Pathophysiology of thrombocytopenia associated with HIV infection in homosexual men. A preliminary report. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Pathophysiology of thrombocytopenia associated with HIV infection in homosexual men. A preliminary report.

Blut. 1989 Jul;59(1):111-4. Unique Identifier : AIDSLINE MED/89323497
Ballem PJ; Belzberg A; Devine D; Doubroff P; Mikulash C; Spurston B; Chambers H; Sartori C; Buskard N; Canadian Red Cross BTS, Vancouver, B.C.

Abstract: The pathophysiology of HIV associated immune thrombocytopenia (HIV-ITP) and its response to AZT was investigated. Using autologous 111Indium-labelled platelets, platelet kinetic were analysed in two patient groups. Group 1 (untreated) was comprised of 13 patients with HIV-ITP. Group 2 (AZT) was comprised of 6 patients with a history of HIV-ITP prior to starting AZT. These patients were studied following a rise in their platelet count on AZT. Platelet survivals in both groups were shortened compared to controls, however there was no significant difference between the 2 groups. However platelet turnover rates were significantly depressed in Group 1 compared to Group 2 (P less than 0.05) and control values (P less than 0.05). The platelet count correlated with platelet turnover in Group 1 but not in AZT treated patients. Thus patients with HIV-ITP appear to have both shortened survivals and suppressed platelet production. The mechanism of the latter is unknown, but the increased turnover rate seen with AZT suggests it is a direct or indirect effect of the HIV virus.
Keywords: Acquired Immunodeficiency Syndrome/*BLOOD/COMPLICATIONS/ IMMUNOLOGY Autoimmune Diseases/PHYSIOPATHOLOGY Blood Platelets/PHYSIOLOGY Cell Survival Homosexuality Human HIV Seropositivity/BLOOD Male Platelet Count Support, Non-U.S. Gov't Thrombocytopenia/*PHYSIOPATHOLOGY Zidovudine/THERAPEUTIC USE JOURNAL ARTICLE

KWDacquiredimmunodeficiencysyndrome/KWDblood/complications/immunologyautoimmunediseases/physiopathologybloodplatelets/physiologycellsurvivalhomosexualityhumanhivseropositivity/bloodmaleplateletcountsupport,non-uKWDsKWDgov'tthrombocytopenia/KWDphysiopathologyzidovudine/therapeuticusejournalarticle
891130
M89B0534

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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