNA of fetuses and to detect genetic defects that would lead to congenital disease. The biggest problem facing researchers has been
Take Y; Kubo T; Takemori E; Inouye Y; Nakamura S; Nishimura T; Suzuki H; Yamaguchi H; Institute of Pharmaceutical Sciences, Hiroshima University School; of Medicine, Japan.
Antitumor antibiotic streptonigrin (STN-COOH) is a potent inhibitor of avian myeloblastosis virus (AMV) and human immunodeficiency virus reverse transcriptases. The carboxyl group at 2 -position of STN-COOH was modified to give esters, hydrazide, amides and amino acid derivatives for biological studies. Against AMV re
Raj NB; Israeli R; Kellum M; Pitha PM; Oncology Center, Johns Hopkins University School of Medicine,; Baltimore, Maryland 21205.
We have identified and functionally characterized DNA sequences that are required for the inducible and cell-restricted expression of the murine alpha 4-interferon gene. Hybrid plasmids in which the alpha 4 promoter region or its 5 deletions were inserted upstream of the CAT gene were constructed, and the expression
Fox PC; Wolff A; Yeh CK; Atkinson JC; Baum BJ; Clinical Studies Unit, National Institute of Dental Research,; 1B-21, Bethesda, MD 20892.
Human salivary gland secretions inhibit infection of human lymphocytes by the human immunodeficiency virus 1 (HIV-1), the causative agent of the acquired immune deficiency syndrome (AIDS). This activity was found in saliva collected directly from the orifice of the major salivary gland ducts and the whole saliva of he
Xu JY; Gorny MK; Zolla-Pazner S; Department of Pathology, New York University Medical Center, New; York 10016.
This paper describes a simple and rapid immuno-dot blot assay for the detection of antibody to HIV. It utilizes nanogram quantities of HIV lysate, immobilized on nitrocellulose paper, and microliter quantities of serum or culture supernatants for the detection of antibody. The test is highly sensitive and specific. It
J Med Virol. 1989 Jun;28(2):81-9. Unique Identifier : AIDSLINE MED/89293109
Harris JR; Kitchen AD; Harrison JF; Tovey G; North East Thames Regional Transfusion Centre, Brentwood, Essex,; England.
Infection of the permissive C8166 CD4+ lymphoid cell line with human immunodeficiency virus (HIV)-I rapidly leads to syncytium formation. Ultrastructural features of medium-sized (40 to 60 microns) syncytia and larger syncytia are presented, with emphasis upon HIV-I release from the syncytial surface and into intrasyn
J Med Virol. 1989 Jun;28(2):96-100. Unique Identifier : AIDSLINE MED/89293111
Miller EJ; Lee CA; Karayiannis P; Holmes S; Thomas HC; Kernoff PB; Academic Department of Haematology, Royal Free Hospital School of; Medicine, London, England.
Seventy-eight patients with congenital coagulation disorders were treated with hepatitis B vaccine either subcutaneously or intradermally. All the children (eight vaccinated subcutaneously and eight vaccinated intradermally) responded. Seventeen of 19 (90%) anti-HIV-negative adults vaccinated subcutaneously and 14/25
Scott JA; Palmer EL; Fischman AJ; Department of Radiology, Massachusetts General Hospital, Boston.
We report a case of myositis associated with human immunodeficiency virus (HIV) reactivity which was demonstrated on bone scan in the presence of normal muscle enzymes, contrast computed tomography, and electromyography. The diagnosis was confirmed by muscle biopsy. Radionuclide bone scanning may be a valuable diagnos
The gay community s response to AIDS is over seven years old. It has proved effective in significant areas and deficient in others. Given the amount of information and number of programs generated by the gay community s response, it is appropriate to examine ways in which the black community can avoid wasting valuable
Kelen GD; DiGiovanna T; Bisson L; Kalainov D; Sivertson KT; Quinn TC; Division of Emergency Medicine, Johns Hopkins University School; of Medicine, Baltimore, MD 21205.
In a study to assess the impact of the human immunodeficiency virus epidemic on The Johns Hopkins Hospital Emergency Department, we found 152 (6.0%) of 2544 consecutive patients to have human immunodeficiency virus infection, an absolute increase of 0.8% from the previous year. Of the 57 patients with a known history
This paper reviews the issues concerning occupational physicians in relation to HIV infection and AIDS, including the epidemiology and the indications for HIV antibody testing in employment. The role of the occupational physician in caring for employees infected with HIV and in educating the workforce is discussed.
Occupational health services need to be active in the development of local policies about AIDS/HIV and employment. Employment issues include the possible hazards from HIV infected employees, which are more fears than real risks, and the problems faced by HIV infected employees. Pre-employment HIV screening does not el
Since the beginning of the acquired immunodeficiency syndrome (AIDS) epidemic, the systems for epidemiological surveillance have monitored the dynamics of spread of the disease, thus permitting to identify the possible risk factors and the evaluation of the preventive measures that have been carried out. In the presen
Selleri L; Grassilli E; Tagliafico E; Corradi M; Luppi M; Ceccherelli G; Borghi V
The Acquired Immune deficiency Syndrome (AIDS), caused by the Human Immunodeficiency Virus (HIV) is now a worldwide social problem. Routine diagnostic procedures to identify infected individuals are based on the presence of antibodies against viral epitopes in the serum. There is nevertheless impelling need to detect
Farinelli M; Camera M; Del Bono V; Fiorelli MA; Panavese C; Valguarnera F
Cerebrospinal fluid (CSP) glucose values were measured in 37 HIV-positive patients with neurologic symptoms and in 35 HIV-negative controls affected by bacterial or viral meningo-encephalitis (ME). Low CSF glucose values were found more frequently in HIV+ patients (49% of cases) than in ME patients (14%). CSF/serum ra
Med Klin. 1989 May 15;84(5):242-5. Unique Identifier : AIDSLINE MED/89295308
Lohmoller G; Matuschke A; Goebel FD
False positive tests for autonomic neuropathy in HIV-infection and AIDS? Case-control-study of heart rate variation in 62 cases Autonomic neuropathy is said to be common in AIDS. In a cross section study we tested heart rate variability, a simple and sensitive test, in relation to disease severity. The expiratory-insp
Smith AG; Bustamante CI; Gilmor GD; Program in Medical Technology, University of Maryland School of; Medicine, Baltimore.
Absidia corymbifera is rarely cited as a cause of zygomycosis in the human host. Presented here is a case of absidiomycosis in a 29 year old construction worker hospitalized with a 6 year of intravenous drug abuse, serological evidence for HIV infection, and the symptomatology of AIDS. A CT scan and gallium uptake ima
Ned Tijdschr Geneeskd. 1989 May 13;133(19):978-80. Unique Identifier : AIDSLINE MED/89295654
Coutinho RA; Boer K; Schutte MF; van der Velde WJ; Mulder DK; van Doornum GJ
Pregnant women who were seen in 3 hospitals in Amsterdam were tested for antibodies to HIV, after informed consent. Out of 2,308 eligible pregnant women, 2,094 (90.7%) participated by name and 21 (0.9%) anonymously; 193 (8.4%) refused to participate. Among refusers there were significantly more women with a non-Dutch
Ned Tijdschr Geneeskd. 1989 May 20;133(20):1033-5. Unique Identifier : AIDSLINE MED/89295670
Wigersma L; Lemette HA; Hochheimer EH
In the Amsterdam gay weekend clinic the trends in numbers and sorts of sexually transmitted diseases (STD) and reasons for consultation about AIDS from 1983 till 1988 were assessed. A strong decrease in STD consultations and diagnoses was seen, especially concerning urethral and anorectal gonorrhoea. At the same time,
Rosenblum M; Scheck AC; Cronin K; Brew BJ; Khan A; Paul M; Price RW; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY 10021.
Although merging clinically within the spectrum of the AIDS dementia complex, vacuolar myelopathy is a pathologically distinct entity detected in up to 30% of autopsied patients succumbing to the late complications of human immunodeficiency virus type 1 (HIV-1) infection. Using imm
Kitay G; Shafer N; College of Physicians and Surgeons, Columbia University, New York; City.
Cafe coronary or foreign body upper airway obstruction claims more than 3,000 deaths each year in the United States . Early recognition of airway obstruction is imperative, because hypoxia of only four to six minutes duration may result in irreversible brain damage. Fortunately, the fo
Goodman E; Cohall AT; Columbia University College of Physicians and Surgeons, New York.
In this survey, the knowledge, attitudes, beliefs, and behaviors concerning acquired immunodeficiency syndrome (AIDS) in a group (N = 196) of innercity adolescents in New York City were assessed. Sexual activity was the major risk factor for AIDS in this population; 58% of the adolescents had engaged in sexual interco
Ratner L; Department of Medicine, Washington University, St Louis, MO; 63110.
Regulation of expression of platelet derived growth factor polypeptide B encoded by the c-sis proto-oncogene is important in a number of physiological and pathological conditions. Sequences in the 1028 nucleotide long 5 untranslated region of the c-sis mRNA were found to inhibit protein synthesis. The inhibition is r
Wormser GP; Joline C; Westchester County Medical Center, Valhalla, NY 10595.
Certain attitudes of healthcare workers toward patients infected with human immunodeficiency virus are inconsistent with medical knowledge and appear unlikely to be changed significantly or quickly by standard educational methods. Such attitudes may be detrimental to the doctor-patient relationship. Also, they detract
Proc Natl Acad Sci U S A. 1989 Jul;86(13):5168-72. Unique Identifier : AIDSLINE MED/89296966
Twu JS; Chu K; Robinson WS; Department of Medicine, Stanford University School of Medicine,; CA 94305.
The role of the hepatitis B virus (HBV) X gene during virus infection has not been defined. We previously showed that expression of the HBV X gene in the human hepatocellular carcinoma cell line HepG2 trans-activates chloramphenicol acetyltransferase gene expression under control of the human immunodeficiency virus 1
A case is described, that came to our attention for suspected acute intermittent porphyria, with abdominal pain and ascending tetraplegia. The patient (HIV positive and with a HBsAg positive chronic aggressive hepatitis) was a heroin addict. In urine: high porphyrins with extremely increased delta amino-levulinic acid
A brief characterization of 27 neurologic syndromes occurring in 44 AIDS patients during two years is presented. In 4 out of 7, intrathecal Ig synthesis was demonstrated without the CSF cell count and blood brain barrier values being within a normal range. Ig intrathecal formation was also observed in 2 LAS patients w
Schweiz Med Wochenschr. 1989 May 20;119(20):653-5. Unique Identifier : AIDSLINE MED/89298353
De Grandi P; Departement de gynecologie-obstetrique, CHUV, Lausanne.
As part of systematic serologic HIV screening offered early in pregnancy since 1 January 1987, a survey was carried out from 1 October 1987 to 30 April 1988 to discover the level of patient acceptability regarding the screening. Among 538 women presenting during this period with early pregnancy, 11 (2%) initially refu
Scott Med J. 1989 Apr;34(2):428-30. Unique Identifier : AIDSLINE MED/89298365
Stone MH; Stone DH; MacGreggor HA; Department of Orthopaedic Surgery, Glasgow Royal Infirmary.
The records of all 77,686 attendances at or via the accident and emergency department of the Glasgow Royal Infirmary in 1986 were examined. Of these, 488 (0.6%) contained evidence of intravenous drug misuse (IDM). Most (68%) of the 354 attenders were male. The mean age of attenders in both sexes was 22 years. Over hal
Scott Med J. 1989 Apr;34(2):433-7. Unique Identifier : AIDSLINE MED/89298367
Kennedy PG; Kennedy D; Love C; Dow MG; Bone I; Glasgow University Department of Neurology, Southern General; Hospital.
The neurological features of 10 patients with HIV-related disease seen in Glasgow between July 1984 and May 1988 are described. Two of these patients presented with ARC and eight with AIDS. Six patients showed features consistent with a diagnosis of AIDS- dementia complex, one had c
Sex Transm Dis. 1989 Apr-Jun;16(2):68-73. Unique Identifier : AIDSLINE MED/89298546
Andes WA; Rangan SR; Wulff KM; Department of Medicine, Tulane University School of Medicine, New; Orleans, LA 70112.
There is risk of transmission of human immunodeficiency virus (HIV) in sexually active couples, one of whom is seropositive. However, the frequency of such HIV transmission is not known. We have surveyed a population of monogamous hemophiliacs treated with potentially-infected coagulation factor concentrates during 19
Cochrane A; Kramer R; Ruben S; Levine J; Rosen CA; Department of Molecular Oncology, Roche Institute of Molecular; Biology, Nutley, New Jersey.
The human Immunodeficiency virus rev protein is one of several key regulatory proteins involved in the control of viral structural protein synthesis and replication. In this report, we identify the 20-kDa rev protein as a nuclear phosphoprotein. Post-translational modification was observed solely on serine residues. I
Z Hautkr. 1989 May 15;64(5):393-4, 397. Unique Identifier : AIDSLINE MED/89299843
Mahrle G; Rasokat H; Kurz K; Steigleder GK; Universitats-Hautklinik Koln.
We report on 3 HIV patients showing atypical courses of syphilis. Both the history and serology of the first patient proved a recent re-infection with T. pallidum, whereas the histopathological findings corresponded to an advanced stage of the disease (S II-III). The second patient showed the clinical picture of syphi
The anonymous survey of the population for the presence of human immunodeficiency virus (HIV) carried out in Moscow in 1987 revealed 4 seropositive persons among 10, 117 persons subjected to examination. These 4 persons belonged to typical risk groups with respect to the acquired immunodeficiency syndrome (AIDS). The
Araga S; Takahashi K; Ooi S; Division of Neurology, Institute of Neurological Sciences, Japan.
We present a case of subacute meningoencephalitis associated with human T-lymphotrophic virus Type I (HTLV-I) infection, for HTLV-I antibody being positive in serum and cerebrospinal fluid. Necropsy findings disclosed leptomeningeal and parenchymal mononuclear cell infiltration with multinucleate giant cells, which ar
Tomita I; Shibayama K; Matsuo H; Kinoshita I; Tsujihata M; Nagataki S; First Department of Internal Medicine, School of Allied Medical; Sciences, Nagasaki University, Japan.
Transcranial electrical stimulation of the motor cortex was performed in 7 patients with human T-lymphotropic virus type-I associated myelopathy (HAM) and 15 normal subjects. The mean value of central motor conduction time (CCT) for the thenar and hypothenar muscles in patients with HAM was not different from that in
Am Fam Physician. 1989 Jul;40(1):153-61. Unique Identifier : AIDSLINE MED/89300504
Jewell ME; Jewell GS; Wyoming AIDS Educational Training Center.
The physician must screen patients for risk of exposure to the human immunodeficiency virus (HIV). This requires direct and specific questioning about blood product exposure, sexual practices and use of intravenous drugs. If risk factors are uncovered, patients must then be counseled on how to minimize their risk. The
Mintz M; Rapaport R; Oleske JM; Connor EM; Koenigsberger MR; Denny T; Epstein LG; Department of Neurosciences, University of Medicine and Dentistry; of New Jersey, New Jersey Medical School, Newark.
The cytokine tumor necrosis factor (TNF) was assayed in the sera (n = 31) and cerebrospinal fluid (n = 26) of children with acquired immunodeficiency syndrome, using a competitive radioimmunoassay. Elevated serum levels of TNF were found in 15 (79%) of 19 patients with progressive encephalopathy (PE), compared with 1
Raphael SA; Wolfson BJ; Parker P; Lischner HW; Faerber EN; Department of Pediatrics, University School of Medicine; Philadelphia, Pa.
