Pacific Immunodeficiency Virus, Human T Lymphotropic Virus - Type I and Hepatitis B Virus Infections in the South Pacific Manila, Philippines : Printed and distributed by the Regional Office, [1988] 27 p. : ill Unique Identifier : AIDSLINE CAT/8915513
[Canberra : Published by the AIDS Council of South Australia on behalf of the Australian Federation of AIDS Organisations, v. : ill Unique Identifier : AIDSLINE CAT/8915229
Amsterdam, The Netherlands : Excerpta Medica, [c1989- v Unique Identifier : AIDSLINE CAT/8915364
Worldwide listing of journal articles. Classified arrangement. Entries give bibliographical information, address of author, and lengthy abstract. Index.
HIV/AIDS [Atlanta, GA] : U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Infectious Diseases, Division of HIV/AIDS ; Rockville, MD : National AIDS Information Clearinghouse [distributor], [1989-1993] v. : ill Unique Identifier : AIDSLINE CAT/8915760
New York : Free Press ; Toronto : Collier Macmillan Canada ; New York : Maxwell Macmillan International, c1990 xiv, 218 p Unique Identifier : AIDSLINE CAT/8915529
Radiology of AIDS. Federle MP et al, eds. New York, Raven, p. 77-105, 1988.. Unique Identifier : AIDSLINE ICDB/89655314
Megibow AJ; Wall SD; Balthazar EJ; Rybak BJ; University Hosp., New York Univ. Medical Center, 560 First Ave.,; New York, NY 10016
Of the 12 diseases indicative of AIDS without proof of HIV infection, 6 may directly or exclusively involve the GI tract. The radiographic features of the most common diseases seen in the alimentary tract and biliary tree of AIDS patients (pts) are reviewed on a regional basis. Emphasis is on those features predominan
Interleukin 2. Smith KA, ed. New York, Academic, p. 179-96, 1988.. Unique Identifier : AIDSLINE ICDB/89656588
Uchiyama T; First Div., Dept. of Internal Medicine, Faculty of Medicine,; Kyoto Univ., Kyoto 606, Japan
Interleukin 2 ( IL-2 ), a polypeptide growth factor, was originally found as a T-cell growth-promoting factor. Specific binding sites for IL-2 were first demonstrated by a binding assay utilizing radiolabeled IL-2. Anti-Tac antibody was made by immunizing a mouse with T
Interleukin 2. Smith KA, ed. New York, Academic, p. 197-222, 1988.. Unique Identifier : AIDSLINE ICDB/89656589
Yodoi J; Tagaya Y; Maeda M; Inst. for Immunology, Faculty of Medicine, Kyoto Univ., Yoshida,; Sakyo-ku, Kyoto 606, Japan
The functional state and expression of hormone and cytokine receptors are regulated by the specific ligands for the respective receptors and by unrelated mediators. Such a regulatory circuit in the interleukin 2 ( IL-2 )/IL-2 receptor (IL-2R) system is discussed and its
Weismann K; Petersen CS; Sondergaard J; Wantzin GL; Univ. Dept. of Dermatology and Venereology, Bispebjerg Hosp.,; Copenhagen, Denmark
Numerous clinical manifestations of AIDS have been defined, but cutaneous symptoms still prevail. Recognition of skin signs in AIDS may not only lead to early diagnosis of infection with HIV, but the various skin symptoms may also serve as markers of considerable prognostic value. Since the skin is readily accessible
Current Communications in Molecular Biology. Gluzman Y, Hughes SH, eds. New York, Cold Spring Harbor Laboratory, 189 p., 1988.. Unique Identifier : AIDSLINE ICDB/89657143
Anonymous; No affiliation given
This volume contains extended abstracts of presentations made at a conference on eukaryotic viral vectors held at Cold Spring Harbor Laboratory in March 1988. Topics covered include bovine papillomavirus, Epstein-Barr virus, adeno-associated virus, simian virus 40/adenovirus recombinant, development of a recombinant a
Unusual Occurrences as Clues to Cancer Etiology. Miller RW et al, eds. Philadelphia, Taylor and Francis, 304 p., 1988.. Unique Identifier : AIDSLINE ICDB/89657146
Anonymous; No affiliation given
Alert clinical observations have played an important role in providing clues to cancer etiology. The next step, epidemiologic study, helps to establish the causal relationship between specific causes and genetic and environmental factors. Laboratory research provides understanding of the mechanisms involved in both ca
Rubin RH; Tolkoff-Rubin NE; Infectious Disease, Units of the Medical Service, Massachusetts; General Hospital, Boston.
The problem of human immunodeficiency virus (HIV) infection and that of the acquired immunodeficiency syndrome (AIDS) are becoming increasingly important in clinical transplantation. The epidemiologic characteristics of this infection are important factors in determining the impact of this infection on transplant pati
Teshigawara K; Maeda M; Nishino K; Nikaido T; Uchiyama T; Tsudo M; Wano Y; Yodoi J; Institute for Immunology, Faculty of Medicine, Kyoto University,; Japan.
Human T-cell leukemia virus (HTLV)-infected cell lines derived from adult T-cell leukemia (ATL) express constitutively the receptor for Interleukin-2 (IL-2-R) and the associated antigen (Tac antigen). In contrast, the same antigen is transiently expressed by normal T-cells only after immune stimulation. Recently, it w
Miwa H; Uchida T; Kobayashi T; Kita K; Shirakawa S; Koyanagi Y; Yamamoto N; Shimizu A; Honjo T; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.
The HTLV-I integrated cell lines originated from human cord blood mononuclear cells were examined for the T-cell receptor beta chain gene rearrangement in conjunction with immunological phenotype analysis. Five of seven cell lines contained the rearranged T-cell receptor beta chain gene. Interestingly, most of the rea
Hemachudha T; Phanuphak P; Sirivichayakul S; Phanthumchinda K; Department of Medicine, Chulalongkorn University Hospital,; Bankok, Thailand.
Antibodies to HTLV-I were assayed in sera of 9 patients with progressive myelopathy, 11 with multiple sclerosis, 5 with myopathy and in 10 HIV-seropositive intravenous heroin abusers. Clinical features in 9 cases with progressive myelopathy were not different from those previously described in tropical spastic parapar
Viney LL; Henry R; Walker BM; Crooks L; Department of Psychology, University of Wollongong, NSW,; Australia.
This study was concerned with the emotional reaction of men who are HIV antibody positive, and with whether their expression of enjoyment is better viewed as the result of rigid defending or flexible coping. A sample of these men was matched with samples of patients with other major illnesses and well controls. Enjoym
Barratt CL; Monteiro EF; Chauhan M; Cooke S; Cooke ID; Harris Birthright Centre for Reproductive Medicine, University; Department of Obstetrics and Gynaecology, Jessop Hospital for; Women, Sheffield.
A survey conducted amongst the 40 donor insemination centres in the UK registered by the Royal College of Obstetricians and Gynaecologists (RCOG) showed that most of the clinics had no structured policy for control of common (non-HIV) sexually transmitted diseases within their programmes.
Abraham NG; Bucher D; Niranjan U; Brown AC; Lutton JD; Distenfeld A; Ahmed T; Levere RD; Department of Medicine, New York Medical College, Valhalla, NY; 10595.
Azidothymidine ( AZT ) is a useful drug in management of AIDS. Nevertheless, its hematologic toxicity such as anemia and neutropenia present further complications to an already compromised hematopoietic state in patients. We studied the effects of AZT o
Laurence J; Sellers MB; Sikder SK; Department of Medicine, Cornell University Medical College, New; York, NY 10021.
Corticosteroids are used in treatment of a variety of human immunodeficiency virus (HIV)-related disorders. Preliminary reports of a temporal relationship between administration of these drugs to viral carriers and development of AIDS raised the possibility that they can modify the course of HIV infection. Because glu
Chen YC; Wang CH; Su IJ; Hu CY; Chou MJ; Lee TH; Lin DT; Chung TY; Liu CH; Yang CS; Department of Laboratory Medicine, National Taiwan University; Medical School, Taipei, Republic of China.
Among 354 adult patients with either hematological malignancy or aplastic anemia, eight were positive for anti-HTLV-I antibodies; six of eight had received multiple transfusions. There was an approximately 3.5-fold increase (P less than .001) of HTLV-I seropositivity in the patients with hematologic disease (8 of 354,
Blood. 1989 Aug 1;74(2):876-81. Unique Identifier : AIDSLINE MED/89323444
Hock RA; Miller AD; Osborne WR; Program in Molecular Medicine, Fred Hutchinson Cancer Research; Center, Seattle, WA 98104.
Adenosine deaminase (ADA) deficiency is associated with a fatal severe combined immunodeficiency. Because most patients do not have a suitable marrow donor, the introduction of a normal ADA gene into the patient s marrow cells is a potentially useful alternative therapy. To identify vectors that provide optimal gene e
Blood. 1989 Aug 15;74(3):1066-72. Unique Identifier : AIDSLINE MED/89323460
Ehrlich GD; Glaser JB; Abbott MA; Slamon DJ; Keith D; Sliwkowski M; Brandis J; Keitelman E; Teramoto Y; Papsidero L; et al; Department of Medicine, SUNY HSC Syracuse, 13210.
The HTLV-I tax gene protein (Tax) is not packaged within the mature viral particle from which the proteins for the commercially available enzyme-linked immunosorbent assay (ELISA) are derived. Screening of 162 individuals within a cohort of white intravenous (IV) drug abusers, previously identified as having an increa
Ballem PJ; Belzberg A; Devine D; Doubroff P; Mikulash C; Spurston B; Chambers H; Sartori C; Buskard N; Canadian Red Cross BTS, Vancouver, B.C.
The pathophysiology of HIV associated immune thrombocytopenia (HIV-ITP) and its response to AZT was investigated. Using autologous 111Indium-labelled platelets, platelet kinetic were analysed in two patient groups. Group 1 (untreated) was comprised of
Spath PJ; Elisa A; Buhlmann U; Luginbuhl L; Imbach P; Central Laboratory, Blood Transfusion Service, Swiss Red Cross,; Berne.
A seven year follow-up of immune parameters is reported for a patient with chronic immune thrombocytopenic purpura (ITP) pre and post human immunodeficiency virus (HIV) seroconversion. Therapies such as intravenous IgG, prednisone, vincristine, or Ciclosporin A had no clear-cut beneficial effect on platelet counts. A
Nydegger UE; Buchs JP; Borradori L; Central Laboratory of Haematology, University of Bern,; Switzerland.
We present measurements of total platelet-associated immunoglobulin G following platelet lysis (PAIgG tot) and surface-restricted IgG (PAIgG ext) on intact, gel-filtered platelets from 36 normal human donors and 9 patients with human immunodeficiency virus (HIV) infection (CDC stages IIb-IV). For this purpose, an indi
McNicholas TA; Jones DJ; Sibley GN; St Peter's Hospital, London.
Increasing numbers of patients infected with the Human Immunodeficiency Virus (HIV) will be encountered in surgical practice. The risk of exposure to the virus during urological surgery is unknown. In an attempt to quantify the risk and to identify procedures that require change, 427 consecutive urological operations
Malim MH; Bohnlein S; Hauber J; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
Human immunodeficiency virus type 1 (HIV-1) encodes a nuclear trans-activator, termed Rev, that is required for the expression of the viral structural proteins and, hence, for viral replication. The Rev protein acts posttranscriptionally to induce the sequence-specific nuclear export of unspliced HIV-1 mRNA species th
Green M; Ishino M; Loewenstein PM; Institute for Molecular Virology, St. Louis University School of; Medicine, Missouri 63110.
The HIV-1 Tat protein is a potent trans-activator essential for virus replication. We reported previously that HIV-1 Tat peptides containing residues 37-48 (mainly region II), a possible activating region, and residues 49-57 (region III), a nuclear targeting and putative nucleic acid binding region, possess minimal bu
Lantin JP; Graf I; Frei PC; Division of Immunology and Allergy, Centre Hospitalier; Universitaire Vaudois, Lausanne, Switzerland.
Between May 1986 and April 1987 routine screening for anti-HIV antibody was performed by enzyme immunoassay (EIA) on 3344 serum samples. The 1160 samples found positive or borderline were further analysed in Western blot (Wb). We analysed the frequency of different patterns of intermediate Wb reactions (1-3 specifi
Magnetic resonance imaging (MRI) of the brain was evaluated in 12 HAM (HTLV-I-associated myelopathy) patients (4 males and 8 females, mean age of 54 yrs) and compared with 36 non-HAM controls (16 males and 20 females mean age of 52 yrs). MRI of the brain was performed using a 0.5 Tesla superconducting unit. Imaging in
A case of multiple sclerosis (MS) in a 39 year old Japanese female with high antibody titer to human T-lymphotropic virus type I (HTLV-I) in serum and cerebrospinal fluid (CSF) was reported. At the age of 15, gait and urinary disturbances accompanied by sensory impairment in the lower abdomen and lower extremities dev
Furuzono H; Nakazato O; Goto K; Akizuki S; Okajima T
An autopsy case of HTLV-I associated myelopathy (HAM) was reported. The patient was a 55-year-old man from Kagoshima, who had no history of blood transfusion. He was admitted to our hospital because of muscle weakness of legs and dysuria, which having since one month ago. On admission, he was able to walk with assista
Riphagen FE; von Schoultz B; International Health Foundation, Geneva, Switzerland.
In 1987, a survey of contraceptive use, knowledge and attitudes was conducted in Sweden by the International Health Foundation (IHF) as part of a multi-country study that has so far involved six other countries in Europe. The women involved, who were aged 15-44, completed a standar
Bharati S; Joshi VV; Connor EM; Oleske JM; Lev M; Congenital Heart and Conduction System Center, Palos Hts, IL; 60463.
Six children died of acquired immunodeficiency syndrome (AIDS), four of them females, ages 7 months, 13 months, 2 years 8 months, and 4 years; and two of them males, aged 2 1/2 and 7 years. They were born to IV drug-addicted parents. The conduction system (CS) and the entire heart were studied by serial section. In al
Katz AS; Niesenbaum L; Mass B; Department of Medicine, Metropolitan Hospital, Philadelphia, PA.
Pleural effusion is an unusual presentation of cryptococcal infection in the acquired immune deficiency syndrome. Previous investigators have established the diagnosis of cryptococcal pleural disease by culturing pleural fluid, bronchial washings, and extrapulmonary sources. We report the first case of cryptococcal pl
Infection of cells with the human immunodeficiency virus type-1 (HIV-1) usually results in the formation of giant multinuclear cells (syncytia) [(1986) Nature 322, 470-474; (1986) Nature 322, 725-728; (1985) Hum. Pathol. 18, 760-765; (1987) Ann. Neurol. 21, 490-496]. The appearance of syncytia is associated with an in
FEBS Lett. 1989 Jul 3;250(2):591-5. Unique Identifier : AIDSLINE MED/89325638
Shimizu N; Okamoto T; Moriyama EN; Takeuchi Y; Gojobori T; Hoshino H; Department of Hygiene, Gunma University School of Medicine,; Japan.
Human immunodeficiency virus (HIV) exhibits immunological hypervariability, which has been an obstacle to successful production of effective anti-HIV vaccines. In this study, we estimated patterns of nucleotide and amino acid substitutions in the env gene of HIVs, with the aim of finding characteristics of the mechani
G Clin Med. 1989 May;70(5):353-6. Unique Identifier : AIDSLINE MED/89325953
Venturini L; Serpelloni G; Parolin A; Mezzelani P
The authors, after reviewing the current literature about the serological pattern of anti-HIV antibodies detected with Western Blot and the research of the viral antigen in AIDS, report the study of the above mentioned parameters in two HIV seropositive drug addicts. Case 1 (symptomless seropositive) presented a react
Bor R; Elford J; Miller R; Perry L; Salt H; District AIDS Counselling Unit, Royal Free Hospital School of; Medicine, London.
The Hampstead district AIDS counselling unit in London was opened in January 1987. It is staffed by a clinical psychologist, a social worker, and an administrator. From April 1987 to March 1988, 141 new patients and their relatives were referred from a range of clinical departments and 544 counselling sessions were pr
Int Dent J. 1989 Jun;39(2):103-7. Unique Identifier : AIDSLINE MED/89326628
Cottone JA; Molinari JA; Department of Dental Diagnostic Science, University of Texas; Dental School, San Antonio 78284.
Hepatitis B virus and hepatitis delta virus among the viral causes of hepatitis are of principal concern to the dentist. A dentist previously infected with HBV is at risk from HDV for there are reservoirs of this infection in the population. Dentists will be most at risk from HBV because of per cutaneous inoculation b
Health Visit. 1989 Jul;62(7):219-21. Unique Identifier : AIDSLINE MED/89326868
Jackson D
One teacher from each of the secondary schools and four special schools in Halton district completed a questionnaire in a semi-structured interview on sex education in their schools. The results showed that a variety of programmes took place but frequently teachers did not feel adequately prepared to teach this vital
Remmel RP; Yeom YH; Hua M; Vince R; Zimmerman CL; Department of Medicinal Chemistry, College of Pharmacy,; University of Minnesota, Minneapolis 55455.
