KAPOSI'S SARCOMA: AN OVERVIEW OF CLASSICAL AND EPIDEMIC FORMS NLM AIDSLINE Important note: Information in this article was accurate in 1989. The state of the art may have changed since the publication date.

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KAPOSI'S SARCOMA: AN OVERVIEW OF CLASSICAL AND EPIDEMIC FORMS

AIDS: Modern Concepts and Therapeutic Challenges. Broder S, ed. New York, Marcel Dekker, p. 205-18, 1987.. Unique Identifier : AIDSLINE ICDB/89650443
Safai B; Dermatology Service, Dept. of Medicine, Memorial Sloan-Kettering; Cancer Center, New York, NY

Abstract: Kaposi's sarcoma (KS) is reviewed under the following headings: history, epidemiology (incidence and sex, age and racial distribution), clinical manifestations and course of the disease, histopathology, associated diseases, and histogenesis. Prior to 1981, KS was considered a rare tumor that occurred in cluster distribution. In this new epidemic form, KS presents with a more aggressive course involving skin, GI tract, lymph nodes, and other organs. The etiology of KS is still unknown. It seems likely that the presence of a certain degree of immune dysbalance, repeated antigenic stimulation, and persistent cytomegalovirus (CMV) infection in a genetically predisposed individual may result in development of KS. CMV has been quite prevalent among homosexual men for some time, but increased incidence of KS is quite recent in this group. This indicates that, while CMV may play a role as a cofactor, it is unlikely to play an etiological role. Infection with human T-lymphotropic virus may cause release of a mediator(s), which in turn may result in proliferation of endothelial cells and formation of KS tumor. (71 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/EPIDEMIOLOGY Adolescence Adult Child Cross-Sectional Studies *Disease Outbreaks Female Human Male Neoplasms, Multiple Primary/PATHOLOGY Sarcoma, Kaposi's/EPIDEMIOLOGY/*PATHOLOGY Skin/PATHOLOGY Skin Neoplasms/EPIDEMIOLOGY/*PATHOLOGY United States MONOGRAPH REVIEW, TUTORIAL REVIEW

KWDacquiredimmunodeficiencysyndrome/KWDcomplications/epidemiologyadolescenceadultchildcross-sectionalstudiesKWDdiseaseoutbreaksfemalehumanmaleneoplasms,multipleprimary/pathologysarcoma,kaposi's/epidemiology/KWDpathologyskin/pathologyskinneoplasms/epidemiology/KWDpathologyunitedstatesmonographreview,tutorialreview
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M8950696

Copyright © 1989 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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