Although common in tropical regions, pyomyositis is rare in the continental United States . Fewer than 50 cases have been reported to date. It is characterized by suppuration of large muscle groups that can, if not quickly and appropriately treated, lead to sepsis and death. Diagnosis c
Am J Gastroenterol. 1989 Jul;84(7):787-9. Unique Identifier : AIDSLINE MED/89300690
Levy JA; Margaretten W; Nelson J; Department of Medicine, University of California, School of; Medicine, San Francisco.
The human immunodeficiency virus (HIV) was detected by in situ hybridization in the bowel crypt and lamina propria in the rectal mucosa of an acquired immune deficiency syndrome (AIDS) patient. More infected cells were noted in the crypts than the lamina propria. The enterochromaffin cell was one cell type showing the
Am J Psychiatry. 1989 Jul;146(7):876-80. Unique Identifier : AIDSLINE MED/89300912
Chuang HT; Devins GM; Hunsley J; Gill MJ; Department of Psychiatry, University of Calgary, Alberta, Canada.
The authors examined levels of psychosocial distress and well-being in 65 gay or bisexual men infected with the human immunodeficiency virus (HIV); 24 of these men had asymptomatic HIV infection, 22 had acquired immune deficiency syndrome (AIDS)-related complex, and 19 had AIDS. All of the men evidenced high levels of
Serum specimens from Puerto Rican residents were tested for antibodies to human T lymphotropic virus type I (HTLV-I) using an enzyme immunoassay, Western immunoblot, and radioimmunoprecipitation assays. Of 1,279 specimens obtained during a dengue virus surveillance program in 1986 and 1987, 3 (0.2%) tested positive; a
We have developed a microtiter-based sandwich hybridization assay for the detection of low copy number HIV-1 sequences. The assay employs a capture DNA sequence covalently coupled to microtiter wells through linker arms. The detection probe is a biotin-labeled DNA fragment derived from sequences adjacent to the captur
Berenguer J; Moreno S; Cercenado E; Bernaldo de Quiros JC; Garcia de la Fuente A; Bouza E; Hospital General Gregorio Maranon, Madrid, Spain.
In an 8-month period nine patients with human immunodeficiency virus (HIV) infection were diagnosed as having visceral leishmaniasis; all diagnoses were based on cultures (eight from bone marrow and one from the skin). Visceral leishmaniasis developed before full-blown acquired immunodeficiency syndrome (AIDS) in seve
Ann Urol (Paris). 1989;23(3):173-7. Unique Identifier : AIDSLINE MED/89301531
Boccon-Gibod L; Delmas V; Baron JC; Service d'Urologie, Hopital Bichat, Paris, France.
The frequency of urological manifestations of AIDS appears to be increasing at the present time: between 1985 and 1988, 38 HIV1 seropositive patients were examined in the Urology department. In seven cases, the positive serology was discovered during investigation of a urogenital infection and 21 patients suffered fro
Four patients with solid genito-urinary tumors and HIV 1 infection have been treated in our institution over the last 2 years, including 2 with seminoma, 1 with renal adenocarcinoma and 1 with renal angiosarcoma. All had severely impaired immunity with a low CD4 level. Three had or developed a true AIDS syndrome accor
Hagen MD; Meyer KB; Kopelman RI; Pauker SG; Department of Medicine, Tufts University School of Medicine, New; England Medical Center, Boston, Mass. 02111.
Physicians and other health care workers are concerned about their occupational risk of acquiring human immunodeficiency virus infection. We have developed an approach that can help health care workers estimate their cumulative risk of infection with human immunodeficiency virus. Illustrations are used to develop a sc
Linn LS; Kahn KL; Department of Medicine, UCLA Center for Health Sciences 90024.
Attitudes of 227 faculty and 148 housestaff physicians toward touching patients were studied in relationship to socio-demographic and job characteristics, previous exposure to and concern about HIV infection, and attitudes toward glove-wearing. Although a majority of the physicians felt that touching patients was pers
The use of both oral and intravenous administration of 3-azido-2,3-dideoxythymidine ( AZT ) to treat AIDS patients is associated with negative side effects, including toxic effects on bone marrow. This study was designed to investigate the release of de
Cancer. 1989 Aug 1;64(3):635-40. Unique Identifier : AIDSLINE MED/89303718
Ono K; Shimamoto Y; Suga K; Tokioka T; Sueoka E; Matsuzaki M; Sano M; Yamaguchi M; Suzuki H; Sato H; et al; Department of Internal Medicine, Saga Medical School, Japan.
Forty-three patients with adult T-cell leukemia (ATL), admitted to the hospital from 1982 to 1987, were studied. Five of those were found to have additional cancer; two of the five had two additional kinds of cancers besides ATL. During the same period, in contrast, the authors encountered only three patients with som
Cancer Detect Prev. 1989;13(5-6):333-6. Unique Identifier : AIDSLINE MED/89303948
Outschoorn IM; Lluberes R; Natta CL; Centro Nacional de Microbiologia, Instituto Carlos III,; Majadahonda, Madrid.
Decreased IgG subclass levels in pyogenic infections and immunocompromised situations have been described. A study was made to determine IgG subclass levels in four groups of 68 Hispanic patients. The first group consisted of 25 terminal patients with AIDS, the second group of 20 i.v. drug abusers, and the third group
Knowledge about AIDS was studied among 4,189 Zimbabwean teacher-trainees from January to March, 1988, about six months after a national AIDS awareness campaign began. Knowledge about AIDS among part of this sample of teacher-trainees surveyed after the AIDS campaign began was also compared with that displayed by 630 t
A retrospective investigation permitted us to show presence of HIV infection in Burundi between 1980 and 1981. 658 sera collected in healthy population of Burundi during this period have been tested for HIV1 and HIV2 with ELISA screening and western-blot analysis. Results complete
Human infestation by retrolentivirus which are incriminated in human disease called AIDS turns to be a serious endemic. Once adequate medicine and vaccine discovered, it could perhaps be jugulated or eradicated in ethno-ecosystems combining a high socioeconomic level and a heavy attendance of efficient biomedicine. Th
Giampalmo A; Pesce C; Ardoino S; Provaggi MA; Quaglia AC; Institute of Anatomical Pathology, University of Genoa, Italy.
Lesions of the central nervous system were seen in 13/22 autopsies of Italian subjects affected by the acquired immune deficiency syndrome and including 19 intravenous drug addicts. Multinucleated cells similar to those originally described by Sharer et al. [1985] in response to direct central nervous system lesions b
The patient was a 49-year-old woman. Since her age of 42, she noticed a proximal weakness of both legs. She also experienced pedal paresthesia and urinary frequency. Physical examination disclosed a diffuse goiter and bilateral Babinski sign. Results of EMG and muscle pathology were compatible with the diagnosis of po
We report two cases of HTLV-I associated myelopathy (HAM) who showed high HTLV-I antibody titers with clinically atypical neurological symptoms compared with typical HAM originally reported by Osame et al. Case 1 is a 59 year-old-woman who showed Shy-Drager syndrome-like symptoms such as a slowly progressive gait dist
Sahashi K; Ibi T; Tuchiya I; Morishima T; Takahashi A
A 36 year-old woman beginning with spastic paraparesis at her age of 11 visited us for evaluation of progressive muscular weakness of the distal portions of the upper extremities and difficulty in speaking at her age of 33. The neurological features at the present are as follows; fine horizontal gaze-nystagmus, impair
While the NHLBI is authorized and funded by the United States government, the Institute recognizes that advances in the science related to the prevention, diagnosis, and treatment of cardiovascular, lung, and blood diseases and to the management and development of blood resources can b
Greenberg RG; Berger TG; Department of Dermatology, University of California, San; Francisco.
We describe a patient with acquired immune deficiency syndrome (AIDS) and disseminated histoplasmosis. He presented with a mild inflammatory dermatitis that improved with topical steroid treatment but was proven to be cutaneous histoplasmosis. The clinical presentations, diagnosis, histopathologic basis, and treatment
Fisher CA; McPoland PR; Department of Dermatology, Naval Hospital, Oakland, California; 94627-5000.
A patient with acquired immunodeficiency syndrome (AIDS) showed longitudinal brownish-gray bands on several fingernails and toenails four months after starting therapy with azidothymidine. Nail changes during azidothymidine therapy and AIDS-related nail changes are discussed briefly.
The first Foster Boarding Home Program for babies with AIDS in the United States was started in New York by The Leake and Watts Children s Home in 1985. The authors describe the stages of the program, the possible reasons for its remarkable success, and some general characteristics of
EMBO J. 1989 Apr;8(4):1169-75. Unique Identifier : AIDSLINE MED/89305519
Guyader M; Emerman M; Montagnier L; Peden K; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.
Nucleotide sequence comparison between HIV-1, HIV-2 and SIV has revealed the presence of an open reading frame (ORF) in the central region of the genomes of HIV-2 and SIV that has no counterpart in HIV-1. This new ORF, called vpx, is highly conserved between HIV-2ROD and SIVmac. Using anti-peptide sera to the predicte
Gamba G; Ippoliti G; Invernizzi R; Gatti V; Zocchi MT; Perugini O; Department of Internal Medicine, University of Pavia, Italy.
We report the cytochemical and immunologic features of lymphocytes of 31 patients (26 with haemophilia A and 5 with haemophilia B) chronically treated with commercial clotting factor concentrates. 6 patients, asymptomatic for AIDS were anti-HIV positive. In comparison to aged cross-matched male controls, significant i
Moller B; Hopf U; Stemerowicz R; Henze G; Gelderblom H; Department of Internal Medicine, Klinikum Rudolf Virchow,; Standort Charlottenburg, Freie Universitat Berlin, Federal; Republic of Germany.
Circulating immune complexes composed of HBcAg and anti-HBc have been demonstrated recently in patients with hepatitis B virus replication. After dissociation of immune complexes by chaotropic ions, HBcAg was quantified radioimmunologically. In the present study, we describe 10 patients with hepatitis B virus replicat
Morgello S; Laufer H; Department of Pathology (Neuropathology), Queens Hospital Center,; NY.
A 22-year-old Haitian man had a 15-month course of progressive meningitis accompanied by multiple cerebral infarcts. Multiple areas of stenosis and occlusion in all branches of the circle of Willis, and hypertrophy of collateral perforating vessels at the base of the brain in a puff of smoke appearance typical of moya
Brabin L; Brabin BJ; Doherty RR; Gust ID; Alpers MP; Fujino R; Imai J; Hinuma Y; Special Programme for Research and Training in Tropical Diseases,; World Health Organisation, Geneva, Switzerland.
The prevalence of infection with human T-cell leukaemia virus (HTLV-I) was studied in Madang Province on the north coast of Papua New Guinea . Serum specimens collected from non-pregnant women in 17 villages were tested for anti-HTLV
Chen CH; Cheng YC; Department of Pharmacology, School of Medicine, University of; North Carolina, Chapel Hill 27599-7365.
The compound 2 ,3 -dideoxycytidine ( ddC ) is a potent inhibitor of human immunodeficiency virus replication in vitro and is currently in clinical trials for treatment of acquired immunodeficiency syndrome. The compound was found to exert delayed cytoto
The nurse is in a position to look holistically at PWAs to diagnose spiritual distress with the same sensitivity and skill as that used to diagnose physical and psychosocial problems. Caring for these persons requires holistic planning and intervening as well, with an awareness of the effect of spirituality on well-be
The validity of TCM remains controversial in the Western culture. Nonetheless, the value of these adjunctive and complementary therapies in treatment of HIV will continue to gain attention as clients experience its benefit. Nurses have the opportunity to validate and educate clients in their search for useful therapie
Therapeutic Touch is a manifestation of compassion. It reaches beyond the physical body and its parts. It connects one with the underlying order of the universe. TT is a skill that is invaluable in the care of the PWA on many levels, whether to ease the transition in dying or to ease the discomforts in living. It lies
Conventional models of nursing are often forced to focus on medical management and pathology reduction outcomes. A holistic model of care allows for mental, emotional, motivational, and spiritual outcomes as well as physical outcomes. Facilitating empowerment for clients with HIV infection is a specific area of challe
Quinn RP; Orban B; Tadepalli S; Department of Experimental Therapy, Burroughs Wellcome Co.,; Research Triangle Park, North Carolina 27709.
A direct radioimmunoassay (RIA) for the quantitation of Retrovir (zidovudine, azidothymidine, AZT ) in biological fluids has been developed. The assay is sensitive with an I50 value of about 30 nM and with a lower limit of detection of about 3 nM. Intr
Brand JA; Tsang VC; Centers for Disease Control, Public Health Service, U.S.; Department of Health and Human Services, Atlanta, GA 30333.
The introduction of the immunoblot into the repertoire of serodiagnostic assays began with the confirmatory testing of human immunodeficiency virus (HIV) antibodies. The difficulty of producing immunoblot strips and the complexity of the time-consuming serum/conjugate incubation steps deterred more widespread use of t
Barbaresi P; Bernardi S; Manzoni T; Institute of Human Physiology, University of Ancona, Italy.
The homotopic and heterotopic callosal connections in the forelimb representations of the second (SII) and fourth (SIV) somatic sensory areas of cats were investigated by means of the axonal transport of horseradish peroxidase (HRP) in conjunction with microelectrode recording. The tracer was injected in the electroph
Cohen LA; Grace EG Jr; Department of Oral Health Care Delivery, Baltimore College of; Dental Surgery, Dental School, University of Maryland, Baltimore; 21201.
Serum thymidine kinase (TK), measured using Prolifigen TK-REA, from AB Sangtec Medical, was investigated in 24 HIV seropositive patients without immunological alterations, 26 seropositives with immunological alterations, 125 LAS, 25 ARC, and 20 AIDS. Subjects with serological markers of prior EBV, HBV, and
Two hundred seventy-two patients infected with human immunodeficiency virus (HIV) have received care from the members of the adult infectious disease section at the University of Oklahoma Health Sciences Center. The majority of these patients met the diagnostic criteria for acquired immunodeficiency syndrome. This gro
Children dying of perinatally-acquired HIV-infection may move from one chaotic system to another as medical and social services scramble to meet the growing need. Incarceration, addiction, illness, abandonment or court removal of children, hospitalization, sibling separation or homelessness may all contribute to famil
J Med Vet Mycol. 1989;27(2):127-30. Unique Identifier : AIDSLINE MED/89310867
del Palacio-Hernanz A; Moore MK; Campbell CK; del Palacio-Perez-Medel A; del Castillo-Cantero R; Department of Microbiology, Hospital 12 de Octubre, Madrid,; Spain.
A case of central nervous system invasion by Rhinocladiella atrovirens is described. The patient was an intravenous drug abuser suffering from acquired immunodeficiency syndrome.
Zhang X; Langford A; Gelderblom H; Reichart P; Department of Oral Pathology, Beijing Medical University, China.
Twelve biopsies of clinically normal oral mucosa taken from HIV seropositive patients have been investigated by means of light- and electron microscopy. Vascular abnormalities were found in all biopsies, regardless of the clinical stage of the HIV infection. In particular slit-like vascular channels, sparseness of int
Porter SR; Luker J; Scully C; Glover S; Griffiths MJ; University Department of Oral Medicine, Surgery and Pathology,; Bristol Dental School and Hospital, England.
The orofacial manifestations of 44 HIV-infected individuals from the South West of England are reported. Oral candidiasis, periodontal disease and cervical lymphadenopathy were the most commonly observed disorders although hairy leukoplakia was also present in 15% of patients. The orofacial features of this group of B
J Med Ethics. 1989 Jun;15(2):61-7. Unique Identifier : AIDSLINE MED/89311352
Orr A; Balliol College, Oxford.