Carbovir is a novel carbocyclic guanosine derivative that has potent in vitro activity against human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome (AIDS). Two methods of sample preparation were developed for the analysis of carbovir in rat blood. Solid-phase extraction on C18 extrac
Kudlac J; Hanan S; McKee GL; Public Health Laboratory, Oklahoma State Department of Health,; Oklahoma City 73124.
A standardized pool of human sera that was positive for human immunodeficiency virus type 1 (HIV-1) antibody was developed. This positive control serum was used to analyze test differences among eight laboratories, among the HIV-1 antibody test kits of three different manufacturers, among different lots of the same te
Bank DE; Cohen PR; Kohn SR; Department of Dermatology, College of Physicians and Surgeons,; Columbia University, New York, NY 10032.
We report reactive perforating collagenosis in an intravenous heroin abuser with acquired immunodeficiency syndrome and end-stage renal disease. The literature on perforating disorders in patients with acquired immunodeficiency syndrome and the pathogenesis of reactive perforating collagenosis in this setting is revie
deShazo RD; Morgan JE; Daul CB; Andes A; Hyslop N; Palmer C; Clinical Immunology Section, Tulane University School of; Medicine, New Orleans, La.
We evaluated the ability of mononuclear cell populations from 56 hemophiliac subjects, 69 homosexuals, and 32 control subjects to proliferate spontaneously in vitro. Levels of spontaneous proliferation (SP) were not significantly different among homosexuals or hemophiliac subjects when they were grouped as asymptomati
Manning DT; Balson PM; Department of Education, Tulane University, New Orleans,; Louisiana.
A survey of 189 Louisiana teenagers and 80 Louisiana family physicians revealed that the teenagers overwhelmingly preferred to learn about acquired immune deficiency syndrome (AIDS) from a physician. This result stimulated an interest in learning whether family physicians shared adolescents opinions that they are the
Wotherspoon AC; Norton AJ; Lees WR; Shaw P; Isaacson PG; Department of Histopathology, University College and Middlesex; School of Medicine, London, U.K.
The use of a technique for safe percutaneous fine needle biopsy of inaccessible lymph nodes is described. In a prospective study of 24 patients, including five cases positive for the human immunodeficiency virus (HIV), this technique was used to provide diagnostic material. A firm diagnosis was made in 21 cases; four
Edwards JR; Ulrich PP; Weintrub PS; Cowan MJ; Levy JA; Wara DW; Vyas GN; Department of Pediatrics, University of California, San Francisco; 94143.
To determine the usefulness of DNA amplification by polymerase chain reaction for the early identification of human immunodeficiency virus type 1 (HIV-1) infection in infants and children, we compared the polymerase chain reaction and concurrent viral cultures of peripheral blood mononuclear cells from 25 high-risk su
Goodenow M; Huet T; Saurin W; Kwok S; Sninsky J; Wain-Hobson S; Laboratorie de Biologie et Immunologie Molecularies des; Retrovirus, Institut Pasteur, Paris, France.
RNA viruses are renowed for their genetic variability. The human immunodeficiency viruses (HIV) are no exception. A rapid method has been established for the genetic identification and differentiation of viral strains based on the sequencing of many M13 clones of gene-amplified products. Some isolates are internally r
Artigas J; Niedobitek F; Grosse G; Heise W; Gosztonyi G; Department of Pathology, Auguste-Viktoria-Krankenhaus, Berlin,; F.R.G.
We describe the morphological findings in the brain of five AIDS patients who died with a clinical diagnosis of dementia . We have found a spongiform change (small rounded vacuoles) in different parts of the brain and a similar but morphologically different sponginess, the status sp
Delaporte E; Peeters M; Durand JP; Dupont A; Schrijvers D; Bedjabaga L; Honore C; Ossari S; Trebucq A; Josse R; et al; Centre International de Recherches Medicales, Franceville,; Gabon.
Between 1987 and 1988, a survey to determine the distribution of HTLV-I infection was conducted in a representative population of adults, living in southern Chad , Cameroon , and Equatorial Guinea . Populations
J Med Chem. 1989 Aug;32(8):1732-8. Unique Identifier : AIDSLINE MED/89328969
Camarasa MJ; Diaz-Ortiz A; Calvo-Mateo A; De las Heras FG; Balzarini J; De Clercq E; Instituto de Quimica Medica, Juan de la Cierva, Madrid, Spain.
A series of 3 -C-cyano-3 -deoxynucleosides have been synthesized and evaluated as antiviral agents. Reaction of 2 ,5 -bis-O-(tert-butyldimethylsilyl)-beta-D-erythro-pentofuranos- 3 -ulosyl derivatives of uracil, 4-N-acetylcytosine, and adenine with sodium cyanide gave a mixture of epimeric cyanohydrins, which after 3
J Med Chem. 1989 Aug;32(8):1743-9. Unique Identifier : AIDSLINE MED/89328971
Van Aerschot A; Herdewijn P; Balzarini J; Pauwels R; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.
A series of 2 - and 3 -fluorinated 2 ,3 -dideoxynucleosides and 3 -azido-2 ,3 -dideoxynucleosides were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus-1 (HIV-1) replication in MT-4 cells. Neither conversion of 3 -fluoro- or 3 -azido-2 ,3 -dideoxyadenosine to the correspondi
J Med Chem. 1989 Aug;32(8):1763-8. Unique Identifier : AIDSLINE MED/89328975
Robins MJ; Wood SG; Dalley NK; Herdewijn P; Balzarini J; De Clercq E; Department of Chemistry, Brigham Young University, Provo, Utah; 84602.
Trimethylsilyl triflate-catalyzed transfer glycosylation of 2,6-diamino-9-(3-azido-2,3-dideoxy-alpha- and beta-D-erythro-pentofuranosyl)purines (3 and 4) in low yields. Selective 2 -O-tosylation of 2,6-diamino-9-(beta-D-ribofuranosyl)purine (2,6-diaminopurine riboside, DAPR, 5) followed by our lithium triethylborohydr
J Med Chem. 1989 Aug;32(8):1891-5. Unique Identifier : AIDSLINE MED/89328992
Lin TS; Shen ZY; August EM; Brankovan V; Yang H; Ghazzouli I; Prusoff WH; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06510.
Several 2,5 -anhydro analogues of 3 -azido-3 -deoxythymidine ( AZT ), 3 -azido-2 3 -dideoxyuridine (AZU), 3 -azido-2 3 -dideoxy-5-bromouridine, 3 -azido-2 ,3 -dideoxy-5-iodouridine, and 3 -deoxythymidine and the 3 -azido derivative of 5-methyl-2 -deoxyi
Ned Tijdschr Geneeskd. 1989 Jun 24;133(25):1273-7. Unique Identifier : AIDSLINE MED/89330616
van Lith JM; Tijmstra TJ; Visser GH
Since July 1987 pregnant women who attend the outpatient clinic of the University Hospital in Groningen are tested for HIV-infection after informed consent. Their opinion of this policy was examined by means of a questionnaire. This questionnaire was answered by a group of women who had delivered and by a group tested
Melnick SL; Engel D; Truelove E; DeRouen T; Morton T; Schubert M; Dunphy C; Wood RW; Division of Epidemiology, School of Public Health, University of; Minnesota.
To assess the relationship between oral lesions and antibodies to the human immunodeficiency virus, oral examinations of 803 homosexual males were conducted at the time of serologic testing. Nineteen percent were HIV seropositive. Thirty percent of antibody-positive subjects had one or more oral lesion(s), as compared
Radiol Med (Torino). 1989 Jun;77(6):602-12. Unique Identifier : AIDSLINE MED/89331977
Cecchini A; Pricca P; Mariani P; Orlandini A; Tansini A; Andreula CF; Carella A; Rosa M; Torti-Donati P; Canevari M; Policlinico S. Matteo, IRCCS, Servizio di Radiodiagnostica,; Pavia.
The results are described of a retrospective multicentric CT/MR study of 141 neuro-AIDS patients (IV group CDC classification); 114 patients were drug addicted, 13 homosexual, 8 polytransfused, and 6 had other risk factors. The mean age was 29.6 years. The pathologic agent was identified in 47 cases by c.s. fluid exam
In the prospective analysis of 45 patients (intravenous drug addicts and homosexuals) with lymphadenopathy and positive HIV virus titers, including serology, immunological and histological lymph node studies, we examined the etiology and diagnostic results of the methods used. We found 19 cases with lymphoid follicula
Cour MI; Martin Cala M; Fernandez Contreras ME; Martin Picola C; Palau L; Garcia Lerin MC; Ferro A; Rodriguez Losas J
The presence of anti-HIV (human immunodeficiency virus) antibodies was determined in 325 subjects. The samples were taken from 138 convicts from Carabanchel and Ocana I jail, 162 parenteral drug addicts (PDA) from a center for rehabilitation of drug addicts (CR), and from 14 family members and 11 stable couples of the
We are reporting 3 cases of lumbo-radiculalgia, simulating the usual picture of herniated disc, and revealing complications related to the virus of acquired human immunodeficiency (HIV). Rheumatologists must be aware of any atypical clinical signs in patients suffering from lumboradicular disease, and search for a HIV
Cunningham I; Department of Sociology and Anthropology, Rio Piedras Campus,; University of Puerto Rico.
All articles using the word AIDS that have appeared in the five major daily newspapers in Puerto Rico since 1982 were studied to analyze the way in which AIDS has been presented in the daily press. Virtually all of the articles regarding AIDS, at least those pertaining to Pue
Krasnik A; Bjoerner J; Christensen BW; Institute of Social Medicine, University of Copenhagen, Panum; Institute, Denmark.
The purpose of the study is to facilitate international co-operation and national development on AIDS-policy by describing and comparing the programmes on the control of AIDS in the five Nordic countries. This article is focusing especially on community and individual considerations in legislation and test policy rega
Central nervous system (CNS) infection by Toxoplasma gondii is not uncommon in patients with acquired immunodeficiency syndrome (AIDS). Extraneural toxoplasmosis has been reported in the heart, lungs, testes, and skin of AIDS patients with concurrent CNS toxoplasmosis. Toxoplasma myocarditis is rare even in AIDS patie
The aim of dermatologic check-up is the early diagnosis of asymptomatic potentially dangerous skin changes. An early melanoma may be cured by simple excision. Dermatologic signs in general medicine are very important. Paraneoplastic symptoms in patients with glucagonoma consist of the typical necrolytic migratory eryt
Pilon VA; Echols RM; Department of Surgical Pathology, Albany Medical College, New; York.
A case of cat-scratch disease (CSD) in a patient with acquired immunodeficiency syndrome (AIDS) is reported. The lymph node pathologic characteristics were altered from those usually seen with CSD, showing clusters of vacuolated macrophages admixed with pycnotic nuclear debris instead of the usual suppurative granulom
Kegeles SM; Adler NE; Irwin CE Jr; Department of Medicine, University of California, San Francisco; 94105.
Sexually active adolescents should use condoms to prevent the transmission of sexually transmitted diseases, including human immunodeficiency virus. This study examined, among male and female adolescents, which beliefs about condoms are associated with intentions to use them if they have coitus in the next year. Teena
Baumgartner DD; Arterbery VE; Hale AJ; Gupta RK; Bradley SF; Department of Internal Medicine, University of Michigan Medical; School, Ann Arbor.
A rare case of tuberculous peritonitis in a continuous ambulatory peritoneal dialysis (CAPD) patient who has multiple risk factors for extrapulmonary disease due to Mycobacterium tuberculosis is presented. This patient acute course was atypical with a predominance of neutrophils and low levels of protein in the perit
Am J Med. 1989 Aug;87(2):173-7. Unique Identifier : AIDSLINE MED/89333778
Holtzman DM; Kaku DA; So YT; Department of Neurology, University of California, San Francisco; 94143.
PURPOSE: We attempt to define the significance and most common causes of new-onset seizures in patients with human immunodeficiency virus (HIV) infection. In addition, we review the seizure type, neurologic examination, and other clinical features to better address diagnostic and management issues in these patients. P
Am J Pathol. 1989 Jun;134(6):1295-303. Unique Identifier : AIDSLINE MED/89333880
Zucker-Franklin D; Termin CS; Cooper MC; Department of Medicine, New York University, Medical Center, New; York.
Although immune mechanisms are known to be partially responsible for the thrombocytopenia of patients infected with HIV-1, an understanding of the mechanism underlying this disorder is incomplete. A casual observation that bone marrow biopsies of HIV-infected individuals seem to exhibit an unusually large number of de
Ann Intern Med. 1989 Aug 15;111(4):280-7. Unique Identifier : AIDSLINE MED/89334183
Kovacs JA; Deyton L; Davey R; Falloon J; Zunich K; Lee D; Metcalf JA; Bigley JW; Sawyer LA; Zoon KC; et al; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland.
STUDY OBJECTIVE: To evaluate the toxicity and potential clinical efficacy of combined therapy with zidovudine and interferon-alpha for patients with Kaposi sarcoma and the acquired immunodeficiency syndrome (AIDS). DESIGN: Nonrandomized, open trial study. SETTING: Outpatient clinic of a government referral-based resea
Ann Pediatr (Paris). 1989 Jun;36(6):400-2. Unique Identifier : AIDSLINE MED/89334221
Blanche S
Transmission of the HIV from mother to fetus is now virtually the only means by which children can be contaminated. Thirty to 40% of infants born to HIV-seropositive mothers are infected. Nearly half of infected neonates develop AIDS within the first two or three years of life. Early diagnosis of HIV infection rests o
Ann Pediatr (Paris). 1989 Jun;36(6):409-12. Unique Identifier : AIDSLINE MED/89334223
Weil-Halpern F
Since the first cases of infantile AIDS, the status of the severely ill child and his or her family has changed. When faced with this shameful disease, transmitted by the mother to her child during pregnancy, parents feel compelled to hide their children s disease and to bear the tragic burden of emotional and social
Ann Radiol (Paris). 1989;32(2):112-6. Unique Identifier : AIDSLINE MED/89334226
Geara F; Le Bourgeois JP; Piedbois P; Haddad E; Levy E; Taghian A
Between June 1986 and August 1988, 129 patients with AIDS-related Kaposi s sarcoma were treated by cutaneous irradiation in our department. According to Mitsuyasu s staging, 25 patients (19%) were stage 1.76 (59%) stage II, no stage III was reported and 28 (22%) stage IV. Fifty four patients (42%) had previously prese
Mirra SS; del Rio C; Veterans Administration Medical Center, Decatur, GA 30033.
Involvement of the central nervous system with the human immunodeficiency virus is thought to underlie the clinical and pathologic features of acquired immunodeficiency syndrome (AIDS) encephalopathy. Although morphologic, immunocytochemical, and molecular data point to predominant human immunodeficiency virus infecti
Katz DA; Berger JR; Department of Neurology, University of Miami, School of Medicine,; FL 33136.
In a retrospective study encompassing 42 months (January 1984 through July 1987), 12 patients were identified as having both neurosyphilis and acquired immunodeficiency syndrome. These patients constituted 44% of the entire group meeting rigorous diagnostic criteria for neurosyphilis and 1.5% of all patients hospitali
Kupferschmidt R; Schmid RW; Laboratory of Psychoactive Drug Analysis, Psychiatric University; Hospital, Vienna, Austria.
A simple isocratic HPLC method for determining azidothymidine ( AZT ) in serum and plasma of patients has been developed. The novel, specific, two-step, solid-phase extraction approach used for sample preparation gives a nearly quantitative recovery (95
Singlas E; Pioger JC; Taburet AM; Colin JN; Fillastre JP; Department of Clinical Pharmacy, Bicetre Hospital, Le Kremlin; Bicetre, France.
Pharmacokinetics of zidovudine (azidothymidine, AZT ) was investigated after oral administration (200 mg) in 25 HIV seronegative subjects: 14 patients with severe renal impairment (creatinine clearance 6 to 31 ml/min), five hemodialyzed anuric patients
Grotz RL; Madden GM; Krisiunas EP; Lyons RW; Klevjer-Anderson P
Between January 1981 and December 1986, 4,178 patients were cultured for mycobacteria at a community teaching hospital in Hartford. The number of patients with positive cultures totaled 278 (6.65%). Mycobacterium other than tuberculosis (MOTT) was isolated from 228 (82%). MOTT isolation increased yearly from 1.5% of t
Biglieri EG; Irony I; Kater CE; University of California Medical Service, San Francisco General; Hospital Medical Center.
One must consider the 17-DOS as a biosynthetic pathway with multiple regulatory factors. ACTH is its dominant regulator but in the absence of ACTH and in conditions where plasma renin activity is increased, this biosynthetic pathway maintains its sensitivity to exogenous ACTH. Suppression of the renin system delays th
Int J Cancer. 1989 Aug 15;44(2):332-6. Unique Identifier : AIDSLINE MED/89339824
Takehara N; Iwahara Y; Uemura Y; Sawada T; Ohtsuki Y; Iwai H; Hoshino H; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.
Two groups of 3 rabbits, each immunized with heat-inactivated HTLV-I or a synthetic env peptide (env175-196), developed antibodies to viral proteins including gp68 and gp46. These immunized rabbits were then challenged with a transfusion of blood from HTLV-I-infected rabbits of the opposite sex. After transfusion chal
Feldman DA; American Anthropological Association, Kew Gardens, NY.
