Chronic immune thrombocytopenic purpura--immunological analyses of a patient pre- and post-HIV seroconversion. NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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Chronic immune thrombocytopenic purpura--immunological analyses of a patient pre- and post-HIV seroconversion.

Blut. 1989 Jul;59(1):115-20. Unique Identifier : AIDSLINE MED/89323498
Spath PJ; Elisa A; Buhlmann U; Luginbuhl L; Imbach P; Central Laboratory, Blood Transfusion Service, Swiss Red Cross,; Berne.

Abstract: A seven year follow-up of immune parameters is reported for a patient with chronic immune thrombocytopenic purpura (ITP) pre and post human immunodeficiency virus (HIV) seroconversion. Therapies such as intravenous IgG, prednisone, vincristine, or Ciclosporin A had no clear-cut beneficial effect on platelet counts. A long-term normalization of platelet counts was achieved by splenectomy. At splenectomy the patient was seropositive for HIV, most likely transmitted by blood products received half a year prior to laparatomy. Mean plasma levels of the second component of complement, C2, were half of the normal values prior to and within the lowest normal range post HIV seroconversion. Nevertheless, the T cell-dependent B cell response to HIV, which is dependent on the activation of C3 via the classical pathway of complement, was normal: Western blot analysis of total IgG and of IgG subclass responses to individual HIV antigens proved to be unimpaired.
Keywords: Antigen-Antibody Complex/ANALYSIS Case Report Child Chronic Disease Complement 2/METABOLISM Complement 4/METABOLISM Female Human HIV Seropositivity/*IMMUNOLOGY Platelet Count Purpura, Thrombocytopenic/*IMMUNOLOGY Splenectomy JOURNAL ARTICLE

KWDantigen-antibodycomplex/analysiscasereportchildchronicdiseasecomplement2/metabolismcomplement4/metabolismfemalehumanhivseropositivity/KWDimmunologyplateletcountpurpura,thrombocytopenic/KWDimmunologysplenectomyjournalarticle
891130
M89B0533

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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