In its approach to AIDS and HIV the law has to protect two conflicting interests; it must recognise the right of the public to be protected against the disease and it must recognise the right of the individual not to be unfairly restricted by having or being at risk of the disease. Consequently the law must make some
J Med Ethics. 1989 Jun;15(2):68-73. Unique Identifier : AIDSLINE MED/89311353
Crisp R; St Anne's College, Oxford.
Many AIDS-related issues are polarised. At the social level, civil rights or liberties are seen as being in conflict with general utility, and an analogous distinction is often assumed to exist at the one-to-one, individual level at which doctors work. In this paper the latter form of the distinction is argued to be f
J Med Ethics. 1989 Jun;15(2):74-81. Unique Identifier : AIDSLINE MED/89311354
Ross MW; South Australian Health Commission.
The psychosocial morbidity associated with HIV infection and responses to such infection may exceed morbidity associated with medical sequelae of such infection. This paper argues that negative judgements on those with HIV infection or in groups associated with such infection will cause avoidable psychological and soc
Eighty patients required surgical drainage of infections in the pleural space or lung during a four-year period (1984-1987). Thirty-nine patients had a history of heavy intravenous drug use and 28 of those not addicted to drugs were addicted to alcohol. Impaired immunity was believed to be present in 72 (90%) due to m
To date, there are no scientific studies describing the crack epidemic, yet the observations reported here suggest that understanding the crack epidemic is urgent. As a cheap, highly addictive drug, crack increases risk for human immunodeficiency virus infection and could have devastating implications for many communi
Weddington WW Jr; Brown BS; Addiction Research Center/National Institute on Drug Abuse,; Baltimore, Maryland 21224.
The purposes of this paper are to summarize issues regarding the administration of HIV-antibody testing and to present an interactional method of communicating information to patients regarding AIDS, transmission of HIV, and the meaning of HIV-antibody test results. HIV-antibody testing, when associated with pretest a
Kramer TH; Cancellieri FR; Ottomanelli G; Mosely JA; Fine J; Bihari B; State University of New York, Health Science Center, Brooklyn.
A nonreactive, observational research method was used to measure AIDS information-seeking behavior of patients on four drug and alcohol inpatient units at a large public hospital in New York City. Results showed only 23 inquiries from 271 male and female patients over a six-week interval. Possible explanations and imp
Sorensen JL; Batki SL; Good P; Wilkinson K; Department of Psychiatry, University of California, San; Francisco.
To slow the spread of AIDS, it may be important for substance abuse treatment programs to give priority admission to patients who are HIV-infected and infectious. A new program is described that provides methadone maintenance treatment to opiate addicts who are AIDS affected--heroin addicts diagnosed with AIDS, AIDS-r
Ruegg CL; Monell CR; Strand M; Department of Pharmacology and Molecular Sciences, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205.
Synthetic peptides containing portions of a highly conserved region of retroviral transmembrane proteins of human and animal retroviruses were tested for their ability to inhibit lymphoproliferation to determine the minimum amino acid sequence required. The previously reported immunosuppression mediated by the peptide
Kawaoka Y; Webster RG; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38101.
The ability of many viruses to replicate in host cells depends on cleavage of certain viral glycoproteins, including hemagglutinin (HA). By generating site-specific mutant HAs of two highly virulent influenza viruses, we established that the relationship between carbohydrate in the stalk and the length of the connecti
Ljunggren K; Biberfeld G; Jondal M; Fenyo EM; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.
Human cell lines were infected with different strains of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) as well as with a simian immunodeficiency virus SIVmac isolate and used as targets in an antibody-dependent cellular cytotoxicity (ADCC) assay. Sera from HIV-1- or HIV-2-infected subjects provided the
A case of AML accompanied by HTLV-I associated myelopathy (HAM) is reported. A 37-year-old woman was admitted to our hospital in April 1985 because of severe anemia, general malaise and fever. On admission, anemia, thrombocytopenia and leukocytosis consisting of 32% myeloblasts and 6% promyelocytes were noted. A bone
Podzamczer D; Bolao F; Pagerols X; Pasarin M; Ferrer I; Romeu A; Gudiol F; Fernandez-Nogues F
In 23 out of 227 patients with positive serological tests for the human immunodeficiency virus (10%), seen between June 1987 and May 1988, lingual lesions of hairy leukoplakia (HL) were found. HL was present in 16/188 drug abusers (9%) and in 7/19 homosexuals (32%). In 3 cases HL was the only clinical manifestation of
In 24 cases of thrombopenic purpura associated with human immunodeficiency virus infection the clinical, immunological and therapeutic features were evaluated. Thrombopenia resulted in clinical manifestations in 20 patients. Splenomegaly was found in only one fourth of patients. Antiplatelet antibodies were found in 9
Md Med J. 1989 Jul;38(7):560-1. Unique Identifier : AIDSLINE MED/89313161
Flynn JP; Israel E
We continue to advance our knowledge regarding susceptible hosts. As people live longer, society is faced with a new problem of dealing with ever-increasing numbers of elderly with inadequate immune defense. HIV infections, cancer drugs, and steroids continue to add more persons to this pool. As we prepare to move int
Med Pediatr Oncol. 1989;17(3):236-8. Unique Identifier : AIDSLINE MED/89313537
Fort JA; Graham-Pole J; Mottshaw G; JHMHSC, Shands Teaching Hospital, University of Florida,; Gainesville 32610.
Recently, a form of T-cell lymphoma associated with seropositivity for human T-lymphotrop virus type 1 (HTLV-1) antibody has been described in the adult population. The lymphoma frequently presents with massive hepatosplenomegaly, lymphadenopathy and circulating malignant cells, with a normal bone marrow. HTLV-1-assoc
Edbrooke MR; Burt DW; Cheshire JK; Woo P; Section of Molecular Rheumatology, MRC Clinical Research Centre,; Harrow, Middlesex, United Kingdom.
We have analyzed the 5 -flanking region of one of the genes coding for the human acute-phase protein, serum amyloid A (SAA). We found that SAA mRNA could be increased fivefold in transfected cells by treatment with phorbol 12-myristate 13-acetate (PMA). To analyze this observation further, we placed a 265-base-pair 5
The human immunodeficiency virus (HIV) is transmitted by sexual contact and by blood products. Patients with acute leukemia are extensively transfused as part of their supportive care. We conducted a retrospective study of the incidence of HIV antibody positivity in patients treated for acute leukemia at The Mount Sin
Goldani LZ; Martinez R; Landell GA; Machado AA; Coutinho V; Department of Internal Medicine, Faculty of Medicine of Ribeirao; Preto, University of Sao Paulo, Brazil.
The authors report a case of paracoccidioidomycosis and other opportunistic diseases in a patient with acquired immunodeficiency syndrome.
Stavrou D; Mehraein P; Mellert W; Bise K; Schmidtke K; Rothemunds E; Funke I; Stocker U; Babaryka I; Zietz C; et al; Institute of Neuropathology, University of Munich, Federal; Republic of Germany.
In this paper we present the results of post-mortem examinations of the central nervous system in 61 male patients who died with Acquired Immunodeficiency Syndrome (AIDS); it includes 23 patients with reported neurological abnormalities at the time of presentation. The analysis revealed central nervous system (CNS) ne
The Light and Electron Microscope aspects of a colonic Cryptosporidiosis in a H.I.V. patient are reported. The authors stresses the importance of Endoscopic biopsies and Electron Microscopic studies in confirming the microbiologic stool examination for oocysts of the parasite. In particular, by an histological point o
Melzer SM; Vermund SH; Shelov SP; Department of Pediatrics, Montefiore Medical Center/Albert; Einstein College of Medicine, Bronx, New York.
Concerns regarding accidental needle puncture wounds, needle injuries among house officers have increased following reports of human immunodeficiency virus (HIV) transmission via this route. Pediatric house officers training in areas with large numbers of children infected with HIV may face a significant risk of occup
Flaskerud JH; Rush CE; AIDS Education for Women, School of Nursing, University of; California, Los Angeles.
This study examines whether traditional health beliefs and practices of black Americans reported in the literature were consistent with those of a target population of low-income black women in Los Angeles County and describes how these traditional classifications of illness and healing practices were related to their
Carmen E; Rieker PP; Boston University School of Medicine; Massachusetts.
The psychosocial model of the victim-to-patient process explains how chronic abuse damages the self and sets into motion psychological processes that may evolve into various forms of mental illness. This model emphasizes the fragmented identity that derives from victims attempts to accommodate to the judgments of oth
Sandhaus LM; Scudder R; Department of Pathology, University of Medicine and Dentistry of; New Jersey, Robert Wood Johnson Medical School, Piscataway 08901.
This study presents the peripheral blood and bone marrow findings in eight children with perinatally acquired HIV infection, ranging in age from 5 months to 3 years. The indications for bone marrow examination were comparable to those for adults with HIV infection and included cytopenia(s), slenomegaly, failure to thr
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5595-9. Unique Identifier : AIDSLINE MED/89315844
Zucker-Franklin D; Cao YZ; New York University Medical Center, NY 10016.
The pathogenesis of thrombocytopenia associated with human immunodeficiency virus (HIV) infection is not fully understood. Immune mechanisms provide a partial explanation but fail to account for a lack of compensatory megakaryocytosis, the rapid reversal after treatment with azidothymidine, and the ultrastructural abe
Fawzy FI; Namir S; Wolcott DL; Mitsuyasu RT; Gottlieb MS; UCLA Department of Psychiatry.
We assessed current medical and psychological status in 50 homosexual/bisexual males who were within 3 months of the diagnosis of AIDS. Subjects had typically impaired cellular immunity, relatively well-maintained physical performance capacity, and reported surprisingly good current health status, in spite of signific
Fawzy FI; Namir S; Wolcott DL; Department of Psychiatry & Biobehavioral Sciences, UCLA School of; Medicine.
We have gathered and analyzed data on 50 gay men with AIDS before and after a ten-week structured group intervention aimed at reducing psychological distress and improving coping skills. Among the major findings have been information relating coping strategies to depression and anxiety, information about the support n
Johnson PC; Hamill RJ; Sarosi GA; Department of Internal Medicine, University of Texas Health; Science Center, Houston 77030.
Progressive disseminated histoplasmosis (PDH) has now been described in acquired immunodeficiency syndrome (AIDS) patients from areas both endemic and nonendemic for histoplasmosis. We review the clinical presentation, diagnosis, and therapy of PDH in patients with AIDS by comparing 64 patients from our series collect
Scheidegger C; Zimmerli W; Department of Medicine, University Hospital, Basel, Switzerland.
In a retrospective survey of patients hospitalized in the Department of Medicine of the University Hospital, Basel, Switzerland , from 1980 to 1986, we found 269 patients with history of past or current drug abuse. The charts of these patients were analyzed for infectious compl
Rev Prat. 1989 Jun 8;39(18):1581-5. Unique Identifier : AIDSLINE MED/89317274
Clair B; Regnier B
Infective pneumonia occurring in immunocompromised patients is characterized by its multiple causes which create diagnostic problems and by the need for a prompt treatment. The principal criteria pointing to a specific organism are the causes of immunodeficiency (now usually due to treatment of blood diseases or cance
Schweiz Med Wochenschr. 1989 May 6;119(18):566-74. Unique Identifier : AIDSLINE MED/89317390
Flepp M; Luthy R; Wust J; Steinke W; Greminger P; Departement fur Innere Medizin, Universitatsspital Zurich.
A case of Rhodococcus equi pneumonia associated with septicemia and metastatic brain abscess in an HIV-infected male is presented. Clinical findings and the diagnostic and therapeutic approach are discussed. Cavitating pulmonary disease was rapidly improved by six-week combined oral and parenteral antibiotic treatment
South Med J. 1989 Jul;82(7):825-8. Unique Identifier : AIDSLINE MED/89317635
Lindsay MK; Peterson HB; Mundy DC; Slade BA; Feng T; Willis S; Stine P; Klein L; Department of Gynecology and Obstetrics, Emory University School; of Medicine, Atlanta, Ga 30335.
To determine the seroprevalence of human immunodeficiency virus infection in prenatal patients at high risk for HIV infection we tested 513 women from December 1985 through July 1987 at an inner-city hospital in Atlanta, Georgia. Demographic and HIV risk information was collected from all seropositive women. Twenty-ni
Vet Rec. 1989 Apr 22;124(16):420-2. Unique Identifier : AIDSLINE MED/89318766
Gourlay RN; Thomas LH; Wyld SG; Agricultural and Food Research Council Institute for Animal; Health, Compton Laboratory, Newbury, Berkshire.
An increase in deaths in calves from respiratory disease from an average of 9.7 per year to 36.5 per year corresponded with the isolation of Mycoplasma bovis from the lungs. It is suggested that this mycoplasma enhanced the severity of the disease which was normally present on the farm. The characteristic microscopic
Navarro MD; Pineda JA; Rey C; Soto B; Flores JM; Leal M; Lissen E; HIV and Hepatitis Virus Study Group, Virgen del Roscio University; Hospital, Sevilla, Spain.
Rodrigues JJ; Israel ZR; Athalye N; Pavri KM; National Institute of Virology, Pune, India.
Screening of blood donations for anti-HIV in western India has shown a rising trend of antibody-positive donors. There was a statistically significant difference between the proportion of positive reactors before 1986 and after 1986 (p less than 0.05).
Osterhaus A; Weijer K; UytdeHaag F; Knell P; Jarrett O; Akerblom L; Morein B; Department of Immunobiology, National Institute of Public Health; and Environmental Protection, Bilthoven, The Netherlands.
Various approaches have been considered for generation of effective and safe vaccines against retroviruses, including HIV, with limited success. In the present vaccination study, encompassing 137 household cats, we have composed an experimental ISCOM subunit vaccine containing gp70 of feline leukaemia virus (FeLV)--th
Bjornson DC; Meyer DE; Cambre JD; Hiner WO Jr; Cammarata FA; Walter Reed Army Medical Center, Washington, DC 20307-5000.
Services developed by the pharmacy department at Walter Reed Army Medical Center (WRAMC) relating to the treatment and study of patients infected with the human immunodeficiency virus (HIV) are described. The WRAMC pharmacy department closely monitored use of azidothymidine (renamed zidovudine) before and after its ap
This report focuses on the abilities of three people diagnosed with acquired immune deficiency syndrome (AIDS) to maximize their state of well-being. The purpose of this ongoing investigation is to identify factors that may help enhance AIDS patients states of well-being, ultimately achieving the provision of holisti
Aust Fam Physician. 1989 Jun;18(6):708-9. Unique Identifier : AIDSLINE MED/89321979
Spelman D
This article outlines an approach to counselling a patient before a HIV test. Preparing such a patient for the possibility of a positive test, and all it means, is essential. It is also important to discuss with a seronegative patient measures to avoid infection. This feature, which presents the latest information on
Oxholm A; Oxholm P; Permin H; Bendtzen K; Department of Dermatology, Gentofte Hospital, Denmark.
Biopsies from 6 patients with AIDS and Kaposi s sarcoma (KS) in the tumour stage, and 6 healthy controls, were immunohistologically examined for the presence of tissue-bound tumour necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6) in the skin. TNF alpha was demonstrated using specific polyclonal antiserum to
Parravicini CL; Petren AL; Vago L; Costanzi G; Gluckman JC; Gallo RC; Biberfeld P; V Cattedra di Anatomia Patologica, Universita di Milano, Italy.
HIV associated subacute, micronodular encephalitis and lymphadenopathy were compared with regard to demonstrable HIV antigens and characterization of HIV antigen expressing cells. In the brain, both gag- and env-coded antigens were confined to cells of micronodular lesions with immunophenotype of monocyte/macrophages
Cancer Res. 1989 Jul 15;49(14):4042-6. Unique Identifier : AIDSLINE MED/89288063
Kiyokawa T; Shirono K; Hattori T; Nishimura H; Yamaguchi K; Nichols JC; Strom TB; Murphy JR; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; Medical School, Japan.