Gay male teenagers face considerable adversity during their coming out process due to the AIDS epidemic. They must decide whether to be tested for HIV-1 infection, whether to postpone sexual activity, how to select a partner, and which kinds of sexual practices to engage in. Gay youth often make such decisions based u
Henderson DK; Gerberding JL; Hospital Epidemiology Service, Warren G. Magnuson Clinical; Center, National Institutes of Health, Bethesda, Maryland 20892.
Note from Dr. Merle A. Sande--Health care workers are at risk of acquiring human immunodeficiency virus (HIV) infection subsequent to accidental sticks with needles contaminated with blood from infected patients. The risk is small but real. Postexposure management is critically important, but few solid data are availa
Kreiss JK; Coombs R; Plummer F; Holmes KK; Nikora B; Cameron W; Ngugi E; Ndinya Achola JO; Corey L; Department of Medicine, University of Washington, Seattle 98104.
Recent epidemiologic studies have implicated genital/anorectal ulcer disease as an important cofactor for acquisition and transmission of human immunodeficiency virus (HIV) during sexual intercourse. To better understand the mechanism for the association between genital ulcers and HIV, exudates from 62 genital ulcers
Belec L; Georges AJ; Steenman G; Martin PM; Institut Pasteur, Bangui, Central African Republic.
To study the local immune response to human immunodeficiency virus type 1 (HIV-1) in women infected by or exposed to HIV-1, 75 women were studied: 15 were IgG-seropositive but clinically asymptomatic, 15 had acquired immune deficiency syndrome (AIDS), 15 were IgG-seronegative with seropositive husbands, and 30 were he
Gray F; Gherardi R; Wingate E; Wingate J; Fenelon G; Gaston A; Sobel A; Poirier J; Departement de Pathologie (Neuropathologie), Hopital Henri; Mondor, Creteil, France.
Four patients with AIDS presented with a rapidly fatal global neurological illness. CT did not show any focal lesion and gross post mortem examination of the brain was normal in three of the four cases. Microscopic examination revealed numerous widespread microglial nodules in the brain parenchyma, most containing cen
Nakai M; Goto T; Imura S; Department of Microbiology, Osaka Medical College, Japan.
HIV particles were usually seen on the surface of established lymphoid cells derived from AIDS patients or on CEM cells infected with HIV, and sometimes in cytoplasmic vacuoles. The virus particles were formed by a budding process from the plasma membrane of an infected cell. The budding particles were of a doughnut f
J Am Podiatr Med Assoc. 1989 Jul;79(7):311-7. Unique Identifier : AIDSLINE MED/89342202
Berlin SJ; Clancy JT; Giordano ML
The authors identify the incidence of Kaposi s sarcoma in the foot, and discuss the increasing incidence of AIDS-related cases, and the increasing chance of mortality when this lesion is seen in patients under the age of 50.
J Med Primatol. 1989;18(3-4):227-36. Unique Identifier : AIDSLINE MED/89342405
Nicol I; Messinger D; Dubouch P; Bernard J; Desportes I; Jouffre R; Snart R; Nara P; Gallo RC; Zagury D; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.
Mangabeys, macaques, and baboons persistently infected with human immunodeficiency virus (HIV)-2 NIH-DZ demonstrated no signs of immunodeficiency disease after 6-11 months following seroconversion. Thus Old World monkeys provide an animal model to investigate the effects of passive immunization (anti-HIV-2 antibodies)
J Med Primatol. 1989;18(3-4):305-9. Unique Identifier : AIDSLINE MED/89342413
Kestler HW 3d; Naidu YN; Kodama T; King NW; Daniel MD; Li Y; Desrosiers RC; New England Regional Primate Research Center, Southborough, MA.
Three infectious molecular clones of SIVmac and one of HIV-2 exhibit remarkable variation in their biological properties despite similarities in genome organization and sequence relatedness. Cloned viruses differed in their ability to grow in various cultured cells, in their ability to infect macaques, and in the loca
J Med Primatol. 1989;18(3-4):337-42. Unique Identifier : AIDSLINE MED/89342417
Castro BA; Walker CM; Tateno M; Cheng-Mayer C; Heberling R; Eichberg JW; Levy JA; Cancer Research Institute, University of California, School of; Medicine, San Francisco.
Human immunodeficiency virus-1 (HIV-1) isolates obtained from chimpanzees that had undergone various immunosuppressive treatments were characterized by growth on various primary cells and cell lines as well as by restriction endonuclease analysis. Viruses recovered from animals inoculated with uncloned HIV showed gene
J Med Primatol. 1989;18(3-4):343-55. Unique Identifier : AIDSLINE MED/89342418
Nara P; Hatch W; Kessler J; Kelliher J; Carter S; Laboratory of Tumor Cell Biology, National Cancer Institute,; Frederick, MD.
Human immunodeficiency virus (HIV)-1 IIIB infection of chimpanzees leads to a compartmentalized, nonpathogenic in vivo and in vitro relationship with the virus. The absence of an acquired immunodeficiency syndrome (AIDS)-like disease in over 100 chimpanzees persistently infected may be related to some or all of the fi
Altschul SF; Carroll RJ; Lipman DJ; Mathematical Research Branch, National Institute of Diabetes and; Digestive and Kidney Diseases, Bethesda, MD 20892.
How can one characterize a set of data collected from different biological species, or indeed any set of data related by an evolutionary tree? The structure imposed by the tree implies that the data are not independent, and for most applications this should be taken into account. We describe strategies for weighting t
Pauza CD; Galindo J; Developmental Biology Laboratory, Salk Institute for Biological; Studies, San Diego, California 92138-9216.
Cell-free virus preparations from persistently infected monoblastoid cells (HU937) become progressively less infectious during long-term passage. This effect is specific for cell lines derived from U937 and is not observed in persistently infected T-cell lines. Reduced infectivity is correlated with accumulation of un
Kim SY; Byrn R; Groopman J; Baltimore D; Whitehead Institute for Biomedical Research, Nine Cambridge; Center, Massachusetts 02142.
The kinetics of retroviral DNA and RNA synthesis are parameters vital to understanding viral growth, especially for human immunodeficiency virus (HIV), which encodes several of its own regulatory genes. We have established a single-cycle growth condition for HIV in H9 cells, a human CD4+ lymphocyte line. The full-leng
Lever A; Gottlinger H; Haseltine W; Sodroski J; Laboratory of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts.
Sequences required for efficient packaging of human immunodeficiency virus type 1 (HIV-1) genome RNA into virus particles were identified. Deletion of 19 base pairs between the 5 long terminal repeat and the gag gene initiation codon of HIV-1 resulted in a virus markedly attenuated for replication in human T lymphocy
Lu Y; Stenzel M; Sodroski JG; Haseltine WA; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115.
The effects of deletions within three functional regions of the long terminal repeat of human immunodeficiency virus type 1 upon the ability of the long terminal repeat to direct production of the chloramphenicol acetyltransferase gene product and upon the ability of viruses that carry the mutations to replicate in hu
Life Sci. 1989;45(4):iii-vii. Unique Identifier : AIDSLINE MED/89343486
Gogu SR; Beckman BS; Agrawal KC; Department of Pharmacology, Tulane University School of Medicine,; New Orleans, LA 70112.
The toxicity of anti-HIV drugs, 3 -azido-3 -deoxythymidine (zidovudine, AZT ), 2 ,3 -dideoxycytidine (DDC), 2 ,3 -dideoxy-2 ,3 -didehydrothymidine ( d4T ) and ribavirin was studied in vi
HIV and AIDS are diseases which have rocked the health care agencies throughout the world in the 1980 s. The editor of Midwifery has tried to secure a paper on the impact of AIDS on midwifery in some parts of the world. As much research has still to be done this paper is not available at the moment. The following pape
Cohen JA; Laudenslager M; Department of Neurology, University of Colorado Health Sciences; Center, Denver.
We used an autonomic nervous system (ANS) testing battery to determine whether ANS dysfunction occurred in HIV infection. Five of 10 seropositive (HIV+) patients had ANS involvement affecting both the parasympathetic and sympathetic divisions. All 5 involved patients were in Group IV of the CDC classification.
Kawai H; Nishida Y; Takagi M; Nakamura K; Masuda K; Saito S; Shirakami A; First Department of Internal Medicine, School of Medicine,; University of Tokushima, Japan.
We report a 42-year-old Japanese woman with HTLV-I-associated myelopathy (HAM) combined with adult T-cell leukemia (ATL). Combination of the 2 diseases has been extremely rare. The infrequency is explained by HLA types unique to each disease. Our patient suggests that the HAM-associated HLA haplotype does not prevent
N Z Med J. 1989 Aug 23;102(874):442-3. Unique Identifier : AIDSLINE MED/89344708
Chetwynd J; Department of Community Health and General Practice, Christchurch; School of Medicine.
Using a postal questionnaire, a random sample of 1000 general practitioners throughout New Zealand were surveyed about their contacts with patients concerning AIDS or HIV infection and about their needs for information on AIDS related matters. A response rate of 86% was achieve
Lindsay MK; Peterson HB; Feng TI; Slade BA; Willis S; Klein L; Department of Gynecology and Obstetrics, Emory University School; of Medicine, Atlanta, Georgia.
Human immunodeficiency virus (HIV) infection occurs disproportionately among inner-city minority women of reproductive age. Once pregnant, these women have a high risk of delivering infants with perinatally acquired infection. Identification and counseling of HIV-infected parturients may be an effective means of preve
Komine S; Yoshida K; Yamashita H; Masaki Z; Department of Surgery, Saga Medical School, Japan.
Voiding dysfunction was evaluated in 16 of 17 patients with human T-lymphotropic virus type-1 associated myelopathy (HAM). Among 16 patients 11 had both frequency and difficulty in voiding and 12 had urge incontinence of urine. Sensation of vesical filling and voiding remained either intact or only slightly suppressed
Fitzgibbon ML; Cella DF; Humfleet G; Griffin E; Sheridan K; Northwestern University Medical School, Chicago, IL.
To examine neuropsychological deficits associated with the human immunodeficiency virus (HIV), 25 asymptomatic homosexual men and sexual partners of intravenous drug users and 25 seronegative homosexual men and nonhigh-risk heterosexuals were assessed on measures of fine motor control, visual scanning, attention, depr
Nurs J India. 1989 Apr;80(4):91-3. Unique Identifier : AIDSLINE MED/89345216
Presented below is the third installment of the series of guidelines developed jointly by the World Health Organization and the International Council of Nurses. They contain basic information on the nursing management of people with HIV infection, including guidance on the prevention o
Mod Pathol. 1989 May;2(3):200-4. Unique Identifier : AIDSLINE MED/89345490
Unger ER; Chandler FW; Chenggis ML; Ou CY; Warfield DT; Feorino PM; Department of Pathology and Laboratory Medicine, Emory; University, Atlanta, Georgia.
A colorimetric method of in situ hybridization has been developed for the rapid detection of human immunodeficiency virus (HIV) in formalin-fixed paraffin-embedded material. Following optimization of digestion conditions, biotin-labeled DNA probes are detected with an alkaline phosphatase conjugate. The method is veri
Mod Pathol. 1989 May;2(3):233-8. Unique Identifier : AIDSLINE MED/89345496
Yoshikawa Y; Truong LD; Fraire AE; Kim HS; Department of Pathology, Baylor College of Medicine, Houston,; Texas.
This study underscores an unexpectedly high incidence of histologic abnormalities in 33 testes from 31 patients who died of acquired immunodeficiency syndrome. Histologic changes of seminiferous tubules were classified into five categories: Sertoli cell only (14 testes, 42%), hypospermatogenesis (9, 27%), peritubular
Mod Pathol. 1989 May;2(3):239-43. Unique Identifier : AIDSLINE MED/89345497
Maygarden SJ; Flanders EL; Department of Pathology, Medical College of Virginia, Richmond.
The cytologic diagnosis of mycobacterial infections has historically depended on the recognition of the characteristic granulomatous or purulent host response and the identification of acid-fast bacilli with special stains. However, immunocompromised patients with infections may not mount the expected response and the
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5974-8. Unique Identifier : AIDSLINE MED/89345587
Duh EJ; Maury WJ; Folks TM; Fauci AS; Rabson AB; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.
Expression of human immunodeficiency virus type 1 (HIV-1) can be activated in a chronically infected T-cell line (ACH2 cells) by a cytokine, human tumor necrosis factor alpha (TNF-alpha). TNF-alpha treatment of ACH2 cells resulted in an increase in steady-state levels of HIV RNA and HIV transcription. Gel mobility shi
An 18-item questionnaire assessing attitudes toward AIDS and homosexuality was administered to 420 Australian tertiary students. The predictive power of attitudes toward homosexuality, empathy toward AIDS sufferers, knowledge about AIDS, church attendance, age, and sex was tested using independent and stepwise multipl
A telephone survey was completed with 400 adults to explore a possible relation between health risk-taking and perceived personal responsibility for health. The attitude that AIDS could be avoided by being careful was weakly associated with responses to questions about wearing seat belts and smoking. The pattern held
Samples were taken from Middletown in 1985, 1986, and 1987 to assess tendencies to discriminate against AIDS victims and what factors were related to this tendency. A tendency to discriminate against AIDS victims has decreased significantly from 1985 to 1987, and those who are most likely to discriminate were members
La Montagne JR; Microbiology and Infectious Diseases Program, National Institute; of Allergy and Infectious Disease, Bethesda, Maryland 20892.
The emergence of human immunodeficiency virus (HIV) in epidemic form has implications for immunization programs. Infection with HIV, which is capable of infecting cells of the immune system and which can remain latent for many years, results in profound and progressive immunosuppression. As a consequence, vaccines may
Maggi E; Mazzetti M; Ravina A; Simonelli C; Parronchi P; Macchia D; Biswas P; Di Pietro M; Romagnani S; Istituto di Clinica Medica 3, Universita degli Studi di Firenze.
Levels of IgE protein and IgE antibodies specific for 8 different allergenic extracts were measured in the serum of a large series of patients infected by the human immunodeficiency virus (HIV) and in HIV-seronegative subjects belonging to the same risk groups (intravenous drug-users, homosexual men and hemophiliacs).
Vuillecard E; Herve V; Martin P; Georges AJ; Service de Stomatologie et Chirurgie Maxillo-faciale, CNHU; Bangui, Republique Centrafricaine.
A new clinical aspect of AIDS in Africa is represented by acute gangrenous cervico-facial cellulitis. In most of cases, the infection was due to infected tooth. Seven patients presenting with such clinical findings were HIV-1 infected (Western Blot). Bacteriological investigations failed to show bacteria responsible o
Ankrah EM; Department of Social Work and Social Administration, Faculty of; Social Sciences, Makerere University, Kampala, Uganda.
This paper outlines some problems in conducting AIDS research in developing countries, discusses the impact of the socio-cultural setting on study efforts, and emphasizes the need for adopting methodological approaches that are highly sensitive to the environment. The importance of seeing AIDS as a disease that affect
South Med J. 1989 Aug;82(8):1062-3. Unique Identifier : AIDSLINE MED/89346940
Parsonnet J; Infectious Disease Unit, Massachusetts General Hospital, Boston.
A patient receiving continuous ambulatory peritoneal dialysis, and who was known to be seropositive for human immunodeficiency virus but without AIDS or ARC, had peritonitis secondary to Trichosporon beigelii. The patient had been receiving oral antibiotics and had had recurrent bouts of bacterial peritonitis. Infecti
The incidence of suicide in patients with the diagnosis of acquired immunodeficiency syndrome (AIDS) in the state of Texas during the period between January 1986 and August 1987 was determined. AIDS patients were found to have a rate of suicide higher than expected when compared to the general population. The results
Poelzleitner D; Huebsch P; Mayerhofer S; Chott A; Zielinski C; Radiological Division of the Second Medical Department,; University of Vienna, Austria.
A case of primary pulmonary lymphoma presenting as a nodular lesion on the chest radiograph in a patient with the acquired immune deficiency syndrome is described.
van dan Meeberg PC; Kooiman RC; Buisman NJ; Goudsmit J; Lange JM; Bannenberg AF; Royal Navy of the Netherlands, Amsterdam.
A seroepidemiological survey conducted from January to May 1986 among 650 pregnant women from mixed rural/urban origin in the Moungo district, Cameroon , revealed a very low prevalence of antibodies to human immunodeficiency viruses (HIV). One subject appeared to be infected with
Naito M; Jogasaki M; Takahashi K; Matsumi S; Hattori T; Takatsuki K; Second Department of Pathology, Kumamoto University Medical; School, Japan.
Human immunodeficiency virus (HIV) was detected ultrastructurally and immunohistochemically in the brain of a Japanese hemophiliac presenting AIDS encephalopathy. The encephalopathy was characterized by the multifocal occurrence of multinucleated giant cells mainly in the subcortical areas. The giant cells were identi
Kitchen AD; Mann GF; Harrison JF; Zuckerman AJ; Regional Blood Transfusion Centre, Brentwood, Essex, UK.