The inhibitory effect of a diphtheria toxin-related interleukin 2 fusion protein, IL-2-toxin, on protein synthesis in adult T-cell leukemia/lymphoma (ATL) cells was examined in vitro. Peripheral blood ATL cells from 12 patients (six acute type, four chronic type, and two smoldering type ATL) and the lymph node cells f
Hofmann B; Langhoff E; Lindhardt BO; Odum N; Hyldig-Nielsen JJ; Ryder LP; Platz P; Jakobsen BK; Bendtzen K; Jacobsen N; et al; Tissue Typing Laboratory, State University Hospital; (Rigshospitalet), Copenhagen, Denmark.
Retroviral infections are accompanied by immunosuppression in a variety of species. For feline leukemia virus, the immunosuppression has been ascribed to the transmembrane envelope protein, p15E, which suppresses the proliferative responses of cat, mouse, and human lymphocytes. A similar suppressive effect has been sh
For more than two years, all HIV-positive women were seen in the Department of Obstetrics and Gynaecology in cooperation with the Department of Internal Medicine of the University of Mainz, for medical care and therapy, if necessary. Of 40 HIV-infected female patients who were treated, 25 women were followed up every
Int J Dermatol. 1989 Mar;28(2):107-13. Unique Identifier : AIDSLINE MED/89291152
Yamada M; Takigawa M; Iwatsuki K; Inoue F; Department of Dermatology, Hamamatsu University School of; Medicine, Japan.
Comparative studies were performed on clinical and laboratory features of four patients with different types of T-cell lymphoma of the skin; adult T-cell leukemia/lymphoma (ATLL), Sezary syndrome, mycosis fungoides, and Ki-1-positive lymphoma. All neoplastic cells studied showed a helper-inducer T-cell phenotype. A Ki
Horsburgh CR Jr; Anderson JR; Boyko EJ; Department of Medicine, University of Colorado Health Sciences; Center.
To ascertain the incidence of infections in intravenous users of illicit drugs, we performed a retrospective study of 270 intravenous drug users (IVDUs) and 562 controls who did not use drugs over a seven-year period from 1978-1985. IVDUs had an increased overall incidence of infections (P less than 0.001) compared to
Public Health. 1989 May;103(3):199-203. Unique Identifier : AIDSLINE MED/89297280
Greatorex IF; Packer JM
A self-administered postal questionnaire was used in a cross-sectional survey of reported sexual behaviour of a random sample of first year university undergraduates. Only 43% answered the questions (149 males and 115 females) despite the cooperation of the Students Union and assurances of anonymity and confidentiali
Public Health. 1989 May;103(3):205-11. Unique Identifier : AIDSLINE MED/89297281
Nutbeam D; Catford JC; Smail SA; Griffiths C
Three independent cross-sectional surveys of public knowledge and attitudes about AIDS were conducted on a representative sample of people aged 15-54 resident in Wales. 1,303 were interviewed in their homes in February 1987, 683 in September 1987 and 676 in March 1988. The results show that most people knew that havin
The results of 115 bronchoscopic examinations and one autopsy in 105 adults with HIV-infection and pulmonary complications are presented. Whereas 51.7% of the events were caused by Pneumocystis carinii pneumonia (PCP), nonspecific interstitial pneumonitis (NIP) without evidence of an infectious or neoplastic condition
Sex Transm Dis. 1989 Apr-Jun;16(2):95-102. Unique Identifier : AIDSLINE MED/89298552
Rietmeijer CA; Penley KA; Cohn DL; Davidson AJ; Horsburgh CR Jr; Judson FN; Disease Control Service, Denver, CO 80204-4507.
The factors associated with infection with the human immunodeficiency virus (HIV) in 216 homosexual men enrolled from November 1982 through December 1985, including 40 asymptomatic HIV seronegative, 20 asymptomatic seropositive, 66 with generalized lymphadenopathy (GLS), 37 with AIDS-related complex (ARC), and 53 with
Wien Klin Wochenschr. 1989 May 26;101(11):388-90. Unique Identifier : AIDSLINE MED/89299671
Fuchs D; Hausen A; Reibnegger G; Werner ER; Werner-Felmayer G; Dierich MP; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck.
AIDS incidence rates were calculated for Austria based on cumulative data up to October 31st 1988. Geographical differences are obvious, provinces of the northwest showing higher incidence rates than south-east provinces. An association of high AIDS incidence rates with intravenou
Wakabayashi Y; Ishiyama T; Sugimoto M; Abe S; Horie S; Matsumoto T; Hirose S
In vitro differentiation and proliferation of precursor T-cells was examined in four homosexual men positive for anti-human immunodeficiency virus (HIV), one of whom had acquired immunodeficiency syndrome (AIDS). Peripheral mononuclear cells from the men were cultured with phytohemagglutinin-P in semi-solid culture me
Bernstein LJ; Bye MR; Rubinstein A; Department of Pediatrics, Albert Einstein College of Medicine,; Bronx, NY 10461.
Eighteen children with the acquired immunodeficiency syndrome (AIDS) were diagnosed as having Pneumocystis carinii pneumonia (PCP) by either open lung biopsy or bronchoalveolar lavage. Seven patients (39%) died during the acute illness. Alveolar-arterial oxygen gradients at the time of presentation and lactate dehydro
Am J Epidemiol. 1989 Jul;130(1):133-42. Unique Identifier : AIDSLINE MED/89300714
Drucker E; Vermund SH; Department of Epidemiology and Social Medicine, Montefiore; Medical Center, Albert Einstein College of Medicine, Bronx, NY; 10467.
The Bronx, a borough of New York City with 1.16 million people, has a distinctive pattern of prevalence and distribution of acquired immunodeficiency syndrome (AIDS), i.e., 62.2% of AIDS patients are intravenous drug users, 20.3% are female, 87.3% are black or Hispanic, and 4.5% are children under age 13 years. Local
Perez G; Ortiz-Interian C; Lee H; de Medina M; Cerney M; Allain JP; Schiff E; Parks E; Parks W; Bourgoignie JJ; Department of Medicine, University of Miami School of Medicine,; FL 33101.
The high prevalence of human immunodeficiency virus (HIV-1) infection in populations at risk in Miami prompted a seroepidemiologic study of both HIV-1 and the human T-cell leukemia virus type I (HTLV-I), a closely related virus, in our patients receiving chronic hemodialysis. One hundred twenty-nine patients undergoin
Kim HC; Raska K Jr; Trooskin S; Saidi P; Department of Medicine, University of Medicine and Dentistry, New; Jersey-Robert Wood Johnson Medical School, New Brunswick 08903.
We studied five patients with hemophilia A in the age range of 18 to 64 years who were infected with human immunodeficiency virus and who developed immune thrombocytopenia. The clinical course of immune thrombocytopenia in relation to human immunodeficiency virus infection and the patients responses to splenectomy an
Schupbach J; Kalyanaraman VS; Swiss National Center for Retroviruses, University of Zurich,; Switzerland.
Circulating immune complexes from sera of 6 patients with adult T-cell leukemia and 8 asymptomatic carriers infected with the human T-cell leukemia virus type 1 (HTLV-1) were precipitated with polyethylene glycol, and the precipitates were tested for the presence of viral antigen p24 by Western blot, using affinity-pu
Ng VL; Chiang CS; Debouck C; McGrath MS; Grove TH; Mills J; Department of Laboratory Medicine, University of California, San; Francisco 94110.
An enzyme-linked immunoassay (ELISA) using six recombinant proteins corresponding to large segments of the human immunodeficiency virus type 1 (HIV-1) gag, pol, and env gene products (HIVAGEN; SmithKline Bio-Science Laboratories, Van Nuys, Calif.) was developed to confirm the presence of antibodies to HIV-1 in sera re
J Immunol. 1989 Aug 1;143(3):858-63. Unique Identifier : AIDSLINE MED/89309759
Tsubota H; Ringler DJ; Kannagi M; King NW; Solomon KR; MacKey JJ; Walsh DG; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.
A detailed definition of AIDS virus-specific T lymphocytes will require the generation and characterization of HIV-1-specific, cloned T cell populations. In our studies, we show that CD8+CD4- lymphocyte lines, derived from PBL of rhesus monkeys infected with simian immunodeficiency virus of macaques and humans infecte
One hundred and thirty-three homosexual men seropositive for the antibody against human immunodeficiency virus (HIV) were enrolled in a prospective study in 1984-85. The 3-year cumulative incidences of the acquired immunodeficiency syndrome (AIDS) and AIDS-related conditions, by life-table analyses, were 18% and 34%.
JAMA. 1989 Aug 11;262(6):779-83. Unique Identifier : AIDSLINE MED/89311817
Miotti PG; Nelson KE; Dallabetta GA; Farzadegan H; Margolick J; Clements ML; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, MD 21205.
We studied whether a two-dose regimen of inactivated influenza virus vaccine was more effective than a single dose in inducing protective hemagglutination-inhibition antibody responses in patients infected with human immunodeficiency virus (HIV). Participants included subjects with acquired immunodeficiency syndrome,
Ogawa K; Matsuda S; Seto A; Department of Pathology, Faculty of Medicine, Kyoto University,; Japan.
An HTLV-I-transformed T-cell line from a (B/J x Chbb:HM)F1 rabbit was intravenously inoculated at a dose of 1 x 10(8) cells into B/J and Chbb:HM adult rabbits. All B/J rabbits died or became moribund 6-13 days later, whereas all Chbb:HM rabbits survived without disease symptoms. Marked leukocytosis was observed in Chb
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5620-4. Unique Identifier : AIDSLINE MED/89315849
Kinoshita T; Shimoyama M; Tobinai K; Ito M; Ito S; Ikeda S; Tajima K; Shimotohno K; Sugimura T; Virology Division, National Cancer Center Research Institute,; Tokyo, Japan.
Expression of human T-cell leukemia virus type I (HTLV-I) is not detectable by immunofluorescence analysis or RNA blot analysis in most fresh peripheral blood mononuclear cells of patients with adult T-cell leukemia or of asymptomatic HTLV-I carriers. However, in this work, mRNA for the HTLV-I tax1/rex1 genes was dete
Luce JM; Clement MJ; University of California, San Francisco.
The wide range of pulmonary infections associated with human immunodeficiency virus (HIV)-seropositivity, coupled with the possible presence of HIV-related neoplasms and non-HIV-related pulmonary processes, requires that most patients who are known to be or suspected of being HIV-seropositive should undergo a thorough
South Med J. 1989 Jul;82(7):829-32. Unique Identifier : AIDSLINE MED/89317636
Yoo OH; Choi HS; Cucco RA; Desmond E; Lesser M; Pulmonary Section, Veterans Administration Medical Center, Bronx,; NY 10468.
Over a 30-month period, we evaluated 74 patients with acquired immunodeficiency syndrome (AIDS) for suspected opportunistic pulmonary infection. All had abnormal findings on chest roentgenogram. Sixty patients (81%) were found to have Pneumocystis carinii pneumonia (PCP). We assessed the yield of various diagnostic me
Seki J; Shimada N; Takahashi K; Takita T; Takeuchi T; Hoshino H; Department of Hygiene, Gumma University School of Medicine,; Japan.
Oxetanocin is a novel nucleoside containing a 4-membered sugar, oxetanosyl-N-glycoside, and adenine. The effects of oxetanocin and related compounds on the infectivity of human immunodeficiency virus (HIV) were examined. They inhibited HIV infectivity in vitro. Allopurinol and mycophenolic acid produced additive anti-
Harel-Bellan A; Korner M; Brini AT; Ferris D; Farrar WL; Laboratory of Molecular Immunology, National Cancer Institute,; Frederick, MD 21701.
Binding activity to the HIV enhancer, a sequence highly homologous to the NF-KB enhancer, is inducible by PMA in human Jurkat T cells. We here show that, similar to what is observed for NF-KB in B cells, mild detergents, such as Deoxycholate, reveal a cryptic binding activity in protein extracts from non activated cel
Bone transplantation is associated with two major problems: the sterility in particular with respect to HIV, and the osteoinductivity of the transplant. We describe a procedure which sterilizes the graft while keeping the osteoinductive potential of the bone. After harvesting the material the bone is immediately deep
Bull Cancer (Paris). 1989;76(3):301-10. Unique Identifier : AIDSLINE MED/89287514
Constans JP; Castresana A; Meder JF; Vedrenne C; Cosset JM; Hayat M; Service de neurochirurgie, hopital Sainte-Anne, Paris, France.
Intracranial localizations of Hodgkin s disease (HD) are uncommon. We report on 2 patients with HD who presented with an intracranial relapse. We discuss 1) the pathogenesis of those rare recurrences; 2) the therapeutic strategy.
Langtry HD; Campoli-Richards DM; ADIS Drug Information Services, Auckland, New Zealand.
Zidovudine (azidothymidine) is a thymidine analogue antiretroviral drug active against human immunodeficiency virus (HIV). In acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC) patients, orally and intravenously administered zidovudine is effective in reducing the incidence of opportunistic infec
Hickl EJ; Koch MG; Frauenklinik Finkenau und Hebammenlehranstalt Hamburg.
There is hardly any other disease where differences of opinion are so dramatic as they are in AIDS. Safely established epidemiologic data are interpreted most controversially and heatedly discussed. Gynaecology and obstetrics are no exception; here, too, scientific discussion is marred by emotional overtones. The arti
Luu JY; Bockus D; Remington F; Bean MA; Hammar SP; Department of Pathology, Virginia Mason Medical Center, Seattle,; WA.
Tubuloreticular structures (TRS) and cylindrical confronting cisternae (CCC) are unique subcellular structures that arise from the membranes of the rough endoplasmic reticulum of a variety of cell types. In vivo, they occur most frequently in endothelial cells and lymphocytes from patients with autoimmune diseases and
Frierson HF Jr; Innes DJ Jr; Mills SE; Wick MR; Department of Pathology, University of Virginia Health Sciences; Center, Charlottesville 22908.
A panel of paraffin effective antibodies recognizing B cells and T cells (LN-2, MB1, L26, MT1, UCHL1, kappa, lambda) was used to characterize the immunophenotypes of 26 sinonasal non-Hodgkin s lymphomas. Seventeen tumors were stage I, five were stage II, one was stage III, and three were stage IV. Nine lymphomas were
Invest New Drugs. 1989 Apr;7(1):51-7. Unique Identifier : AIDSLINE MED/89291322
Horwitz JP; Department of Chemistry, Michigan Cancer Foundation, Detroit.
3 -Azido-2 3 -dideoxythymidine ( AZT ), a thymidine analogue with potent antiretroviral activity against human immunodeficiency virus (HIV) in vitro, has been shown to confer a clinical benefit in patients with advanced acquired immune deficiency syndro
Hawaii Med J. 1989 Apr;48(4):131-4. Unique Identifier : AIDSLINE MED/89291412
Tom LA
Since the first reports of unusual opportunistic infections and Kaposi s Sarcoma (KS) in homosexual men in New York and California, attention has been focused on a new epidemic: The Acquired Immunodeficiency Syndrome (AIDS). One manifestation of this disease is Kaposi s Sarcoma. Usually a rare tumor, it occurs with a
Gordon R; Department of Botany, University of Manitoba, Winnipeg, Canada.
Condom failure rates for HIV are substantially greater than for pregnancy, even for highly motivated people who may reach the limit set by allowed manufacturing imperfections. This makes condoms ineffective for lifelong protection from HIV-infected sexual partners; therefore, in general, condoms provide inadequate ris
Matsuo H; Nakamura T; Tsujihata M; Motomura M; Nagasato K; Nagataki S; First Department of Internal Medicine, Nagasaki University School; of Medicine, Japan.
The clinical features of 21 patients (7 men and 14 women, aged 24-65) with human T-lymphotropic virus type I (HTLV-I) associated myelopathy (HAM) in Nagasaki were reviewed. Gait disturbance with spastic paraplegia and bladder dysfunction were the main clinical symptoms. Gait disturbance was observed in all patients an
Amin NM; Kern Medical Center, Bakersfield, CA 93305-4197.
Zidovudine (Retrovir) is the only drug found to be useful for managing human immunodeficiency virus (HIV) infection in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. The drug is virostatic, ie, it prevents replication of HIV by inhibiting the enzyme reverse transcriptase. Zidovudine
Weisberg LA; Ross W; Department of Psychiatry and Neurology, Tulane University Medical; Center, New Orleans, LA 70112.
A common complication of acquired immunodeficiency syndrome (AIDS) is being increasingly recognized. Known as AIDS dementia complex, the disorder is characterized by global impairment of intellectual and cognitive functions, personality and behavioral disturbances, and motor dysfun
Rosenberg J; Becker CE; Cone JE; Hazard Evaluation Systems and Information Service, Department of; Health Services, Berkeley, California.
Estimating the risks of blood-borne diseases to health care workers is an important area of concern for occupational health physicians. It is best now to view this risk as an occupational injury that can be prevented. The specific numbers estimating risks are rarely as important to the worker as are methods that are a
Scott CD; Jaffe DT; Department of Family and Community Medicine, University of; California, San Francisco School of Medicine 94117.
There is a crisis in health care that has to do with the ability of health-care workers to provide the long-term care and help for AIDS patients. Although more severe, it is just an extreme form of the denial among health care professionals of their own needs, and lack of ability to manage stress. The situation also r
West J Med. 1989 May;150(5):557-61. Unique Identifier : AIDSLINE MED/89299651
Neely SM
Adult T-cell leukemia-lymphoma, an aggressive T-cell leukemia, is characterized by the presence in the peripheral blood of malignant T cells that have highly indented or lobulated nuclei. Phenotypically the cells are usually helper T cells, but functionally they behave as suppressor cells. Patients have skin and lung
Z Hautkr. 1989 May 15;64(5):364-6, 369-70, 373. Unique Identifier : AIDSLINE MED/89299840
Dettke T; Plettenberg A; Meigel WN; Dermatologische Abteilung, Allgemeines Krankenhaus St. Georg,; Hamburg.
We report on the clinical course, the staging, and the theories regarding the etiopathogenesis and possible prognostic factors of Kaposi s sarcoma. In addition, we refer to the significance of viral, mycotic, and bacterial infections in HIV infection.
Z Hautkr. 1989 May 15;64(5):374, 379-82, 387. Unique Identifier : AIDSLINE MED/89299841
Rasokat H; Universitats-Hautklinik Koln.
Improvement regarding the diagnostics and therapy of secondary manifestations in HIV infection has had a positive influence on the quality of life as well as life-expectancy of AIDS patients. Early treatment with high doses, critical evaluation, and prophylactic therapy are of outstanding importance. Since recently, e
Am J Nephrol. 1989;9(2):129-32. Unique Identifier : AIDSLINE MED/89300861
Spector DA; Katz RS; Fuller H; Cristiano LM; Vitalis S; Jarrow J; Johns Hopkins University School of Medicine, Baltimore, Md.
A 30-year-old male who presented with acute renal failure was found to have acquired immunodeficiency syndrome (AIDS). Although sonography and computerized tomography did not show urinary tract dilatation, obstructive renal failure was demonstrated by retrograde pyelography. Relief of obstruction(s) due to encasement
An Esp Pediatr. 1989 Apr;30(4):265-8. Unique Identifier : AIDSLINE MED/89301298
Espanol Boren T; Curell Aguila N; Bertran Sanges JM; Fortuny Guasch C; Munoz Lopez F; Jimenez Gonzalez R; Mur Sierra A; Marti Gaudes C; Llorens Terol J; Seculi Palacios JL; et al; Residencia Sanitaria, Valle de Hebron, Barcelona.
Two hundred and ninety three cases of children born of HIV positive mothers have been observed between January 1984 and June 1988 in Catalonia and Balearic Islands, with a ration of 9.5/10,000 newborns. Sex was not significant in the infected group. Most of the cases (68%) have been detected since 1987 and represent a
Kaye BR; Santa Clara Valley Medical Center, San Jose, California.
PURPOSE: To review the various rheumatologic manifestations of human immunodeficiency virus (HIV) infection and to discuss their potential pathogenic mechanisms. DATA IDENTIFICATION: A literature search using MEDLINE (1981 to 88) and Index Medicus (1981 to 88) and review of references from all identified articles. STU
ANNA J. 1989 Jun;16(4):287-9. Unique Identifier : AIDSLINE MED/89301675
McFarland HF
A literature search was done on the human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) to determine the scope of the epidemic and whether routine testing in dialysis units might prevent the spread of the HIV infection. It was discovered that numbers of deaths from AIDS are far fewer than
Biochem Biophys Res Commun. 1989 Jun 30;161(3):1056-63. Unique Identifier : AIDSLINE GENBANK/M27885
Hostomsky Z; Appelt K; Ogden RC; Agouron Pharmaceuticals Inc., La Jolla, CA 92037.
A synthetic gene coding for HIV-1 protease (PR) has been constructed and a system for its efficient expression in E. coli has been established: PR is synthesized as a fusion protein with E. coli dihydrofolate reductase under the control of a bacteriophage T7 promoter. The synthetic gene was constructed to enable rapid
Bull Int Union Tuberc Lung Dis. 1989 Mar;64(1):8-11. Unique Identifier : AIDSLINE MED/89303334
In a number of developing countries, particularly in Sub-Saharan Africa, infection with both M. tuberculosis and human immunodeficiency virus (HIV) is highly prevalent. HIV infection results in an impairment of the immune system and entails a substantial risk of TB in those individuals who are or become infected with
Stingl G; Department of Dermatology I, University of Vienna Medical School,; Austria.
HIV has several characteristics that make it difficult to combat; namely its ability to integrate into the host genome, its tendency to mutate, and its ability to infect at least one organ (the brain) with limited regenerative potential. Although these features of HIV make it quite unlikely that a curative therapy for
Emerg Med Clin North Am. 1989 Aug;7(3):575-89. Unique Identifier : AIDSLINE MED/89305437
Katz MH; French DM; Robert Wood Johnson Foundation, University of California, San; Francisco.
The authors describe the common causes of abdominal pain in HIV-infected patients, with particular attention to distinguishing patients who have acute abdominal syndromes from those with chronic illness. Specific etiologic agents, as well as clinical syndromes, are discussed.
Vlasuk GP; Waxman L; Davis LJ; Dixon RA; Schultz LD; Hofmann KJ; Tung JS; Schulman CA; Ellis RW; Bencen GH; et al; Department of Biological Chemistry, Merck Sharp and Dohme; Research Laboratories, West Point, Pennsylvania 19486.
The core structure of retroviruses, including the human immunodeficiency virus (HIV), consists of proteins that are initially synthesized as polyprotein precursors and then processed by a virally encoded protease yielding the mature core polypeptides. To obtain sufficient quantities of the purified HIV core precursor
Hatanaka M; Nam SH; Institute for Virus Research, Kyoto University, Japan.
The full-length provirus of human T-cell leukemia virus type I (HTLV-I) was isolated from MT-2, a lymphoid cell line producing HTLV-I. In transfected cells, structural proteins of HTLV-I, the gag and env products, were formed and processed in the same manner as observed in MT-2 cells. The nucleotide sequence was deter
Although PNI is a relatively new field, basic research has demonstrated the interconnectedness of immune and neurological systems, alerting nurses to the need to conduct multisystem assessments and provide holistic nursing care to persons with AIDS. Although the burden of research does not support the notion that the
Malnutrition of protein, calories, and micronutrients can magnify the immunosuppression of HIV. The goal of nutritional therapy in the HIV-infected population is the maintenance of optimal nutritional status. This may not always be realistic because of the vast number of nutrition-related problems that can occur. In s
JAMA. 1989 Aug 11;262(6):784-94. Unique Identifier : AIDSLINE MED/89311818
Andrulis DP; Weslowski VB; Gage LS; National Public Health and Hospital Institute, Washington, DC; 20004.
In 1987, the National Public Health and Hospital Institute conducted a national survey of 623 acute-care hospitals to obtain information relating to inpatient and outpatient care for persons with acquired immunodeficiency syndrome (AIDS). Two hundred seventy-six hospitals reported treating persons with AIDS; the avera
Martenet AC; Clinique Ophtalmologique universitaire de Zurich.
Diagnosis of intraocular inflammations can be difficult, particularly if the patient is suffering from immunodeficiency. Among the endogenous inflammations this applies mainly to cases of hyaloretinitis caused by Candida or other fungi, often presenting as an acute hyalitis with sudden onset; the various ocular compli
Med Decis Making. 1989 Apr-Jun;9(2):76-83. Unique Identifier : AIDSLINE MED/89313184
Onorato IM; Orenstein WA; Hinman AR; Rogers MF; Koplan JP; Division of Immunization, Center for Prevention Services,; Atlanta, Georgia 30333.
Because HIV infection is associated with immunologic abnormalities, concerns have been expressed about the safety and efficacy of vaccination of infected children with live virus vaccines. The authors used decision analysis to assess the likely impacts of four alternative policies for immunization of asymptomatic HIV-
History offers some guidance for understanding social and policy responses to the AIDS epidemic. Pertinent themes in the history of responses to epidemic disease in the United States in the past two hundred years include an initial underestimation of the severity of the epidemic; the p
Pathologic findings in 25 autopsies of AIDS. The common and severe changes of the central nervous system, lungs, adrenals, heart, kidneys and gonads are reviewed in a series of autopsies of AIDS. In the brain, HIV infection induces directly inflammatory infiltrates including the typical multinucleated giant cells desc
Pathol Res Pract. 1989 May;184(5):494-7. Unique Identifier : AIDSLINE MED/89315464
Grigoriev VB; Kadochnicov JP; Rudneva IA; Karamov EV; Klimenko SM; Escaig F; Fournier JG; D.I. Ivanovsky Institute of Virology, Academies of Science and; Medicine, Moscouw, USSR.
A post-embedding technique for immunocytochemical analysis at the ultrastructural level was used to detect and localize HIV antigens on ultrathin sections of Lowicryl K4M-embedded HIV-infected cells. With serum from an AIDS patient, specific immunogold labelling was obtained exclusively on mature viral extracellular s
Isolation and structure determination, accompanied by measurement of various biological activities of each isolated tannin, particularly of ellagitannins, have brought about a marked change in the concept of tannins as active constituents of medicinal plants. Their biological activities should now be discussed on the
Van Gorp WG; Satz P; Hinkin C; Evans G; Miller EN; Department of Psychiatry & Biobehavioral Sciences, UCLA School of; Medicine.
A relatively high prevalence of neuropsychological impairment has been reported among individuals within the spectrum of HIV-1 disease. These deficits range from mild motoric slowness to a severe dementia characterized by forgetfulness, psychomotor slowing, impaired performance on
Montgomery AB; State University of New York, Stony Brook 11794.
The continuing growth of the acquired immunodeficiency syndrome (AIDS) epidemic has caused a parallel increase in patients with Pneumocystis carinii pneumonia (PCP). PCP has a wide spectrum of severity, from mild disease to severe parenchymal lung damage. Outcome is determined by severity of lung injury, the underlyin
Hopewell PC; Department of Medicine, University of California.
Because of the abnormalities of host defenses caused by the human immunodeficiency virus (HIV), persons with HIV infection are vulnerable to tuberculosis. Inferential data from several parts of the country indicate increases in tuberculosis case rates, probably occurring in patients with HIV infection. In a person inf
MacDonell KB; Glassroth J; Department of Medicine, Northwestern University Medical School.
Nontuberculous mycobacteria (NTM) have been frequently identified as opportunistic pathogens in individuals with advanced human immunodeficiency virus (HIV) infection. The majority of these infections have been caused by members of the Mycobacterium avium-intracellulare complex (MAC). Disseminated MAC infection has ge
Beck JM; Shellito J; Cardiovascular Research Institute, University of California San; Francisco.
The ability of a microorganism to establish pulmonary infection depends not only upon its pathogenicity, but also on its ability to overcome host defense mechanisms. The frequency of pulmonary infections in patients with the acquired immunodeficiency syndrome (AIDS) suggests that pulmonary host defenses are compromise
Schnittman SM; Psallidopoulos MC; Lane HC; Thompson L; Baseler M; Massari F; Fox CH; Salzman NP; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
Human immunodeficiency virus type 1 (HIV-1) selectively infects cells expressing the CD4 molecule, resulting in substantial quantitative and qualitative defects in CD4+ T lymphocyte function in patients with acquired immunodeficiency syndrome (AIDS). However, only a very small number of cells in the peripheral blood o
Tidsskr Nor Laegeforen. 1989 Jun 30;109(19-21):1986-9. Unique Identifier : AIDSLINE MED/89318149
Haavik J
The first report on the isolation of pteridines from biological materials was published in 1889. During the last 100 years a large number of pteridines have been isolated from many different organisms and have been shown to be involved in several biochemical processes. The best characterized biologically occurring unc
West J Med. 1989 Jun;150(6):700-4. Unique Identifier : AIDSLINE MED/89318967
Theuer CP
Tuberculosis is a frequent complication of human immunodeficiency virus (HIV)-induced immunosuppression. The diagnosis of extrapulmonary tuberculosis in patients with evidence of HIV infection qualifies as a criterion of the acquired immunodeficiency syndrome. Demographic characteristics of patients with tuberculosis
Purdy BD; Plaisance KI; Albany Medical Center, Albany, NY.
The epidemiology, pathogenesis, transmission, and manifestations of infection with the human immunodeficiency virus (HIV) are described, along with the development of diagnostic tests and drugs to combat it. Acquired immunodeficiency syndrome (AIDS) is caused by HIV infection. The syndrome was first reported in 1981,
Spandidos DA; Yiagnisis M; Pintzas A; Beatson Institute for Cancer Research, Glasgow, Scotland, U.K.
We have employed a short term transfection assay to examine the response of HIV-1 LTR to transformation by the human normal and mutant T24 H-ras1 genes. The plasmid pBC12HIVCAT which carries the HIV-1 LTR sequences linked to the reporter gene chloramphenicol acetyl transferase (CAT) was transfected into rat 208F fibro
Forman D; Chilvers C; Imperial Cancer Research Fund, Radcliffe Infirmary, Oxford.
Establishing patterns of sexual behaviour is essential in predicting the future spread of HIV. The sexual behaviour patterns of a randomly selected sample of 480 white men aged 15 to 49 were obtained by interview and analysed in relation to age, social class, and area of residence. Over half of the men had first had i
Linnemann CC Jr; Baughman RP; Frame PT; Floyd R; Department of Medicine, University of Cincinnati College of; Medicine 45267-0560.
Published reports indicate that HIV is recovered from BAL fluid of patients with AIDS who have LIP but not with other AIDS-related pulmonary disease. Our experience has been different. Ten BAL specimens from nine patients with AIDS were cultured directly in peripheral blood mononuclear cells, and all ten cultures were
Since 1983 the morbidity and mortality rates as well as results of haematological, immunological and (later) HIV serological tests were recorded prospectively for 497 HIV-positive patients during 1837 clinic visits at least twice within at most six months for a median period of observation of 18 months (range 6-64 mon
Cohen H; Mackie IJ; Anagnostopoulos N; Savage GF; Machin SJ; Department of Haematology, University College and Middlesex; School of Medicine, London.