The effect of gamma irradiation on HIV and plasma coagulation factors F VIII:C, F VIII:vWF and FIX was studied. Donor plasma was harvested from single donations, frozen and irradiated in the frozen state at target doses from 0 to 40 kGy (0-4 mRad). HIV was inoculated into human plasma and irradiated in a similar manne
Hamamoto Y; Harada S; Kobayashi S; Yamaguchi K; Iijima H; Manabe S; Tsurumi T; Aizawa H; Yamamoto N; Department of Virology and Parasitology, Yamaguchi University; School of Medicine, Japan.
We propose a new method to rid solutions of a virus by using a novel regenerated multilayered structured cellulose membrane (BMM). When the filtrate of human immunodeficiency virus (HIV) preparation was obtained through BMM it showed no infectivity. Electron microscopic observation revealed that HIV was completely cau
Janvier D; Reviron M; Reviron J; Centre de Secteur d'Hemobiologie-Transfusion, Hopital St.; Louis, Paris, France.
One serum from a blood donor, which had both HIV-antibodies and rheumatoid factor, gave positive results with EIA anti-HIV screening tests and Western blot, but negative results with the Abbott s ENVACOR assay. Moreover, this serum and 5 out of 6 sera containing only rheumatoid factors were able to interfere with ENV
Blood samples were collected on cotton wool and stored at +20 degrees C. These samples were tested in an enzyme linked immunosorbent assay and the immunoblotting test. HIV-antibodies could be detected in samples stored up to four month.
Am J Drug Alcohol Abuse. 1989;15(3):251-60. Unique Identifier : AIDSLINE MED/89349143
Rose MR; Brown BS; Haertzen CA; Addiction Research Center/National Institute on Drug Abuse,; Baltimore, Maryland 21224.
Comparisons were made of the functioning and characteristics of cocaine-abusing volunteers to a research ward (N = 25) and to an outpatient treatment program (N = 33) at the same research facility. It was hypothesized that individuals volunteering for clinical studies and for treatment-related studies would represent
Am J Drug Alcohol Abuse. 1989;15(3):261-74. Unique Identifier : AIDSLINE MED/89349144
Brown BS; Hickey JE; Chung AS; Craig RD; Jaffe JH; Addiction Research Center, Baltimore, Maryland 21224.
Using structured interviews and the SCL-90R, study was made of the behaviors of 29 applicants to a residential treatment program for cocaine abuse who had been placed on the program s waiting list for periods ranging from 1 to 6 months. It was hypothesized that applicants waiting treatment for 3 months or less (N = 16
Ho HT; Hitchcock MJ; Pharmaceutical Research and Development Division, Bristol-Myers; Company, Wallingford, Connecticut 06492-7660.
2 ,3 -Dideoxy-2 ,3 -didehydrothymidine (D4T) is a thymidine nucleoside analog which has potent anti-human immunodeficiency virus activity in vitro. We have studied its metabolism in cells to assist in determining its mechanism of action. D4T is metabolized in cells to the mono-, di-, and triphosphate nucleotides. Our
Kloser PC; Mangia AJ; Leonard J; Lombardo JM; Michaels J; Denny TN; Sharer L; Sathe S; Weiss SH; Schable C; et al; Department of Medicine, University of Medicine and Dentistry of; New Jersey, Newark 07103-2757.
A 41-year-old woman from the Cape Verde Islands, Africa, who had been residing in the United States for 11 months was found to have human immunodeficiency virus type 2 (HIV-2)-associated acquired immunodeficiency syndrome (AIDS). Antibody to HIV-
Scaff M; Rabello GD; Marchiori PE; Departamento de Neurologia, Faculdade de Medicina, Universidade; de Sao Paulo, Brasil.
A 50-year-old man with positive test for human immunodeficiency virus (HIV) by enzyme-linked-immunoassy and Western-blot, without clinical manifestations of acquired immunodeficiency syndrome (AIDS), developed acute polyradiculoneuritis and was treated by plasmapheresis with improvement. We believe that chemical homol
Aust N Z J Med. 1989 Apr;19(2):103-7. Unique Identifier : AIDSLINE MED/89350710
Jones MR; Neale TJ; Say PJ; Horne JG; Division of Microbiology, Wellington Hospital, New Zealand.
Human infection with Rhodococcus equi is apparently rare with most published reports describing the development of lung abscesses in immunocompromised hosts. Of only 18 cases of infection previously recorded, four have recently occurred in patients with the acquired immune deficiency syndrome (AIDS). In Australasia, R
J Cancer Res Clin Oncol. 1989;115(3):279-84. Unique Identifier : AIDSLINE MED/89327338
Suetake N; Takeuchi Y; Shimizu N; Uesato H; Kuroume T; Hoshino H; Department of Pediatrics, Gunma University School of Medicine,; Japan.
Specificities of antibodies against human T-cell leukemia virus type I (HTLV-I) in sera of 27 patients with adult T-cell leukemia (ATL) were studied. All sera were positive for HTLV-I antigens by immunofluorescence assay using cells expressing HTLV-I antigens; sera from five ATL patients, however, did not react or har
Norman GL; Barker SS; Rasheed S; Laboratory of Viral Oncology and AIDS Research, University of; Southern California School of Medicine, Los Angeles.
Examination of serum for the presence of antibodies to the human immunodeficiency virus (HIV) by immunoblot analysis requires precise identification of reactivities with various HIV specific proteins. During a recent survey of approximately 2,000 sera, we identified 22 sera from non-HIV-reactive blood donors and 2 fro
G Ital Cardiol. 1989 Feb;19(2):123-7. Unique Identifier : AIDSLINE MED/89339076
Mutinelli M; Corallo S; Santoli E; Castelli P; Morandi A; Condemi A; Santoli C; Presidio Multizonale, Ospedale L. Sacco, Milano.
Blood autotransfusion has entered a new phase in blood transfusion technique, since it represents an important alternative in eliminating the risks connected with blood transfusion: viral hepatitis, AIDS, blood transfusion reactions, and alloimmunization. Transfusion requirements during cardiac surgical procedures hav
van den Hoek JA; van Haastrecht HJ; Scheeringa-Troost B; Goudsmit J; Coutinho RA; Department of Public Health and Environment, University of; Amsterdam, The Netherlands.
To assess the potential role of drug using prostitutes in the heterosexual transmission of human immunodeficiency virus (HIV), 117 prostitutes, recruited from December 1985 to November 1987 at a weekly evening sexually transmitted diseases (STD) clinic for drug using prostitutes only, were studied for the prevalence o
Macatonia SE; Patterson S; Knight SC; Division of Immunological Medicine, MRC Clinical Research Centre,; Harrow, Middlesex, U.K.
Evidence of human immunodeficiency virus (HIV) replication both in the skin Langerhans cells of AIDS patients (Tschachler et al., 1987) and in normal, peripheral blood dendritic cells (DC) (Patterson & Knight, 1987; Knight & Patterson, 1989) suggests that infection of these antigen-presenting cells may contribu
Novick DM; Ochshorn M; Ghali V; Croxson TS; Mercer WD; Chiorazzi N; Kreek MJ; Rockefeller University, New York, New York.
We studied natural killer (NK) activity and lymphocyte subsets in 11 active parenteral heroin abusers, 11 long-term methadone-maintained former heroin abusers and 11 apparently healthy individuals. All subjects were males aged 23 to 49 and none had active infectious or inflammatory diseases. All current or former hero
Kawamura I; Koga Y; Oh-Hori N; Onodera K; Kimura G; Nomoto K; Department of Immunology, Kyushu University, Fukuoka, Japan.
A CD4+ human monocytoid cell line, U937, was transfected with a constructed plasmid which has the envelope gene of human immunodeficiency virus under the transcriptional control of the human metallothionein IIA promoter and was cloned thereafter. These cloned cell lines (EH and EL cells) expressed the viral gp160 in t
Strebel K; Klimkait T; Maldarelli F; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
We have performed a detailed analysis of the biochemical properties of the human immunodeficiency virus (HIV) type 1 vpu gene product to elucidate its function during virus replication. Our data suggest that vpu is posttranslationally modified by phosphorylation, since a 16-kilodalton phosphoprotein can be specificall
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5781-5. Unique Identifier : AIDSLINE MED/89345550
Gottlinger HG; Sodroski JG; Haseltine WA; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, MA 02115.
The effects on human immunodeficiency virus type 1 virion morphogenesis and on virus replication of mutations that affect posttranslational processing of the capsid precursor protein are described. A change in the glycine residue at position two from the N terminus abolishes the myristoylation of the precursor protein
Proc Natl Acad Sci U S A. 1989 Aug;86(16):6111-5. Unique Identifier : AIDSLINE MED/89345615
Ahmad N; Maitra RK; Venkatesan S; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, MD 20892.
The replication of human immunodeficiency virus type 1 (HIV-1) requires the concerted action of two virus-encoded transactivator proteins, Tat and Rev, and is in turn moderated by the viral transcriptional repressor Nef. We show here that the phenotype of a Rev- HIV-1 provirus was nonreplicating and was distinguished
Bataller A; Abengochea A; San Miguel G; Pertusa V; Granda D; Montero Benzo R
A study has been performed on 200 patients at the Recovery Department of our hospital during 1987. This study was carried out in order to determine patients with human immunodeficiency virus (HIV) antibody. This group was randomized and consisted of 154 men and 46 women, with an average age of 35.6 +/- 3.9, a total we
The value of differential cell counts in bronchoalveolar lavage fluid in patients who were serologically positive for the human immunodeficiency virus (HIV) was studied in 30 patients with classified into four groups according to the severity of illness: (1) seven subjects with the AIDS related complex without clinica
Ups J Med Sci. 1989;94(2):183-94. Unique Identifier : AIDSLINE MED/89347848
Dolk T; Department of Orthopaedics, Regionsjukhuset, Orebro, Sweden.
A consecutive series of 282 patients with hip fractures, with a mean age of 76 years, was studied. Two-thirds of the patients (182) lived in their own homes, half of them alone and one-third of the 182 requiring regular help. Widows were more common in the age group 75-84 years and widowers and single men in the age g
Enhancement of HIV-I production by immunostimulators leakadine (5 micrograms/ml) and thymosin (10 micrograms/ml) by 40 +/- 10% and a significant inhibition of HIV-I production by immunosuppressors cortisone and dexasone was demonstrated in H9 culture. HIV-I production was estimated by the number of cells expressing vi
Acta Med Okayama. 1989 Jun;43(3):143-51. Unique Identifier : AIDSLINE MED/89348887
Akagi T; Takata H; Yoshino T; Teramoto N; Yano S; Oka T; Second Department of Pathology, Okayama University Medical; School, Japan.
Co-cultivation of thymus and spleen cells of Fisher and Lewis rats with lethally irradiated MT-2 cells harboring human T-cell leukemia virus type I (HTLV-I) resulted in the establishment of lymphoid cell lines, FIRT-1, FIRS-1, LERT-1, and LERS-1, respectively. Cells of these cell lines had rat T-cell characters as dem
Biochem Biophys Res Commun. 1989 Aug 15;162(3):963-70. Unique Identifier : AIDSLINE MED/89350998
Kubota S; Siomi H; Satoh T; Endo S; Maki M; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.
We have tested the functional compatibility between rev protein of human immunodeficiency virus type I (HIV-I) and rex protein of human T-cell lymphotropic virus type I (HTLV-I). Each protein recognized the other s cis-acting sequence, albeit at reduced levels. Both proteins localize predominantly in the nucleolus. We
Fuchs D; Spira TJ; Hausen A; Reibnegger G; Werner ER; Felmayer GW; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.
We assessed the value of urinary neopterin concentrations for prognosis of disease progression in HIV-1-infected patients. Sixty-eight anti-HIV-1 seropositive homosexuals with lymphadenopathy syndrome were tested for urinary neopterin and T-cell subset counts in 1982-83, and the incidence rate at which they developed
Klaassen RJ; van der Lelie J; Vlekke AB; Weigel HM; Eeftinck Schattenkerk JK; Reiss P; von dem Borne AE; Department of Immunohaematology, The Netherlands Red Cross Blood; Transfusion Service, Amsterdam.
A study was carried out on the presence of platelet-bound immunoglobulins, platelet-bound complement and serum immunoglobulin reactive with platelets in the blood of persons infected with HIV and those at risk of HIV infection. Platelet-bound immunoglobulins, predominantly IgG and IgM, but not complement, were demonst
Buchanan GR; Department of Pediatrics, University of Texas Southwestern; Medical Center, Dallas 75235-9063.
Patients with idiopathic thrombocytopenia purpura (ITP) are frequently encountered by the pediatrician and pediatric hematologist. The clinical and laboratory features of ITP are quite uniform and facilitate prompt and accurate diagnosis. Bone marrow examination is not required in most cases since patients with altern
Bull Cancer (Paris). 1989;76(4):383-94. Unique Identifier : AIDSLINE MED/89323527
Ngendahayo P; Mets T; Bugingo G; Parkin DM; Service d'Anatomie Pathologique, Faculte de Medecine, Butare,; Rwanda.
The clinico-pathological and epidemiological features of 119 cases of Kaposi s sarcoma diagnosed during the years 1979-1986 in the main pathology department of Rwanda are presented. Skin involvement (89%) was predominant with almost 70% of cutaneous lesions localised on the lower l
Women are vulnerable to the acquired immunodeficiency syndrome (AIDS), and are now contracting the disease at a faster rate than men. However, many are ignorant of their potential risk of infection and it is only recently that the scientific community has begun to look at human immunovirus (HIV) infection in women. Th
Mahony J; Rosenthal K; Chernesky M; Castriciano S; Scheid E; Blajchman M; Harnish D; McMaster University Regional Virology Laboratory at St. Joseph's; Hospital, Hamilton, Ontario, Canada.
A total of 114 serum specimens from 76 blood donors, 21 patients with acquired immune deficiency syndrome or acquired immune deficiency syndrome-related complex, 7 multiply transfused patients, 3 hemophiliacs, and 7 others were tested for anti-human immunodeficiency virus type 1 (HIV-1) antibody by enzyme immunoassay
Brawner DL; Cutler JE; Department of Microbiology, Montana State University, Bozeman; 57917.
A total of 128 human oral isolates of Candida albicans were collected from asymptomatic healthy carriers (64 isolates); asymptomatic, nonimmunosuppressed, hospitalized patients (25 isolates); immunosuppressed transplant patients (19 isolates); and human immunodeficiency virus-infected patients with symptoms of acquire
This study was undertaken to evaluate the sensitivity and specificity of a commercial enzyme immunoassay in detecting antibody to human immunodeficiency virus type 1 using whole-blood specimens collected onto filter paper. Results obtained with specimens collected onto filter paper were comparable with those obtained
Krigel RL; Padavic-Shaller KA; Rudolph AR; Poiesz BJ; Comis RL; Department of Medicine, Fox Chase Cancer Center, Philadelphia,; Pennsylvania 19111.
Epidemic Kaposi s sarcoma (EKS) is the most common neoplastic manifestation of acquired immune deficiency syndrome (AIDS). The underlying immune deficiency can be partially reversed in vitro with interleukin-2 ( IL-2 ). The type 1 interferons (IFN), alpha and beta, inhib
The pandemic proportions of human immunodeficiency virus (HIV) have already begun impacting health care in the United States . It is safe to say that in the near future nursing will have to formulate an aggressive response to this situation. This article addresses the origins of HIV and
Haseltine WA; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115.
This review makes it clear that there are numerous possibilities for the development of antiviral drugs for the treatment of AIDS. Drug design based on a profound understanding of specific enzymatic regulatory proteins and structural requirements for virus replication is possible. Information regulating these specific
Jacobson MA; McGrath MS; Joseph P; Molaghan JB; Tadepalli S; Quinn R; Department of Medicine, University of California San Francisco.
Zidovudine (3 -azido-3 deoxythymidine, AZT , Retrovir) is the first antiretroviral drug to demonstrate clinical efficacy for symptomatic human immunodeficiency virus infection. In a large, placebo-controlled trial, nausea and hematologic toxicity, but
Golombok S; Sketchley J; Rust J; Department of Psychology, City University, London, U.K.
Following a postal questionnaire survey of 262 homosexual men carried out to investigate condom use during sexual activity, a sample of 97 men who used condoms during anogenital sex was identified. Thirty-one percent of those who had used a condom during anal intercourse reported at least one incident of condom breaka
Homologous blood transfusion without risk is an unobtainable goal. Infection with human immunodeficiency virus continues to occur at an average rate of one infection per 100,000 transfusions, in spite of the most sensitive and specific testing available. In the past 30 years, the number of red cell antigens identified
Med Cutan Ibero Lat Am. 1989;17(2):113-6. Unique Identifier : AIDSLINE MED/89329945
Allegue F; Boixeda P; Espana A; Moreno R; Ledo A; Servicio de Dermatologia, Hospital Ramon y Cajal, Madrid.
A 26-year-old man, with a personal history of drug abuse and positive serology for HIV, had Reiter s syndrome for six years. He experienced progressive worsening of his cutaneous lesions after initiation of indomethacin therapy. The skin lesions were almost completely resolved after the discontinuance of the drug and
Staib F; Seibold M; L'age M; Heise W; Skorde J; Grosse G; Nurnberger F; Bauer G
In a 33-year-old HIV-positive homosexual male suffering from unexplained headache, cryptococcosis was diagnosed in a progressive secondary stage. After treatment with the standard combination therapy of amphotericin B + flucytosine for 34 d, the patient was clinically
Nature. 1989 Aug 3;340(6232):397-400. Unique Identifier : AIDSLINE MED/89330564
Loeb DD; Swanstrom R; Everitt L; Manchester M; Stamper SE; Hutchison CA 3d; Department of Microbiology and Immunology, University of North; Carolina, Chapel Hill 27599.