The prevalence of lupus anticoagulant, using the dilute Russell s viper venom time (DRVT), was determined in 22 patients with mild to severe haemophilia A to see if there was any association with the presence of viral disease. Twelve haemophiliacs (58%) were lupus anticoagulant positive, with a mean patient:control ra
The investigation was intended to analyse the attitude towards hygiene and cleanliness in the Federal Republic of Germany , France , and Spain . On the basis of a theoretical explanatory model and empirically ga
Am J Hematol. 1989 Jul;31(3):181-7. Unique Identifier : AIDSLINE MED/89300740
Lust JA; Banks PM; Hooper WC; Paya CV; Kueck BD; Hanson GA; Ritch PS; Woloschak GE; Division of Hematology and Internal Medicine, Mayo Clinic,; Rochester, Minnesota 55905.
We present two patients with human immunodeficiency virus-1 (HIV-1) infection in whom T-cell non-Hodgkin lymphoma developed, based on pathologic diagnosis, immunophenotyping, and T-cell receptor gene rearrangement. Both cases were positive for human immunodeficiency virus-1 by enzyme-linked immunosorbent assay and imm
Mortimer JY; Public Health Laboratory Service Communicable Disease; Surveillance Centre, London, UK.
Tests for anti-HIV can be used (1) to establish for clinical or other reasons whether an individual has developed antibody to the virus, (2) to screen donated blood for evidence of infection and (3) to provide estimates of the prevalence of infection in a population. It is suggested that different testing strategies,
Parisi A; Di Perri G; Strosselli M; Nappi G; Minoli L; Rondanelli EG; Department of Infectious Diseases, University of Pavia, Italy.
One hundred and one subjects, with various degrees of HIV infection, were enrolled in a longitudinal study aimed at evaluating the correlation between clinical and instrumental findings in the development of HIV-related subacute encephalitis. The method used was electroencephalography coupled with computerized spectra
Sabatier JM; Clerget-Raslain B; Fontan G; Fenouillet E; Rochat H; Granier C; Gluckman JC; Van Rietschoten J; Montagnier L; Bahraoui E; CNRS UA 1179-INSERM U 172, Laboratoire de Biochimie, Faculte de; Medecine Nord, Marseille, France.
Human sera were tested for the presence of anti-nef antibodies by radioimmunoassay (RIA), with recombinant radiolabelled nef expressed in E. coli. Of the 300 HIV-positive sera tested by RIA, 70 +/- 5.3% were found to be anti-nef positive. Anti-nef antibodies bound to nef with a high affinity (K 0.5 = 2.2 x 10(-9) M).
Lepage P; van de Perre P; Dabis F; Commenges D; Orbinski J; Hitimana DG; Bazubagira A; van Goethem C; Allen S; Butzler JP; et al; Department of Paediatrics, Centre Hospitalier de Kigali, Rwanda.
The World Health Organization (WHO) clinical case definition for paediatric AIDS was tested during a 1-month period on 221 consecutive hospitalized children in Kigali, Rwanda . Relevant clinical features not included in the WHO case definition were a
Reiss P; de Ronde A; Lange JM; de Wolf F; Dekker J; Debouck C; Goudsmit J; Department of Virology, University of Amsterdam, the Netherlands.
Antibody responses against the nef gene product of HIV-1 were determined in sequential sera from a longitudinally studied cohort of 194 initially asymptomatic HIV-1-seropositive individuals and 72 individuals who seroconverted for antibodies to HIV-1 structural proteins (gag/env). In the majority of men, nef-specific
Grieco MH; Reddy MM; Fusillo CA; Sorrell SJ; Buimovici-Klein E; Gindi EJ; Brown DK; Saxinger WC; Weiss SH; Flaster ER; R.A. Cooke Institute of Allergy, St Luke's-Rossevelt Hospital; Center, New York, New York 10019.
One hundred and ninety-nine patients with a history of intravenous drug abuse, and enrolled on the St Luke s-Roosevelt Hospital Center Methadone Program, had baseline evaluations performed from September 1984 to April 1987. The study was designed to examine immunologic parameters associated with HIV seropositivity and
Peuchmaur M; Emilie D; Vazeux R; Pons JC; Delfraissy JF; Lemaigre G; Galanaud P; Service de Pathologie, Hopital A. Beclere, Paris, France.
Using immunohistochemical staining, in situ hybridization and a combination of both, we demonstrate here the replication of HIV in the endometrial stroma. Infected cells do not belong to the T-lymphocyte lineage but rather to a monocyte-macrophage cell type. This report suggests a possible relationship between HIV inf
Cancer Res. 1989 Aug 15;49(16):4488-92. Unique Identifier : AIDSLINE MED/89303877
Kimura N; Takihara Y; Akiyoshi T; Yoshida T; Ohshima K; Kawara T; Hisano S; Kozuru M; Okumura M; Kikuchi M; First Department of Internal Medicine Fukuoka University School; of Medicine, Japan.
We analyzed the rearrangement of T-cell receptor (TcR) delta chain gene in 88 cases of lymphoproliferative disorders; 31 acute lymphoblastic leukemias/lymphoblastic lymphomas (ALL/LBL); 27 adult T-cell leukemias/lymphomas, 9 angioimmunoblastic lymphoadenopathies (AILD); 10 T-cell lymphomas (
d'Onofrio G; Menichella G; Zini G; Rumi C; Pierelli L; Quarantelli M; Puggioni PL; Mango G
Using monoclonal antibodies against CD2, CD4, CD8 and CD19 antigens and an automated biotin-avidin immunoperoxidase technique on whole blood samples, we evaluated the technical performance and clinical usefulness of lymphocyte subset counting by the routine hematology analyzer Technicon H*1. Statistical evaluation dem
Schmidt G; Amiraian K; Frey H; Wethers J; Stevens RW; Berns DS; Wadsworth Center for Laboratories and Research, New York State; Department of Health, Albany 12201.
Antibody responses of 85 patients to human immunodeficiency virus type 1 antigens were quantitated by densitometric analysis of Western blot (immunoblot) assays. All patients had been classified into the following three clinical categories: asymptomatic (ASY), acquired immunodeficiency syndrome (AIDS)-related complex
Rinaldo C; Kingsley L; Neumann J; Reed D; Gupta P; Lyter D; Department of Pathology, School of Medicine, University of; Pittsburgh, Pennsylvania 15261.
Human immunodeficiency virus (HIV) p24 antigenemia was assessed in a longitudinal study of 52 homosexual men who developed serum antibody to HIV. Antibody seroconversion to HIV as defined by a positive HIV enzyme immunoassay (EIA) confirmed by Western (immuno-) blot was associated with three major patterns of HIV anti
Josephson SL; Swack NS; Ramirez MT; Hausler WJ Jr; Hygienic Laboratory, University of Iowa, Iowa City 52242.
Serum specimens which originally exhibited a narrow (indeterminate) 24-kilodalton core protein (p24) or p24/p55 pattern of reactivity with human immunodeficiency virus (HIV) in the Western blot (immunoblot) test were studied to gather information on antibody specificity. A total of 12 specimens were initially reevalua
Ellinger S; Glockshuber R; Jahn G; Pluckthun A; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Federal Republic of Germany.
The proteins p15 and p24 of the human immunodeficiency virus (HIV) type 1 gag gene were expressed as fusion proteins in Escherichia coli for detecting antibodies against the acquired immunodeficiency virus by Western blot (immunoblot) analysis. These fusion proteins contain amino acids 1 to 375 of the E. coli beta-gal
General practitioners in the Severn Faculty of the Royal College of General Practitioners were asked about their knowledge and practice in dealing with HIV infected patients. 62% responded to our anonymous questionnaire. Overall, four-fifths of the doctors expressed confidence in their ability to advise HIV antibody p
J Med Eng Technol. 1989 May-Jun;13(3):177-80. Unique Identifier : AIDSLINE MED/89311377
Corner GA; Shaw A; Department of Clinical Physics and Bio-Engineering, Glasgow, UK.
The risks of infection in servicing medical and hospital laboratory equipment are reviewed. Recommended procedures and precautions for dealing with these risks are detailed. These are based upon the practice adopted in the authors own department. A permit to work scheme is not felt to be universally applicable and
Nagata K; Ohtani K; Nakamura M; Sugamura K; Department of Microbiology, Tohoku University School of Medicine,; Sendai, Japan.
We examined the ability of the trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I), which is thought to be a crucial molecule in T-cell transformation by HTLV-I, to activate expression of a set of endogenous cellular genes related to T-cell proliferation. For this purpose we established a subclon
Chaisson RE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.
Human immunodeficiency virus (HIV) infection is associated with abnormalities of humoral immunity that result in an increased incidence of bacterial pneumonia. From 2% to 10% of acquired immunodeficiency syndrome (AIDS)-associated pneumonia is caused by encapsulated bacteria. Clinical features are usually typical of c
Rev Med Brux. 1989 Apr;10(4):125-30. Unique Identifier : AIDSLINE MED/89317049
Van Laethem Y
Blood transfusions may lead to immunologic but also infectious problems. If bacterial pathogens are rarely involved, blood pathogens - especially malaria - and viruses are dominant. Non-a non-b hepatitis is the most frequently encountered viral infection, with a risk of 1% for each blood unit. Screening of SGPT and an
Weinstein RE; Division of Hematology/Oncology, University of Connecticut Health; Center, Farmington 06032.
The development of factor VIII concentrates has greatly facilitated hemophilia care and has made the home care of hemophilia possible. However, factor VIII concentrate that has been produced using traditional methods contains large amounts of foreign proteins and viruses. This has resulted in the development of immuno
MacDonald KS; Cameron DW; D'Costa L; Ndinya-Achola JO; Plummer FA; Ronald AR; Department of Internal Medicine, University of Manitoba,; Winnipeg, Canada.
Chancroid is gaining importance as a sexually transmitted disease because of its association with transmission of human immunodeficiency virus type 1 (HIV-1). Effective, simply administered therapy for chancroid is necessary. Fleroxacin is effective against Haemophilus ducreyi in vitro. We performed an initial randomi
Scheutz F; Department of Child Dental Health and Community Dentistry, Royal; Dental College, Aarhus, Denmark.
The aims of the study were to study Danish dentists attitudes and behavior with regard to providing dental care to HIV-infected persons and to look for explanatory variables for the dentists attitudes and behavior. Two hundred and twenty-eight Danish dentists responded to a questionnaire on dental treatment of HIV-i
Fromowitz FB; Mann WJ; Golightly MG; Dattwyler RJ; Department of Pathology, University Hospital, State University of; New York, Stony Brook 11794.
Patients with non-HIV (Human Immunodeficiency Virus) related cancers may also have HIV infection. Inverted peripheral blood lymphocyte T helper/T suppressor ratios with selective loss of T helper cells may be used as a clinical screening test for HIV infection in these patients since they may be seronegative for retro
The general fear of catching HIV infection during surgery, medical examination, patient care or emergency care has prompted a discussion and some research regarding the quality of throwaway gloves. Technical regulations regarding the demands to be made on most gloves made of latex that are packed individually and ster
Different opinions on AIDS phobia are presented, referring to five cases of AIDS phobia, selected from clients frequently visiting the AIDS consultation office in the Department of Public Health in Ulm. This problematic and difficult group of clients can be offered help only by close cooperation with therapeutical ins
Sowa PE; Miller D; San Francisco General Hospital, California 94110.
This last example raises the philosophical side of the cost question. The guarantee of a safe work environment is a goal. The efforts to achieve this goal are balanced with the mission of the hospital to provide medical care to those in need. The leadership of the hospital adjusts this balance through the endorsement
Z Hautkr. 1989 May 15;64(5):353-4, 357-8, 363. Unique Identifier : AIDSLINE MED/89299839
Arndt R; Keeser D
CD4 + T-helper lymphocytes are the main target cells in HIV infection. Since CD4 molecules are not restricted to T-cells but also found on monocytes, macrophages, follicular dendritic cells, Langerhans cells, and microglial brain cells, these cells might be affected, too, by HIV. HIV binds via the gp 120 envelope prot
The Fc receptors for IgG(Fc gamma R) play a major role in the removal of antibody-coated infectious agents and may be important molecules for triggering cytotoxicity of tumor cells; they may also serve as an entry for infection of Fc gamma R-bearing cells by viral (including HIV and Dengue), and perhaps other infectio
Naito K; Morioka S; Nakajima S; Ogawa H; Department of Dermatology, Juntendo University School of; Medicine, Tokyo, Japan.
In organ culture experiments, the induction of pemphigus acantholysis is known to be blocked by the addition of serine proteinase inhibitors. Recently, nontoxic synthesized low molecular weight proteinase inhibitors have been clinically available for the treatment of disseminated intravascular coagulation and pancreat
Ruegg CL; Monell CR; Strand M; Department of Pharmacology and Molecular Sciences, Johns Hopkins; University School of Medicine, Baltimore, Maryland 21205.
Peptides were synthesized that contained sequences from two regions (env amino acids [aa] 581 to 597 and 655 to 671) of the transmembrane protein gp41 and one region of the external envelope glycoprotein gp120 (aa 457 to 464) of human immunodeficiency virus type 1. Selection of these sequences was based on their homol
Thromb Haemost. 1989 Feb 28;61(1):81-5. Unique Identifier : AIDSLINE MED/89318007
Panzer S; Stain C; Hartl H; Dudczak R; Lechner K; First Medical Clinic, University of Vienna, Austria.
Levels of anticardiolipin antibodies (ACA) were measured in 55 patients with haemophilia A in serum samples obtained in 1983 and in 1987. Twenty-one patients were negative for anti HIV-1 antibodies in 1983 and remained negative in 1987; 34 patients had anti HIV-1 antibodies in 1983; 17 of these latter patients remaine
Zahn Mund Kieferheilkd Zentralbl. 1989;77(1):40-3. Unique Identifier : AIDSLINE MED/89319293
Poschmann M; Bohm B; Voigt I; Eckelt U; Reinhard U
Increased consciousness of oral hygiene, improvement of sanitation degree and decrease of the number tooth extractions have been proved a success and an expression of high compliance within the scope of long-term interdisciplinary care of haemophilic patients. At the same time both patients registration and concentrat
Koshida R; Vrang L; Gilljam G; Harmenberg J; Oberg B; Wahren B; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
We describe a synergistic effect of combinations of foscarnet and 3 -azido-3 -deoxythymidine against human immunodeficiency virus type 1 multiplication in cell culture, an additive effect of foscarnet and 3 -azido-3 -deoxythymidine triphosphate against human immunodeficiency virus type 1 reverse transcriptase, and a l
Uccini S; Vitolo D; Monardo F; Faggioni A; Monarca B; Vitale A; Ruco LP; Baroni CD; II Pathological Anatomy, University La Sapienza, Rome, Italy.
The presence of Epstein-Barr virus antigens and genome was studied in lymph nodes from HIV + patients affected by PGL. Cryostat sections from 50 lymph nodes of HIV + patients were immunostained with EBV-VCA (viral capsid antigen), EBV-EA (early antigen) and p24 HIV major core protein monoclonal antibodies. In situ hyb
Ernberg I; Altiok E; Department of Tumor Biology, Karolinska Institute, Stockholm; Sweden.