Retroviruses encode a protease which needs to be active for the production of infectious virions. A disabling mutation in the protease results in the production of non-infectious virus particles and examination of proteins from these mutant virions reveals unprocessed Gag and Gag-Pol precursor proteins, the substrates
Sarti GM; Department of Family Practice, Wright State University School of; Medicine, Dayton, Ohio.
Pneumocystis carinii pneumonia is the most common life-threatening disease diagnosed in patients infected with the human immunodeficiency virus (HIV). Patients treated for their initial episode are at risk for recurrence of the disease. HIV-positive patients with low T4 lymphocyte counts are also at risk. Conventional
Tuberculosis is on the increase in the United States , so physicians would be prudent to renew familiarity with the disease. Physicians should be prepared to administer the Mantoux test correctly and interpret the results according to the specific condition of each patient. Patients wit
Duruble M; Duvelleroy M; Laboratoire de Biophysique, Hopital Fernand Widal, Paris.
The risk of contracting certain disorders following a blood transfusion is currently becoming worrisome not only for physicians who are aware of this problem, but also for patients who, with increased media attention on AIDS, are more afraid of this potential risk than of the surgical or anesthetic risks. In fact, hep
Sex Transm Dis. 1989 Jan-Mar;16(1):15-20. Unique Identifier : AIDSLINE MED/89332570
Leslie-Harwit M; Meheus A; Programme for Sexually Transmitted Diseases, World Health; Organization, Geneva, Switzerland.
In most cultures sexually transmitted diseases (STD) and unwanted pregnancy are major health problems for sexually active youths aged 15-24. Since the early 1970s contraceptive use has increased in developed countries, but as few as 4-6% of young people in developing countries have access to reliable, modern contracep
The Food and Drug Administration has recommended that blood donated for transfusion in the United States be screened for antibodies to human T lymphotropic virus type I. Since seropositive donors will be referred to health care providers for advice, physicians should become familiar wi
Barak M; Merzbach D; Gruener N; Department of Biochemistry, Carmel Hospital, Haifa, Israel.
In this solid-phase competitive enzyme-linked immunosorbant assay for neopterin (a product of activated macrophages) in serum or supernates of cell cultures, we incubate antiserum to neopterin with standards or samples in the presence of solid-phase-bound conjugate of carrier-neopterin. Incubation with second antibody
FEBS Lett. 1989 Aug 14;253(1-2):214-6. Unique Identifier : AIDSLINE MED/89338740
Richards AD; Broadhurst AV; Ritchie AJ; Dunn BM; Kay J; Dept of Biochemistry, University of Wales College of Cardiff.
Kinetic constants were determined for the interaction of the HIV-2 aspartic proteinase with a synthetic substrate and a number of inhibitors at several pH values. Acetyl-pepstatin was more effective towards HIV-2 proteinase than the renin inhibitor, H-261; this effect is exactly the opposite from that observed previou
Dev Biol Stand. 1989;70:211-4. Unique Identifier : AIDSLINE MED/89338983
Hoffman T; Fratantoni J; Murano G; Center for Biologics Evaluation and Research, Bethesda, MD.
Recent advances in biotechnology, namely DNA cloning and hybridoma formation, have greatly increased the availability of biologicals for clinical use. cDNA directed proteins and monoclonal antibodies may now be produced in sufficient quantities for wide-ranging experimental uses and, in some cases, licensed applicatio
The growing number of AIDS cases among older Americans (50 years and older) is of increasing concern. In the context of primary prevention, findings are reviewed that bear on the modes of HIV transmission (blood transfusion, sexual) among older individuals and knowledge of the magnitude of the AIDS problem represented
Human Immunodeficiency Virus (HIV) has neurotropic effects that are independent of the well-known lymphotropism. They have been proved by various techniques, but their pathogenesis is not clear. It is remarkable that the neuropathological features do not correlate with the degree of the clinical symptomatology. HIV an
Pol S; Dubois F; Roingeard P; Zignego L; Housset C; Brechot C; Goudeau A; Berthelot P; Unite d'Hepatologie, Hopital Laennec, INSERM U-99, Paris,; France.
The prevalence and serological features of hepatitis delta virus infections were studied in a French population of chronic, non-drug addict, hepatitis B surface antigen carriers: 42 male homosexual patients were compared to 30 nonhomosexuals (20 who evidently had not been exposed to any of the usual hepatitis B virus-
Pietroboni GR; Harnett GB; Bucens MR; Virus Laboratory, Combined Microbiology Service, Queen Elizabeth; II Medical Centre, Nedlands, Australia.
The effect of centrifugal inoculation of human immunodeficiency virus (HIV) and human herpesvirus-6 (HHV-6) on the infectivity of the viruses for cell cultures was examined. Three HIV-1 strains, ARV-2, HTLV-IIIb and a local isolate, WA-46c, were tested in peripheral blood lymphocytes, HUT-78, H9 and MT-2 cells. The HH
Recombinant polypeptides representing various parts of structural proteins of HIV-1 and HIV-2 were expressed in E. coli. Fragments of the transmembrane proteins gp41 of HIV-1 (HTLV-IIIB) and gp38 of HIV-2 (LAV-2 ROD) proved to be highly antigenic in the immunoblot test system. Each protein was found to be suitable for
We recall the medical obligation to perform an HIV serology on corneal donors before keratoplasty. The ways to take samples of blood from a deceased person and the techniques which detect HIV antibodies are discussed. We emphasize on the contribution of preservation mediums in order to complete the investigations on t
Hook EW 3d; Department of Medicine, Johns Hopkins University School of; Medicine, Maryland.
While infectious diseases clinicians have been schooled in syphilology for generations, new aspects of syphilis continue to appear. Such is the case in HIV-infected individuals, in whom the clinical, diagnostic, and therapeutic implications are quite confusing. Dr. Edward W. Hook III, associate professor of medicine a
Lunardi-Iskandar Y; Georgoulias V; Bertoli AM; Augery-Bourget Y; Ammar A; Vittecoq D; Rosenbaum W; Meyer P; Jasmin C; Unite d'Oncogenese Appliquee (INSERM U 268), Villejuif,; France.
Patients with acquired immunodeficiency syndrome (AIDS) and persistent lymphadenopathy syndrome (LAS) display significant hematological abnormalities of one or more cell lineages. In order to understand the pathophysiologic mechanisms leading to these abnormalities we studied the proliferation capacity of pluripotent
Mod Pathol. 1989 Jul;2(4):277-94. Unique Identifier : AIDSLINE MED/89345504
Miller-Catchpole R; Variakojis D; Anastasi J; Abrahams C; Department of Pathology, Evanston Hospital, Chicago, Illinois.
The Chicago acquired immunodeficiency syndrome (AIDS) autopsy study evaluated the first 38 AIDS autopsies through January 1, 1985 from 14 participating institutions in the Chicago area. A complete analysis of neoplasms and opportunistic infections from this material as well as a discussion of pathologic features that
Cordaro JC; Division of Research and Testing, Food and Drug Administration,; Washington, D.C. 20204.
Historically, mice have served a routine and useful purpose in the research, development, and testing of biologicals, chemicals, and drugs for efficacy, toxicity, and carcinogenic risk. The literature is replete with examples using mice to study organic compounds both in short-term tests involving tumor initiation and
Kaplan HB; Department of Sociology, College Liberal Arts, Texas A&M; University, College Station 77843-4351.
Recent psychosocial research on the onset and course of AIDS is reviewed toward the goal of identifying major methodological problems in carrying out such research. The problems are identified as related to guiding theoretical statements, sampling plans, validity of measurement models, and analytic strategies. Increas
South Med J. 1989 Aug;82(8):999-1004. Unique Identifier : AIDSLINE MED/89346964
Fernandez F; Ruiz P; Department of Psychiatry, Baylor University College of Medicine,; Houston, Tex.
Psychiatric disorders associated with human immunodeficiency virus (HIV) infection are increasingly prevalent. The psychologic, sociocultural, and medicolegal dimensions of HIV disease further fragment and complicate the care of these individuals. This article reviews the psychiatric aspects of HIV disease and suggest
Vet Parasitol. 1989 Jul 1;32(1):37-55. Unique Identifier : AIDSLINE MED/89347952
Eckert J; Institute of Parasitology, University of Zurich, Switzerland.
Selected parasitic zoonoses are discussed with emphasis on epidemiological, diagnostic and some chemotherapeutic aspects. Pneumocystosis, toxoplasmosis, cryptosporidiosis and microsporidiosis are briefly reviewed as AIDS-related zoonoses. Up to now 5 genera of Microspo
Sera from 867 donors were tested for antibodies to the virus of T-lymphocyte leukemia of adults (HTLV-I) in parallel by indirect immunofluorescence on acetone-fixed cells of HUT-102 culture producing HTLV-I and by agglutination test using a commercial set (Serodia-ATLA, Japan ). Twel
Am J Epidemiol. 1989 Sep;130(3):530-9. Unique Identifier : AIDSLINE MED/89349162
Munoz A; Wang MC; Bass S; Taylor JM; Kingsley LA; Chmiel JS; Polk BF; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, MD.
To estimate the time interval between human immunodeficiency virus type 1 (HIV-1) seroconversion and acquired immunodeficiency syndrome (AIDS) diagnosis in homosexual men, prospective incident cohorts are difficult to obtain and, if assembled, provide few events owing to the long incubation time. Although seroprevalen
Am J Med Sci. 1989 Aug;298(2):89-92. Unique Identifier : AIDSLINE MED/89349202
Zhou DB; Ipp E; Harbor-UCLA Medical Center, Department of Medicine, Torrance; 90502.
The incidence of beta cell damage attributable to pentamidine treatment of pneumocystis pneumonia is increasing in frequency because of the AIDS epidemic. We carried out in vitro studies in perfused rat islets using insulin secretion as an index of beta cell damage to study the effects of pentamidine and to test wheth
Raffin TA; Department of Medicine, Stanford University School of Medicine,; CA 94305-5236.
Many patients with systemic illness are admitted to intensive care units (ICUs) and placed on life support. This occurs in patient populations even when the projected mortality rate might be as high as 80 to 90%. Patients with systemic illness often are life-support-dependent in ICUs as chronically critically ill pati
Gelderblom HR; Ozel M; Pauli G; Robert Koch-Institut, Berlin.
Fine structure and antigenic make-up analysis of HIV were combined in a 2D model, from which functional aspects can be deduced. On the envelope 72 probably trimeric surface knobs (gp120) are connected to the virion via the transmembrane protein gp41. Gp120 is shed during ageing of the virion, but host cell antigens st
Curry CJ; O'Lague P; Tsai J; Hutchison HT; Jaspers NG; Wara D; Gatti RA; Hutchinson HT/[corrected to Hutchison HT]; Department of Medical Genetics, Valley Children's Hospital,; Fresno/University of California, San Francisco.
This report describes twin girls with typical features of ataxia-telangiectasia, including increased alpha-fetoprotein, radio-resistant DNA synthesis, characteristic chromosome abnormality, and immunodeficiency. They have, in addition, microcephaly and mental retardation. Complementation studies were performed utilizi
The CD4 and CD8 glycoproteins play an important role in T-cell activation by binding to major histocompatibility complex (MHC) class II or class I molecules, respectively, and stabilizing their interactions with the T-cell receptor-CD3 complex during antigen presentation. Recent evidence suggesting that the cytoplasmi
Schechter MT; Craib KJ; Le TN; Willoughby B; Douglas B; Sestak P; Montaner JS; Weaver MS; Elmslie KD; O'Shaughnessy MV; Vancouver Lymphadenopathy--AIDS Study Group, St. Paul's Hospital,; Canada.
As part of an ongoing prospective study of seropositive homosexual men in Vancouver, Canada , a seroprevalent cohort of 246 subjects (i.e. duration of infection unknown) and a seroincident cohort of 102 subjects (i.e. duration of infection known) were followed a median of 63 and 45
Batalla J; Gatell JM; Cayla JA; Plasencia A; Jansa JM; Parellada N; Institut Municipal de la Salut, Barcelona, Spain.
Factors influencing the outcome of disease were analysed in 289 adults presenting with AIDS in Barcelona, Spain from January 1986 (31 cases) to December 1987 (258 cases). One hundred and fifty-four (53.3%) were parenteral drug addicts and 100 (34.6%) were male homosexuals. Ninety-si
Johnson AM; Petherick A; Davidson SJ; Brettle R; Hooker M; Howard L; McLean KA; Osborne LE; Robertson R; Sonnex C; et al; School of Medicine, London, UK.
Future heterosexual spread of HIV will in part depend on the efficiency of transmission from men to women and from women to men. We studied seventy-eight female sexual partners of men infected with HIV and 18 male sexual partners of infected women. Participants were interviewed concerning sexual practices, use of cont
Bongaarts J; Reining P; Way P; Conant F; Research Division, New York City, New York 10017.
The relationship between HIV seroprevalence and the proportion of uncircumcised males in African countries is examined to determine whether circumcision practices play a role in explaining the large existing variation in the sizes of African HIV epidemics. A review of the anthropological literature yielded estimates o
Ujhelyi E; Fust G; Illei G; Salavecz V; Allam S; Szelenyi J; Hollan SR; National Institute of Haematology and Blood Transfusion,; Budapest, Hungary.
In order to clarify whether HIV-1 core and env antigens are destroyed during pepsin treatment, used previously for detecting HIV-1 core and env antibodies hidden in circulating immune complexes, purified recombinant env and core antigen preparations were treated with pepsin. Core antigen was found to be extremely sens
Swinne D; Deppner M; Laroche R; Floch JJ; Kadende P; Laboratory for Mycology, Institute of Tropical Medicine, Antwerp,; Belgium.
Cryptococcus neoformans var. neoformans, which is responsible for AIDS-associated cryptococcosis in Bujumbura, was isolated in the domestic environment of seven out of 20 patients with AIDS-associated cryptococcosis. The findings prove that in his own domestic environment, the HIV-positive patient in central Africa is
d'Arminio Monforte A; Novati R; Marchisio P; Zanchetta N; Uberti-Foppa C; Tornaghi R; Massironi E; Lazzarin A; Principi N; Clinic of Infectious Diseases, University of Milan, L. Sacco; Hospital, Italy.
Eighteen infants born to anti-HIV-positive mothers were tested bimonthly for immunoglobulin M (IgM) anti-HIV by Western blot and HIV p24 antigen (Ag) by enzyme-linked immunosorbent assay (ELISA) in order to determine the role of these markers in the early diagnosis of HIV infection. Twelve healthy infants were also st
Patterson TF; Andriole VT; Yale University School of Medicine, Department of Medicine, New; Haven, Connecticut 06510.
Cryptococcus neoformans has become an increasingly important pathogen. Cryptococcosis is an important cause of morbidity and mortality in immunocompromised hosts and is the second most common fungal infection complicating AIDS. In recent years, research has focused on the host defenses against Cryptococcus and has led
Hawaii Med J. 1989 May;48(5):194-9. Unique Identifier : AIDSLINE MED/89326835
Abou-Sayf FK; Marzolf JR
A study of the acquired immunodeficiency syndrome in Hawaii indicates the presence of an estimated 334 patients, 49 (14.7) of them females, between 1985 and mid-1988. Regression analysis yielded an expected count of 1200 patients by 1991, with a total cost of $50 million for care. The cost per patient was $37,053. The
Sanada I; Yamaguchi K; Yoshida M; Ishii T; Tsukamoto A; Sato M; Obata S; Shido T; Department of Internal Medicine, Kumamoto National Hospital.
A married couple who developed adult T-cell leukemia (ATL) is described. The husband presented with acute ATL and died soon after admission in spite of aggressive chemotherapy, and his wife, who is diagnosed as smoldering ATL, has been followed in the out-patient clinic. The couple had serum antibodies against human T
Ando Y; Kakimoto K; Tanigawa T; Furuki K; Saito K; Nakano S; Hashimoto H; Moriyama I; Ichijo M; Toyama T; Obstetrics and Gynecology, Nara Medical University.
Breast feeding is known to be a major cause of vertical transmission of HTLV-I from mothers to her children. The infectiousness of HTLV-I in breast milk was reported to be lost during freezing and thawing processes. We therefore administered frozen-and-thawed breast milk of HTLV-I carriers to their babies. Among the 1
Jackson JB; Sannerud KJ; Balfour HH Jr; Department of Laboratory Medicine and Pathology, University of; Minnesota Health Science Center, Minneapolis 55455.
The detection and recruitment of HIV antigen-positive asymptomatic individuals for clinical trials is important. Two commercial enzyme-linked immunosorbent assays (ELISA) for the detection and quantitation of human immunodeficiency virus (HIV) antigens were evaluated for sensitivity by testing serum samples from 155 a
J Natl Cancer Inst. 1989 Aug 16;81(16):1254-8. Unique Identifier : AIDSLINE MED/89329058
Gustafson KR; Cardellina JH 2d; Fuller RW; Weislow OS; Kiser RF; Snader KM; Patterson GM; Boyd MR; Division of Cancer Treatment, National Cancer Institute,; Bethesda, MD.
A recently developed tetrazolium-based microculture assay was used to screen extracts of cultured cyanobacteria (blue-green algae) for inhibition of the cytopathic effects of the human immunodeficiency virus (HIV-1), which is implicated as a causative agent of AIDS. A number of extracts were found to be remarkably act
Public Health Rep. 1989 Jul-Aug;104(4):388-91. Unique Identifier : AIDSLINE MED/89331809
Kappel S; Vogt RL; Brozicevic M; Kutzko D; Vermont Department of Health, Montpelier.
To design a statewide educational campaign, the Vermont Department of Health attempted to measure knowledge about AIDS among residents of the State. During the period November 1986 through January 1987, the authors conducted a telephone survey of noninstitutionalized residents ages 18 and over. The results were examin
Public Health Rep. 1989 Jul-Aug;104(4):391-5. Unique Identifier : AIDSLINE MED/89331810
St Lawrence JS; Hood HV; Brasfield T; Kelly JA; Jackson State University, MS.
Several studies have found reductions in acquired immunodeficiency syndrome (AIDS) risk practices among gay men in high AIDS-prevalence cities since the start of the AIDS crisis. Much less is known about risk behavior patterns among gay men in smaller cities, where AIDS cases are less common and the prevalence of huma
Yarchoan R; Mitsuya H; Thomas RV; Pluda JM; Hartman NR; Perno CF; Marczyk KS; Allain JP; Johns DG; Broder S; Clinical Oncology Program, National Cancer Institute, Bethesda,; MD 20892.
The purine analog 2 ,3 -dideoxyinosine (ddI), which has anti-retroviral activity in vitro was administered for up to 42 weeks to 26 patients with acquired immunodeficiency syndrome (AIDS) or severe AIDS-related complex (ARC). Ten of these individuals were AZT-intolerant. Eight dose regimens were studied. The drug was
Lee CA; Kernoff PB; Karayiannis P; Thomas HC; Haemophilia Centre, Royal Free Hospital, Hampstead, London.
The case histories of a carrier of haemophilia A with chronic post transfusion non-A non-B hepatitis and a severe haemophiliac with chronic delta hepatitis are described. Therapy with lymphoblastoid alpha interferon resulted in improvement of NANB and HDV related chronic hepatitis and resolution of HIV related thrombo
BMJ. 1989 Jun 3;298(6686):1495-6. Unique Identifier : AIDSLINE MED/89336020
Lorge RE
A study was conducted to assess how informed the consent of patients is to the release of confidential information to insurance companies. Questionnaires were sent to 226 consecutive patients from four practices whose general practitioners had received requests to complete a personal medical attendant s report for an
BMJ. 1989 Jun 10;298(6687):1563-6. Unique Identifier : AIDSLINE MED/89336056
Shapiro JA; Department of Community Health, University of Leicester.
A short questionnaire on general practitioners self perceived and actual knowledge of AIDS and their attitudes to the illness was sent to 1824 general practitioners throughout the United Kingdom . The rate of response was 70%. Women doctors, those who trained overseas, and those who we
Sinclair D; Galloway E; McKenzie S; Follett EA; Wallace L; Institute of Biochemistry, Royal Infirmary, Glasgow, U.K.
We tested 150 patients infected with human immunodeficiency virus (HIV) for the presence of oligoclonal bands in serum, prompted by reports that these abnormal proteins may have prognostic significance. Sixty HIV-negative individuals from at-risk groups were tested along with 80 HIV-negative, healthy blood donors for
Filomena CA; Department of Pathology, Thomas Jefferson University,; Philadelphia, PA 19107.
Monoclonal and oligoclonal banding has been observed in electrophoretograms of serum, cerebrospinal fluid, and urinary protein from patients infected with the human immunodeficiency virus (HIV). This is the first report of kappa oligoclonal banding in the protein electrophoretograms for urine but not for serum of two
Broliden PA; Morfeldt-Mansson L; Rosen J; Jondal M; Wahren B; Department of Virology, National Bacteriological Laboratory,; Stockholm, Sweden.
There is an association between the clinical stage of HIV-1 infection and the presence of antibodies against viral gag proteins (p17 and p24). The IgG subclass (G1 and G3) pattern against these antigens was analysed in stable patients and HIV patients progressing to AIDS. Antibodies were analysed with whole viral or p
Sawada T; Tohmatsu J; Obara T; Koide A; Kamihira S; Ichimaru M; Kashiwagi S; Kajiyama W; Matsumura N; Kinoshita K; et al; Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki.
A new enzyme-linked immunosorbent assay (ELISA) for detecting the antibody to a human T-lymphotropic virus type I (HTLV-I) tax gene product, p40tax, has been developed. By this ELISA method, we have investigated the relationship between the presence of p40tax antibody in HTLV-I-infected mothers and the virus transmiss
Kodaka T; Uchiyama T; Umadome H; Uchino H; First Division of Internal Medicine, Faculty of Medicine, Kyoto; University.
HTLV-I infection of peripheral mature T cells appears to induce the expression of cellular genes including those of some cytokines and their receptors. We examined the expression of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2 , IL-3, IL-4 and granulocyte/macrophag
Lau AS; Livesey JF; Department of Pediatrics, The Hospital for Sick Children,; Toronto, Ontario, Canada.
High levels of an acid-labile IFN-alpha have been demonstrated in the sera of patients with symptomatic HIV infection. IFNs have been shown to enhance the cytotoxic and antiproliferative actions of tumor necrosis factor (TNF), which is a potent mediator of inflammation and sepsis. We show that the acid-labile IFN-alph
Reddy MM; McKinley G; Englard A; Grieco MH; R.A. Cooke Institute of Allergy, St. Luke's-Roosevelt Hospital; Center, New York, New York 10019.
Circulating HIV P24 antigen levels at baseline and following AZT therapy were measured in 9 patients with ARC and 11 patients with AIDS. Eight of these patients had no detectable levels of P24. The P24 antigen levels in the remaining 12 patients decre
J Med Primatol. 1989;18(3-4):329-35. Unique Identifier : AIDSLINE MED/89342416
McClure MO; Schulz TF; Tedder RS; Gow J; McKeating JA; Weiss RA; Baskerville A; Institute of Cancer Research, Chester Beatty Laboratories,; London, England.
The susceptibility of common marmosets and cotton-top tamarins to infection by HIV-2 in vivo was tested. One year and 19 months, respectively, post-inoculation, sera taken from three of four animals from each species are reactive for HIV-2 antibodies and HIV-specific nucleotide sequences were demonstrated in short-ter
Laurent AG; Krust B; Rey MA; Montagnier L; Hovanessian AG; Unite d'Oncologie Virale (URA 153 Centre National de la; Recherche Scientifique), Institut Pasteur, Paris, France.
The major core protein (p25) of the human immunodeficiency virus type 1 (HIV-1) was characterized by two-dimensional-gel isoelectric focusing. The p25 detectable in HIV-1-infected cells is composed of four species with related isoelectric points. This is due in part to the phosphorylated state of p25. The four species
Virus isolation from peripheral blood lymphocytes and antigen detection in serum by ELISA were compared in 75 patients with a serologically confirmed HIV infection. 25 per cent of the lymphocyte cultures were HIV positive, but only 2 of the 14 patients were also antigen positive. In addition, infectious virus was not
Stimmler MM; Quismorio FP Jr; McGehee WG; Boylen T; Sharma OP; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033.
We undertook a prospective study of IgG and IgM anticardiolipin antibodies (ACAs) to determine their clinical significance in patients with acquired immunodeficiency syndrome (AIDS). IgG ACAs were found in 24 (92.3%) of 26 patients with AIDS who were hospitalized for pulmonary complaints (group 1) and in 13 (93%) of 1
G Clin Med. 1989 Feb;70(2):105-7. Unique Identifier : AIDSLINE MED/89325944
Marra R; Schifano F; Rinaldo E
HIV infection prevalence and CD4/CD8 ratio alterations in asymptomatic heroin abusers. Authors evaluated HIV infection prevalence and presence of possible CD4/CD8 ratio alteration in a asymptomatic heroin abusers sample. Drug addicts consecutively arrived to Local Health Unit No 12-Drug Addicts Advisory Unit. In this
Winkelstein A; Kingsley LA; Weaver LD; Machen LL; Department of Medicine, Montefiore Hospital, University of; Pittsburgh, School of Medicine, PA 15213.
HIV infection is known to induce a progressive T helper/inducer (CD4) lymphopenia and to impair the functional activities of residual cells. The present studies examined the relationship between the CD4 cell count and three functional assays: T cell colony formation in semisolid media, the capacity of PHA-stimulated c
Putkonen P; Bottiger B; Warstedt K; Thorstensson R; Albert J; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
Ten healthy adult cynomolgus monkeys (Macaca fascicularis) were inoculated with two different isolates of human immunodeficiency virus type 2 (HIV-2), SBL-6669 and SBL-K135, to establish an animal model for HIV infection. HIV-2SBL-6669 had been propagated for a long time in continuous human cell lines whereas HIV-2SBL
Shafer RW; Seitzman PA; Tapper ML; Department of Medicine, Lenox Hill Hospital, New York, New York; 10021.
Thirty-four homosexual patients with AIDS were treated for Pneumocystis carinii pneumonia between April 1984 and November 1985. All 31 survivors were treated with oral trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis immediately upon completion of intravenous therapy, despite the prior occurrence of hypersensitivit
Brinchmann JE; Vartdal F; Thorsby E; Institute of Transplantation Immunology, National Hospital, Oslo,; Norway.
The absolute number of CD4+ and CD8+ T cells was determined by an immunomagnetic technique directly in the blood of 75 healthy controls and 223 HIV-infected individuals. The HIV-seropositive individuals were also classified clinically according to the system recommended by the Centers for Disease Control (CDC), and th
Higginbotham DJ; State University of New York, Buffalo.
This study sought to determine how augmentative communication device output modes differentially affected various aspects of interactions between nonspeaking persons (NSPs) and their speaking partners (SPs). It was hypothesized that when an electronic output display (EOD) was added to a communication board, the semipe
Med Cutan Ibero Lat Am. 1989;17(2):93-7. Unique Identifier : AIDSLINE MED/89329952
Baradad M; Zamora E; Castel T; Iranzo P; Azon A; Barrios C; Servicio de Dermatologia, Hospital Clinic i Provincial,; Barcelona.
A case of clinically characteristic hypersensitivity reaction to phenytoin in a AIDS patient with cerebral toxoplasmosis is reported. There was response to therapy with systemic steroids. Laboratory data and histopathologic features of the skin are reported.
A case with oral Kaposi s sarcoma (KS) is reported that regressed during therapy with Zidovudine ( AZT ) which was started 5 months after the first dermal and oral tumours were noted. After 6 months of treatment the absolute number of T-helper cells had
Telfer NR; Matthews JM; Wojnarowska F; Department of Dermatology, Slade Hospital, Oxford, U.K.
Forty-one patients routinely attending the Oxford Haemophilia Centre entered a controlled, blind investigation in order to determine whether HIV antibody status was related to the presence of skin disease. Twenty-four of the 41 patients (58.5%) were HIV antibody positive and none had any general symptoms. Comparison o
Bielinska A; Krasnow S; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Ann Arbor 48109.
The activation of the human immunodeficiency virus (HIV) enhancer in T cells can occur through multiple independent pathways. This enhancer is stimulated by NF-kappa B or through alternative mechanisms, including E1A transactivation, which is dependent on the TATA box. In this report, the role of the TATA box in activ
Williams JL; Cann AJ; Leff T; Sassone-Corsi P; Chen IS; Department of Medicine, UCLA School of Medicine.
The tax protein of HTLV-II increases the level of steady-state mRNA produced from the HTLV-II long terminal repeat (LTR) and also activates heterologous promoters. We have previously shown that the adenovirus E3 promoter, which is trans-activated by the adenovirus E1a protein, is also trans-activated by the tax protei
Z Hautkr. 1989 Jun 15;64(6):452-4. Unique Identifier : AIDSLINE MED/89348325
Vocks E; Engst R; Worret WI; Dermatologische Klinik und Poliklinik der Technischen; Universitat Munchen.
A 38-year-old male homosexual patient, who had suffered from hepatopathy for many years and from rosacea since 15 years, showed pronounced exacerbation of the rosacea following HIV infection.
Byrne MA; Taylor-Robinson D; Munday PE; Harris JR; Jefferiss Research Wing, Praed Street Clinic, St Mary's Hospital,; London, UK.
Eighteen out of 19 women who were clinically well but infected by HIV showed abnormalities of the lower genital tract. Seven patients had intraepithelial neoplasia, histologically verified in five, involving the cervix in four, the vulva in three and the perineum in one. Lesions (clinical and/or subclinical) compatibl
Braddock M; Chambers A; Wilson W; Esnouf MP; Adams SE; Kingsman AJ; Kingsman SM; Virus Molecular Biology Group Department of Biochemistry, Oxford,; England.
Replication of the human immunodeficiency virus (HIV-1) depends upon the viral TAT protein. TAT stimulates gene expression via a target response sequence (TAR) located within the HIV-1 LTR. As TAR is located in the transcribed region it could act as a signal in either the DNA, the RNA, or both. To test whether TAT act
Penneys NS; Department of Dermatology, University of Miami School of; Medicine, Florida.
In this article, selected aspects of human immunodeficiency virus (HIV) infection are reviewed, particularly as it relates to cutaneous signs and symptoms. Included are discussions of the classification, epidemiology, and clinical manifestations of this complex infectious process.
Vogl T; Dresel S; Kang K; Grevers G; Riederer A; Spath M; Lissner J; Radiologische Klinik, Universitat Munchen.
Pathological lesions of the parotid gland were examined comparatively with different examination sequences both plain and with the contrast medium Gd-DTPA. There were 36 benign lesions (parotitis, Sjogren s syndrome, adenoma, etc.) and 24 malignant tumours (squamous cell carcinoma, adenocarcinoma, adenoid cystic carci
Graybill JR; University of Texas Health Science Center, San Antonio 78284.
For more than two decades, amphotericin B has been the single broad-spectrum agent for the treatment of systemic mycoses. Amphotericin B is not always effective, must be given parenterally, and is associated with a host of adverse reactions. Despite amphotericin B toxicity, until recently the systemic mycoses did not
Putkonen P; Warstedt K; Thorstensson R; Benthin R; Albert J; Lundgren B; Oberg B; Norrby E; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.
Five healthy cynomolgus monkeys were inoculated intravenously with simian immunodeficiency virus (SIVsm) propagated in human lymphocytes. All five animals became infected. Virus was recovered from blood mononuclear cells and viral antigen was detected in serum 12 days postinoculation (PI) in all inoculated animals. Vi
Guiloff RJ; Department of Neurology, Westminster Hospital, London.
Twenty six (41%) of 64 central London cases of AIDS with nervous system involvement during the course of the illness had neurological opportunist infection. Cytomegalovirus and Toxoplasma gondii were the commonest agents in 22 cases with central nervous system (CNS) infection. Eight cases had herpes zoster radiculopat
J Med Chem. 1989 Aug;32(8):1754-7. Unique Identifier : AIDSLINE MED/89328973
Ng KM; Orgel LE; Salk Institute for Biological Studies, San Diego, California; 92138.
We have prepared (4R)-4-thyminyl-D-prolinol, an analogue of 3 -deoxythymidine in which the sugar has been replaced by D-prolinol. This strongly basic secondary amine has been converted to the corresponding hydroxylamine, an analogue of either thymidine or 2 -deoxyxylofuranosylthymine. We have also synthesized a number
Mizrachi Y; Cedars-Sinai Medical Center, UCLA School of Medicine 90024.
Glucophosphoisomerase (GPI), a glycolytic enzyme, was recently described to share 90% sequence homology with neuroleukin, a recently discovered growth factor which promotes motor neuron regeneration in vivo, survival of peripheral and central neurons in vitro, and affects B cell immunoglobulin synthesis. Interestingly
We studied the sensitivity of human herpesvirus-6 (HHV-6) to 4 antiviral drugs known to be effective in the treatment of infections with other human herpesviruses and human immunodeficiency virus. HHV-6 was grown in peripheral blood lymphocytes, and virus multiplication was quantified by evaluation of the cytopathic e
Voelkerding KV; Sandhaus LM; Kim HC; Wilson J; Chittenden T; Levine AJ; Raska K Jr; Department of Pathology, University of Medicine and Dentistry of; New Jersey-Robert Wood Johnson Medical School, Piscataway.
The development of high-grade, malignant B-cell lymphoma is a well-recognized complication of human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features of an unusual plasma cell tumor o
Ann Intern Med. 1989 Aug 15;111(4):293-6. Unique Identifier : AIDSLINE MED/89334185
Bonetti A; Weber R; Vogt MW; Wunderli W; Siegenthaler W; Luthy R; Department of Medicine, University Hospital, University of; Zurich, Switzerland.