A substantial proportion of the lymphomas in HIV-carriers are EBV positive. Together with the fact that there are multiple signs of EBV-activation in AIDS-patients and patients with ARC or PGL, this suggests that these virus carrying tumors develop as results of the immunosuppression, and that EBV has an important rol
The transactivating protein from human immunodeficiency virus type 1 (HIV-1), Tat, was found to bind to the nuclear matrix from uninfected and HIV-1-infected H9 cells. Addition of the Zn2+, Cd2+ and Cu2+ chelator o-phenanthroline destroyed the matrix fibrils and the binding affinity of Tat to the matrix. A sequential
Cancer Res. 1989 Jul 15;49(14):3849-52. Unique Identifier : AIDSLINE MED/89288030
Fukumoto S; Matsumoto T; Watanabe T; Takahashi H; Miyoshi I; Ogata E; Fourth Department of Internal Medicine, University of Tokyo; School of Medicine, Japan.
Because many patients with adult T-cell leukemia/lymphoma (ATLL) develop hypercalcemia with similar characteristics to those of humoral hypercalcemia of malignancy (HHM) (Arch. Intern. Med., 148: 921-925, 1988), we investigated if ATLL cells produce parathyroid hormone (PTH)-like activity. Conditioned media from cultu
Nine patients with unilateral cytomegalovirus ( CMV ) retinitis were treated with intravenous infusions of the new virustatic drug DHPG (Ganciclovir). The induction dose was 10 mg/kg body weight per day (2-5 weeks). In six case
Clouse KA; Robbins PB; Fernie B; Ostrove JM; Fauci AS; Department of Microbiology, Georgetown University, Washington,; D.C. 20007.
We have previously described model systems for cytokine-induced regulation of chronically HIV-infected promonocyte and T cell clones. Using these systems, we have shown that monokines contained in supernatants from LPS-stimulated human monocyte/macrophages (MO) up-regulate HIV expression, reflected by an increase in r
Lackner AA; Marx PA; Lerche NW; Gardner MB; Kluge JD; Spinner A; Kwang HS; Lowenstine LJ; California Primate Research Center, Davis 95616.
The aetiological agent of spontaneously occurring simian acquired immune deficiency syndrome (SAIDS) in rhesus monkeys (Macaca mulatta) at the California Primate Research Center is a type D retrovirus designated SAIDS retrovirus serotype 1 (SRV-1). SRV-1 DNA and RNA have previously been detected in the brains of rhesu
Medicine (Baltimore). 1989 Jul;68(4):189-209. Unique Identifier : AIDSLINE MED/89295104
Quinn TC; Zacarias FR; St. John RK; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland.
With over 143,000 cases of AIDS reported to the World Health Organization from 145 countries and with an estimated 5 to 10 million people worldwide infected with HIV, AIDS has become firmly established as a global pandemic. In the region of the Americas over 100,862 cases of AIDS have
Lehoang P; Girard B; Robinet M; Marcel P; Zazoun L; Matheron S; Rozenbaum W; Katlama C; Morer I; Lernestedt JO; et al; Department of Ophthalmology, Pitie-Salpetriere Hospital,; Paris, France.
Cytomegalovirus ( CMV ) retinitis is the major cause of visual loss in acquired immune deficiency syndrome (AIDS). Thirty-one patients with active CMV retinitis were treated with the new antiviral drug, Foscarnet (trisodium phosphonoformate). After a 3-week course
Presse Med. 1989 Jun 24;18(25):1239-42. Unique Identifier : AIDSLINE MED/89296815
Caubel P; Foulques H; Blondon J; Lefranc JP; Departement de Pathologie cervico-vaginale, Hopital de la; Salpetriere, Paris.
In a series of 29 HIV-seropositive women (mean age 27.4 years; 75.9 per cent acquired HIV by intravenous drug abuse) observed over a 2 years period, we were able to determine the main epidemiological characteristics of cervico-vaginal and vulvar lesions caused by human papillomavirus (HPV). More than 58 per cent of c
Proc Natl Acad Sci U S A. 1989 Jul;86(13):4813-7. Unique Identifier : AIDSLINE GENBANK/M23165
Colombini S; Arya SK; Reitz MS; Jagodzinski L; Beaver B; Wong-Staal F; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20892.
Three full-length cDNA clones were obtained from cells infected with the simian immunodeficiency virus (SIV) isolated from captive macaques (SIVMAC). Nucleotide sequence analyses suggested that these represented mRNA for the SIV MAC genes tat, rev (formerly, art/trs), and nef (formerly, 3 orf). The putative tat-specif
Proc Natl Acad Sci U S A. 1989 Jul;86(13):4858-62. Unique Identifier : AIDSLINE MED/89296903
Gaynor R; Soultanakis E; Kuwabara M; Garcia J; Sigman DS; Molecular Biology Institute, School of Medicine, University of; California, Los Angeles.
The transactivator protein, tat, encoded by the human immunodeficiency virus is a key regulator of viral transcription. Activation by the tat protein requires sequences downstream of the transcription initiation site called the transactivating region (TAR). RNA derived from the TAR is capable of forming a stable stem-
Austin JH; Schulman LL; Mastrobattista JD; Department of Radiology, Columbia-Presbyterian Medical Center,; New York, NY 10032.
Forty-one episodes of radiographically demonstrated pulmonary infection developed in 35 (30%) of 118 cardiac transplant recipients treated with cyclosporine. The most common pathogens were cytomegalovirus ( CMV ) (13 episodes),
Sex Transm Dis. 1989 Apr-Jun;16(2):51-6. Unique Identifier : AIDSLINE MED/89298542
Judson FN; Ehret JM; Bodin GF; Levin MJ; Rietmeijer CA; Department of Medicine, University of Colorado, Denver.
Simulated in vitro intercourse conditions demonstrated that unlubricated latex condoms provide an effective physical barrier to high concentrations of Chlamydia trachomatis, herpes simplex virus type 2, and human immunodeficiency virus. However, since condoms can be damaged after manufacturing inspection and prior to
Hughes JM; Center for Infectious Diseases, Centers for Disease Control,; Atlanta, Georgia 30333.
We know that the risk to health-care workers of acquiring HBV infection in the health-care setting is greater than that of acquiring HIV infection. We know that blood is the primary concern and that the risk following needlestick injury or a cut involving exposure to blood from an HIV-infected individual is approximat
Gourdou I; Mazarin V; Querat G; Sauze N; Vigne R; Laboratoire de Virologie, Faculte de Medecine Nord, Marseille,; France.
Soon after infection of ovine cell cultures, visna virus expression is first indicated by the accumulation of two multi-spliced transcripts of 1.2 and 1.6 kb that at present we have renamed 1.4 and 1.7 kb according to their exact length. The early 1.4-kb mRNA encodes for a protein which increases the level of transcri
Am J Gastroenterol. 1989 Jul;84(7):790-3. Unique Identifier : AIDSLINE MED/89300691
Wajsman R; Cappell MS; Biempica L; Cho KC; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York.
A 41-yr-old homosexual male had cytomegalovirus infection localized to the terminal ileum as his initial and sole evident opportunistic infection due to the acquired immune deficiency syndrome. The symptoms, signs, roentgenographic findings, and appearance at surgery were suggestiv
Larsen RA; Bozzette S; McCutchan JA; Chiu J; Leal MA; Richman DD; Los Angeles County-University of Southern California Medical; Center.
STUDY OBJECTIVE: To assess the frequency of persistent Cryptococcus neoformans infection in patients with the acquired immunodeficiency syndrome (AIDS) after receiving apparently adequate treatment for meningitis. DESIGN: Blood, urine, and cerebrospinal fluid were cultured at the conclusion of primary therapy to asses
This revision of the General Recommendations on Immunization updates the 1983 statement. Changes or new sections include 1) listing of vaccines available in the United States by type and recommended routes, 2) updated schedules for immunizing infants and children, 3) clarification of t
Ann Neurol. 1989 Jun;25(6):561-6. Unique Identifier : AIDSLINE MED/89301554
Grafe MR; Wiley CA; Department of Pathology (Neuropathology), University of; California, San Diego.
We examined spinal cords, nerve roots, or peripheral nerves of 27 patients who died with acquired immunodeficiency syndrome (AIDS) for the presence of cytomegalovirus ( CMV ) and human immunodeficiency virus (HIV) by immunopero
Balzarini J; Herdewijn P; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
3 -Azido-2,6-diaminopurine-2 ,3 -dideoxyriboside (AzddDAPR) is a potent and selective inhibitor of human immunodeficiency virus (HIV) replication in vitro. It also inhibits Moloney murine sarcoma virus (MSV)-induced transformation of murine C3H/3T3 embryo fibroblasts. AzddDAPR causes a marked dose-dependent suppressio
Nokta MA; Pollard RB; Department of Internal Medicine, University of Texas Medical; Branch, Galveston 77550.
Zidovudine (ZDV), an anti-human immunodeficiency virus (HIV) therapy, has been associated with reduction in mortality and improvement of patients with acquired immunodeficiency syndrome (AIDS). The ZDV recipients, however, experience a multitude of side effects of which bone marrow suppression is the most noteworthy,
Weir AB 3d; Herrod HG; Lester EP; Holbert J; Department of Medicine, University of Tennessee, Memphis.
An increased incidence of non-Hodgkin s lymphoma has been described in patients with rheumatoid arthritis. Mechanisms related to abnormal immune regulation have been postulated, but no patients with rheumatoid arthritis and lymphoma have been previously well characterized immunolog
Kucera LS; Raben D; Iyer N; Ricardo MJ Jr; Department of Microbiology and Immunology, Bowman Gray School of; Medicine, Wake Forest University, Winston-Salem, NC 27103.
Unstimulated human leukemia T-cell lines (MOLT-4, MT-4) were tested for their susceptibility to herpes simplex virus type 2 (HSV-2) infection. Permissive infection of MT-4 cells was demonstrated by growth curve and infectious center assays. In growth curve experiments new progeny virus replication was detected by 24 h
Schultz KT; Thomas C; Toohey K; Curro T; Department of Pathobiological Sciences, School of Veterinary; Medicine, University of Wisconsin, Madison.
An ELISA was developed to detect antibodies to a Type D retrovirus, SRV-W. The interpretation of the ELISA results were based on: 1) Comparisons of known antibody positive (to a closely related type D retrovirus) and negative serum samples, 2) the ability of ELISA reactivity to be absorbed with a Type D virus but not
Manuelidis EE; Manuelidis L; Yale University School of Medicine, Section of Neuropathology,; New Haven, CT 06510.
Several lines of investigation identify common features of Creutzfeldt-Jakob disease, Alzheimer disease, and retroviral CNS infections. We discuss salient neuropathological, genetic, transmission, and transformation properties that suggest there may be common pathways in the pathogenesis of dementias. We also briefly
Casareale D; Fiala M; Chang CM; Cone LA; Mocarski ES; Electron Microscopy Laboratory, Scripps Clinic and Research; Foundation, La Jolla, CA 92307.
A T4+ lymphoblastoid cell line (CR-10) persistently infected with the human immunodeficiency virus (HIV) and designated CR-10/NIT was superinfected with cytomegalovirus ( CMV ) isolated from peripheral blood mononuclear cells o
J Immunol. 1989 Aug 1;143(3):844-50. Unique Identifier : AIDSLINE MED/89309757
Morse HC 3d; Yetter RA; Via CS; Hardy RR; Cerny A; Hayakawa K; Hugin AW; Miller MW; Holmes KL; Shearer GM; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
The functional and phenotypic characteristics of Ly-4(CD4)+ and Ly-2(CD8)+ T cells were studied after induction of murine AIDS with LP-BM5 murine leukemia virus. Assays of spleen cells for their ability to generate in vitro CTL responses to TNP-modified autologous cells (self + x CTL) and to alloantigens (allo CTL) sh
J Immunol. 1989 Aug 15;143(4):1149-54. Unique Identifier : AIDSLINE MED/89309791
Lederman S; Gulick R; Chess L; Department of Medicine, Columbia University, College of; Physicians and Surgeons, NY 10032.
Dextran sulfate, heparin, and certain other sulfated polysaccharides potently inhibit the adsorption of HIV to CD4+ cells. The mechanism of this inhibition is unclear and, specifically, it is unknown if these agents act at the level of CD4-gp120 binding. For example, previous reports have demonstrated that dextran sul
Protein myristoylation was first discovered in the catalytic subunit of adenosine 3 ,5 -cyclic monophosphate-dependent protein kinase. Subsequently, various cellular and viral myristoylated proteins were detected. In each case, the myristoyl moiety was found in an amide linkage with the amino terminal glycine residue
Syrjanen S; Laine P; Niemela M; Happonen RP; Department of Oral Pathology, University of Kuopio, Finland.
Oral hairy leukoplakia (HL) has been regarded as an early sign of HIV infection, and its clinical importance related to the poor outcome of the patients has been emphasized. Initially, HL was observed exclusively among male homosexuals, but subsequently demonstrated in all risk groups of HIV infection. The patient des
Greenspan D; Greenspan JS; de Souza Y; Levy JA; Ungar AM; Department of Stomatology, University of California, San; Francisco 94143-0512.
Oral hairy leukoplakia (HL) has been seen exclusively in those infected with HIV or at risk for AIDS. This case report describes an example of HL seen in a renal transplant recipient who was negative for HIV on serology and culture. The diagnosis of HL was confirmed using in situ hybridization for EBV DNA.
Schulten EA; ten Kate RW; van der Waal I; Department of Oral Pathology, Free University Hospital/ACTA,; Amsterdam, The Netherlands.
Seventy-five consecutive HIV-infected patients, including 33 AIDS cases were examined. One or more oral mucosal lesions were observed in 57 (76%); candidiasis was the most common finding (52%). Others included hairy leukoplakia (16%), periodontal disease (16%) and Kaposi s sarcoma (4%). Diversity of study design and m
Malim MH; Fenrick R; Ballard DW; Hauber J; Bohnlein E; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
Transcriptional trans activation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) by the viral tat trans activator is mediated by an LTR-specific sequence located immediately 3 to the start of transcription initiation. We have used a range of molecular techniques to examine DNA-protein in
Fujisawa J; Toita M; Yoshida M; Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
The trans activator (p40tax) of human T-cell leukemia virus type I (HTLV-I) is a transcriptional factor that activates the long terminal repeat (LTR) of HTLV-I and interleukin-2 receptor alpha. We examined the HTLV-I enhancer responsible for tax-mediated trans activation and identified (A/T)(G/C)(G/C)CNNTGACG(T/A) as
Berman PW; Riddle L; Nakamura G; Haffar OK; Nunes WM; Skehel P; Byrn R; Groopman J; Matthews T; Gregory T; Department of Developmental Biology, Genentech, Inc., South San; Francisco, California 94080.
The envelope glycoprotein of human immunodeficiency virus type 1 is synthesized as a precursor, gp160, that subsequently is cleaved to yield mature gp120 and gp41. In these studies, the gene encoding gp160 was mutagenized so as direct the synthesis of a truncated protein consisting of the extracellular domains of both
A 40-year old homosexual AIDS patient recovering from a Pneumocystis carinii pneumonia developed a Cryptococcus neoformans infection with involvement of the central nervous system (CNS) which could be treated successfully with amphotericin B and flucytosine. After a symptom-free interval of 4 1/2 months, a new acute f
Wallace JM; Department of Medicine, Olive View Medical Center, Sylmar, CA; 91342.
Viral pneumonitides are among the known pulmonary complications of human immunodeficiency virus (HIV) infection. Cytomegalovirus ( CMV ) pneumonitis is the most frequently recognized viral infection involving the lung. Although CMV may occasionally be the sole pat
Marks GL; Nolan PE; Erlich KS; Ellis MN; Division of Infectious Diseases, University of South Alabama; College of Medicine, Mobile 36688.