A mononucleosis-like illness is frequently recognized retrospectively as the first manifestation of infection with human immunodeficiency virus-type 1 (HIV-1). This acute but transient retroviral syndrome may include symptoms such as malaise, fever, sweats, myalgia, arthralgia, maculopapular rash, diarrhea, and lympho
Shoji S; Tashiro A; Furuishi K; Takenaka O; Kida Y; Horiuchi S; Funakoshi T; Kubota Y; Department of Biochemistry, Faculty of Pharmaceutical Sciences,; Kumamoto University, Japan.
Novel antibodies were raised against a synthetic NH2-terminal myristoyl glycine moiety which is characteristic of N-myristoyl-proteins. Antisera raised against N-myristoyl-Gly-hemocyanin reacted with N-myristoyl-Gly-[125I]albumin. The immunoreaction was competed for by albumin conjugated with N-myristoyl-glycine, whil
Renouf JA; Wood A; Frazer IH; Thong YH; Chalmers AH; Department of Pathology, Mater Misericordiae Public Hospital,; Queensland, Australia.
Enzyme activities were studied in peripheral blood lymphocytes from patients infected with, or at risk for, infection with human immunodeficiency virus (HIV). No significant differences were observed in the HIV-infected and HIV-seronegative high-risk patients with regard to enzyme activities of hypoxanthine-guanine ph
Spector SA; Hsia K; Denaro F; Spector DH; Department of Pediatrics, University of California, San Diego.
Human cytomegalovirus (HCMV) and human immunodeficiency virus (HIV) cause severe disease. The identification of these viruses in clinical specimens and understanding the progression of infection and diseases relating to HCMV and HIV are essential to develop effective means for trea
Previously it was established [Pahwa, S., Pahwa, R., Saxinger, C., Gallo, R. C. & Good, R. A. (1985) Proc. Natl. Acad. Sci. USA 82, 8198] that nonviable preparations of human immunodeficiency virus 1 (HIV-1) abolish the proliferative response of human lymphocytes to phytohemagglutinin A. Now we describe that this e
Severin M; Hartmann C; Schadlich HJ; Brunner R; Rasokat H
In patients with the typical features of intraocular cytomegalovirus infection endothelial precipitates were identified that had a characteristic morphology, which included subtle, non-pigmented linear deposits with reticular arrangement that can spread diffusely over the corneal e
Of 147 patients with AIDS (Walter Reed 3-6), 28 showed signs of retinal infection. Toxoplasmic retinochoroiditis had developed in 5 eyes of 4 patients, whereas cytomegalovirus ( CMV ) retinitis occurred in 40 eyes of 24 patient
Carne CA; Stibe C; Bronkhurst A; Newman SP; Weller IV; Kendall BE; Harrison MJ; Department of Genitourinary Medicine, Middlesex Hospital and; Medical School, London.
Thirty one homosexual men with antibody to human immunodeficiency virus (HIV) but without major neurological complaints were assessed in a cross sectional study of neurological and neuropsychological function. Eleven patients had AIDS, 10 had persistent generalised lymphadenopathy (PGL), and 10 had HIV infection witho
Kim DS; Anthone R; Anthone S; Milgrom F; Department of Microbiology, School of Medicine, State University; of New York, Buffalo.
In conducting double diffusion gel precipitation tests, unexpected, strong precipitation reactions were noticed between a serum originating from a renal graft recipient and many pathological human sera. The highest frequency of positive reactions were produced by sera of patients with infectious mononucleosis (83%), c
Lehtinen T; Lehtinen M; Aine R; Dammert K; Kulomaa P; Alavaikko M; Leinikki P; Department of Oncology and Pathology, Tampere University Central; Hospital, Finland.
The quantity of nuclear DNA in 90 tumours with a strong probability of being associated with Epstein-Barr virus (EBV) (11 cases with nasopharyngeal carcinomas, seven cases of endemic and 26 of non-endemic Burkitt s lymphoma, and 46 cases of Hodgkin s disease) were analysed by flow cytometry. Twenty three cases with be
Verdier M; Denis F; Sangare A; Barin F; Gershy-Damet G; Rey JL; Soro B; Leonard G; Mounier M; Hugon J; Bacteriology-Virology Department, CHU Dupuytren, Limoges, France.
A large cross-sectional serologic survey for human T cell leukemia virus type 1 (HTLV-1) antibody was conducted in 3,177 Ivory Coast residents to evaluate the prevalence of HTLV-1 and to determine possible risk factors and correlates of HTLV-1 infection. Of the 3,177 serum sam
Gormus BJ; Murphey-Corb M; Martin LN; Zhang JY; Baskin GB; Trygg CB; Walsh GP; Meyers WM; Delta Regional Primate Research Center, Tulane University,; Covington, Louisiana 70433.
Thirty-four rhesus monkeys were inoculated with Mycobacterium leprae inoculum isolated from sooty mangabey monkeys with leprosy. Later it was learned that one of the M. leprae-donor mangabeys was asymptomatically infected with simian immunodeficiency virus (SIV). Thus, five of the rhesus monkey were coinoculated with
J Med Primatol. 1989;18(3-4):167-74. Unique Identifier : AIDSLINE MED/89342399
Lairmore MD; Kaplan JE; Daniel MD; Lerche NW; Nara PL; McClure HM; McVicar JW; McKinney RW; Hendry M; Gerone P; et al; Division of Viral Diseases, Centers For Disease Control, Atlanta,; GA.
The authors are members of a working group that formulated guidelines to minimize transmission of simian immunodeficiency virus (SIV) infection to man. Biosafety level (BSL) 2 standards are recommended for handling of clinical specimens and housing of SIV inoculated animals. Manipulation of SIV preparations may be per
J Med Primatol. 1989;18(3-4):175-83. Unique Identifier : AIDSLINE MED/89342400
Tsai CC; Tsai CC; Sligh JM; Yarnall M; Follis KE; Roodman ST; Department of Pathology, St. Louis University School of Medicine,; MO.
Monoclonal antibodies (MoAbs) to the major gag core protein p27 and a viral protein p44 of type D retrovirus (SRV-2) were produced and used in the detection of SRV-2 antigens in infected Raji cells and in tissues from macaques with simian acquired immunodeficiency syndrome (SAIDS) and retroperitoneal fibromatosis (RF)
J Med Primatol. 1989;18(3-4):185-93. Unique Identifier : AIDSLINE MED/89342401
Shiigi S; Wilson B; Leo G; MacDonald N; Toyooka D; Hallick L; Karty R; Belozer ML; McNulty W; Wolff J; et al; Division of Primate Medicine, Oregon Regional Primate Research; Center, Beaverton.
Celebes macaques were tested for type D simian retrovirus (SRV) infection. SRV infection was first detected in one serum sample collected during 1980. By 1983, 32 of 46 monkeys (70%) were infected. Serotyping of the SRV isolates determined that 0/26 of the isolates were SRV-1; 24/26 were SRV-2; 1/26 was SRV-5; and 1/2
J Med Primatol. 1989;18(3-4):195-207. Unique Identifier : AIDSLINE MED/89342402
Lackner AA; Schiodt M; Armitage GC; Moore PF; Munn RJ; Marx PA; Gardner MB; Lowenstine LJ; California Primate Research Center, University of California,; Davis.
Simian acquired immune deficiency syndrome (SAIDS) caused by the type D retrovirus SRV-1 results in opportunistic infections and a spectrum of oral lesions similar to those seen in humans with AIDS. To better understand the pathogenesis of these oral lesions we have retrospectively examined the oral mucosa from ten rh
J Med Primatol. 1989;18(3-4):209-15. Unique Identifier : AIDSLINE MED/89342403
Wyand MS; Ringler DJ; Mattmuller M; Daniel MD; Desrosiers RC; King NW; Department of Comparative Pathology, Harvard Medical School, MA.
A tritium-labeled DNA envelope gene probe was used to detect Simian Immunodeficiency Virus in formalin fixed lymph nodes from rhesus monkeys experimentally inoculated with SIVmac251. Cells containing SIV RNA produced strong hybridization signal and were present in small numbers in biopsy specimens and in much greater
J Med Primatol. 1989;18(3-4):237-45. Unique Identifier : AIDSLINE MED/89342406
Morton WR; Kuller L; Benveniste RE; Clark EA; Tsai CC; Gale MJ; Thouless ME; Overbaugh J; Katze MG; Regional Primate Research Center, University of Washington,; Seattle.
A primate lymphotropic lentivirus was isolated on Hut 78 cells after cocultivation of a lymph node from a macaque that died with malignant lymphoma. In earlier studies SIV/Mne was inoculated into 17 macaques and two baboons. All of the macaques became viremic and seropositive. Fifteen of the macaques succumbed to a cl
J Med Primatol. 1989;18(3-4):247-54. Unique Identifier : AIDSLINE MED/89342407
Gravell M; London WT; Hamilton RS; Stone G; Monzon M; Infectious Diseases Branch, National Institute of Neurological; Disorders and Stroke, Bethesda, MD.
The virulence of three isolates of simian immunodeficiency virus from African green monkeys (SIVagm) was studied in rhesus and pigtailed macaques. None of 15 rhesus monkeys and one of four pigtailed monkeys died from infection during the time they were studied (up to 33 months). SIVagm was only isolated from rhesus mo
J Med Primatol. 1989;18(3-4):255-9. Unique Identifier : AIDSLINE MED/89342408
Miura T; Tsujimoto H; Fukasawa M; Ohta Y; Honjo S; Hayami M; Institute for Virus Research, Kyoto University, Japan.
Recently, the authors determined the partial sequence of simian immunodeficiency virus (SIV) from the mandrill (SIVMND) and found SIVMND to be a new member of the HIV/SIV group, equidistant from other members, including SIVAGM. Experimentally, the African green monkey and cynomolgus monkey could be infected with SIVAG
J Med Primatol. 1989;18(3-4):271-7. Unique Identifier : AIDSLINE MED/89342410
Johnson PR; Gravell M; Allan J; Goldstein S; Olmsted RA; Dapolito G; McGann C; London WT; Purcell RH; Hirsch VM; Department of Microbiology, Georgetown University, Washington,; DC.
To characterize isolates further within the SIVagm subtype, we studied four SIVagm isolates by cross-hybridization, molecular cloning, and nucleotide sequencing. Our results indicate an unexpected degree of genetic variation among isolates within the SIVagm subtype comparable to the variation between SIVmac and HIV-2.
J Med Primatol. 1989;18(3-4):279-85. Unique Identifier : AIDSLINE MED/89342411
Hirsch VM; Dapolito G; McGann C; Olmsted RA; Purcell RH; Johnson PR; Department of Microbiology, Georgetown University, Washington,; DC.
We derived two infectious molecular clones of SIV from sooty mangabey monkeys (Cercocebus atys) and compared them by restriction enzyme mapping and limited DNA sequencing to other known primate lentiviruses. These analyses show that SIVsmm is closely related to, but distinct from, SIVmac and HIV-2. Our data suggest th
J Med Primatol. 1989;18(3-4):287-303. Unique Identifier : AIDSLINE MED/89342412
Benveniste RE; Raben D; Hill RW; Knott WB; Drummond JE; Arthur LO; Jahrling PB; Morton WR; Henderson LE; Heidecker G; Laboratory of Viral Carcinogenesis, National Cancer Institute,; Frederick, MD.
Simian immunodeficiency virus (SIV)/Mne has been inoculated into three species of macaques and into baboons. Virus was isolated from all the macaques who subsequently died at 15 to 120 weeks (mean 80 weeks) with various manifestations of immune deficiency. Individual animals varied in their viral antibody profile as a
J Med Primatol. 1989;18(3-4):311-9. Unique Identifier : AIDSLINE MED/89342414
Marthas ML; Banapour B; Sutjipto S; Siegel ME; Marx PA; Gardner MB; Pedersen NC; Luciw PA; Department of Veterinary Medicine, School of Veterinary Medicine,; Davis, CA.
We have isolated a biologically active molecular clone of simian immunodeficiency virus (SIV), SIVmac 1A11, originally obtained from a rhesus macaque at the New England Regional Primate Research Center. Virus derived from cells transfected with this clone is cytopathic for rhesus peripheral blood mononuclear cells, re
J Med Primatol. 1989;18(3-4):321-8. Unique Identifier : AIDSLINE MED/89342415
Gardner MB; Jennings M; Carlson JR; Lerche N; McGraw T; Luciw P; Marx P; Pedersen N; Department of Medical Pathology, University of California, Davis.
An inactivated whole simian immunodeficiency virus (SIV) immunogen given to healthy, seropositive rhesus macaques 4 months after infection had no effect on the humoral immune response to SIV, the presence of antigenemia, cell-associated viremia, or disease course. Further immunotherapeutic trials in this highly suscep
J Med Primatol. 1989;18(3-4):363-9. Unique Identifier : AIDSLINE MED/89342420
Krohn K; Ranki A; Lusso P; Moss B; Ashorn P; Arthur LO; Putney SD; Gallo RC; Institute of Biomedical Sciences, University of Tampere, Finland.
Human immunodeficiency virus (HIV)-specific helper T-cell response was studied in human subjects and nonhuman primates either infected with HIV or immunized with different HIV protein preparations. A strong group-specific T-cell response involving T-cell proliferation and lymphokine secretion was observed in immunized
Willey RL; Ross EK; Buckler-White AJ; Theodore TS; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
A previously reported amino acid substitution within the second conserved domain of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope results in the production of noninfectious particles. Molecular characterization of spontaneous revertant viruses, which arose during long-term cocultures of this env mutan
Activation of genes for interleukin 2 (IL2) and its receptor by the tat gene product of the human retrovirus HTLV-I has been linked to the pathogenesis of adult T cell leukemia. In earlier studies we have demonstrated that IL2-induced inhibition of erythropoiesis is mediated by activated T-Lymphocytes expressing the I
Nakamura M; Niki M; Ohtani K; Sugamura K; Department of Microbiology, Tohoku University School of Medicine,; Sendai, Japan.
A transcriptional trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I) functions as an inducer for expression of HTLV-I provirus via activation of the enhancer in the long terminal repeat of HTLV-I. In addition to p40tax and a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5963-7. Unique Identifier : AIDSLINE MED/89345585
Lavie G; Valentine F; Levin B; Mazur Y; Gallo G; Lavie D; Weiner D; Meruelo D; Department of Pathology, Kaplan Cancer Center, New York; University Medical Center, NY 10016.
Administration of the aromatic polycyclic dione compounds hypericin or pseudohypericin to experimental animals provides protection from disease induced by retroviruses that give rise to acute, as well as slowly progressive, diseases. For example, survival from Friend virus-induced leukemia is significantly prolonged b
Proc Natl Acad Sci U S A. 1989 Aug;86(16):6353-7. Unique Identifier : AIDSLINE MED/89345662
Desrosiers RC; Wyand MS; Kodama T; Ringler DJ; Arthur LO; Sehgal PK; Letvin NL; King NW; Daniel MD; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.
Rhesus monkeys were immunized by multiple inoculations with purified, disrupted, noninfectious simian immunodeficiency virus (SIV) in adjuvant. Immunized monkeys developed anti-SIV antibodies detectable by whole-virus ELISA and by immunoblot reactivity; these antibodies had weak neutralizing activity. One week after t
Science. 1989 Aug 11;245(4918):616-21. Unique Identifier : AIDSLINE MED/89346747
Wlodawer A; Miller M; Jaskolski M; Sathyanarayana BK; Baldwin E; Weber IT; Selk LM; Clawson L; Schneider J; Kent SB; Crystallography Laboratory, NCI-Frederick Cancer Research; Facility, MD 21701.
The rational design of drugs that can inhibit the action of viral proteases depends on obtaining accurate structures of these enzymes. The crystal structure of chemically synthesized HIV-1 protease has been determined at 2.8 angstrom resolution (R factor of 0.184) with the use of a model based on the Rous sarcoma viru
South Med J. 1989 Aug;82(8):1056-7. Unique Identifier : AIDSLINE MED/89346936
Tucker RM; Swanson S; Wenzel RP; Department of Medicine, University of Virginia, Charlottesville.
We have reported the case of a patient with AIDS who had appendiceal perforation and periappendiceal abscess. Extensive infection with cytomegalovirus was found in the appendix; no other pathogen could be implicated in the perforation. This case emphasizes the broad spectrum of dis
Sculley TB; Apolloni A; Stumm R; Moss DJ; Mueller-Lantczh N; Misko IS; Cooper DA; Queensland Institute of Medical Research, Herston, Brisbane,; Australia.
A high proportion of HIV-positive sera were found to react with 130- and 180-kDa antigens which were present in the Jijoye cell line. The majority of the HIV-positive sera which detected these antigens also contained antibodies to Epstein-Barr virus (EBV) nuclear antigen 2B (EBNA2B) suggesting a relationship between B
Ho DD; Bredesen DE; Vinters HV; Daar ES; Cedars-Sinai Medical Center, Los Angeles, CA 90048.
The acquired immunodeficiency syndrome (AIDS) dementia complex is a frequent and devastating complication of infection with human immunodeficiency virus-type 1 (HIV-1). Features of the AIDS dementia complex include decreased memory, the inability to concentrate, apathy, and psychom
Spector SA; Ripley D; Hsia K; Department of Pediatrics, University of California, San Diego; 92103.