Infections caused by herpes simplex virus (HSV) are a significant source of morbidity in immunocompromised patients. Acyclovir is often used prophylactically and therapeutically in patients with human immunodeficiency virus infection. The emergence of acyclovir-resistant strains
During a three-week period in March/April 1987, the authors examined 253 consecutive patients referred to a rural hospital in northwestern Tanzania . Sera were tested for antibodies to human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), and hu
Ann Intern Med. 1989 Aug 1;111(3):223-31. Unique Identifier : AIDSLINE MED/89321190
Masur H; Ognibene FP; Yarchoan R; Shelhamer JH; Baird BF; Travis W; Suffredini AF; Deyton L; Kovacs JA; Falloon J; et al; National Institutes of Allergy and Infectious Diseases, Bethesda,; Maryland.
STUDY OBJECTIVE: To determine if circulating CD4+ lymphocyte counts are predictive of specific infectious or neoplastic processes causing pulmonary dysfunction. DESIGN: Retrospective, consecutive sample study. SETTING: Referral-based clinic and wards. PATIENTS: We studied 100 patients infected with human immunodeficie
Eriksson BF; Schinazi RF; Veterans Administration Medical Center Atlanta, Decatur, Georgia; 30033.
Combinations of 3 -azido-3 -deoxythymidine and phosphonoformate produced a moderate synergistic inhibitory effect against human immunodeficiency virus type 1 in vitro at concentrations that are easily achieved in humans. The synergistic effect was more pronounced with increasing concentrations and was not secondary to
Jacobson MA; O'Donnell JJ; Mills J; Department of Medicine, University of California, San Francisco.
Ten patients with acquired immunodeficiency syndrome with newly diagnosed cytomegalovirus ( CMV ) retinitis were treated with an induction regimen of intravenous foscarnet, 60 mg/kg of body weight, administered as a 2-h infusio
Aweeka F; Gambertoglio J; Mills J; Jacobson MA; Division of Clinical Pharmacy, University of California, San; Francisco 94143-0622.
Foscarnet has been shown to be active in vitro against the human immunodeficiency virus and all human herpesviruses including cytomegalovirus ( CMV ). A pharmacokinetic study was carried out as part of a clinical trial designed
Dennehy PJ; Warman R; Flynn JT; Scott GB; Mastrucci MT; Department of Ophthalmology, Bascom Palmer Eye Institute,; Detroit, Mich.
Forty pediatric patients seropositive for human immunodeficiency virus antibody and conforming to Centers for Disease Control, Atlanta, Ga, case definition of acquired immunodeficiency syndrome underwent ophthalmic examinations to evaluate prospectively the incidence, type, and natural history of ocular involvement in
Coates D; Wilson M; Public Health Laboratory, Preston, Lancashire.
The use of chlorine-containing granules for disinfecting body fluid spills has been evaluated by hospital trials and laboratory tests. Hospital trials were carried out by nurses using Presept disinfectant granules according to a protocol. In general they preferred using granules to bleach and, in 50 tests using gran
Webster A; Lee CA; Cook DG; Grundy JE; Emery VC; Kernoff PB; Griffiths PD; Department of Virology, Royal Free Hospital, School of Medicine,; London.
To examine whether cytomegalovirus ( CMV ) infection could accelerate progression of human immunodeficiency virus (HIV) infection to AIDS, serological studies were done on 108 HIV-infected haemophiliacs. In the 1.3-9 years from
Hanson PJ; Gor D; Clarke JR; Chadwick MV; Nicholson G; Shah N; Gazzard B; Jeffries DJ; Gaya H; Collins JV; Brompton Hospital, London.
Contamination of twenty endoscopes used in patients with AIDS was assessed. The suction-biopsy, air, and water channels and the insertion tube were sampled after use, after washing in detergent, and after disinfection for 2 min in 2% alkaline glutaraldehyde. The polymerase chain reaction with Southern blotting, cell c
Shaunak S; Bartlett JA; Division of Infectious Diseases, Duke University Medical Center,; Durham, North Carolina 27710.
30 patients with recurrent zidovudine-induced neutropenia were followed up for a total of 493 months of treatment to evaluate their risk of bacterial infection. Zidovudine was temporarily discontinued only when the polymorphonuclear (PMN) cell count fell to less than 500/microliters. The incidence of bacterial infecti
Schweiz Rundsch Med Prax. 1989 May 16;78(20):576-81. Unique Identifier : AIDSLINE MED/89297934
Wuthrich B
Urticaria is a rather common, often vexing skin disease, characterized by evanescent, pruritic, erythematous wheals, and sometimes by giant hives (angioedema). The cause of chronic urticaria remains unknown in 75 to 80 percent of the cases. Its pathogenesis is related to the activation of tissue mast cells by many imm
A 30-year-old homosexual man developed multiple skin umbilicated lesions resembling molluscum contagiosum. Initially the lesions were on his face but they rapidly spread. Histopathology and mycologic cultures of a skin biopsy revealed cryptococcus neoformans which was also identified in cerebrospinal fluid and in bron
Gen Hosp Psychiatry. 1989 Jul;11(4):248-53. Unique Identifier : AIDSLINE MED/89306555
Swenson JR; Erman M; Labelle J; Dimsdale JE; Department of Psychiatry, University of California, San Diego.
The use of neuroleptic medication as antiemetics, or in the treatment of neuropsychiatric disorders in patients with AIDS, may be associated with extrapyramidal side effects and lead to difficulty with diagnosis and management. Two cases are presented that describe severe extrapyramidal syndromes occurring in two pati
A group of 173 subjects affected by congenital clotting factor deficiencies was evaluated with regard to the impact of HIV infection. On the whole, 78 patients (45%) were found to be HIV Ab-positive. As of March, 1988, of the seropositive patients, 63 (80.8%) had an asymptomatic HIV infection (Group II/CDC), three (3.
51 patients infected with the human immunodeficiency virus (HIV) and with suspected Pneumocystis carinii pneumonia underwent sputum induction. Sputum specimens from 18 patients were positive for P carinii and patients were treated appropriately 25 of the 33 patients with negative specimens underwent bronchoscopy and b
Kennedy-Stoskopf S; Zink C; Narayan O; Division of Comparative Medicine, Johns Hopkins School of; Medicine, Baltimore, Maryland 21205.
Sheep and goats develop a chronic, progressive arthritis reminiscent of rheumatoid arthritis, but caused by lentiviruses related to human immunodeficiency virus. The distribution of T lymphocytes in peripheral circulation of two infected sheep with arthritis, one infected sheep with interstitial pneumonia, three asymp
Lohr HF; Ramadori G; Mayet WJ; Hess G; Meyer zum Buschenfelde KH; I. Medizinische Klinik und Poliklinik der Universitat Mainz.
A lambda-light chain-IgA plasmocytoma, accompanied by a changing clinical picture of fever, nocturnal perspirations and weight loss, developed in a 46-year-old homosexual male with AIDS, stage IV (classification according to the Centers for Disease Control). He had been suffering from recurrent Salmonella septicaemia.
Mathiesen T; Chiodi F; Broliden PA; Albert J; Houghten RA; Utter G; Wahren B; Norrby E; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
To define the amino acids involved in IgG subclass reactivity to two overlapping HIV-1 gp41 (E34/32; amino acid positions 582-613) peptides, sera from 18 HIV-infected individuals were studied. Peptides mimicking E34 but with single amino acid deletions or glycine substitutions were used to define the amino acid residu
Proc Natl Acad Sci U S A. 1989 Jul;86(13):4803-7. Unique Identifier : AIDSLINE MED/89296892
Larder BA; Kemp SD; Purifoy DJ; Wellcome Research Laboratories, Department of Molecular Sciences,; Beckenham, Kent, United Kingdom.
There is considerable interest in the potential of human immunodeficiency virus type 1 (HIV-1) to develop drug resistance, especially as 3 -azido-3 -deoxythymidine (Retrovir) is now in widespread clinical use to treat people with AIDS and AIDS-related complex (ARC). To address this possibility, mutations in the HIV re
Proc Natl Acad Sci U S A. 1989 Jul;86(13):4958-62. Unique Identifier : AIDSLINE MED/89296922
Bednarik DP; Mosca JD; Raj NB; Pitha PM; Department of Molecular Biology and Genetics, Johns Hopkins; University, Baltimore, MD 21205.
We have prepared stable cell lines, derived from Vero cells and A3.01 cells, that express a hybrid human alpha 2-interferon gene under control of the human immunodeficiency virus (HIV) long terminal repeat. These cells constitutively produced low levels (50-150 units/ml) of alpha 2-interferon. However, high levels of
Proc Natl Acad Sci U S A. 1989 Jul;86(13):5163-7. Unique Identifier : AIDSLINE MED/89296965
Terwilliger EF; Cohen EA; Lu YC; Sodroski JG; Haseltine WA; Department of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, MA 02115.
To investigate the role of vpu in the replication and cytopathicity of human immunodeficiency virus type 1 (HIV-1), infectious proviruses were constructed that were isogenic except for the ability to produce the protein product of vpu. The vpu-encoded protein is shown to decrease the rate of syncytium formation and ce
Lyme disease is of interest to the neurologist and neuroscientist for a variety of reasons. As more arthropod hosts throughout the world are infected with the causative organism, Borrelia burgdorferi, the illness in humans is becoming more prevalent; in addition, recognition of the disease in humans and susceptible an
Tersmette M; Winkel IN; Groenink M; Gruters RA; Spence RP; Saman E; Van Der Groen G; Miedema F; Huisman JG; Central Laboratory, Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
A panel of monoclonal antibodies (Mabs) was used to analyze the number and localization of B-cell epitopes on human immunodeficiency virus (HIV) p24gag and the variability of these epitopes in sequential HIV isolates and in isolates from different geographical origin. The specificity of these Mabs was demonstrated by
Am J Med. 1989 Jul;87(1):57-61. Unique Identifier : AIDSLINE MED/89300845
Gill PS; Akil B; Colletti P; Rarick M; Loureiro C; Bernstein-Singer M; Krailo M; Levine AM; Department of Internal Medicine, University of Southern; California School of Medicine, Los Angeles.
PURPOSE: Kaposi s sarcoma occurs commonly in patients with the acquired immunodeficiency syndrome (AIDS). Kaposi s sarcoma may remain localized or disseminate to involve visceral organs such as the lungs. Disseminated pulmonary involvement, when it occurs, is often fatal. Effective therapy may improve survival in such
Vrang L; Oberg B; Lower J; Kurth R; Department of Virology, Karolinska Institute, Stockholm, Sweden.
Reverse transcriptases from human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV) were investigated with respect to susceptibilities to the reverse transcriptase inhibitors foscarnet and 3 -azido-3 -deoxythymidine triphosphate (AZTTP). The different reverse transcriptases had the
Baba M; Snoeck R; Pauwels R; de Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
Several sulfated polysaccharides (dextran sulfate, pentosan polysulfate, fucoidan, and carrageenans) proved to be potent inhibitors for herpes simplex virus, human cytomegalovirus , vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus. They were moderately inh
Mathiesen T; Sonnerborg A; Wahren B; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
Fifteen HIV seropositive patients were studied. It was possible to enhance detection of HIV antigen and HIV and myelin basic protein (MBP) antibodies after dissociation of immune complexes by acid hydrolysis. HIV p24 antigen was then detected in four patients, three of whom were previously antigen negative. In 14 pati
Atsumi S; Muraoka Y; Nogami T; Hoshino H; Takeuchi T; Umezawa K; Institute of Microbial Chemistry, Tokyo, Japan.
A semi-synthetic bleomycin analogue and its DNA binding moiety, an alkylamino-2-methoxy-6-chloroacridine, have been found to inhibit human immunodeficiency virus-associated reverse transcriptase. The authors have synthesized various new alkylaminoacridine derivatives. Alkylaminoacridines with basic functional groups s
Brusamolino E; Lazzarino M; Morra E; Inverardi D; Merante S; Castelli G; Canevari A; Dornini G; Bernasconi C
Fifty untreated adult patients with advanced Hodgkin s disease (HD) were given alternating MOPP-ABVD chemotherapy in a prospective eight-cycle program. This series included 33 patients with stage II-III disease and bulky lymphoma and/or B symptoms, and 17 patients with stage IV disease. Nodular sclerosis amounted to 5
Dutt K; York D; Kaplan HJ; Semple E; Verly G; Srinivasan A; Department of Pathology, Morehouse School of Medicine, Atlanta,; Georgia 30310.
The ability of the human immunodeficiency virus type 1 (HIV-1) to replicate in cells derived from ocular tissue was studied. Primary retinal cultures (containing both glial and neuronal cells) were found to support the replication of HIV upon transfection with molecularly cloned proviral DNA. In addition, established
J Immunol. 1989 Aug 15;143(4):1327-33. Unique Identifier : AIDSLINE MED/89309820
Inatsuki A; Yasukawa M; Kobayashi Y; First Department of Internal Medicine, Ehime University School of; Medicine, Japan.
In an attempt to understand the mechanisms of immunodeficiency induced by human T lymphotropic virus type I (HTLV-I), HSV-specific CD4+ human multifunctional T cell clones were infected with HTLV-I in vitro. Early after HTLV-I infection, when their growth was still IL-2-dependent, clones were found to have almost comp
Sano K; Yagi T; Morimatsu S; Kato K; Sakanaka M; Okubo S; Yasunaga K; Nakai M
To investigate a non-RI test which is equivalent to the reverse transcriptase inhibiting antibody test, a reverse transcriptase inhibiting antibody was compared to the absolute number of CD-4 or CD-8 cells or CD-4/-8 ratio and also to photodensitometric analysis for western blotting. There is no correlation of the rev
Niedrig M; Hinkula J; Weigelt W; L'age-Stehr J; Pauli G; Rosen J; Wahren B; Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, Federal; Republic of Germany.
Murine monoclonal antibodies directed against the structural proteins p17 and p24 of human immunodeficiency virus type 1 were investigated in an epitope mapping system. Overlapping peptides consisting of 15 amino acids of the p17 and p24 protein, respectively, were used as competitors in an enzyme-linked immunosorbent
Hadley WK; Ng VL; Department of Laboratory Medicine, University of California, San; Francisco.
When faced with the ever-increasing demand for the rapid laboratory diagnosis of Pneumocystis carinii pneumonia (PCP), as well as a variety of fungal, parasitic, and bacterial opportunistic infections in Human Immunodeficiency Virus (HIV)-infected individuals, the Chest Service and the Clinical Microbiology Laboratory
Pedersen M; Nielsen CM; Permin H; Norn S; University Clinic for Infectious Diseases M, Rigshospitalet,; Copenhagen, Denmark.
HIV antigen-induced histamine release was examined in leukocyte suspensions from 12 patients with AIDS and 10 healthy controls. Nine of the twelve patients released histamine, while no release was obtained in cells from the control group. The mechanism was examined by removal of immunoglobulins (Ig) from the patient c
Maehlen T; Degre M; Wilhelmsens Institute of Bacteriology, Rikshospitalet, University; of Oslo, Norway.
The effect of fusidic acid on the multiplication of human immunodeficiency virus in monocyte-derived macrophages was examined in in vitro cultures. Virus titers, measured by reverse transcriptase and by p24 antigen in the supernatants and in lysed cells, were reduced in some experiments by 50 micrograms/ml or more; in
Pepose JS; Linette G; Lee SF; MacRae S; Department of Ophthalmology, Washington University School of; Medicine, St. Louis, Mo 63110.
Goldmann tonometer tips were inoculated with 5 X 10(5) IU of cell-free or cell-associated human immunodeficiency virus type 1 (lymphadenopathy virus type 1 isolate) or 10(4) plaque-forming units of herpes simplex virus type 1 (McKrae strain) or type 2 (Hicks strain). In an effort to mimic a worst case clinical scenari
This information is designed to support, not replace, the relationship that exists between you and your doctor.