The inhibition of the lymphadenopathy-associated virus strain of human immunodeficiency virus (HIV) by alternating regimens of two dideoxynucleosides, 3 -azido-3 -deoxythymidine ( AZT ) (zidovudine) and 2 ,3 -dideoxycytidine (
Laga M; Taelman H; Van der Stuyft P; Bonneux L; Vercauteren G; Piot P; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
To define the rate of HIV infection and associated risk factors among heterosexual partners of HIV-infected individuals, 80 partners and 77 index cases were examined for clinical, behavioural and virological variables. The study population included 61 male and 16 female index cases, of whom 40 were European and 37 Afr
Cohen JH; Geffriaud C; Caudwell V; Kazatchkine MD; Laboratoire d'Immunologie, Hopital R. Debre, Reims, Paris,; France.
The number of C3b receptor (CR1) molecules on erythrocytes is genetically determined by two codominant autosomal alleles. The genetic polymorphism of CR1 expression correlates with a Hind III restriction fragment length polymorphism (RFLP) of the CR1 gene. The relative frequency of individuals homozygous for the allel
Weimer R; Schweighoffer T; Schimpf K; Opelz G; Department of Transplantation Immunology, University of; Heidelberg, West Germany.
T-lymphocyte helper and suppressor functions were assessed in 61 hemophilia patients. Twenty one patients were HIV-negative (Group 1), 27 were HIV-positive without having AIDS-related complex (ARC)/AIDS (Group 2), and 13 had ARC/AIDS (Group 3). T, CD4-positive, or CD8-positive T lymphocytes were cocultured with B lymp
Penneys NS; Nayar JK; Bernstein H; Knight JW; Department of Dermatology, University of Miami School of; Medicine, FL.
Five of seven patients with acquired immunodeficiency syndrome (AIDS) who had pruritus and a chronic, nonspecific-appearing skin eruption had increased antibody titers to antigens in the salivary glands of Aedes taeniorhynchus, a salt marsh mosquito common to South Florida. We hypothesize that the pruritus and skin le
Lancet. 1989 Aug 5;2(8658):294-7. Unique Identifier : AIDSLINE MED/89330029
Esteban JI; Esteban R; Viladomiu L; Lopez-Talavera JC; Gonzalez A; Hernandez JM; Roget M; Vargas V; Genesca J; Buti M; et al; Department of Internal Medicine, Hospital Vall d'Hebron,; Universitat Autonoma, Barcelona, Spain.
The frequency of hepatitis C virus (HCV) infection in Spain was assessed by means of a recombinant-based immunoassay for serum anti-HCV antibodies. 836 serum samples were tested from 676 patients selected according to their risk of blood-borne viral infections and presence of liver
Prince HE; Lesar WJ; American Red Cross Blood Services, Los Angeles, California 90006.
A distinguishing feature of the Spectrum III flow cytometer is its capacity to analyze a constant volume of cell suspension. The authors have capitalized on this feature to directly and simultaneously measure the absolute numbers of all lymphocytes and CD4+ lymphocytes per microliter of peripheral blood. The study gro
Marra R; Schifano F; Rinaldo E; Favaro W; Gavioli A
The OKT4 (helper) and OKT8 (suppressor) lymphocytic subpopulations were enumerated in a sample of 60 asymptomatic drug addicts and in 17 controls. No significant differences in the ratio could be found that could not be explained by the action of HIV. It can be concluded that heroin itself was not responsible for any
J Med Primatol. 1989;18(3-4):261-9. Unique Identifier : AIDSLINE MED/89342409
Li Y; Naidu Y; Fultz P; Daniel MD; Desrosiers RC; New England Regional Primate Research Center, Southborough, MA.
We have demonstrated that the genetic diversity of simian immunodeficiency virus from African green monkeys (SIVagm) is much greater than that observed previously for individual HIV-1, HIV-2, or SIVmac isolates. Extensive genetic variation among SIVagm isolates and the high prevalence of green monkey infection without
Lancet. 1989 Aug 19;2(8660):403-7. Unique Identifier : AIDSLINE MED/89343393
Cameron DW; Simonsen JN; D'Costa LJ; Ronald AR; Maitha GM; Gakinya MN; Cheang M; Ndinya-Achola JO; Piot P; Brunham RC; et al; Department of Medical Microbiology, University of Nairobi, Kenya.
To determine the frequency and risk factors for female to male sexual transmission of human immunodeficiency virus type 1 (HIV-1), a prospective study was carried out in 422 men who had acquired a sexually transmitted disease (STD) from a group of prostitutes with a prevalence of HIV-1 infection of 85%. The initial se
Between July and November, 1988, 1501 consecutive adult medical admissions to the two largest hospitals in Abidjan, Ivory Coast , were studied. The overall prevalence of infection with human immunodeficiency virus (HIV) types 1 and 2 was 43% in hospital A and 28% in hospital B.
Etkin AF; Litvinov SV; Gurevich MM; Central Research Institute of Epidemiology, U.S.S.R. Ministry of; Health, Moscow.
A panel of 11 retroviruses including animal retroviruses types B, C, D and human retroviruses HTLV-I and HTLV-III was used as antigen for detection of antibodies in 265 sera of patients suffering from haematologic and autoimmune diseases and in 98 control sera. In contrast to the control sera, the 39 patients sera con
Polsky B; Segal SJ; Baron PA; Gold JW; Ueno H; Armstrong D; Infectious Disease Service, Memorial Sloan-Kettering Cancer; Center, New York, New York.
Gossypol, a polyphenolic aldehyde extracted from cottonseed, is a male anti-fertility agent which has been reported to have anti-viral activity. In this paper we report that gossypol inactivates human immunodeficiency virus (HIV) in an in vitro system. Following exposure of cell-free incubates of HIV to 100 uM gossypo
Damstrup L; Daugaard G; Gerstoft J; Rorth M; Department of Oncology ONB, Finsen Institute, Copenhagen,; Denmark.
Among 101 patients with testicular cancer referred to the Department of Oncology ONB, Finsen Institute, four were proven HIV-positive before admission. Three of these patients were treated with cisplatin, 4-epi-podophyllotoxin (VP-16, Etoposide) and bleomycin. One patient with stage I of the testicular cancer was obse
The modulatory activity of dextran sulfate with a relative molecular mass of 8 and 500 kDa and pentosan polysulfate with a relative molecular mass of 6 kDa on human T cell surface molecules CD2, CD3, CD4, CD8 and HLA-DR was investigated by analytical flow cytometry. The 500-kDa dextran sulfate induces a complete disap
J Med Virol. 1989 Jul;28(3):129-32. Unique Identifier : AIDSLINE MED/89328405
Furlini G; Re MC; Ferranti G; Dalla Casa P; La Placa M; Institute of Microbiology, University of Bologna, St. Orsola; Hospital, Italy.
Forty children born to mothers seropositive for the human immunodeficiency virus type 1 (HIV-1) followed-up to 15 months after birth were studied by means of serum antibody patterns to individual viral polypeptides, by the presence of detectable levels of viral core antigen (p24) and virus in serum and peripheral bloo
Wolf P; Reiser JR; Fellow JE; Haghighi P; Department of Internal Medicine, University of California Medical; Center, San Diego 92103.
We have studied two patients who developed pancreatitis and who died of complications of acquired immune deficiency syndrome (AIDS). From clinical analysis, presumptively, both patients developed CMV pancreatitis as a complication of AIDS.
Finch W; Veterans Administration Medical Center, Phoenix.
The term enteropathic arthritis describes joint manifestations that occur in conjunction with gastrointestinal disease. Underlying causes include inflammatory bowel disease, reactive arthritis, iatrogenic disease. Whipple s disease, and other gastrointestinal diseases. A possible association between Reiter s syndrome
Philos Trans R Soc Lond B Biol Sci. 1989 Jun 12;323(1217):535-44. Unique Identifier : AIDSLINE MED/89331587
Berzofsky JA; Metabolism Branch, National Cancer Institute, Bethesda, Maryland; 20892.
T lymphocytes, in contrast to antibodies, appear to recognize primarily a limited number of antigenic sites on any given antigenic protein. We find that a single site can so dominate the T-cell repertoire that the presence or absence of a response to one immunodominant site can make the difference between a high respo
Am J Pathol. 1989 Jun;134(6):1329-38. Unique Identifier : AIDSLINE MED/89333883
Schuurman HJ; Krone WJ; Broekhuizen R; van Baarlen J; van Veen P; Golstein AL; Huber J; Goudsmit J; Department of Internal Medicine University Hospital, The; Netherlands.
The authors studied thymus specimens taken at autopsy from eight acquired immune deficiency syndrome (AIDS) patients and compared these with those taken from four patients with congenital immunodeficiency (unrelated to an intrinsic thymus defect) and seven patients after allogeneic bone marrow transplantation. In all
Muller B; Restle T; Weiss S; Gautel M; Sczakiel G; Goody RS; Abteilung Biophysik, Max-Planck Institut fur Medizinische; Forschung, Heidelberg, Federal Republic of Germany.
Expression of the 66-kDa form of human immunodeficiency virus, type 1 reverse transcriptase in Escherichia coli leads to isolation of small amounts of a 2 x 66-kDa homodimer and larger amounts of a heterodimer form of the enzyme in which the 66-kDa protein is complexed with its carboxyl-terminally truncated is complex
Spickett G; Beattie RE; Bountiff L; Dalgleish AG; Webster AD; Department of Immunological Medicine, Clinical Research Centre,; Harrow, Oxford, U.K.
We have compared the infectivity titres, reverse transcriptase levels and antigen titres in the supernatants from persistently infected cell lines that produce a variety of HIV-1 isolates. We found a poor correlation between the different assays, and a variability in viral activity dependent on culture medium.
Molina JM; Scadden DT; Byrn R; Dinarello CA; Groopman JE; Division of Hematology/Oncology, New England Deaconess Hospital,; Boston, Massachusetts 02215.
The production of tumor necrosis factor alpha (TNF alpha) and IL-1 beta by the monocytic cell line THP-1, productively infected with HIV-1, was investigated using specific RIA and Northern blot analysis. HIV-infected cells, like uninfected cells, did not constitutively produce any detectable amounts of protein or mRNA
McKhann G 2d; Gibbs CJ Jr; Mora CA; Rodgers-Johnson PE; Liberski PP; Gdula WJ; Zaninovic V; Laboratory of Central Nervous System Studies, National Institute; of Neurological Disorders and Stroke, Bethesda, Maryland.
Human T lymphotropic virus type I (HTLV-I) was isolated from peripheral blood- and cerebrospinal fluid-derived mononuclear cells of a 13-y-old boy and from the peripheral blood lymphocytes of both his parents. All three had IgG antibodies to HTLV-I and varying degrees of the clinical features of tropical spastic parap
Pfister HW; Einhaupl KM; Wick M; Fateh-Moghadam A; Huber M; Schielke E; Goebel FD; Matuschke A; Heinrich B; Bogner JR; et al; Neurologische Klinik, Universitat Munchen, Federal Republic of; Germany.
The major pathological abnormalities of HIV encephalopathy are infiltrates of macrophages, multinucleated giant cells, microglial nodules and demyelination. Elevated myelin basic protein (MBP) levels in the cerebrospinal fluid (CSF) provide a marker for central nervous system demyelination. The purpose of this study w
J Med Primatol. 1989;18(3-4):217-26. Unique Identifier : AIDSLINE MED/89342404
Ringler DJ; Wyand MS; Walsh DG; MacKey JJ; Sehgal PK; Daniel MD; Desrosiers RC; King NW; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA.
Alveolar macrophages obtained from healthy rhesus monkeys were infected with SIV in vitro as documented by the appearance of reverse transcriptase activity in the cell-free supernatant, electronmicroscopy, and immunohistochemical methods detecting SIV-related core protein. The results demonstrate permissive infection
J Med Primatol. 1989;18(3-4):357-62. Unique Identifier : AIDSLINE MED/89342419
Goudsmit J; Bakker M; Smit L; Meloen RH; Human Retrovirus Laboratory, Academic Medical Center, Amsterdam,; The Netherlands.
Sera from three chimpanzees infected with a primary lymphadenopathy-associated virus (LAV-1) or human T-lymphotropic virus type III (HTLV-IIIB) passage, from two chimpanzees infected with blood from the primary infected chimpanzees, and from one chimpanzee infected with blood from a secondary passage animal all bound
Sun NC; Ho DD; Sun CR; Liou RS; Gordon W; Fung MS; Li XL; Ting RC; Lee TH; Chang NT; et al; Tanox Biosystems, Inc., Houston, Texas 77025.
A panel of seven monoclonal antibodies against the relatively conserved CD4-binding domain on human immunodeficiency virus type 1 (HIV-1) gp120 was generated by immunizing mice with purified gp120. These monoclonal antibodies reacted specifically with gp120 in an enzyme-linked immunosorbent assay and Western blots (im
Tan TH; Jia R; Roeder RG; Laboratory of Biochemistry and Molecular Biology, Rockefeller; University, New York, New York 10021-6399.
The human T-cell leukemia virus type I (HTLV-I) trans-activator (tax)-inducible enhancer was localized to three copies of 21-base-pair repeats within the long terminal repeat. Interestingly, the TGACG motif found in the center of the 21-base-pair tax-responsive element (TRE) is also present in the cyclic AMP (cAMP)-re
Windheuser MG; Tegtmeier GE; Wood C; Department of Microbiology, University of Kansas, Lawrence,; Kansas 66045.
The human immunodeficiency virus (HIV) p24 core protein is one of the most immunogenic of HIV structural proteins. Infected individuals develop high titers of antibodies against p24 early in infection, which makes anti-p24 antibodies important serological markers. However, despite the clinical importance of the anti-p
Mutations were introduced by recombinant DNA techniques into the vpr open reading frame of an infectious molecular clone of human immunodeficiency virus type 1. The effect of these changes on the replicative and cytopathologic properties of the virus recovered from transfected cells was studied in several human CD4+ l
Marshall DW; Brey RL; Butzin CA; Department of Neurology, Wilford Hall USAF Medical Center, San; Antonio, TX.
We evaluated 130 consecutive HIV-infected neurologically asymptomatic individuals for intrathecal IgG production and myelin basic protein (MBP) levels. Although 56.7% of immunologically normal and 68.8% of immunocompromised patients had some CSF abnormality, no patient had an abnormal MBP level. The lack of MBP elevat
Several gene fusions have been constructed in which coding sequences for antigenic regions of the pre-S sequences of hepatitis B virus, hepatitis B surface antigen, and the envelope protein of human immunodeficiency virus were linked to the 3 end of that for the first 144 residues of hepatitis B core antigen. The seq
Proc Natl Acad Sci U S A. 1989 Aug;86(16):6388-92. Unique Identifier : AIDSLINE MED/89345669
Srinivasan A; York D; Jannoun-Nasr R; Kalyanaraman S; Swan D; Benson J; Bohan C; Luciw PA; Schnoll S; Robinson RA; et al; Retrovirus Diseases Branch, Centers for Disease Control, Atlanta,; GA 30333.
Human immunodeficiency virus (HIV) type 1, isolated from diverse sources, exhibits genomic diversity. The mechanisms by which the genomic diversity takes place in individuals exposed to multiple virus isolates is yet to be elucidated. Genetic variation, in general, might result from mutagenic events such as point muta
South Med J. 1989 Aug;82(8):957-9. Unique Identifier : AIDSLINE MED/89346952
Moas CM; Evans DA; Stein-Streilein J; Ganjei P; Pitchenik AE; Department of Medicine, University of Miami Medical Center, Fla.
Over a three-month period at the pathology laboratory of Jackson Memorial Hospital, 110 sputum samples from 62 hospitalized patients with suspected AIDS were examined for Pneumocystis carinii. Sputum specimens were either expectorated spontaneously (most patients) or expectorated after the inhalation of small amounts
Starnes MC; Cheng YC; Department of Pharmacology, School of Medicine, University of; North Carolina, Chapel Hill 27599.
The 2 ,3 -dideoxynucleoside triphosphates (ddNTPs) are potent substrate analog inhibitors of human immunodeficiency virus (HIV) reverse transcriptase and have clinical utility in the treatment of acquired immunodeficiency syndrome. Several issues regarding the interaction of these compounds with HIV reverse transcript
North TW; North GL; Pedersen NC; Division of Biological Sciences, University of Montana, Missoula; 59812.
Feline immunodeficiency virus (FIV), formerly called feline T-lymphotropic lentivirus, causes an immune deficiency in cats that is very similar to the acquired immune deficiency syndrome in humans (N. C. Pedersen, E. M. Ho, M. L. Brown, and J. K. Yamamoto, Science 235:790-793, 1987). We have examined the reverse trans
Federal Supplement. 1987 Aug 5 (date of decision);666:1524-1538. Unique Identifier : AIDSLINE KIE/28196
The parents of three hemophiliac school children who tested seropositive for human immunodeficiency virus (HIV) established irreparable injury arising from the continued denial of access to a classroom for the children and were granted an injunction by the U.S. District Court in Tampa, Florida, admitting the children
London: The Association; available from the National Reference Center for Bioethics Literature, Kennedy Institute of Ethics, Georgetown University, Washington, D.C. 20057, 1-800-MED-ETHX or (202) 687-3885, 1989 Feb 3 p Unique Identifier : AIDSLINE KIE/28254
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